CN101466298A - 用于样本的偏振敏感光频域成像的方法、装置和*** - Google Patents
用于样本的偏振敏感光频域成像的方法、装置和*** Download PDFInfo
- Publication number
- CN101466298A CN101466298A CNA2007800162663A CN200780016266A CN101466298A CN 101466298 A CN101466298 A CN 101466298A CN A2007800162663 A CNA2007800162663 A CN A2007800162663A CN 200780016266 A CN200780016266 A CN 200780016266A CN 101466298 A CN101466298 A CN 101466298A
- Authority
- CN
- China
- Prior art keywords
- electromagnetic radiation
- equipment
- polarization
- sample
- radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
- G01B9/02001—Interferometers characterised by controlling or generating intrinsic radiation properties
- G01B9/02002—Interferometers characterised by controlling or generating intrinsic radiation properties using two or more frequencies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
- G01B9/02001—Interferometers characterised by controlling or generating intrinsic radiation properties
- G01B9/02002—Interferometers characterised by controlling or generating intrinsic radiation properties using two or more frequencies
- G01B9/02004—Interferometers characterised by controlling or generating intrinsic radiation properties using two or more frequencies using frequency scans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
- G01B9/02001—Interferometers characterised by controlling or generating intrinsic radiation properties
- G01B9/02011—Interferometers characterised by controlling or generating intrinsic radiation properties using temporal polarization variation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
- G01B9/0209—Low-coherence interferometers
- G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B2290/00—Aspects of interferometers not specifically covered by any group under G01B9/02
- G01B2290/70—Using polarization in the interferometer
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
提供了用于获取与样本相关联的数据的装置和方法。例如,可以向样本提供至少一个第一电磁辐射并且可以向参考物(例如,无反射参考物)提供至少一个第二电磁辐射。这样的辐射的频率可以以第一特征周期随着时间反复地变化。另外,第一电磁辐射、第二电磁辐射、第三电磁辐射(与第一辐射相关联)或第四电磁辐射(与第二辐射相关联)的偏振状态以短于第一周期的第二特征周期随着时间反复地改变。可以根据偏振状态来提供用于对样本的至少一部分进行成像的数据。另外地或替选地,第三和第四电磁辐射可以被组合以确定样本的至少一部分的轴向反射轮廓。
Description
相关申请的交叉引用
本申请基于2006年4月5日提交的序列号为60/789,739的美国专利申请,并且要求该美国专利申请的优先权,该美国专利申请的全部公开内容通过引用结合于此。
关于联邦赞助研究的声明
导致本发明的研究至少部分地由国家健康协会-NCRR的第R019768号基金以及国家健康协会-NEI的第EY014975号基金所支持。因此,美国政府可以享有本发明的某些权利。
技术领域
本发明涉及利用光学显微镜来获得与解剖结构或样本相关联的信息的方法、装置和***,更具体地,涉及提供解剖结构/样本的偏振敏感光频域成像的方法、***和装置。
背景技术
光频域成像(OFDI)技术也可以被称为扫描源或傅立叶域光学相干断层扫描(OCT)技术,是通常使用扫描激光源的OCT过程。例如,光束聚焦到组织内,并且当源激光波长快速地并反复地扫描时,通过检测组织样本和参考物之间的光谱分辨干涉来确定从不同深度的组织微结构反射的光的回波时间延迟和振幅。信号的傅立叶变换通常沿轴线(例如A线)形成图像数据。当成像束在与轴线正交的一个或两个方向上横向扫描通过组织时,连续地得到A线。由此产生的二维或三维数据集可以以任意取向被再现或察看以便进行总体筛查,并且可以在感兴趣的特定位置显示单独的高分辨率的横截面。这个示例过程允许临床医生察看活体病人的组织的微观内部结构,促进或实现从疾病研究和诊断到术中组织鉴定和图像引导治疗的广泛临床应用。
OFDI中的对比机制通常是由样本或组织内的空间折射率变化引起的光学背反射(back reflection)。结果可能是所谓的强度图像(intensityimage),所述强度图像可以以范围通常从2到20μm的空间分辨率来指示深度达到几个毫米的组织的解剖结构。尽管强度图像可以提供大量的形态信息,但是组织内的双折射可以提供在比如量化组织内的胶原含量和评估涉及组织内双折射变化的疾病等几种应用中有用的另一种对比。已经使用了所谓偏振敏感OFDI或OCT的特定方法和装置。在传统的方法中,当探测束横向地扫描通过样本时,探测束的偏振状态在连续轴线(A线)扫描过程中可以在两个状态之间交替。每一对连续偏振测量可以通过矢量分析而形成样本的单轴双折射轮廓。这种传统的方法利用了样本中的探测束在两个A线扫描之间的大范围交叠来避免散斑引起的错误。因此,可以探究在双折射测量的精确度和图像获取速度之间的折中。此外,由于A线扫描之间的相对长的延迟,传统方法对于样本或导管的机械运动可能是敏感的。
示例的用于获取偏振敏感信息的***和方法在第6,208,415号美国专利中描述。示例的OFDI技术和***在第PCT/US04/029148号国际申请中描述。确定组织的偏振属性的方法和***在第PCT/US05/039374号国际申请中描述。利用示例的OFDI技术,实施平衡检测可能是所希望的。然而,平衡检测可能使偏振灵敏度和偏振分集(polarization diversity)的光纤实现变得复杂,因为两个平衡的信号通道可以具有不同的偏振状态。
因此,需要克服在上文描述的不足。
发明内容
为了处理和/或克服上面描述的问题和/或不足,可以提供具有例如平衡检测模式能力的***、装置和过程的示例实施例,其中通道不是通过两个信号传送通道来平衡,而是通过信号传送通道和参考通道来平衡。
例如,根据本发明的示例实施例,可以提供用于偏振敏感OFDI的方法、***和装置,所述方法、***和装置克服了前述的在高速OFDI应用中是重要的缺点。具体而言,可能相对于连续波长样本(successivewavelength sample)而不是相对于A线扫描来快速地交替探测束的偏振状态。这一示例技术可以允许每对偏振测量结果即时地(每波长地)被捕获,显著地减轻横向扫描速度和运动伪影的问题。根据本发明的另一示例实施例,可以使用能够独立地控制两个偏振状态之间的相位和群延迟的快速偏振调制器。本发明的示例实施例可以用于冠状动脉、胃肠道以及眼睛的临床体积测量成像。
在本发明的一个示例实施例中,可以提供用于通过对来自样本的依赖于偏振的背反射的测量来执行对生物样本的横截面成像的装置、***和方法。根据一个示例实施例,偏振调制装置可以用于在光源的每个波长扫描期间快速地且周期性地根据波长(或时间)来改变成像光束的偏振状态。例如,偏振调制器可以是电或声光调制器和/或双折射介质。
根据本发明的另一示例实施例,可以提供用于获取与样本相关联的数据的装置和方法。例如,可以向样本提供至少一个第一电磁辐射并且向参考物(例如,无反射参考物)提供至少一个第二电磁辐射。这些辐射的频率可以以第一特征周期随时间反复地改变。另外,第一电磁辐射、第二电磁辐射、第三电磁辐射(与第一辐射相关联)或第四电磁辐射(与第二辐射相关联)的偏振状态可以以短于第一周期的第二特征周期随时间反复地改变。可以根据偏振状态来提供用于对样本的至少一部分进行成像的数据。另外或替选地,可以组合第三和第四电磁辐射以便确定样本的至少一部分的轴向反射轮廓。
根据本发明的另一示例实施例,可以通过偏振源来提供第一和/或第二电磁辐射。可以利用偏振调制器、延迟干涉仪、移频器和/或双折射介质来得到偏振状态。可以提供偏振装置,所述偏振装置可以配置用于使第一、第二、第三和/或第四电磁辐射偏振。可通过偏振调制源来提供第一和/或第二电磁辐射并获得偏振状态。可以从样本提供第三电磁辐射,并且可以从参考物提供第四电磁辐射。
在本发明的另一示例实施例中,可以在第一偏振状态下检测第三和第四辐射之间的第一干涉信号,并且在第二偏振状态下检测第三和第四电磁辐射之间的第二干涉信号,第一偏振状态和第二偏振状态彼此不同。可以将第一和第二干涉信号数字化,并且可以确定样本的至少一部分的偏振属性。第一和第二偏振状态可以相对于彼此近似正交。
根据本发明的另一示例实施例,可以生成样本的偏振属性的至少一个图像。偏振属性可以包括双折射、双折射轴、衰减(diattenuation)和/或衰减轴。
根据本发明的另一示例实施例,第一特征周期可以比第二特征周期短大约100微秒。第一和/或第二电磁辐射扫描的频率在第一特征周期内改变大约至少1太赫兹,并且/或者在第二特征周期内改变大约至多100GHz。第二周期可以是第一周期的大约1/10。
当结合所附的权利要求考虑时,本发明的这些和其它目的、特性和优点可以通过阅读本发明实施例的以下详细描述而变得明显。
附图说明
本发明的更多目的、特性和优点将根据结合附图的以下详细描述而变得明显,所述附图示出本发明的示例实施例,其中:
图1是示例性传统OFDI***的配置的框图;
图2是采用偏振分集检测装置/技术的另一传统OFDI***的框图;
图3A是另一传统偏振敏感OFDI***的框图;
图3B是图3A的OFDI***所提供的偏振状态和输出的图;
图4A-4C是根据本发明示例实施例的使用快速偏振调制技术的偏振敏感OFDI***、方法和装置的状态、时钟输出和信号的图;
图5是根据本发明示例实施例的信号处理技术和方法的概要流程图;
图6A是根据本发明的偏振调制装置/***的一个示例实施例的框图;
图6B是根据本发明的偏振调制装置/***的另一示例实施例的框图;
图6C是根据本发明的偏振调制装置/***的另一示例实施例的框图。
图6D是根据本发明的偏振调制装置/***的另一示例实施例的框图;
图7是具有多于一个信号传送通道的平衡检测装置/***的第一示例实施例的框图;
图8是具有单个信号传送通道的平衡检测装置/***的第二示例实施例的框图;
图9是具有单个信号传送通道的平衡检测装置/***的第三示例实施例的框图;
图10是具有单个信号传送通道的平衡检测装置/***的第四示例实施例的框图;
图11是具有单个信号传送通道的平衡检测装置/***的第五示例实施例的框图;
图12是具有单个信号传送通道的平衡检测装置/***的第六示例实施例的框图;
图13是具有单个信号传送通道和无反射参考物的平衡检测装置/***的第七示例实施例的框图;
图14是具有单个信号传送通道和无反射参考物的平衡检测装置/***的第八示例实施例的框图;
图15是具有单个信号传送通道和无反射参考物的平衡检测装置/***的第九示例实施例的框图;以及
图16是具有单个信号传送通道和无反射参考物的平衡检测装置/***的第十示例实施例的框图;
在附图中,除非另有说明,否则同样的参考号和符号用来表示所示出的实施例的相似特征、元件、部件或部分。此外,尽管现在将参考附图来描述本发明,但是也将结合说明性实施例来描述本发明。意图是在不背离通过所附的权利要求所限定的本发明的确切范围和精神的情况下,可以对所述实施例做出改变和修改。
具体实施方式
图1说明了示例性传统OFDI***的框图,如在S.H.Yun等人的“High-speed optical frequency-domain imaging”,Opt.Express 11,2953-2963(2003)中所述,该OFDI***包括光源10、光纤干涉仪以及检测装置。光源10所提供的电磁辐射的输出波长可以在光谱范围内在时间上进行扫描。优选地,该调谐使得输出波数k作为时间的线性函数而给出。然而,通常k可以作为时间的非线性函数而给出,但此非线性可以在信号处理过程中被校正。干涉仪可以包括由单模光纤制成的熔接耦合器(fusedcoupler)20。耦合器20的一个端口(port)可以作为带有参考镜24的参考臂22。耦合器20的另一端口可以作为连接到探头40的样本臂30。探头40通常分别对去往和来自样本44的样本光42进行聚焦和采集。例如,光源10的输出可以被单独地偏振。
偏振控制器50可以用于对准从镜24返回的的参考光和从组织44返回的采样光之间的偏振状态。可以利用光检测器60来测量参考和样本光之间的干涉信号。检测器信号可以利用模拟到数字板70被数字化,并且在计算机72上被处理并转换为图像。可以在时间上均匀地采样检测器输出,并且进行对采样数据的插值以在离散傅立叶变换前在线性k空间生成干涉信号。可替选地,可以以非均匀采样时间间隔来在k空间中线性地采样检测器信号。图像中的轴线(A线)可以通过对在光源10的每个波长扫描期间获取的数字数据进行离散傅立叶变换来获得。通过在探测束42横向扫描通过样本44时获取多个A线,可以生成横截面图像。使用单个图像检测器60可能导致主要是样本光中与参考偏振状态对准的偏振分量可以被检测到,而正交偏振分量将可能丢失。然而,偏振分集可以解决这个问题。
图2示出了另一传统OFDI***,其采用偏振分集方案,在本图中所提供的相同参考号与以上相对于图1所描述的这样的部件/特征相关联。该传统***还包括声光移频器100、102和磁光环行器106、108。可以不需要移频器100、102中的一个。移频器100、102可以消除干涉信号中正和负深度之间的模糊,有效地增大深度范围。可以利用50/50熔接耦合器来组合从参考镜24和样本44返回的光。偏振分集检测在虚线框120中示出。耦合器20的每个输出端口可以经由偏振控制器136和/或138而连接到偏振束分路器130和/或132。偏振控制器136、138允许来自耦合器的两个光纤路径的双折射在偏振分路器130、132以大约相等的比率与参考光匹配。在分路器之后的标记为x或y的相应偏振状态可以被定向到双平衡检测器140、142。可以用两通道模拟到数字板150和计算机152对检测器信号进行低通滤波和数字化。两通道数据可以被独立地处理以提供两个强度图像。这两个强度图像可以加到一起以产生其中偏振导致的伪像大大受抑制的偏振分集图像。
作为对比,偏振敏感OCT是一种可以用于利用组织双折射来获取组织的至少一部分的横截面图像的技术,如在第6,208,415号美国专利中所述。例如,可以使用偏振调制器,其使进入样本的光的偏振状态在庞加莱球(Poincare sphere)中彼此正交的两个状态之间交替,即在下文中被称为“半正交”偏振状态的关系。两状态对的例子可以是相对于彼此呈45度角的线性偏振状态,例如X和X+Y状态。这使得两个输入偏振状态中的至少一个偏振状态与组织的双折射轴对准,有助于依赖于深度的双折射测量。PS-OCT的原理和信号处理算法在本领域是公知的。
类似的技术可以与OFDI***一起使用,如在J.Zhang等人的“Fullrange polarization-sensitive Fourier domain optical coherencetomography”,Optics Express 12,6033-6039(2004)中所述,利用了如在第6,208,415号美国专利中提供的扫描激光器。例如,图3A示出了以上引用的Zhang的发表文章中描述的另一传统***的框图,在该图中所提供的相同参考号与以上相对于图1和图2所描述的这样的部件/特征相关联。例如,可以在源臂30中设置电光偏振调制器170。该装置170可以在时间上周期性地在两个“半正交”偏振状态之间调制源光的偏振状态,如图3B所示。调制周期可以同步于波长扫描。检测端口可以包括偏振束分路器180和两个或多个光检测器190、192。可以利用偏振控制器50来控制参考光的偏振状态,以在偏振分路器180以相等强度分开所述参考光。可以以两通道模拟到数字转换器150和计算机152来采集干涉信号。在完整的偏振调制周期期间的每对连续偏振测量结果可以通过本领域公知的矢量分析来形成样本的单轴双折射轮廓。该示例技术的一个缺点是其依赖样本中的探测束在两个A线扫描之间的大范围交叠来避免散斑导致的错误。此外,由于在A线扫描之间相对长的延迟,这种技术可能对样本或导管的机械运动敏感。
因此,有益的是在双折射测量的精度和图像获取速度之间取得平衡,以及处理其它不足。
根据本发明的一个实施例,至少一些上述不足可以被克服,这在高速OFDI应用中是有益的。例如,在每个A线扫描期间调制探测束的偏振状态可能是有益的。图4描绘了这种构思。如在图4A中所示,探测束的偏振状态可以在例如彼此半正交两个状态之间周期性地变化。调制频率可以基本上高于波长扫描或A线扫描的频率。调制频率可以优选地是采样率的一半或四分之一,使得两个相邻的采样可以与探测束的两个不同偏振状态相关联。
图4B示出了另一个可能的示例调制形式,即正弦调制。在庞加莱球中的周期之后,偏振状态可以在X和Y状态之间变化。在这个示例中,调制频率可以是采样率的四分之一。因而,在一个调制周期中可以获取4个样本。如图4C的曲线图所示,假设在波长扫描周期或单个A线扫描期间总共获取4N个样本,第一组4个样本可以标记为从1到1”’,下一组可以标记为从2到2”’,并且最后一组可以设置为从N到N”’。如在图5中示出的根据本发明的方法的实施例的流程图中所示,组可以用四个群(1,2...,N)、(1’,2’,...,N’)、(1”,2”...,N”)、(1”’,2”’...,N”’)来解调。结果可以提供强度和/或双折射图像。例如,解调可以在时域或频域中进行。每个群被处理以产生与不同偏振状态相关联的图像。利用公知的矢量分析,可以确定双折射量值、双折射轴线以及衰减的空间映射。
根据本发明的实施例的该示例方法和技术可以通过以合适的电压驱动器操作偏振调制器170来实施。例如,谐振电光调制器可以被用于正弦调制。图6描绘了偏振调制的替选方案。图6A示出了根据本发明的***的示例实施例的框图,所述***在样本臂30内使用了正的双折射延迟件200,在该图中所提供的相同参考号与以上相对于图1和图2所描述的这样的部件/特征相关联。该示例双折射延迟件200可以包括光纤干涉仪和/或自由空间干涉仪,所述光纤干涉仪和/或自由空间干涉仪可以包括两个或多个偏振束分路器210、212。臂220、222的偏振状态可以彼此正交。
这一示例装置在源的波长变化时可以有效地导致偏振调制。臂210、212之间的延迟ΔL可以被选择成满足等式ΔL*Δk=π/m,其中Δk表示两个相邻样本或空间采样间隔之间的波数差,并且m是整数。对于m非整数也是可能的,并且可以使用频域解调。然而,优选地,例如m=1或2。根据本发明的另一示例实施例,双折射延迟件可以是具有ΔL=Δn*L的一段高双折射光纤,其中Δn表示在两个本征偏振状态之间的折射率差,而L是该光纤的长度。到双折射延迟件的输入偏振状态可以被调节以使得延迟装置的每个本征状态由相等的功率激励。图6B描绘了根据本发明的偏振调制装置的另一示例实施例的示图,所述偏振调制装置包括光纤干涉仪。例如,在图6B中示出的偏振控制器240、242(其用于图6A的双折射延迟件200)可以调节成使两个臂的偏振状态彼此半正交。两个半正交状态之间的延迟优选地满足ΔL*Δk=π/2。
在图6A和6B中示出的示例实施例中,偏振调制可以通过在两个偏振状态之间引起群延迟来实现。当扫描源10的相干长度有限时(通常是这种情况),这些示例装置可以产生显著的信噪比(SNR)降级,因为可见度由于光学延迟而降低。为了处理这个问题,可以使用根据本发明的另一示例实施例的偏振调制装置,该偏振调制装置不依赖于群延迟,而是考虑相位延迟。例如,如图3A中示出的电光调制装置可以根据本发明被使用以引起基本上零或非常小的群延迟。
图6C示出了本发明的另一示例实施例,其使用声光移频器250、252以在两个偏振状态之间引起连续的相位延迟,其被用做图6A的双折射延迟件200。例如,如图6C所示,可以在参考臂22中采用另一个移频器154。使用图6C的装置的示例操作模式可以如下:(a)移频器250可以产生上移f_s/8,其中f_s是采样率,移相器252可以产生上移f_s/4,而参考移相器254可以产生零频移;和/或(b)由装置250、252、254移动的频率的量值可以分别为零、+f_s/8和-f_s/8。例如,与两个不同的偏振状态相关联的两个图像可以在傅立叶域被分离并且进一步被处理以获取双折射信息或图像。根据本发明的另外的可选示例处理过程可以包括在频域解复用之前的背景减除(background subtraction)、插值、开窗或振幅补偿。信号可以可选地被进一步补偿以去除由获取导致的任何伪像。以此方式,由于移频器或调制装置中两个臂之间的精确长度差导致的信号之间的相位变化可以得到处理。
