CN101596204A - 一种复方氟康唑软膏及其制备方法 - Google Patents
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Abstract
本发明的复方氟康唑软膏由氟康唑、硫酸新霉素、凡士林、羊毛脂、液体石蜡、硬脂酸、司盘－80、司盘－85、吐温－80、山梨酸、A－200、A－380、甘油、DMF、乙酸乙酯和蒸馏水所组成。本发明将耳肤灵中的制霉菌素用新一代***类药物氟康唑代替，并将氟康唑与硫酸新霉素联合使用治疗深度真菌感染，具有良好的疗效。本软膏抗菌谱扩大，抗菌性增强，毒副作用减小，并能达到深度治疗的效果。药敏及临床实验表明本发明能够有效控制动物耳道挠痒症以及皮肤和耳道内的霉菌及酵母菌感染，对犬、猫的局部霉菌感染也有效，还能够治疗任何可能的原发性及继发性细菌感染。使用于皮肤及耳道表面，可有效舒解炎症反应及止痒。
Description
技术领域
本发明涉及一种用于治疗狗、猫等宠物耳道或皮肤真菌感染的复方氟康唑软膏及其制备方法。
背景技术
耳道真菌病多数因为环境和湿度增加有利于真菌生长或慢性中耳炎易合并真菌感染所致。狗、猫等宠物患耳道病及皮肤感染病的机率比较高，目前国内市场上治疗耳道真菌感染的药物比较匮乏。常用的治疗宠物耳道病感染的软膏制剂为法国威隆Oridermyl的耳肤灵软膏。该耳肤灵软膏的主要成分为硫酸新霉素和制霉菌素，制霉菌素多用于浅部真菌的治疗，局部用药不被皮肤粘膜吸收，且毒性大，缺乏特异性。目前，法国威隆耳肤灵软膏在我国的售价很高，10g/支的价格为60元左右，迫切需要我们研制出一种疗效更好，毒性更小，成本更低的替代药物。
发明内容
本发明的目的是提供一种复方氟康唑软膏及其制备方法，它能满足现有技术的上述需求。
一种复方氟康唑软膏，其特征在于它的组分和质量百分数为：氟康唑0.6-5、硫酸新霉素0.2-2、凡士林6-11、羊毛脂2-5、液体石蜡38-46、硬脂酸2-5、司盘-80 4-13、司盘-85 3-6、吐温-80 3-7、山梨酸0.2-0.5、A-200 3-5、A-380 2-5、甘油1-2、DMF1-5、乙酸乙酯3-9、蒸馏水6-15。
上述复方氟康唑软膏的制备方法，其特征在于先称取液体石蜡、凡士林、羊毛脂、硬脂酸、司盘-80、司盘-85、吐温-80和山梨酸，将它们置于水浴中加热融熔，温度保持在80-85℃形成基质；再称取A-200和A-380加入上述基质中，搅拌均匀形成油相；另将硫酸新霉素加入蒸馏水中，溶解，再加入甘油，加热至85-90℃，搅拌溶解形成为水相；将该水相加入上述油相中，搅拌制成乳化液；另将氟康唑加入N，N-二甲基甲酰胺中，搅拌溶解，再加入乙酸乙酯，搅拌均匀形成氟康唑溶液；在50-60℃、1000r/min搅拌下，将该氟康唑溶液加入到上述乳化液中，室温匀速搅拌，成型。
本发明的软膏参考了法国威隆耳肤灵的组方，在设计方面更加灵活，将耳肤灵中的制霉菌素用新一代***类药物氟康唑代替，并将氟康唑与硫酸新霉素联合使用治疗深度真菌感染，具有良好的疗效。与耳肤灵软膏相比，本软膏的组方抗菌谱扩大，抗菌性增强，毒副作用减小，并能达到深度治疗的效果。药敏及临床实验表明本发明能够有效控制动物耳道挠痒症以及皮肤和耳道内的霉菌及酵母菌感染，对犬、猫的局部霉菌感染也有效；同时能够治疗任何可能的原发性及继发性细菌感染。使用于皮肤及耳道表面，可有效舒解炎症反应及止痒。
本发明的制备方法简单，经过稳定性试验表明，制得的产品稳定性和安全性均良好。开发本产品，不但可以降低药品的价格，为兽医临床提供优质产品，还可以填补国内空白，创造出较大的经济效益和社会效益。
具体实施方式
本发明根据氟康唑和硫酸新霉素的性质，选用了合适的油相和水相以及药物溶剂相，选用合适的油溶性基质和水溶性基质，组成了复方氟康唑软膏的组方，通过优选工艺参数，选择了最优工艺，制备了均匀细腻稳定性和疗效良好的复方氟康唑软膏。
