CN101495118B - Mek的n-(芳基氨基)磺酰胺抑制剂 - Google Patents

Mek的n-(芳基氨基)磺酰胺抑制剂 Download PDF

Info

Publication number: CN101495118B
Authority: CN; China
Prior art keywords: chemical compound; fluoro; phenyl; methyl; iodophenyl
Prior art date: 2005-07-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CN2006800349355A

Other languages

English (en)

Chinese (zh)

Other versions

CN101495118A (zh

Inventor

A·马德纳

J·-M·韦尼耶

D·巴劳卡

V·查马库拉

H·E·阿布德劳伊

Z·洪

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ardea Biociences Inc

Original Assignee

Ardea Biociences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-21

Filing date

2006-07-21

Publication date

2012-09-05

2006-07-21 Application filed by Ardea Biociences Inc filed Critical Ardea Biociences Inc

2006-07-21 Priority claimed from PCT/US2006/028326 external-priority patent/WO2007014011A2/en

2009-07-29 Publication of CN101495118A publication Critical patent/CN101495118A/zh

2012-09-05 Application granted granted Critical

2012-09-05 Publication of CN101495118B publication Critical patent/CN101495118B/zh

Status Expired - Fee Related legal-status Critical Current

2026-07-21 Anticipated expiration legal-status Critical

Links

0 CO*(cc1*)c(C(S(C2(CC(CO)O)CC2)(=O)=O)=C)c(Nc(c(F)c2)ccc2I)c1F Chemical compound CO*(cc1*)c(C(S(C2(CC(CO)O)CC2)(=O)=O)=C)c(Nc(c(F)c2)ccc2I)c1F 0.000 description 3
FQWVVSZRJNZEFF-UHFFFAOYSA-N COCCOc(cc(c(F)c1F)F)c1[N+]([O-])=O Chemical compound COCCOc(cc(c(F)c1F)F)c1[N+]([O-])=O FQWVVSZRJNZEFF-UHFFFAOYSA-N 0.000 description 1
RDSACQWTXKSHJT-LLVKDONJSA-N COc(cc(c(F)c1Nc(ccc(I)c2)c2F)F)c1NS(C1(C[C@H](CO)O)CC1)(=O)=O Chemical compound COc(cc(c(F)c1Nc(ccc(I)c2)c2F)F)c1NS(C1(C[C@H](CO)O)CC1)(=O)=O RDSACQWTXKSHJT-LLVKDONJSA-N 0.000 description 1
YAFSEBUXRRDMRZ-UHFFFAOYSA-N Cc(c(F)c1Nc(ccc(I)c2)c2F)ccc1NS(c1c(C(OC)=O)[s]cc1)(=O)=O Chemical compound Cc(c(F)c1Nc(ccc(I)c2)c2F)ccc1NS(c1c(C(OC)=O)[s]cc1)(=O)=O YAFSEBUXRRDMRZ-UHFFFAOYSA-N 0.000 description 1
KUVHAROVDXTOGN-UHFFFAOYSA-N Cc(cc(c(F)c1F)F)c1[N+]([O-])=O Chemical compound Cc(cc(c(F)c1F)F)c1[N+]([O-])=O KUVHAROVDXTOGN-UHFFFAOYSA-N 0.000 description 1
WKGPJUHIWKGVMP-UHFFFAOYSA-N Cc(cc1)cc(F)c1Nc(c(F)c(C)cc1C)c1N Chemical compound Cc(cc1)cc(F)c1Nc(c(F)c(C)cc1C)c1N WKGPJUHIWKGVMP-UHFFFAOYSA-N 0.000 description 1
CDTYNKPBWIMIAW-UHFFFAOYSA-N Cc1ccc(CCNc(c(Nc(ccc(I)c2)c2F)c2F)ccc2F)[s]1 Chemical compound Cc1ccc(CCNc(c(Nc(ccc(I)c2)c2F)c2F)ccc2F)[s]1 CDTYNKPBWIMIAW-UHFFFAOYSA-N 0.000 description 1
NWMQCWMVNBHMCG-UHFFFAOYSA-N O=S(c(cccc1)c1F)(Nc(ccc(F)c1F)c1Nc(ccc(I)c1)c1F)=O Chemical compound O=S(c(cccc1)c1F)(Nc(ccc(F)c1F)c1Nc(ccc(I)c1)c1F)=O NWMQCWMVNBHMCG-UHFFFAOYSA-N 0.000 description 1
XYSDQSBVOZVFKL-UHFFFAOYSA-N O=S(c1ccc(-c2n[s]c(Cl)n2)[s]1)(Nc(c(Nc(c(F)c1)ccc1I)c1F)ccc1F)=O Chemical compound O=S(c1ccc(-c2n[s]c(Cl)n2)[s]1)(Nc(c(Nc(c(F)c1)ccc1I)c1F)ccc1F)=O XYSDQSBVOZVFKL-UHFFFAOYSA-N 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CN2006800349355A 2005-07-21 2006-07-21 Mek的n-(芳基氨基)磺酰胺抑制剂 Expired - Fee Related CN101495118B (zh)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US70181405P	2005-07-21	2005-07-21
US60/701,814		2005-07-21
US70671905P	2005-08-08	2005-08-08
US60/706,719		2005-08-08
US73163305P	2005-10-28	2005-10-28
US60/731,633		2005-10-28
PCT/US2006/028326 WO2007014011A2 (en)	2005-07-21	2006-07-21	N-(arylamino)-sulfonamide inhibitors of mek