图6D示出本发明的另一示例实施例,其使用声光移频器250、252以便在两个偏振状态之间引起连续的相位延迟,其被用于图6A的双折射延迟件200。可以在参考臂22中采用另一个移频器254。装置/***的示例实施例的该示例部分可以利用第一偏振束分路器256来将输入束分为具有相互正交的偏振状态的两个束x、y。通过移频器250、252之后,利用第二偏振束分路器258来组合两个束x、y。这个装置的组合光输出具有作为波长或时间的函数的快速偏振改变。如先前段落中所述的类似方法可以被用于解调干涉信号。解调可以在时域或频域进行。
用于在多于一个偏振的基础上检测干涉信号的各种配置在本领域是公知的。这些配置可以采用偏振束分路器和多个检测器。参考束可以以例如相等的功率被分到检测器中。可实现双平衡检测以抑制光源的强度噪声和自干涉噪声。用于同时偏振敏感和双平衡检测的基于光纤和自由空间的各种方案在本领域也是公知的。
如上所述,利用OFDI技术和结构,实施平衡检测技术可以是所希望的。然而,平衡检测技术可能使偏振灵敏度和偏振分集的光纤实现变得复杂。这可能是因为利用平衡检测技术和装置,平衡的两个信号通道可以具有不同的偏振状态。
图7示出了具有多于一个信号传送通道的平衡检测装置/***的第一示例实施例的框图,并且更详细地图示了利用具有信号传送通道的平衡检测技术/装置的缺点。例如,从源10发射出的电磁辐射或光可以被连接或转发到偏振控制器400,所述偏振控制器400可以可选地连接到偏振调制器和/或双折射材料405(和/或图6B或6C中示出的实施例的部分)。环行器106可以可选地将电磁辐射/光引导到偏振调制器和/或双折射材料410(和/或图6B或6C中示出的示例实施例的一个或多个部分)。熔接耦合器20可以将电磁辐射/光引导到经由可选地偏振调制器和/或双折射材料412(和/或图6B或6C中描绘的实施例的一个或多个部分)的样本臂30和具有可变衰减器和/或偏振控制器430的参考臂22。
熔接耦合器420可以组合从样本臂30和参考臂22返回的电磁辐射/光,并将该组合的信号/光/辐射分离为A、B两个部分以用于平衡检测。偏振束分路器130、132可以将组合的信号/光/辐射分离到平衡检测器通道对D1(140)、D2(142)。A、B两段都可以传送参考臂22的干涉信号和具有相反相位的样本臂30的干涉信号。可以在段A、B之后提供的偏振分路器分别将干涉信号分离为正交偏振。在理想的示例情况下,平衡检测通道(D1)140可以用相反的相位和相同的偏振状态来平衡干涉信号。对于平衡检测通道(D2)142可以出现同样的情况。然而,由于在段A、B中对于段A、B来说是不同的偏振状态的可能交替,平衡检测通道(D1)140、(D2)142可能在平衡不相同的偏振状态。
如图7所示及以上所述,其中不经历不同偏振状态的平衡检测装置/***/技术是所希望的。例如图8-16和以下相关描述图示和描述了平衡检测装置/***/技术的各种示例实施例,其中通道不必通过两个信号传送通道来平衡,而是可能通过信号传送通道和参考通道来平衡。在这些示例性的平衡检测实施例中,来自源的相对强度噪声可以通过这些示例装置/***/技术被抑制。
例如,在示出了具有单个信号传送通道的平衡检测装置/***的第二示例实施例的框图的图8中,光源10可以连接到偏振控制器400,所述偏振控制器400连接到可选的偏振调制器和/或双折射材料405(和/或图6B或6C中示出的示例实施例的一部分)。电磁辐射/光可以被引导到环行器106,环行器106可以将电磁辐射/光引导到熔接耦合器20,熔接耦合器20可以将电磁辐射/光分离到样本臂30和参考臂22中。来自样本臂30的电磁辐射/光可以通过熔接耦合器20传播回来,其中其可以与从样本臂30反射的电磁辐射/光相干涉,并由环行器106引导至偏振控制器400和偏振分路器440,偏振分路器440将电磁辐射/光分离成正交状态。干涉条纹可以由平衡检测器(D1)140、(D2)142检测到。
参考臂22的电磁辐射/光可以耦合到熔接耦合器450,熔接耦合器450可以将大部分电磁辐射/光引导到偏振器460。在反射时,电磁辐射/光可以通过另一偏振器460和另一熔接耦合器450而传播回来,并且可以被分离到与熔接耦合器20耦合的参考臂部分中,以便与样本臂30相干涉。另外的部分可以是用于平衡检测的无信号传送参考通道,其可以被引导到可变衰减器和/或偏振控制器430,并且可以形成用于平衡接收器(D1)140、(D2)142的平衡信号。如图8所示,平衡接收器接收一个信号传送通道和一个不传送信号但是可能可以平衡源10的电磁辐射/光的相对强度噪声的参考通道。
在示出了具有单个信号传送通道的平衡检测装置/***的第三示例实施例的框图的图9中,熔接耦合器450的替选端口可以用于无信号传送参考通道。
在示出了具有单个信号传送通道的平衡检测装置/***的第四示例实施例的框图的图10中,无信号传送参考通道可以通过另一熔接耦合器470获得,熔接耦合器470可以设置在环行器106之前。
在示出了具有单个信号传送通道的平衡检测装置/***的第五示例实施例的框图的图11中,无信号传送参考通道可以通过另一熔接耦合器480获得,熔接耦合器480可以设置在环行器106之后。
在示出了具有单个信号传送通道的平衡检测装置/***的第六示例实施例的框图的图12中,无信号传送参考通道可以通过另一熔接耦合器490获得,熔接耦合器490可以设置在偏振调制器和/或双折射材料405(和/或图6B或6C中示出的示例实施例的一部分)之前。
图13示出了具有单个信号传送通道和无反射参考臂的平衡检测装置/***的第七示例实施例的框图。在这个示例实施例中,熔接耦合器500可以将来自参考臂22的电磁辐射/光分离到被引导到衰减器和/或偏振控制器430的无信号传送参考,以及被引导到偏振控制器400和另一熔接耦合器510的参考部分,在具有单个信号传送通道和无反射参考的平衡检测装置/***的第七示例实施例的框图中,来自参考臂22和样本臂30的光相干涉。
图14示出了具有单个信号传送通道和无反射参考臂的平衡检测装置/***的第八示例实施例的框图。其中无信号传送参考通道通过熔接耦合器470获得,熔接耦合器470可以设置在环行器106之前。
图15示出了具有单个信号传送通道和无反射参考臂的平衡检测装置/***的第九示例实施例的框图。例如,无信号传送参考通道可以通过熔接耦合器480获得,熔接耦合器480可以设置在环行器106之后。
图16示出了具有单个信号传送通道和无反射参考臂的平衡检测装置/***的第十示例实施例的框图。这一示例实施例中的无信号传送参考通道可以通过熔接耦合器490获得,熔接耦合器490可以设置在偏振调制器和/或双折射材料405(和/或图6B或6C中示出的示例实施例的一部分)之前。
根据本发明的另一示例实施例,可以通过自由空间传播或通过光纤例如单模光纤来提供一些、大多数或全部连接。
由于这里的教导,前述内容仅仅说明了发明的原理。对所述实施例的各种修改和选择对本领域技术人员将是明显的。事实上,根据本发明的示例实施例的装置、***和方法可以用于任何OCT***、OFDI***、SD-OCT***或其它成像***,以及用于例如在2004年9月8日提交的国际专利申请PCT/US2004/029148、2005年11月2日提交的第11/266,779号美国专利申请和2004年7月9日提交的第10/501,276号美国专利申请中所描述的***,这些专利申请的公开内容通过引用而完整地结合于此。因而应理解,本领域技术人员能够设计出大量的虽然没有明确地被示出或描述于此但实现了本发明的原理、因而也在本发明的精神和范围内的***、装置和方法。另外,就没有在以上通过引用明确地结合于此的现有技术知识来说,其现在完整地被结合于此。以上引用于此的全部出版物通过引用完整地结合于此。
Claims (46)
1.一种设备,包括:
至少一个第一装置,其向样本提供至少一个第一电磁辐射并且向参考物提供至少一个第二电磁辐射,其中由所述至少一个第一装置提供的辐射的频率以第一特征周期随着时间反复地变化;
至少一个第二装置,其被配置为以第二特征周期随着时间反复地改变所述第一电磁辐射、所述第二电磁辐射、第三电磁辐射或第四电磁辐射中的至少一个电磁辐射的偏振状态;以及
至少一个第三装置,其被配置为根据所述偏振状态来提供用于对所述样本的至少一部分进行成像的数据,
其中,所述第三电磁辐射与所述至少一个第一辐射相关联并且所述第四电磁辐射与所述至少一个第二辐射相关联,并且其中所述第二周期短于所述第一周期。
2.根据权利要求1的设备,其中所述至少一个第一装置是偏振源。
3.根据权利要求1的设备,其中所述至少一个第二装置是偏振调制器、延迟干涉仪、移频器或双折射介质中的至少一个。
4.根据权利要求1的设备,其中所述至少一个第一装置是非偏振源,并且所述设备还包括偏振装置,所述偏振装置被配置为使所述第一、第二、第三或第四电磁辐射中的至少一个电磁辐射偏振。
5.根据权利要求1的设备,其中所述第一和第二装置在偏振调制源中提供。
6.根据权利要求1的设备,其中所述第三电磁辐射从所述样本提供,并且其中所述第四电磁辐射从所述参考物提供。
7.根据权利要求1的设备,还包括:
至少一个第四装置,其被配置为在第一偏振状态下检测所述第三和第四辐射之间的第一干涉信号;以及
至少一个第五装置,其被配置为在第二偏振状态下检测所述第三和第四电磁辐射之间的第二干涉信号,其中所述第一和第二偏振状态彼此不同。
8.根据权利要求7的设备,其中所述第四装置或所述第五装置中的至少一个装置被配置为接收所述第一电磁辐射、所述第二电磁辐射或所述第四电磁辐射中的至少一个电磁辐射的一部分,并且其中所述第四电磁辐射从所述参考物提供。
9.根据权利要求7的设备,还包括至少一个第六装置,所述第六装置被配置为数字化所述第一和第二干涉信号,并确定所述样本的至少一部分的偏振属性。
10.根据权利要求7的设备,其中所述第一和第二偏振状态相对于彼此大约正交。
11.根据权利要求1的设备,其中所述至少一个第三装置产生所述样本的偏振属性的至少一个图像。
12.根据权利要求11的设备,其中所述偏振属性包括双折射、双折射轴、衰减或衰减轴中的至少一个。
13.根据权利要求1的设备,其中所述参考物是无反射参考物。
14.根据权利要求1的设备,其中所述第一特征周期短于大约100微秒。
15.根据权利要求1的设备,其中由所述至少一个第一装置提供的所述辐射的频率在所述第一特征周期内变化大约至少1THz。
16.根据权利要求1的设备,其中由所述至少一个第一装置提供的所述辐射的频率在所述第二特征周期内变化大约至多100GHz。
17.根据权利要求1的设备,其中所述第二周期短于所述第一周期的大约1/10。
18.根据权利要求1的设备,还包括至少一个波导第二装置,所述波导第二装置被配置为在所述第一特征周期中组合所述第三电磁辐射和所述第四电磁辐射,以确定所述样本的至少一部分的轴向反射轮廓。
19.根据权利要求18的设备,其中所述数据包括所述样本的偏振属性。
20.根据权利要求18的设备,其中所述至少一个波导第二装置包括至少一个光纤。
21.一种设备,包括:
至少一个第一装置,其向样本提供至少一个第一电磁辐射并向参考物提供至少一个第二电磁辐射,其中由所述至少一个第一装置提供的辐射的频率以第一特征周期随着时间反复地变化;
至少一个波导第二装置,其被配置为组合第三电磁辐射和第四电磁辐射,以确定所述样本的至少一部分的轴向反射轮廓,其中所述第三和第四电磁辐射分别与所述第一和第二电磁辐射相关联;
至少一个第三装置,其被配置为以第二特征周期随着时间反复地改变所述第一电磁辐射、所述第二电磁辐射、所述第三电磁辐射或所述第四电磁辐射中的至少一个电磁辐射的偏振状态;以及
至少一个第四装置,其被配置为根据所述偏振状态来提供用于对所述样本的至少一部分进行成像的数据,其中所述第二周期短于所述第一周期。
22.根据权利要求21的设备,其中所述至少一个第一装置是偏振源。
23.根据权利要求21的设备,其中所述至少一个第三装置是偏振调制器、延迟干涉仪、移频器或双折射介质中的至少一个。
24.根据权利要求21的设备,其中所述至少一个第一装置是非偏振源,并且所述设备还包括偏振装置,所述偏振装置被配置为使所述第一、第二、第三或第四电磁辐射中的至少一个电磁辐射偏振。
25.根据权利要求21的设备,其中所述第一和第三装置在偏振调制源中提供。
26.根据权利要求21的设备,其中所述第三电磁辐射从所述样本提供,并且其中所述第四电磁辐射从所述参考物提供。
27.根据权利要求21的设备,还包括:
至少一个第五装置,其被配置为在第一偏振状态下检测所述第三和第四辐射之间的第一干涉信号;以及
至少一个第六装置,其被配置为在第二偏振状态下检测所述第三和第四电磁辐射之间的第二干涉信号,其中所述第一和第二偏振状态彼此不同。
28.根据权利要求27的设备,其中所述第五装置或所述第六装置中的至少一个装置被配置为接收所述第一电磁辐射、所述第二电磁辐射或所述第四电磁辐射中的至少一个电磁辐射的一部分,并且其中所述第四电磁辐射从所述参考物提供。
29.根据权利要求27的设备,还包括至少一个第七装置,所述第七装置被配置为数字化所述第一和第二干涉信号,并确定所述样本的至少一部分的偏振属性。
30.根据权利要求27的设备,其中所述第一和第二偏振状态相对于彼此大约正交。
31.根据权利要求21的设备,其中所述至少一个第四装置产生所述样本的偏振属性的至少一个图像。
32.根据权利要求31的设备,其中所述偏振属性包括双折射、双折射轴、衰减或衰减轴中的至少一个。
33.根据权利要求21的设备,其中所述参考物是无反射参考物。
34.根据权利要求21的设备,其中所述第一特征周期短于大约100微秒。
35.根据权利要求21的设备,其中由所述至少一个第一装置提供的所述辐射的频率在所述第一特征周期内变化大约至少1THz。
36.根据权利要求21的设备,其中由所述至少一个第一装置提供的所述辐射的频率在所述第二特征周期内变化大约至多100GHz。
37.根据权利要求21的设备,其中所述第二周期短于所述第一周期的大约1/10。
38.根据权利要求21的设备,其中所述轴向反射轮廓在第一特征周期中被确定。
39.根据权利要求38的设备,其中所述第一电磁辐射、所述第二电磁辐射、所述第三电磁辐射或所述第四电磁辐射中的所述至少一个电磁辐射以第二特征周期随着时间反复地改变。
40.根据权利要求39的设备,其中所述第二周期短于所述第一周期。
41.根据权利要求21的设备,其中所述数据包括所述样本的偏振属性。
42.根据权利要求21的设备,其中所述至少一个波导第二装置包括至少一个光纤。
43.一种用于提供与样本相关联的数据的方法,包括:
向所述样本提供至少一个第一电磁辐射并且向参考物提供至少一个第二电磁辐射,其中所述第一和第二电磁辐射中的至少一个电磁辐射的频率以第一特征周期随着时间反复地变化;
以第二特征周期随着时间反复地改变所述第一电磁辐射、所述第二电磁辐射、第三电磁辐射或第四电磁辐射中的至少一个电磁辐射的偏振状态;以及
根据所述偏振状态来提供用于对所述样本的至少一部分进行成像的所述数据,
其中所述第三电磁辐射与所述至少一个第一辐射相关联并且所述第四电磁辐射与所述至少一个第二辐射相关联,并且其中所述第二周期短于所述第一周期。
44.一种用于提供与样本相关联的数据的方法,包括:
向所述样本提供至少一个第一电磁辐射并且向参考物提供至少一个第二电磁辐射,其中由所述至少一个第一装置提供的辐射的频率以第一特征周期随着时间反复地变化;
组合第三电磁辐射和第四电磁辐射,以确定所述样本的至少一部分的轴向反射轮廓,其中所述第三和第四电磁辐射分别与所述第一和第二电磁辐射相关联;
以第二特征周期随着时间反复地改变所述第一电磁辐射、所述第二电磁辐射、所述第三电磁辐射或所述第四电磁辐射中的至少一个电磁辐射的偏振状态;以及
根据所述偏振状态来提供用于对所述样本的至少一部分进行成像的所述数据,其中所述第二周期短于所述第一周期。
45.一种设备,包括:
至少一个第一装置,其向样本提供至少一个第一电磁辐射,并且向参考物提供至少一个第二电磁辐射,其中由所述至少一个第一装置提供的辐射的频率随着时间反复地变化;
至少一个第二装置,其被配置为随着时间反复地改变所述第一电磁辐射、所述第二电磁辐射、第三电磁辐射或第四电磁辐射中的至少一个电磁辐射的偏振状态;以及
至少一个第三装置,其被配置为根据所述偏振状态来提供用于对所述样本的至少一部分进行成像的数据,
其中,所述第三电磁辐射与所述至少一个第一辐射相关联,并且所述第四电磁辐射与所述至少一个第二辐射相关联。
46.一种用于提供与样本相关联的数据的方法,包括:
向所述样本提供至少一个第一电磁辐射并且向无反射参考物提供至少一个第二电磁辐射,其中所述第一和第二辐射中的至少一个电磁辐射的频率随着时间反复地变化;
随着时间反复地改变所述第一电磁辐射、所述第二电磁辐射、第三电磁辐射或第四电磁辐射中的至少一个电磁辐射的偏振状态;以及
根据所述偏振状态来提供用于对所述样本的至少一部分进行成像的所述数据,
其中,所述第三电磁辐射与所述至少一个第一辐射相关联,并且所述第四电磁辐射与所述至少一个第二辐射相关联。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78973906P | 2006-04-05 | 2006-04-05 | |
US60/789,739 | 2006-04-05 | ||
PCT/US2007/066017 WO2007118129A1 (en) | 2006-04-05 | 2007-04-05 | Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101466298A true CN101466298A (zh) | 2009-06-24 |
CN101466298B CN101466298B (zh) | 2011-08-31 |
Family
ID=38328493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007800162663A Active CN101466298B (zh) | 2006-04-05 | 2007-04-05 | 用于样本的偏振敏感光频域成像的方法、装置和*** |
Country Status (5)
Country | Link |
---|---|
US (1) | US7742173B2 (zh) |
EP (2) | EP2564769B1 (zh) |
JP (2) | JP5135324B2 (zh) |
CN (1) | CN101466298B (zh) |
WO (1) | WO2007118129A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104180892A (zh) * | 2013-05-27 | 2014-12-03 | 综合工艺有限公司 | 光学干涉仪和具有这种光学干涉仪的振动计 |
CN104634282A (zh) * | 2015-02-28 | 2015-05-20 | 清华大学 | 光学探针干涉相位测量中相位误差补偿装置 |
CN113703148A (zh) * | 2020-05-20 | 2021-11-26 | 奥林巴斯株式会社 | 显微镜***、控制方法、计算机可读介质 |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7231243B2 (en) | 2000-10-30 | 2007-06-12 | The General Hospital Corporation | Optical methods for tissue analysis |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
WO2002088705A2 (en) | 2001-05-01 | 2002-11-07 | The General Hospital Corporation | Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties |
US7355716B2 (en) | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
US8054468B2 (en) | 2003-01-24 | 2011-11-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
EP1596716B1 (en) | 2003-01-24 | 2014-04-30 | The General Hospital Corporation | System and method for identifying tissue using low-coherence interferometry |
JP4805142B2 (ja) | 2003-03-31 | 2011-11-02 | ザ ジェネラル ホスピタル コーポレイション | 光路長が変更された異なる角度の光の合成により光学的に干渉する断層撮影におけるスペックルの減少 |
US7519096B2 (en) | 2003-06-06 | 2009-04-14 | The General Hospital Corporation | Process and apparatus for a wavelength tuning source |
EP2293031B8 (en) | 2003-10-27 | 2024-03-20 | The General Hospital Corporation | Method and apparatus for performing optical imaging using frequency-domain interferometry |
KR101239250B1 (ko) | 2004-05-29 | 2013-03-05 | 더 제너럴 하스피탈 코포레이션 | 광간섭 단층촬영 화상 진단에서 반사층을 이용한 색 분산보상을 위한 프로세스, 시스템 및 소프트웨어 배열 |