本发明的复方氟康唑软膏，选用主要常用的软膏剂基质：以液体石蜡为主要基质，通过加入凡士林、羊毛脂来调节软膏的稠度和吸水性，加入硬脂酸作为珠光剂，加入纳米级的A-200和A-380来增加软膏的防沉和铺展性能，通过加入非离子型的表面活性剂来增加两相体系的相容性。加入少量的N，N-二甲基甲酰胺(DMF)溶解氟康唑，并在其中加入少量乙酸乙酯，能保证氟康唑在加入到软膏剂基质中时，能迅速分散成分子和微晶的形态，增加药物的使用效果。在水相中加入甘油来增加软膏的抗冻性能。
制备本发明的复方氟康唑软膏时，先称取将液体石蜡460g、凡士林110g、羊毛脂60g、硬脂酸40g及40g司盘-80、30g司盘-85、30g吐温-80和山梨酸2g，将它们置于水浴中加热融熔，温度保持在80-85℃形成基质，再称取30g A-200和20g A-380加入上述基质中，搅拌均匀，形成油相；另将硫酸新霉素5.4g，使其溶解在56.6g加蒸馏水中，再加入甘油10g，加热至85℃，搅拌溶解，形成水相；将该水相加入上述油相中，以800-1000r/min搅拌，制成乳化液；另将氟康唑16g加入30gN，N-二甲基甲酰胺DMF中，搅拌溶解，再加入乙酸乙酯60g，搅拌均匀，制成氟康唑溶液；在50-60℃、1000r/min搅拌下，将该氟康唑溶液加入到上述乳化液中，室温匀速搅拌，成型。
本发明中所述的各组分及其质量百分数分别为：氟康唑0.6-5％、硫酸新霉素0.2-2％、凡士林6-11％、羊毛脂2-5％、液体石蜡38-46％、硬脂酸2-5％、司盘-80 4-13％、司盘-853-6％、吐温-80 3-7％、山梨酸0.2-0.5％、A-200 3-5％、A-380 2-5％、甘油1-2％、DMF1-5％、乙酸乙酯3-9％、蒸馏水6-15％。
Claims (2)
1、一种复方氟康唑软膏，其特征在于它的组分和质量百分数为：氟康唑0.6-5、硫酸新霉素0.2-2、凡士林6-11、羊毛脂2-5、液体石蜡38-46、硬脂酸2-5、司盘-80 4-13、司盘-85 3-6、吐温-80 3-7、山梨酸0.2-0.5、A-200 3-5、A-380 2-5、甘油1-2、DMF 1-5、乙酸乙酯3-9、蒸馏水6-15。
2、权利要求1所述的复方氟康唑软膏的制备方法，其特征在于先称取液体石蜡、凡士林、羊毛脂、硬脂酸、司盘-80、司盘-85、吐温-80和山梨酸，将它们置于水浴中加热融熔，温度保持在80-85℃形成基质，再称取A-200和A-380加入上述基质中，搅拌均匀形成油相；另将硫酸新霉素加入蒸馏水中，溶解，再加入甘油，加热至85-90℃，搅拌溶解形成为水相；将该水相加入上述油相中，搅拌制成乳化液；另将氟康唑加入N，N-二甲基甲酰胺中，搅拌溶解，再加入乙酸乙酯，搅拌均匀形成氟康唑溶液；在50-60℃、1000r/min搅拌下，将该氟康唑溶液加入到上述乳化液中，室温匀速搅拌，成型。
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105169462A (zh) * | 2015-10-22 | 2015-12-23 | 江苏科技大学 | 改善硫酸新霉素在凡士林中分散均匀性的混合方法 |
| CN108338968A (zh) * | 2018-03-14 | 2018-07-31 | 青岛科技大学 | 一种用于宠物中耳炎治疗膏剂及其制备方法 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105169462A (zh) * | 2015-10-22 | 2015-12-23 | 江苏科技大学 | 改善硫酸新霉素在凡士林中分散均匀性的混合方法 |
| CN105169462B (zh) * | 2015-10-22 | 2017-10-17 | 江苏科技大学 | 改善硫酸新霉素在凡士林中分散均匀性的混合方法 |
| CN108338968A (zh) * | 2018-03-14 | 2018-07-31 | 青岛科技大学 | 一种用于宠物中耳炎治疗膏剂及其制备方法 |
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