CN101596204A - 一种复方氟康唑软膏及其制备方法 - Google Patents
一种复方氟康唑软膏及其制备方法 Download PDFInfo
- Publication number
- CN101596204A CN101596204A CNA2009100161252A CN200910016125A CN101596204A CN 101596204 A CN101596204 A CN 101596204A CN A2009100161252 A CNA2009100161252 A CN A2009100161252A CN 200910016125 A CN200910016125 A CN 200910016125A CN 101596204 A CN101596204 A CN 101596204A
- Authority
- CN
- China
- Prior art keywords
- fluconazol
- ointment
- arlacel
- polygynax
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 239000002674 ointment Substances 0.000 title claims abstract description 24
- 150000001875 compounds Chemical class 0.000 title claims abstract description 13
- 229960004884 fluconazole Drugs 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 108010019657 polymyxin drug combination nystatin neomycin dimethicone acetarsol Proteins 0.000 claims abstract description 11
- VQGBOYBIENNKMI-LJAQVGFWSA-N 5-[(3-phenoxyphenyl)methyl-[(1s)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid Chemical compound C1=C(C(O)=O)C(C(=O)O)=CC(C(O)=O)=C1C(=O)N([C@@H]1C2=CC=CC=C2CCC1)CC1=CC=CC(OC=2C=CC=CC=2)=C1 VQGBOYBIENNKMI-LJAQVGFWSA-N 0.000 claims abstract description 8
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 8
- 229940057995 liquid paraffin Drugs 0.000 claims abstract description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000008117 stearic acid Substances 0.000 claims abstract description 8
- 229940099259 vaseline Drugs 0.000 claims abstract description 8
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 7
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 7
- 229940075582 sorbic acid Drugs 0.000 claims abstract description 7
- 235000010199 sorbic acid Nutrition 0.000 claims abstract description 7
- 239000004334 sorbic acid Substances 0.000 claims abstract description 7
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims abstract description 6
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims abstract description 6
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims description 21
- 239000000758 substrate Substances 0.000 claims description 7
- 239000000839 emulsion Substances 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 206010017533 Fungal infection Diseases 0.000 abstract description 10
- 208000031888 Mycoses Diseases 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 6
- 241000282326 Felis catus Species 0.000 abstract description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 229960000988 nystatin Drugs 0.000 abstract description 4
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000035143 Bacterial infection Diseases 0.000 abstract description 2
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 241001465754 Metazoa Species 0.000 abstract description 2
- 230000000845 anti-microbial effect Effects 0.000 abstract description 2
- 230000001139 anti-pruritic effect Effects 0.000 abstract description 2
- 239000003908 antipruritic agent Substances 0.000 abstract description 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract description 2
- 230000003115 biocidal effect Effects 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 238000001228 spectrum Methods 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 150000003852 triazoles Chemical class 0.000 abstract description 2
- GSNUFIFRDBKVIE-UHFFFAOYSA-N DMF Natural products CC1=CC=C(C)O1 GSNUFIFRDBKVIE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003883 ointment base Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000024035 chronic otitis media Diseases 0.000 description 1
- 239000003684 drug solvent Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 208000024386 fungal infectious disease Diseases 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 201000009862 superficial mycosis Diseases 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100161252A CN101596204B (zh) | 2009-06-04 | 2009-06-04 | 一种复方氟康唑软膏及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100161252A CN101596204B (zh) | 2009-06-04 | 2009-06-04 | 一种复方氟康唑软膏及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101596204A true CN101596204A (zh) | 2009-12-09 |
CN101596204B CN101596204B (zh) | 2011-04-06 |
Family
ID=41417921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009100161252A Expired - Fee Related CN101596204B (zh) | 2009-06-04 | 2009-06-04 | 一种复方氟康唑软膏及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101596204B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105169462A (zh) * | 2015-10-22 | 2015-12-23 | 江苏科技大学 | 改善硫酸新霉素在凡士林中分散均匀性的混合方法 |
CN108338968A (zh) * | 2018-03-14 | 2018-07-31 | 青岛科技大学 | 一种用于宠物中耳炎治疗膏剂及其制备方法 |
-
2009
- 2009-06-04 CN CN2009100161252A patent/CN101596204B/zh not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105169462A (zh) * | 2015-10-22 | 2015-12-23 | 江苏科技大学 | 改善硫酸新霉素在凡士林中分散均匀性的混合方法 |
CN105169462B (zh) * | 2015-10-22 | 2017-10-17 | 江苏科技大学 | 改善硫酸新霉素在凡士林中分散均匀性的混合方法 |
CN108338968A (zh) * | 2018-03-14 | 2018-07-31 | 青岛科技大学 | 一种用于宠物中耳炎治疗膏剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101596204B (zh) | 2011-04-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Weifang Noted Pharmaceutical Ltd. Assignor: Qingdao Liuhe Pharmaceuticals Ltd.|Qingdao Vland Biotech INC. Contract record no.: 2011370000086 Denomination of invention: Compound fluconazole ointment and preparation method thereof Granted publication date: 20110406 License type: Exclusive License Open date: 20091209 Record date: 20110412 |
|
C56 | Change in the name or address of the patentee |
Owner name: QINGDAO CONTINENT PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: QINGDAO CONTINENT BIOTECH CO., LTD. |
|
CP01 | Change in the name or title of a patent holder |
Address after: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 605 high speed Co-patentee after: QINGDAO KDN BIOTECH Co.,Ltd. Patentee after: QINGDAO KDN PHARMACEUTICAL Co.,Ltd. Address before: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 605 high speed Co-patentee before: Qingdao Liuhe Pharmaceuticals Ltd. Patentee before: Qingdao Vland Biotech INC. |
|
C56 | Change in the name or address of the patentee |
Owner name: QINGDAO WEILAN BIOLOGY CO., LTD. Free format text: FORMER NAME: QINGDAO KDN PHARMACEUTICAL CO., LTD. |
|
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 12F high speed Patentee after: QINGDAO VLAND BIOTECH Inc. Patentee after: QINGDAO KDN BIOTECH Co.,Ltd. Address before: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 605 high speed Patentee before: QINGDAO KDN PHARMACEUTICAL Co.,Ltd. Patentee before: QINGDAO KDN BIOTECH Co.,Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110406 |