US7447408B2 (en) | 2004-07-02 | 2008-11-04 | The General Hospital Corproation | Imaging system and related techniques |
JP5053845B2 (ja) | 2004-08-06 | 2012-10-24 | ザ ジェネラル ホスピタル コーポレイション | 光学コヒーレンス断層撮影法を使用して試料中の少なくとも1つの位置を決定するための方法、システムおよびソフトウェア装置 |
WO2006024015A1 (en) | 2004-08-24 | 2006-03-02 | The General Hospital Corporation | Method and apparatus for imaging of vessel segments |
EP1793730B1 (en) | 2004-08-24 | 2011-12-28 | The General Hospital Corporation | Process, system and software arrangement for determining elastic modulus |
WO2006039091A2 (en) | 2004-09-10 | 2006-04-13 | The General Hospital Corporation | System and method for optical coherence imaging |
EP2329759B1 (en) | 2004-09-29 | 2014-03-12 | The General Hospital Corporation | System and method for optical coherence imaging |
US7995210B2 (en) | 2004-11-24 | 2011-08-09 | The General Hospital Corporation | Devices and arrangements for performing coherence range imaging using a common path interferometer |
JP2008521516A (ja) | 2004-11-29 | 2008-06-26 | ザ ジェネラル ホスピタル コーポレイション | サンプル上の複数の地点を同時に照射し検出することによって光学画像生成を実行する構成、装置、内視鏡、カテーテル、及び方法 |
ES2337497T3 (es) | 2005-04-28 | 2010-04-26 | The General Hospital Corporation | Evaluacion de caracteristicas de la imagen de una estructura anatomica en imagenes de tomografia de coherencia optica. |
JP5702049B2 (ja) | 2005-06-01 | 2015-04-15 | ザ ジェネラル ホスピタル コーポレイション | 位相分解光学周波数領域画像化を行うための装置、方法及びシステム |
US7428053B2 (en) * | 2005-07-08 | 2008-09-23 | Imalux Corporation | Common path frequency domain optical coherence reflectometry/tomography device |
ES2354287T3 (es) | 2005-08-09 | 2011-03-11 | The General Hospital Corporation | Aparato y método para realizar una desmodulación en cuadratura por polarización en tomografía de coherencia óptica. |
WO2007041382A1 (en) | 2005-09-29 | 2007-04-12 | General Hospital Corporation | Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures |
US7889348B2 (en) | 2005-10-14 | 2011-02-15 | The General Hospital Corporation | Arrangements and methods for facilitating photoluminescence imaging |
US7796270B2 (en) | 2006-01-10 | 2010-09-14 | The General Hospital Corporation | Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques |
WO2007084903A2 (en) | 2006-01-19 | 2007-07-26 | The General Hospital Corporation | Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements |
PL1973466T3 (pl) | 2006-01-19 | 2021-07-05 | The General Hospital Corporation | Balonowy cewnik do obrazowania |
EP2659852A3 (en) | 2006-02-01 | 2014-01-15 | The General Hospital Corporation | Apparatus for applying a plurality of electro-magnetic radiations to a sample |
JP5524487B2 (ja) | 2006-02-01 | 2014-06-18 | ザ ジェネラル ホスピタル コーポレイション | コンフォーマルレーザ治療手順を用いてサンプルの少なくとも一部分に電磁放射を放射する方法及びシステム。 |
WO2007092911A2 (en) | 2006-02-08 | 2007-08-16 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy |
JP2009527770A (ja) | 2006-02-24 | 2009-07-30 | ザ ジェネラル ホスピタル コーポレイション | 角度分解型のフーリエドメイン光干渉断層撮影法を遂行する方法及びシステム |
EP2517616A3 (en) | 2006-05-10 | 2013-03-06 | The General Hospital Corporation | Processes, arrangements and systems for providing frequency domain imaging of a sample |
US7869054B2 (en) * | 2006-05-26 | 2011-01-11 | Medeikon Corporation | Polarization insensitive multiple probe |
US7742174B2 (en) * | 2006-07-17 | 2010-06-22 | Bioptigen, Inc. | Methods, systems and computer program products for removing undesired artifacts in fourier domain optical coherence tomography (FDOCT) systems using continuous phase modulation and related phase modulators |
EP2054712B1 (en) | 2006-08-25 | 2015-10-07 | The General Hospital Corporation | Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques |
WO2008049118A2 (en) * | 2006-10-19 | 2008-04-24 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s) |
JP2008128926A (ja) * | 2006-11-24 | 2008-06-05 | Fujifilm Corp | 光断層画像化装置 |
EP2662674A3 (en) | 2007-01-19 | 2014-06-25 | The General Hospital Corporation | Rotating disk reflection for fast wavelength scanning of dispersed broadbend light |
EP1962050B1 (de) * | 2007-02-21 | 2015-12-23 | Agfa HealthCare N.V. | System und Verfahren zur optischen Kohärenztomographie sowie Verfahren zur Kalibrierung eines solchen Systems |
JP5142564B2 (ja) * | 2007-03-20 | 2013-02-13 | オリンパス株式会社 | 蛍光内視鏡装置 |
EP2132840A2 (en) | 2007-03-23 | 2009-12-16 | The General Hospital Corporation | Methods, arrangements and apparatus for utlizing a wavelength-swept laser using angular scanning and dispersion procedures |
WO2008121844A1 (en) | 2007-03-30 | 2008-10-09 | The General Hospital Corporation | System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque |
WO2008131082A1 (en) | 2007-04-17 | 2008-10-30 | The General Hospital Corporation | Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy techniques |
JP5917803B2 (ja) | 2007-07-31 | 2016-05-18 | ザ ジェネラル ホスピタル コーポレイション | 高速ドップラー光周波数領域撮像法のためのビーム走査パターンを放射するシステムおよび方法 |
WO2009033110A2 (en) | 2007-09-05 | 2009-03-12 | Lensx Lasers, Inc. | Laser-induced protection shield in laser surgery |
US9456925B2 (en) | 2007-09-06 | 2016-10-04 | Alcon Lensx, Inc. | Photodisruptive laser treatment of the crystalline lens |
US20100324543A1 (en) * | 2007-09-18 | 2010-12-23 | Kurtz Ronald M | Method And Apparatus For Integrating Cataract Surgery With Glaucoma Or Astigmatism Surgery |
WO2009059034A1 (en) | 2007-10-30 | 2009-05-07 | The General Hospital Corporation | System and method for cladding mode detection |
US20100324542A1 (en) * | 2007-11-02 | 2010-12-23 | Kurtz Ronald M | Method to Guide a Cataract Procedure by Corneal Imaging |
US7916303B2 (en) * | 2007-11-13 | 2011-03-29 | Optoplan As | Non-uniform sampling to extend dynamic range of interferometric sensors |
US7894046B2 (en) * | 2008-01-07 | 2011-02-22 | Darren Ross Morofke | Two-dimensional estimation technique for doppler optical coherence tomography (OCT) |
PT3363415T (pt) | 2008-01-09 | 2019-11-05 | Alcon Lensx Inc | Fragmentação curva de tecido por laser fotodisruptivo |
US7884946B2 (en) * | 2008-04-28 | 2011-02-08 | Lumetrics, Inc. | Apparatus for measurement of the axial length of an eye |
US7898656B2 (en) | 2008-04-30 | 2011-03-01 | The General Hospital Corporation | Apparatus and method for cross axis parallel spectroscopy |
JP5607610B2 (ja) | 2008-05-07 | 2014-10-15 | ザ ジェネラル ホスピタル コーポレイション | 構造の特徴を決定する装置、装置の作動方法およびコンピュータアクセス可能な媒体 |
WO2009155536A2 (en) | 2008-06-20 | 2009-12-23 | The General Hospital Corporation | Fused fiber optic coupler arrangement and method for use thereof |
WO2010009136A2 (en) | 2008-07-14 | 2010-01-21 | The General Hospital Corporation | Apparatus and methods for color endoscopy |
WO2010045286A1 (en) * | 2008-10-14 | 2010-04-22 | Schlumberger Canada Limited | Polarization-diverse, heterodyne optical receiving system |
US20120099113A1 (en) * | 2008-11-05 | 2012-04-26 | The General Hospital Corporation | System and method for providing full jones matrix-based analysis to determine non-depolarizing polarization parameters using optical frequency domain imaging |
US8937724B2 (en) | 2008-12-10 | 2015-01-20 | The General Hospital Corporation | Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling |
EP2389093A4 (en) | 2009-01-20 | 2013-07-31 | Gen Hospital Corp | APPARATUS, SYSTEM AND METHOD FOR ENDOSCOPIC BIOPSY |
WO2010085775A2 (en) | 2009-01-26 | 2010-07-29 | The General Hospital Corporation | System, method and computer-accessible medium for providing wide-field superresolution microscopy |
JP6053284B2 (ja) | 2009-02-04 | 2016-12-27 | ザ ジェネラル ホスピタル コーポレイション | ハイスピード光学波長チューニング源の利用のための装置及び方法 |
US8139226B2 (en) * | 2009-04-28 | 2012-03-20 | Axsun Technologies, Inc. | Soft clock delay for OCT system and method therefor |
WO2011008822A2 (en) | 2009-07-14 | 2011-01-20 | The General Hospital Corporation | Apparatus, systems and methods for measuring flow and pressure within a vessel |
WO2011109828A2 (en) | 2010-03-05 | 2011-09-09 | The General Hospital Corporation | Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution |
JP5666617B2 (ja) * | 2010-03-17 | 2015-02-12 | ライトラボ・イメージング・インコーポレーテッド | 干渉センシングおよび画像取得システムのための強度雑音を低減する方法および装置 |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
JP5637730B2 (ja) * | 2010-05-14 | 2014-12-10 | キヤノン株式会社 | 撮像装置及びその撮像方法 |
WO2011149972A2 (en) | 2010-05-25 | 2011-12-01 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
EP2575598A2 (en) | 2010-05-25 | 2013-04-10 | The General Hospital Corporation | Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images |
US10285568B2 (en) | 2010-06-03 | 2019-05-14 | The General Hospital Corporation | Apparatus and method for devices for imaging structures in or at one or more luminal organs |
WO2012012355A1 (en) | 2010-07-19 | 2012-01-26 | Lumetrics, Inc. | Fiber-based interferometric device for measuring axial dimensions of a human eye |
US9510758B2 (en) | 2010-10-27 | 2016-12-06 | The General Hospital Corporation | Apparatus, systems and methods for measuring blood pressure within at least one vessel |
EP2574273B1 (en) * | 2011-06-23 | 2014-09-24 | Nidek Co., Ltd. | Optical coherence tomography apparatus |
ES2396391B2 (es) * | 2011-06-28 | 2014-12-04 | Medlumics, S.L. | Dispositivo de retardo óptico variable para interferometría de baja coherencia. |
WO2013013049A1 (en) | 2011-07-19 | 2013-01-24 | The General Hospital Corporation | Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography |
CN102322880B (zh) * | 2011-08-18 | 2013-06-05 | 天津大学 | 偏振敏感的分布式光频域反射扰动传感装置和解调方法 |
US10241028B2 (en) | 2011-08-25 | 2019-03-26 | The General Hospital Corporation | Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures |
JP5984351B2 (ja) * | 2011-09-14 | 2016-09-06 | キヤノン株式会社 | 計測装置 |
EP2769491A4 (en) | 2011-10-18 | 2015-07-22 | Gen Hospital Corp | DEVICE AND METHOD FOR PRODUCING AND / OR PROVIDING RECIRCULATING OPTICAL DELAY (DE) |
EP2833776A4 (en) | 2012-03-30 | 2015-12-09 | Gen Hospital Corp | IMAGING SYSTEM, METHOD AND DISTAL FIXATION FOR MULTIDIRECTIONAL FIELD ENDOSCOPY |
WO2013177154A1 (en) | 2012-05-21 | 2013-11-28 | The General Hospital Corporation | Apparatus, device and method for capsule microscopy |
DE102012211549B3 (de) * | 2012-07-03 | 2013-07-04 | Polytec Gmbh | Vorrichtung und Verfahren zur interferometrischen Vermessung eines Objekts |
EP2888616A4 (en) | 2012-08-22 | 2016-04-27 | Gen Hospital Corp | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIA FOR MANUFACTURING MINIATURE ENDOSCOPES USING SOFT LITHOGRAPHY |
US9677869B2 (en) | 2012-12-05 | 2017-06-13 | Perimeter Medical Imaging, Inc. | System and method for generating a wide-field OCT image of a portion of a sample |
EP2948758B1 (en) | 2013-01-28 | 2024-03-13 | The General Hospital Corporation | Apparatus for providing diffuse spectroscopy co-registered with optical frequency domain imaging |
US10893806B2 (en) | 2013-01-29 | 2021-01-19 | The General Hospital Corporation | Apparatus, systems and methods for providing information regarding the aortic valve |
WO2014121082A1 (en) | 2013-02-01 | 2014-08-07 | The General Hospital Corporation | Objective lens arrangement for confocal endomicroscopy |
JP6378311B2 (ja) | 2013-03-15 | 2018-08-22 | ザ ジェネラル ホスピタル コーポレイション | 物体を特徴付ける方法とシステム |
JP2014206433A (ja) * | 2013-04-12 | 2014-10-30 | 株式会社トーメーコーポレーション | 光断層画像撮影装置 |
US9784681B2 (en) | 2013-05-13 | 2017-10-10 | The General Hospital Corporation | System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence |
JP6346410B2 (ja) * | 2013-05-24 | 2018-06-20 | 国立大学法人 筑波大学 | ジョーンズマトリックスoctシステム及び該octで得られた計測データを画像処理するプログラム |
WO2015009932A1 (en) | 2013-07-19 | 2015-01-22 | The General Hospital Corporation | Imaging apparatus and method which utilizes multidirectional field of view endoscopy |
US10117576B2 (en) | 2013-07-19 | 2018-11-06 | The General Hospital Corporation | System, method and computer accessible medium for determining eye motion by imaging retina and providing feedback for acquisition of signals from the retina |
EP3025173B1 (en) | 2013-07-26 | 2021-07-07 | The General Hospital Corporation | Apparatus with a laser arrangement utilizing optical dispersion for applications in fourier-domain optical coherence tomography |
WO2015084964A1 (en) * | 2013-12-03 | 2015-06-11 | The General Hospital Corporation | Compensating for input polarization mode variations |
KR101538044B1 (ko) * | 2013-12-30 | 2015-07-22 | 광주과학기술원 | 편광 민감 전역 광단층 장치 및 그 제어시스템 및 제어방법 |
WO2015105870A1 (en) | 2014-01-08 | 2015-07-16 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
CN103776474A (zh) * | 2014-01-10 | 2014-05-07 | 江苏昂德光电科技有限公司 | 一种3d矩阵式多通道光纤传感解调*** |
US9291500B2 (en) * | 2014-01-29 | 2016-03-22 | Raytheon Company | Configurable combination spectrometer and polarizer |
WO2015116986A2 (en) | 2014-01-31 | 2015-08-06 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
WO2015153982A1 (en) | 2014-04-04 | 2015-10-08 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
JP6357346B2 (ja) * | 2014-05-02 | 2018-07-11 | 株式会社トーメーコーポレーション | 眼科装置 |
JP6256879B2 (ja) * | 2014-06-06 | 2018-01-10 | 国立大学法人 筑波大学 | 偏光感受型光画像計測システム及び該システムに搭載されたプログラム |
EP3171766B1 (en) | 2014-07-25 | 2021-12-29 | The General Hospital Corporation | Apparatus for in vivo imaging and diagnosis |
JP6463051B2 (ja) * | 2014-09-10 | 2019-01-30 | 株式会社トーメーコーポレーション | 光断層画像撮影装置 |
KR102329767B1 (ko) * | 2015-01-22 | 2021-11-23 | 엘지전자 주식회사 | 편광 민감도 광간섭성 단층 촬영 장치 및 그 제어방법 |
US20180028059A1 (en) * | 2015-03-24 | 2018-02-01 | Forus Health Private Limited | An apparatus for multi-mode imaging of eye |
CN107949311B (zh) | 2015-04-16 | 2021-04-16 | Gentuity有限责任公司 | 用于神经病学的微光探针 |
WO2017040484A1 (en) | 2015-08-31 | 2017-03-09 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
US10578422B2 (en) * | 2016-06-08 | 2020-03-03 | Canon U.S.A., Inc. | Devices, systems, methods and storage mediums using full range optical coherence tomography |
AU2018211563A1 (en) * | 2017-01-30 | 2019-05-23 | Alcon Inc. | System and method for cutting a flap using polarization sensitive optical coherence tomography |
DE102017115922C5 (de) * | 2017-07-14 | 2023-03-23 | Precitec Gmbh & Co. Kg | Verfahren und Vorrichtung zur Messung und Einstellung eines Abstands zwischen einem Bearbeitungskopf und einem Werkstück sowie dazugehöriges Verfahren zur Regelung |
EP3655748B1 (en) | 2017-07-18 | 2023-08-09 | Perimeter Medical Imaging, Inc. | Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis |
US11684242B2 (en) | 2017-11-28 | 2023-06-27 | Gentuity, Llc | Imaging system |
US11309973B2 (en) * | 2018-01-31 | 2022-04-19 | Nokia Solutions And Networks Oy | Optical burst monitoring |
US10948733B2 (en) * | 2018-05-09 | 2021-03-16 | The Regents Of The University Of California | Systems, methods, and devices for detecting magneto-optic Kerr effect |
US11175126B2 (en) | 2019-04-08 | 2021-11-16 | Canon U.S.A., Inc. | Automated polarization control |
WO2020247473A1 (en) * | 2019-06-03 | 2020-12-10 | The General Hospital Corporation | Systems and methods for stimulated brillouin microscopy |
Family Cites Families (329)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US135101A (en) * | 1873-01-21 | Improvement in turn-tables | ||
US26735A (en) * | 1860-01-03 | Washing-machine | ||
US171691A (en) * | 1876-01-04 | Improvement in heating-stoves | ||
US142735A (en) * | 1873-09-09 | Improvement in window-screens | ||
US238040A (en) * | 1881-02-22 | Seed-sower | ||
US163622A (en) * | 1875-05-25 | Improvement in school-seats | ||
US161357A (en) * | 1875-03-30 | Improvement in fire-proof floors and ceilings | ||
US138820A (en) * | 1873-05-13 | Improvement in corks for bottles | ||
US254027A (en) * | 1882-02-21 | Back roll and support therefor for looms | ||
US166593A (en) * | 1875-08-10 | Improvement in grain-meters | ||
US1426799A (en) * | 1921-03-12 | 1922-08-22 | Edward L Weil | Valve remover |
US2339754A (en) | 1941-03-04 | 1944-01-25 | Westinghouse Electric & Mfg Co | Supervisory apparatus |
US3020119A (en) * | 1958-04-17 | 1962-02-06 | Marchal Maurice | Apparatus for recording light spot traces on film |
US3090753A (en) | 1960-08-02 | 1963-05-21 | Exxon Research Engineering Co | Ester oil compositions containing acid anhydride |
US3463313A (en) * | 1967-09-15 | 1969-08-26 | Entoleter | Aspirating machine and method |
GB1257778A (zh) | 1967-12-07 | 1971-12-22 | ||
US3601480A (en) | 1968-07-10 | 1971-08-24 | Physics Int Co | Optical tunnel high-speed camera system |
JPS4932484U (zh) | 1972-06-19 | 1974-03-20 | ||
US3872407A (en) | 1972-09-01 | 1975-03-18 | Us Navy | Rapidly tunable laser |
JPS584481Y2 (ja) | 1973-06-23 | 1983-01-26 | オリンパス光学工業株式会社 | ナイシキヨウシヤヘンカンコウガクケイ |
FR2253410A5 (zh) | 1973-12-03 | 1975-06-27 | Inst Nat Sante Rech Med | |
US3941121A (en) | 1974-12-20 | 1976-03-02 | The University Of Cincinnati | Focusing fiber-optic needle endoscope |
US3983507A (en) | 1975-01-06 | 1976-09-28 | Research Corporation | Tunable laser systems and method |
US3973219A (en) | 1975-04-24 | 1976-08-03 | Cornell Research Foundation, Inc. | Very rapidly tuned cw dye laser |
US4035316A (en) * | 1975-11-24 | 1977-07-12 | California Institute Of Technology | Cell specific, variable density, polymer microspheres |
US4135550A (en) * | 1977-03-11 | 1979-01-23 | Trelleborg Rubber Company, Inc. | Pinch valve control circuit |
US4141362A (en) | 1977-05-23 | 1979-02-27 | Richard Wolf Gmbh | Laser endoscope |
US4135551A (en) * | 1977-05-31 | 1979-01-23 | Fmc Corporation | Modified dry-break coupler |
US4224929A (en) | 1977-11-08 | 1980-09-30 | Olympus Optical Co., Ltd. | Endoscope with expansible cuff member and operation section |
GB2030313A (en) | 1978-06-29 | 1980-04-02 | Wolf Gmbh Richard | Endoscopes |
FR2448728A1 (fr) | 1979-02-07 | 1980-09-05 | Thomson Csf | Dispositif joint tournant pour liaison par conducteurs optiques et systeme comportant un tel dispositif |
US4295738A (en) | 1979-08-30 | 1981-10-20 | United Technologies Corporation | Fiber optic strain sensor |
US4300816A (en) | 1979-08-30 | 1981-11-17 | United Technologies Corporation | Wide band multicore optical fiber |
US4428643A (en) | 1981-04-08 | 1984-01-31 | Xerox Corporation | Optical scanning system with wavelength shift correction |
US5065331A (en) | 1981-05-18 | 1991-11-12 | Vachon Reginald I | Apparatus and method for determining the stress and strain in pipes, pressure vessels, structural members and other deformable bodies |
GB2106736B (en) | 1981-09-03 | 1985-06-12 | Standard Telephones Cables Ltd | Optical transmission system |
US4479499A (en) | 1982-01-29 | 1984-10-30 | Alfano Robert R | Method and apparatus for detecting the presence of caries in teeth using visible light |
US4601036A (en) | 1982-09-30 | 1986-07-15 | Honeywell Inc. | Rapidly tunable laser |
HU187188B (en) | 1982-11-25 | 1985-11-28 | Koezponti Elelmiszeripari | Device for generating radiation of controllable spectral structure |
CH663466A5 (fr) | 1983-09-12 | 1987-12-15 | Battelle Memorial Institute | Procede et dispositif pour determiner la position d'un objet par rapport a une reference. |
EP0590268B1 (en) | 1985-03-22 | 1998-07-01 | Massachusetts Institute Of Technology | Fiber Optic Probe System for Spectrally Diagnosing Tissue |
US5318024A (en) | 1985-03-22 | 1994-06-07 | Massachusetts Institute Of Technology | Laser endoscope for spectroscopic imaging |