Publications (2)

Publication Number	Publication Date
CN101495118A CN101495118A (zh)	2009-07-29
CN101495118B true CN101495118B (zh)	2012-09-05

Family

ID=40925319

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN2006800349355A Expired - Fee Related CN101495118B (zh)	2005-07-21	2006-07-21	Mek的n-(芳基氨基)磺酰胺抑制剂

Country Status (3)

Country	Link
CN (1)	CN101495118B (sl)
SI (1)	SI1912636T1 (sl)
ZA (1)	ZA200801443B (sl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9034861B2 (en)	2009-10-13	2015-05-19	Allomek Therapeutics Llc	MEK inhibitors useful in the treatment of diseases

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI524890B (zh) *	2009-07-24	2016-03-11	亞德生化公司	（ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備
SG189038A1 (en)	2010-10-01	2013-05-31	Bayer Ip Gmbh	Substituted n-(2-arylamino)aryl sulfonamide-containing combinations
WO2013094546A1 (ja) *	2011-12-19	2013-06-27	住友化学株式会社	スルホン酸塩の製造方法
US9668990B1 (en) *	2016-06-10	2017-06-06	Gongwin Biopharm Holdings Co., Ltd.	Benzenesulfonamides compositions for treatment of malignant pleural effusions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004083167A1 (ja) *	2003-03-18	2004-09-30	Sankyo Company Limited	スルファミド誘導体及びその医薬組成物

2006
- 2006-07-21 CN CN2006800349355A patent/CN101495118B/zh not_active Expired - Fee Related
- 2006-07-21 SI SI200631805T patent/SI1912636T1/sl unknown
2008
- 2008-02-12 ZA ZA200801443A patent/ZA200801443B/xx unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004083167A1 (ja) *	2003-03-18	2004-09-30	Sankyo Company Limited	スルファミド誘導体及びその医薬組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JT Lee Jr，等.The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia.《Leukemia》.2002,第16卷(第4期),486-507. *
Melanie H Cobb,等.How MAP Kinases Are Regulated.《Journal of Biological Chemistry》.1995,第270卷(第25期),14843-14846. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9034861B2 (en)	2009-10-13	2015-05-19	Allomek Therapeutics Llc	MEK inhibitors useful in the treatment of diseases

Also Published As

Publication number	Publication date
SI1912636T1 (sl)	2014-08-29
ZA200801443B (en)	2009-08-26
CN101495118A (zh)	2009-07-29

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