US4607622A (en) | 1985-04-11 | 1986-08-26 | Charles D. Fritch | Fiber optic ocular endoscope |
US4631498A (en) | 1985-04-26 | 1986-12-23 | Hewlett-Packard Company | CW Laser wavemeter/frequency locking technique |
US4650327A (en) | 1985-10-28 | 1987-03-17 | Oximetrix, Inc. | Optical catheter calibrating assembly |
US5040889A (en) | 1986-05-30 | 1991-08-20 | Pacific Scientific Company | Spectrometer with combined visible and ultraviolet sample illumination |
CA1290019C (en) | 1986-06-20 | 1991-10-01 | Hideo Kuwahara | Dual balanced optical signal receiver |
US4770492A (en) | 1986-10-28 | 1988-09-13 | Spectran Corporation | Pressure or strain sensitive optical fiber |
JPH0824665B2 (ja) | 1986-11-28 | 1996-03-13 | オリンパス光学工業株式会社 | 内視鏡装置 |
US4744656A (en) | 1986-12-08 | 1988-05-17 | Spectramed, Inc. | Disposable calibration boot for optical-type cardiovascular catheter |
US4751706A (en) | 1986-12-31 | 1988-06-14 | The United States Of America As Represented By The Secretary Of The Army | Laser for providing rapid sequence of different wavelengths |
US4834111A (en) | 1987-01-12 | 1989-05-30 | The Trustees Of Columbia University In The City Of New York | Heterodyne interferometer |
CA1339426C (en) | 1987-09-01 | 1997-09-02 | Michael R. Layton | Hydrophone demodulator circuit and method |
US4909631A (en) | 1987-12-18 | 1990-03-20 | Tan Raul Y | Method for film thickness and refractive index determination |
US4890901A (en) | 1987-12-22 | 1990-01-02 | Hughes Aircraft Company | Color corrector for embedded prisms |
US4892406A (en) | 1988-01-11 | 1990-01-09 | United Technologies Corporation | Method of and arrangement for measuring vibrations |
FR2626367B1 (fr) | 1988-01-25 | 1990-05-11 | Thomson Csf | Capteur de temperature multipoints a fibre optique |
FR2626383B1 (fr) | 1988-01-27 | 1991-10-25 | Commissariat Energie Atomique | Procede de microscopie optique confocale a balayage et en profondeur de champ etendue et dispositifs pour la mise en oeuvre du procede |
US4925302A (en) | 1988-04-13 | 1990-05-15 | Hewlett-Packard Company | Frequency locking device |
US4998972A (en) | 1988-04-28 | 1991-03-12 | Thomas J. Fogarty | Real time angioscopy imaging system |
US5730731A (en) | 1988-04-28 | 1998-03-24 | Thomas J. Fogarty | Pressure-based irrigation accumulator |
US5242437A (en) | 1988-06-10 | 1993-09-07 | Trimedyne Laser Systems, Inc. | Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium |
WO1990000754A1 (en) | 1988-07-13 | 1990-01-25 | Martin Russell Harris | Scanning confocal microscope |
GB8817672D0 (en) | 1988-07-25 | 1988-09-01 | Sira Ltd | Optical apparatus |
US5214538A (en) | 1988-07-25 | 1993-05-25 | Keymed (Medical And Industrial Equipment) Limited | Optical apparatus |
US4868834A (en) | 1988-09-14 | 1989-09-19 | The United States Of America As Represented By The Secretary Of The Army | System for rapidly tuning a low pressure pulsed laser |
DE3833602A1 (de) | 1988-10-03 | 1990-02-15 | Krupp Gmbh | Spektrometer zur gleichzeitigen intensitaetsmessung in verschiedenen spektralbereichen |
ATE133545T1 (de) | 1988-12-21 | 1996-02-15 | Massachusetts Inst Technology | Verfahren für laserinduzierte fluoreszenz von gewebe |
US5046501A (en) | 1989-01-18 | 1991-09-10 | Wayne State University | Atherosclerotic identification |
US5085496A (en) | 1989-03-31 | 1992-02-04 | Sharp Kabushiki Kaisha | Optical element and optical pickup device comprising it |
US5317389A (en) | 1989-06-12 | 1994-05-31 | California Institute Of Technology | Method and apparatus for white-light dispersed-fringe interferometric measurement of corneal topography |
US4965599A (en) | 1989-11-13 | 1990-10-23 | Eastman Kodak Company | Scanning apparatus for halftone image screen writing |
KR930003307B1 (ko) | 1989-12-14 | 1993-04-24 | 주식회사 금성사 | 입체용 프로젝터 |
DD293205B5 (de) | 1990-03-05 | 1995-06-29 | Zeiss Carl Jena Gmbh | Lichtleiterfuehrung fuer ein medizinisches Beobachtungsgeraet |
US5039193A (en) | 1990-04-03 | 1991-08-13 | Focal Technologies Incorporated | Fibre optic single mode rotary joint |
US5262644A (en) | 1990-06-29 | 1993-11-16 | Southwest Research Institute | Remote spectroscopy for raman and brillouin scattering |
US5197470A (en) | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
GB9015793D0 (en) | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
US5127730A (en) | 1990-08-10 | 1992-07-07 | Regents Of The University Of Minnesota | Multi-color laser scanning confocal imaging system |
US5845639A (en) | 1990-08-10 | 1998-12-08 | Board Of Regents Of The University Of Washington | Optical imaging methods |
US5305759A (en) | 1990-09-26 | 1994-04-26 | Olympus Optical Co., Ltd. | Examined body interior information observing apparatus by using photo-pulses controlling gains for depths |
US5241364A (en) | 1990-10-19 | 1993-08-31 | Fuji Photo Film Co., Ltd. | Confocal scanning type of phase contrast microscope and scanning microscope |
US5202745A (en) | 1990-11-07 | 1993-04-13 | Hewlett-Packard Company | Polarization independent optical coherence-domain reflectometry |
JP3035336B2 (ja) | 1990-11-27 | 2000-04-24 | 興和株式会社 | 血流測定装置 |
US5228001A (en) | 1991-01-23 | 1993-07-13 | Syracuse University | Optical random access memory |
US6198532B1 (en) | 1991-02-22 | 2001-03-06 | Applied Spectral Imaging Ltd. | Spectral bio-imaging of the eye |
US5293872A (en) | 1991-04-03 | 1994-03-15 | Alfano Robert R | Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy |
DE69227902T3 (de) | 1991-04-29 | 2010-04-22 | Massachusetts Institute Of Technology, Cambridge | Vorrichtung für optische abbildung und messung |
US6485413B1 (en) | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US6501551B1 (en) | 1991-04-29 | 2002-12-31 | Massachusetts Institute Of Technology | Fiber optic imaging endoscope interferometer with at least one faraday rotator |
US6564087B1 (en) | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
US5465147A (en) | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US6111645A (en) | 1991-04-29 | 2000-08-29 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US6134003A (en) | 1991-04-29 | 2000-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope |
US5748598A (en) | 1995-12-22 | 1998-05-05 | Massachusetts Institute Of Technology | Apparatus and methods for reading multilayer storage media using short coherence length sources |
US5956355A (en) | 1991-04-29 | 1999-09-21 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser |
US5441053A (en) | 1991-05-03 | 1995-08-15 | University Of Kentucky Research Foundation | Apparatus and method for multiple wavelength of tissue |
DE4128744C1 (zh) | 1991-08-29 | 1993-04-22 | Siemens Ag, 8000 Muenchen, De | |
US5353790A (en) | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
US5212667A (en) | 1992-02-03 | 1993-05-18 | General Electric Company | Light imaging in a scattering medium, using ultrasonic probing and speckle image differencing |
US5248876A (en) | 1992-04-21 | 1993-09-28 | International Business Machines Corporation | Tandem linear scanning confocal imaging system with focal volumes at different heights |
US5486701A (en) | 1992-06-16 | 1996-01-23 | Prometrix Corporation | Method and apparatus for measuring reflectance in two wavelength bands to enable determination of thin film thickness |
US5716324A (en) | 1992-08-25 | 1998-02-10 | Fuji Photo Film Co., Ltd. | Endoscope with surface and deep portion imaging systems |
US5772597A (en) | 1992-09-14 | 1998-06-30 | Sextant Medical Corporation | Surgical tool end effector |
US5698397A (en) | 1995-06-07 | 1997-12-16 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
US5383467A (en) | 1992-11-18 | 1995-01-24 | Spectrascience, Inc. | Guidewire catheter and apparatus for diagnostic imaging |
AU5672194A (en) | 1992-11-18 | 1994-06-22 | Spectrascience, Inc. | Apparatus for diagnostic imaging |
JP3250628B2 (ja) * | 1992-12-17 | 2002-01-28 | 東芝セラミックス株式会社 | 縦型半導体熱処理用治具 |
US5987346A (en) | 1993-02-26 | 1999-11-16 | Benaron; David A. | Device and method for classification of tissue |
FI93781C (fi) | 1993-03-18 | 1995-05-26 | Wallac Oy | Biospesifinen multiparametrinen määritysmenetelmä |
DE4309056B4 (de) | 1993-03-20 | 2006-05-24 | Häusler, Gerd, Prof. Dr. | Verfahren und Vorrichtung zur Ermittlung der Entfernung und Streuintensität von streuenden Punkten |
DE4310209C2 (de) | 1993-03-29 | 1996-05-30 | Bruker Medizintech | Optische stationäre Bildgebung in stark streuenden Medien |
US5485079A (en) | 1993-03-29 | 1996-01-16 | Matsushita Electric Industrial Co., Ltd. | Magneto-optical element and optical magnetic field sensor |
DE4314189C1 (de) | 1993-04-30 | 1994-11-03 | Bodenseewerk Geraetetech | Vorrichtung zur Untersuchung von Lichtleitfasern aus Glas mittels Heterodyn-Brillouin-Spektroskopie |
US5454807A (en) | 1993-05-14 | 1995-10-03 | Boston Scientific Corporation | Medical treatment of deeply seated tissue using optical radiation |
DE69418248T2 (de) | 1993-06-03 | 1999-10-14 | Hamamatsu Photonics Kk | Optisches Laser-Abtastsystem mit Axikon |
JP3234353B2 (ja) | 1993-06-15 | 2001-12-04 | 富士写真フイルム株式会社 | 断層情報読取装置 |
US5803082A (en) | 1993-11-09 | 1998-09-08 | Staplevision Inc. | Omnispectramammography |
US5983125A (en) | 1993-12-13 | 1999-11-09 | The Research Foundation Of City College Of New York | Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy |
US5450203A (en) | 1993-12-22 | 1995-09-12 | Electroglas, Inc. | Method and apparatus for determining an objects position, topography and for imaging |
US5411016A (en) | 1994-02-22 | 1995-05-02 | Scimed Life Systems, Inc. | Intravascular balloon catheter for use in combination with an angioscope |
US5590660A (en) | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
DE4411017C2 (de) | 1994-03-30 | 1995-06-08 | Alexander Dr Knuettel | Optische stationäre spektroskopische Bildgebung in stark streuenden Objekten durch spezielle Lichtfokussierung und Signal-Detektion von Licht unterschiedlicher Wellenlängen |
TW275570B (zh) | 1994-05-05 | 1996-05-11 | Boehringer Mannheim Gmbh | |
US5459325A (en) | 1994-07-19 | 1995-10-17 | Molecular Dynamics, Inc. | High-speed fluorescence scanner |
US6159445A (en) | 1994-07-20 | 2000-12-12 | Nycomed Imaging As | Light imaging contrast agents |
EP0697611B9 (en) | 1994-08-18 | 2003-01-22 | Carl Zeiss | Optical coherence tomography assisted surgical apparatus |
US5491524A (en) | 1994-10-05 | 1996-02-13 | Carl Zeiss, Inc. | Optical coherence tomography corneal mapping apparatus |
US5740808A (en) | 1996-10-28 | 1998-04-21 | Ep Technologies, Inc | Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions |
US5817144A (en) | 1994-10-25 | 1998-10-06 | Latis, Inc. | Method for contemporaneous application OF laser energy and localized pharmacologic therapy |
US6033721A (en) | 1994-10-26 | 2000-03-07 | Revise, Inc. | Image-based three-axis positioner for laser direct write microchemical reaction |
US5600486A (en) | 1995-01-30 | 1997-02-04 | Lockheed Missiles And Space Company, Inc. | Color separation microlens |
US5648848A (en) | 1995-02-01 | 1997-07-15 | Nikon Precision, Inc. | Beam delivery apparatus and method for interferometry using rotatable polarization chucks |
DE19506484C2 (de) | 1995-02-24 | 1999-09-16 | Stiftung Fuer Lasertechnologie | Verfahren und Vorrichtung zur selektiven nichtinvasiven Lasermyographie (LMG) |
RU2100787C1 (ru) | 1995-03-01 | 1997-12-27 | Геликонов Валентин Михайлович | Оптоволоконный интерферометр и оптоволоконный пьезоэлектрический преобразователь |
US5526338A (en) | 1995-03-10 | 1996-06-11 | Yeda Research & Development Co. Ltd. | Method and apparatus for storage and retrieval with multilayer optical disks |
US5697373A (en) | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
US5735276A (en) | 1995-03-21 | 1998-04-07 | Lemelson; Jerome | Method and apparatus for scanning and evaluating matter |
JP3945820B2 (ja) | 1995-03-24 | 2007-07-18 | オプティスキャン ピーティーワイ リミテッド | 可変近共焦点制御手段を備えた光ファイバ共焦点像形成装置 |
US5785651A (en) | 1995-06-07 | 1998-07-28 | Keravision, Inc. | Distance measuring confocal microscope |
US5621830A (en) | 1995-06-07 | 1997-04-15 | Smith & Nephew Dyonics Inc. | Rotatable fiber optic joint |
WO1997001167A1 (en) | 1995-06-21 | 1997-01-09 | Massachusetts Institute Of Technology | Apparatus and method for accessing data on multilayered optical media |
ATA107495A (de) | 1995-06-23 | 1996-06-15 | Fercher Adolf Friedrich Dr | Kohärenz-biometrie und -tomographie mit dynamischem kohärentem fokus |
EP0846262A4 (en) | 1995-08-24 | 1999-11-03 | Purdue Research Foundation | IMAGING SPECTROSCOPY OF TISSUE AND OTHER STRONG DISTRIBUTING MEDIA BASED ON FLUORESCENT LIFETIME |
FR2738343B1 (fr) | 1995-08-30 | 1997-10-24 | Cohen Sabban Joseph | Dispositif de microstratigraphie optique |
US6615071B1 (en) | 1995-09-20 | 2003-09-02 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
CA2231425A1 (en) | 1995-09-20 | 1997-03-27 | Texas Heart Institute | Detecting thermal discrepancies in vessel walls |
DE19542955C2 (de) | 1995-11-17 | 1999-02-18 | Schwind Gmbh & Co Kg Herbert | Endoskop |
US5719399A (en) | 1995-12-18 | 1998-02-17 | The Research Foundation Of City College Of New York | Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough |
US5748318A (en) | 1996-01-23 | 1998-05-05 | Brown University Research Foundation | Optical stress generator and detector |
US5840023A (en) | 1996-01-31 | 1998-11-24 | Oraevsky; Alexander A. | Optoacoustic imaging for medical diagnosis |
US5642194A (en) | 1996-02-05 | 1997-06-24 | The Regents Of The University Of California | White light velocity interferometer |
US5862273A (en) | 1996-02-23 | 1999-01-19 | Kaiser Optical Systems, Inc. | Fiber optic probe with integral optical filtering |
US5843000A (en) | 1996-05-07 | 1998-12-01 | The General Hospital Corporation | Optical biopsy forceps and method of diagnosing tissue |
ATA84696A (de) | 1996-05-14 | 1998-03-15 | Adolf Friedrich Dr Fercher | Verfahren und anordnungen zur kontrastanhebung in der optischen kohärenztomographie |
US6020963A (en) | 1996-06-04 | 2000-02-01 | Northeastern University | Optical quadrature Interferometer |
US5795295A (en) | 1996-06-25 | 1998-08-18 | Carl Zeiss, Inc. | OCT-assisted surgical microscope with multi-coordinate manipulator |
US5842995A (en) | 1996-06-28 | 1998-12-01 | Board Of Regents, The Univerisity Of Texas System | Spectroscopic probe for in vivo measurement of raman signals |
US6245026B1 (en) | 1996-07-29 | 2001-06-12 | Farallon Medsystems, Inc. | Thermography catheter |
US5840075A (en) | 1996-08-23 | 1998-11-24 | Eclipse Surgical Technologies, Inc. | Dual laser device for transmyocardial revascularization procedures |
US6396941B1 (en) | 1996-08-23 | 2002-05-28 | Bacus Research Laboratories, Inc. | Method and apparatus for internet, intranet, and local viewing of virtual microscope slides |
JPH1090603A (ja) | 1996-09-18 | 1998-04-10 | Olympus Optical Co Ltd | 内視鏡光学系 |
WO1998013715A1 (fr) | 1996-09-27 | 1998-04-02 | Vincent Lauer | Microscope generant une representation tridimensionnelle d'un objet |
DE19640495C2 (de) | 1996-10-01 | 1999-12-16 | Leica Microsystems | Vorrichtung zur konfokalen Oberflächenvermessung |
US5843052A (en) | 1996-10-04 | 1998-12-01 | Benja-Athon; Anuthep | Irrigation kit for application of fluids and chemicals for cleansing and sterilizing wounds |
US6044288A (en) | 1996-11-08 | 2000-03-28 | Imaging Diagnostics Systems, Inc. | Apparatus and method for determining the perimeter of the surface of an object being scanned |
US5872879A (en) | 1996-11-25 | 1999-02-16 | Boston Scientific Corporation | Rotatable connecting optical fibers |
US5871449A (en) | 1996-12-27 | 1999-02-16 | Brown; David Lloyd | Device and method for locating inflamed plaque in an artery |
US5991697A (en) | 1996-12-31 | 1999-11-23 | The Regents Of The University Of California | Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media |
US5760901A (en) | 1997-01-28 | 1998-06-02 | Zetetic Institute | Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation |
US5801826A (en) | 1997-02-18 | 1998-09-01 | Williams Family Trust B | Spectrometric device and method for recognizing atomic and molecular signatures |
US6010449A (en) | 1997-02-28 | 2000-01-04 | Lumend, Inc. | Intravascular catheter system for treating a vascular occlusion |
US5968064A (en) | 1997-02-28 | 1999-10-19 | Lumend, Inc. | Catheter system for treating a vascular occlusion |
US6120516A (en) | 1997-02-28 | 2000-09-19 | Lumend, Inc. | Method for treating vascular occlusion |
AU6604998A (en) | 1997-03-13 | 1998-09-29 | Biomax Technologies, Inc. | Methods and apparatus for detecting the rejection of transplanted tissue |
US5994690A (en) | 1997-03-17 | 1999-11-30 | Kulkarni; Manish D. | Image enhancement in optical coherence tomography using deconvolution |
US6117128A (en) | 1997-04-30 | 2000-09-12 | Kenton W. Gregory | Energy delivery catheter and method for the use thereof |
US5887009A (en) | 1997-05-22 | 1999-03-23 | Optical Biopsy Technologies, Inc. | Confocal optical scanning system employing a fiber laser |
US6002480A (en) | 1997-06-02 | 1999-12-14 | Izatt; Joseph A. | Depth-resolved spectroscopic optical coherence tomography |
DE69840791D1 (de) | 1997-06-02 | 2009-06-10 | Joseph A Izatt | Doppler-abbildung einer strömung mittels optischer kohaerenztomografie |
US6208415B1 (en) | 1997-06-12 | 2001-03-27 | The Regents Of The University Of California | Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography |
US5920390A (en) | 1997-06-26 | 1999-07-06 | University Of North Carolina | Fiberoptic interferometer and associated method for analyzing tissue |
US6048349A (en) | 1997-07-09 | 2000-04-11 | Intraluminal Therapeutics, Inc. | Systems and methods for guiding a medical instrument through a body |
US5921926A (en) | 1997-07-28 | 1999-07-13 | University Of Central Florida | Three dimensional optical imaging colposcopy |
US5892583A (en) | 1997-08-21 | 1999-04-06 | Li; Ming-Chiang | High speed inspection of a sample using superbroad radiation coherent interferometer |
US6014214A (en) | 1997-08-21 | 2000-01-11 | Li; Ming-Chiang | High speed inspection of a sample using coherence processing of scattered superbroad radiation |
US6069698A (en) | 1997-08-28 | 2000-05-30 | Olympus Optical Co., Ltd. | Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object |
US6297018B1 (en) | 1998-04-17 | 2001-10-02 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
US5920373A (en) | 1997-09-24 | 1999-07-06 | Heidelberg Engineering Optische Messysteme Gmbh | Method and apparatus for determining optical characteristics of a cornea |
US6193676B1 (en) | 1997-10-03 | 2001-02-27 | Intraluminal Therapeutics, Inc. | Guide wire assembly |
US5951482A (en) | 1997-10-03 | 1999-09-14 | Intraluminal Therapeutics, Inc. | Assemblies and methods for advancing a guide wire through body tissue |
US6091984A (en) | 1997-10-10 | 2000-07-18 | Massachusetts Institute Of Technology | Measuring tissue morphology |
US5955737A (en) | 1997-10-27 | 1999-09-21 | Systems & Processes Engineering Corporation | Chemometric analysis for extraction of individual fluorescence spectrum and lifetimes from a target mixture |
US6134010A (en) | 1997-11-07 | 2000-10-17 | Lucid, Inc. | Imaging system using polarization effects to enhance image quality |
US6165170A (en) | 1998-01-29 | 2000-12-26 | International Business Machines Corporation | Laser dermablator and dermablation |
US6831781B2 (en) | 1998-02-26 | 2004-12-14 | The General Hospital Corporation | Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy |
US6048742A (en) | 1998-02-26 | 2000-04-11 | The United States Of America As Represented By The Secretary Of The Air Force | Process for measuring the thickness and composition of thin semiconductor films deposited on semiconductor wafers |
WO1999044089A1 (en) | 1998-02-26 | 1999-09-02 | The General Hospital Corporation | Confocal microscopy with multi-spectral encoding |
US6134033A (en) | 1998-02-26 | 2000-10-17 | Tyco Submarine Systems Ltd. | Method and apparatus for improving spectral efficiency in wavelength division multiplexed transmission systems |
US6066102A (en) | 1998-03-09 | 2000-05-23 | Spectrascience, Inc. | Optical biopsy forceps system and method of diagnosing tissue |
US6174291B1 (en) | 1998-03-09 | 2001-01-16 | Spectrascience, Inc. | Optical biopsy system and methods for tissue diagnosis |
US6151522A (en) | 1998-03-16 | 2000-11-21 | The Research Foundation Of Cuny | Method and system for examining biological materials using low power CW excitation raman spectroscopy |
US6384915B1 (en) | 1998-03-30 | 2002-05-07 | The Regents Of The University Of California | Catheter guided by optical coherence domain reflectometry |
DE19814057B4 (de) | 1998-03-30 | 2009-01-02 | Carl Zeiss Meditec Ag | Anordnung zur optischen Kohärenztomographie und Kohärenztopographie |
US6175669B1 (en) | 1998-03-30 | 2001-01-16 | The Regents Of The Universtiy Of California | Optical coherence domain reflectometry guidewire |
US6053613A (en) | 1998-05-15 | 2000-04-25 | Carl Zeiss, Inc. | Optical coherence tomography with new interferometer |
US6549801B1 (en) | 1998-06-11 | 2003-04-15 | The Regents Of The University Of California | Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity |
US6379345B1 (en) | 1998-07-15 | 2002-04-30 | Corazon Technologies, Inc. | Methods and devices for reducing the mineral content of vascular calcified lesions |
US6166373A (en) | 1998-07-21 | 2000-12-26 | The Institute For Technology Development | Focal plane scanner with reciprocating spatial window |
WO2000019889A1 (en) | 1998-10-08 | 2000-04-13 | University Of Kentucky Research Foundation | Methods and apparatus for in vivo identification and characterization of vulnerable atherosclerotic plaques |
US6274871B1 (en) | 1998-10-22 | 2001-08-14 | Vysis, Inc. | Method and system for performing infrared study on a biological sample |
US6324419B1 (en) | 1998-10-27 | 2001-11-27 | Nejat Guzelsu | Apparatus and method for non-invasive measurement of stretch |
EP1002497B1 (en) | 1998-11-20 | 2006-07-26 | Fuji Photo Film Co., Ltd. | Blood vessel imaging system |
US5975697A (en) | 1998-11-25 | 1999-11-02 | Oti Ophthalmic Technologies, Inc. | Optical mapping apparatus with adjustable depth resolution |
US6191862B1 (en) | 1999-01-20 | 2001-02-20 | Lightlab Imaging, Llc | Methods and apparatus for high speed longitudinal scanning in imaging systems |
US6272376B1 (en) | 1999-01-22 | 2001-08-07 | Cedars-Sinai Medical Center | Time-resolved, laser-induced fluorescence for the characterization of organic material |
US6445944B1 (en) | 1999-02-01 | 2002-09-03 | Scimed Life Systems | Medical scanning system and related method of scanning |
US6615072B1 (en) | 1999-02-04 | 2003-09-02 | Olympus Optical Co., Ltd. | Optical imaging device |
US6185271B1 (en) | 1999-02-16 | 2001-02-06 | Richard Estyn Kinsinger | Helical computed tomography with feedback scan control |
US6264610B1 (en) | 1999-05-05 | 2001-07-24 | The University Of Connecticut | Combined ultrasound and near infrared diffused light imaging system |
US6353693B1 (en) | 1999-05-31 | 2002-03-05 | Sanyo Electric Co., Ltd. | Optical communication device and slip ring unit for an electronic component-mounting apparatus |
US6208887B1 (en) | 1999-06-24 | 2001-03-27 | Richard H. Clarke | Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions |
US7426409B2 (en) | 1999-06-25 | 2008-09-16 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
GB9915082D0 (en) | 1999-06-28 | 1999-08-25 | Univ London | Optical fibre probe |
US6359692B1 (en) | 1999-07-09 | 2002-03-19 | Zygo Corporation | Method and system for profiling objects having multiple reflective surfaces using wavelength-tuning phase-shifting interferometry |
EP1199986B1 (en) | 1999-07-30 | 2005-06-01 | Boston Scientific Limited | Rotational and translational drive coupling for catheter assembly |
JP2001046321A (ja) | 1999-08-09 | 2001-02-20 | Asahi Optical Co Ltd | 内視鏡装置 |
US6687010B1 (en) | 1999-09-09 | 2004-02-03 | Olympus Corporation | Rapid depth scanning optical imaging device |
US6198956B1 (en) | 1999-09-30 | 2001-03-06 | Oti Ophthalmic Technologies Inc. | High speed sector scanning apparatus having digital electronic control |
US6308092B1 (en) | 1999-10-13 | 2001-10-23 | C. R. Bard Inc. | Optical fiber tissue localization device |
US6393312B1 (en) | 1999-10-13 | 2002-05-21 | C. R. Bard, Inc. | Connector for coupling an optical fiber tissue localization device to a light source |
US6538817B1 (en) | 1999-10-25 | 2003-03-25 | Aculight Corporation | Method and apparatus for optical coherence tomography with a multispectral laser source |
JP2001125009A (ja) | 1999-10-28 | 2001-05-11 | Asahi Optical Co Ltd | 内視鏡装置 |
EP1232377B1 (de) | 1999-11-24 | 2004-03-31 | Haag-Streit Ag | Verfahren und vorrichtung zur messung optischer eigenschaften wenigstens zweier voneinander distanzierter bereiche in einem transparenten und/oder diffusiven gegenstand |
US6738144B1 (en) | 1999-12-17 | 2004-05-18 | University Of Central Florida | Non-invasive method and low-coherence apparatus system analysis and process control |
US6680780B1 (en) | 1999-12-23 | 2004-01-20 | Agere Systems, Inc. | Interferometric probe stabilization relative to subject movement |
US6445485B1 (en) | 2000-01-21 | 2002-09-03 | At&T Corp. | Micro-machine polarization-state controller |
EP1251779A1 (en) | 2000-01-27 | 2002-10-30 | National Research Council of Canada | Visible-near infrared spectroscopy in burn injury assessment |
US6475210B1 (en) | 2000-02-11 | 2002-11-05 | Medventure Technology Corp | Light treatment of vulnerable atherosclerosis plaque |
US6556305B1 (en) | 2000-02-17 | 2003-04-29 | Veeco Instruments, Inc. | Pulsed source scanning interferometer |
US6567585B2 (en) | 2000-04-04 | 2003-05-20 | Optiscan Pty Ltd | Z sharpening for fibre confocal microscopes |
AU2001259435A1 (en) | 2000-05-03 | 2001-11-12 | Stephen T Flock | Optical imaging of subsurface anatomical structures and biomolecules |
JP4460117B2 (ja) | 2000-06-29 | 2010-05-12 | 独立行政法人理化学研究所 | グリズム |
AU2001279603A1 (en) | 2000-08-11 | 2002-02-25 | Crystal Fibre A/S | Optical wavelength converter |
US7625335B2 (en) | 2000-08-25 | 2009-12-01 | 3Shape Aps | Method and apparatus for three-dimensional optical scanning of interior surfaces |
WO2002021170A1 (en) | 2000-09-05 | 2002-03-14 | Arroyo Optics, Inc. | System and method for fabricating components of precise optical path length |
US7231243B2 (en) | 2000-10-30 | 2007-06-12 | The General Hospital Corporation | Optical methods for tissue analysis |
JP3842101B2 (ja) | 2000-10-31 | 2006-11-08 | 富士写真フイルム株式会社 | 内視鏡装置 |
US6687036B2 (en) | 2000-11-03 | 2004-02-03 | Nuonics, Inc. | Multiplexed optical scanner technology |
US6665075B2 (en) | 2000-11-14 | 2003-12-16 | Wm. Marshurice University | Interferometric imaging system and method |
DE10057539B4 (de) | 2000-11-20 | 2008-06-12 | Robert Bosch Gmbh | Interferometrische Messvorrichtung |
US6558324B1 (en) | 2000-11-22 | 2003-05-06 | Siemens Medical Solutions, Inc., Usa | System and method for strain image display |
US6856712B2 (en) | 2000-11-27 | 2005-02-15 | University Of Washington | Micro-fabricated optical waveguide for use in scanning fiber displays and scanned fiber image acquisition |
US6687007B1 (en) | 2000-12-14 | 2004-02-03 | Kestrel Corporation | Common path interferometer for spectral image generation |
US6501878B2 (en) | 2000-12-14 | 2002-12-31 | Nortel Networks Limited | Optical fiber termination |
CN103251453A (zh) | 2000-12-28 | 2013-08-21 | 帕洛玛医疗技术有限公司 | 用于皮肤的emr治疗处理的方法和装置 |
US7177491B2 (en) | 2001-01-12 | 2007-02-13 | Board Of Regents The University Of Texas System | Fiber-based optical low coherence tomography |
EP1358443A2 (en) | 2001-01-22 | 2003-11-05 | Jonathan E. Roth | Method and apparatus for polarization-sensitive optical coherence tomography |
US20020140942A1 (en) | 2001-02-17 | 2002-10-03 | Fee Michale Sean | Acousto-optic monitoring and imaging in a depth sensitive manner |
US6563995B2 (en) | 2001-04-02 | 2003-05-13 | Lightwave Electronics | Optical wavelength filtering apparatus with depressed-index claddings |
US6552796B2 (en) | 2001-04-06 | 2003-04-22 | Lightlab Imaging, Llc | Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography |
US20020158211A1 (en) | 2001-04-16 | 2002-10-31 | Dakota Technologies, Inc. | Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures |
DE10118760A1 (de) | 2001-04-17 | 2002-10-31 | Med Laserzentrum Luebeck Gmbh | Verfahren zur Ermittlung der Laufzeitverteilung und Anordnung |
EP2333523B1 (en) | 2001-04-30 | 2020-04-08 | The General Hospital Corporation | Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating |
US7616986B2 (en) | 2001-05-07 | 2009-11-10 | University Of Washington | Optical fiber scanner for performing multimodal optical imaging |
US6701181B2 (en) | 2001-05-31 | 2004-03-02 | Infraredx, Inc. | Multi-path optical catheter |
CA2449828A1 (en) | 2001-06-04 | 2003-01-16 | The General Hospital Corporation | Detection and therapy of vulnerable plaque with photodynamic compounds |
US6879851B2 (en) | 2001-06-07 | 2005-04-12 | Lightlab Imaging, Llc | Fiber optic endoscopic gastrointestinal probe |
US6702744B2 (en) | 2001-06-20 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery |
US20040166593A1 (en) | 2001-06-22 | 2004-08-26 | Nolte David D. | Adaptive interferometric multi-analyte high-speed biosensor |
US6685885B2 (en) | 2001-06-22 | 2004-02-03 | Purdue Research Foundation | Bio-optical compact dist system |
DE10137530A1 (de) | 2001-08-01 | 2003-02-13 | Presens Prec Sensing Gmbh | Anordnung und Verfahren zur Mehrfach-Fluoreszenzmessung |
US7061622B2 (en) | 2001-08-03 | 2006-06-13 | Case Western Reserve University | Aspects of basic OCT engine technologies for high speed optical coherence tomography and light source and other improvements in optical coherence tomography |
US6961123B1 (en) * | 2001-09-28 | 2005-11-01 | The Texas A&M University System | Method and apparatus for obtaining information from polarization-sensitive optical coherence tomography |
US6980299B1 (en) | 2001-10-16 | 2005-12-27 | General Hospital Corporation | Systems and methods for imaging a sample |
US7006231B2 (en) | 2001-10-18 | 2006-02-28 | Scimed Life Systems, Inc. | Diffraction grating based interferometric systems and methods |
US20030216719A1 (en) | 2001-12-12 | 2003-11-20 | Len Debenedictis | Method and apparatus for treating skin using patterns of optical energy |
US6947787B2 (en) | 2001-12-21 | 2005-09-20 | Advanced Cardiovascular Systems, Inc. | System and methods for imaging within a body lumen |
EP1324051A1 (en) | 2001-12-26 | 2003-07-02 | Kevin R. Forrester | Motion measuring device |
US7355716B2 (en) | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
WO2003062802A2 (en) | 2002-01-24 | 2003-07-31 | The General Hospital Corporation | Apparatus and method for rangings and noise reduction of low coherence interferometry lci and optical coherence tomography (oct) signals by parallel detection of spectral bands |
WO2003069272A1 (fr) * | 2002-02-14 | 2003-08-21 | Imalux Corporation | Procede d'examen d'objet et interferometre optique permettant la mise en oeuvre dudit procede |
US7116887B2 (en) | 2002-03-19 | 2006-10-03 | Nufern | Optical fiber |
US7113818B2 (en) | 2002-04-08 | 2006-09-26 | Oti Ophthalmic Technologies Inc. | Apparatus for high resolution imaging of moving organs |
US7016048B2 (en) | 2002-04-09 | 2006-03-21 | The Regents Of The University Of California | Phase-resolved functional optical coherence tomography: simultaneous imaging of the stokes vectors, structure, blood flow velocity, standard deviation and birefringence in biological samples |
US20030236443A1 (en) | 2002-04-19 | 2003-12-25 | Cespedes Eduardo Ignacio | Methods and apparatus for the identification and stabilization of vulnerable plaque |
JP4135551B2 (ja) | 2002-05-07 | 2008-08-20 | 松下電工株式会社 | ポジションセンサ |
US7283247B2 (en) | 2002-09-25 | 2007-10-16 | Olympus Corporation | Optical probe system |
EP1551273A4 (en) | 2002-10-18 | 2011-04-06 | Arieh Sher | ATHEREOMETRY SYSTEM WITH IMAGING GUIDE WIRE |
US6847449B2 (en) | 2002-11-27 | 2005-01-25 | The United States Of America As Represented By The Secretary Of The Navy | Method and apparatus for reducing speckle in optical coherence tomography images |
JP4148771B2 (ja) | 2002-12-27 | 2008-09-10 | 株式会社トプコン | 医療機械のレーザ装置 |
US7123363B2 (en) | 2003-01-03 | 2006-10-17 | Rose-Hulman Institute Of Technology | Speckle pattern analysis method and system |
EP1596716B1 (en) | 2003-01-24 | 2014-04-30 | The General Hospital Corporation | System and method for identifying tissue using low-coherence interferometry |
JP4805142B2 (ja) | 2003-03-31 | 2011-11-02 | ザ ジェネラル ホスピタル コーポレイション | 光路長が変更された異なる角度の光の合成により光学的に干渉する断層撮影におけるスペックルの減少 |
JP4135550B2 (ja) | 2003-04-18 | 2008-08-20 | 日立電線株式会社 | 半導体発光デバイス |
US7376455B2 (en) | 2003-05-22 | 2008-05-20 | Scimed Life Systems, Inc. | Systems and methods for dynamic optical imaging |
US7697145B2 (en) | 2003-05-28 | 2010-04-13 | Duke University | System for fourier domain optical coherence tomography |
EP1644697A4 (en) | 2003-05-30 | 2006-11-29 | Univ Duke | SYSTEM AND METHOD FOR BROADBAND QUADRATURE INTERFEROMETRY WITH LOW COHERENCE |
US7263394B2 (en) | 2003-06-04 | 2007-08-28 | Tomophase Corporation | Coherence-gated optical glucose monitor |
US6943881B2 (en) | 2003-06-04 | 2005-09-13 | Tomophase Corporation | Measurements of optical inhomogeneity and other properties in substances using propagation modes of light |
US20040260182A1 (en) | 2003-06-23 | 2004-12-23 | Zuluaga Andres F. | Intraluminal spectroscope with wall contacting probe |
US20050083534A1 (en) | 2003-08-28 | 2005-04-21 | Riza Nabeel A. | Agile high sensitivity optical sensor |
JP2005077964A (ja) | 2003-09-03 | 2005-03-24 | Fujitsu Ltd | 分光装置 |
US6949072B2 (en) | 2003-09-22 | 2005-09-27 | Infraredx, Inc. | Devices for vulnerable plaque detection |
EP2293031B8 (en) * | 2003-10-27 | 2024-03-20 | The General Hospital Corporation | Method and apparatus for performing optical imaging using frequency-domain interferometry |
DE10351319B4 (de) | 2003-10-31 | 2005-10-20 | Med Laserzentrum Luebeck Gmbh | Interferometer für die optische Kohärenztomographie |
WO2005054780A1 (en) | 2003-11-28 | 2005-06-16 | The General Hospital Corporation | Method and apparatus for three-dimensional spectrally encoded imaging |
US7359062B2 (en) | 2003-12-09 | 2008-04-15 | The Regents Of The University Of California | High speed spectral domain functional optical coherence tomography and optical doppler tomography for in vivo blood flow dynamics and tissue structure |
DE10358735B4 (de) | 2003-12-15 | 2011-04-21 | Siemens Ag | Kathetereinrichtung umfassend einen Katheter, insbesondere einen intravaskulären Katheter |
JP2007522456A (ja) * | 2004-02-10 | 2007-08-09 | オプトビュー,インコーポレーテッド | 高効率低コヒーレンス干渉法 |
EP1722669A4 (en) | 2004-02-27 | 2009-05-27 | Optiscan Pty Ltd | OPTICAL ELEMENT |
US7242480B2 (en) | 2004-05-14 | 2007-07-10 | Medeikon Corporation | Low coherence interferometry for detecting and characterizing plaques |
US7190464B2 (en) | 2004-05-14 | 2007-03-13 | Medeikon Corporation | Low coherence interferometry for detecting and characterizing plaques |
US7447408B2 (en) | 2004-07-02 | 2008-11-04 | The General Hospital Corproation | Imaging system and related techniques |
JP5053845B2 (ja) * | 2004-08-06 | 2012-10-24 | ザ ジェネラル ホスピタル コーポレイション | 光学コヒーレンス断層撮影法を使用して試料中の少なくとも1つの位置を決定するための方法、システムおよびソフトウェア装置 |
WO2006039091A2 (en) | 2004-09-10 | 2006-04-13 | The General Hospital Corporation | System and method for optical coherence imaging |
EP2329759B1 (en) | 2004-09-29 | 2014-03-12 | The General Hospital Corporation | System and method for optical coherence imaging |
US7417740B2 (en) | 2004-11-12 | 2008-08-26 | Medeikon Corporation | Single trace multi-channel low coherence interferometric sensor |
GB0426609D0 (en) | 2004-12-03 | 2005-01-05 | Ic Innovations Ltd | Analysis |
US7450242B2 (en) | 2004-12-10 | 2008-11-11 | Fujifilm Corporation | Optical tomography apparatus |
US7336366B2 (en) | 2005-01-20 | 2008-02-26 | Duke University | Methods and systems for reducing complex conjugate ambiguity in interferometric data |
US7267494B2 (en) | 2005-02-01 | 2007-09-11 | Finisar Corporation | Fiber stub for cladding mode coupling reduction |
EP1887926B1 (en) | 2005-05-31 | 2014-07-30 | The General Hospital Corporation | System and method which use spectral encoding heterodyne interferometry techniques for imaging |
US7391520B2 (en) | 2005-07-01 | 2008-06-24 | Carl Zeiss Meditec, Inc. | Fourier domain optical coherence tomography employing a swept multi-wavelength laser and a multi-channel receiver |
US7668342B2 (en) | 2005-09-09 | 2010-02-23 | Carl Zeiss Meditec, Inc. | Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues |
WO2007041382A1 (en) | 2005-09-29 | 2007-04-12 | General Hospital Corporation | Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures |
DE102005054677A1 (de) | 2005-11-16 | 2007-06-06 | Siemens Ag | Berührungsempfindliche Bedieneinheit mit haptischer Rückmeldung |
GB0601183D0 (en) | 2006-01-20 | 2006-03-01 | Perkinelmer Ltd | Improvements in and relating to imaging |
US20070291277A1 (en) | 2006-06-20 | 2007-12-20 | Everett Matthew J | Spectral domain optical coherence tomography system |
-
2007
- 2007-04-05 EP EP12194876.4A patent/EP2564769B1/en active Active
- 2007-04-05 WO PCT/US2007/066017 patent/WO2007118129A1/en active Search and Examination
- 2007-04-05 CN CN2007800162663A patent/CN101466298B/zh active Active
- 2007-04-05 EP EP07760147.4A patent/EP2004041B1/en active Active
- 2007-04-05 JP JP2009504470A patent/JP5135324B2/ja active Active
- 2007-04-05 US US11/697,012 patent/US7742173B2/en active Active
-
2012
- 2012-11-12 JP JP2012248595A patent/JP5536854B2/ja active Active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104180892A (zh) * | 2013-05-27 | 2014-12-03 | 综合工艺有限公司 | 光学干涉仪和具有这种光学干涉仪的振动计 |
CN104180892B (zh) * | 2013-05-27 | 2019-05-17 | 综合工艺有限公司 | 光学干涉仪和具有这种光学干涉仪的振动计 |
CN104634282A (zh) * | 2015-02-28 | 2015-05-20 | 清华大学 | 光学探针干涉相位测量中相位误差补偿装置 |
CN113703148A (zh) * | 2020-05-20 | 2021-11-26 | 奥林巴斯株式会社 | 显微镜***、控制方法、计算机可读介质 |
Also Published As
Publication number | Publication date |
---|---|
US20070236700A1 (en) | 2007-10-11 |
JP5135324B2 (ja) | 2013-02-06 |
JP2013064748A (ja) | 2013-04-11 |
EP2004041B1 (en) | 2013-11-06 |
US7742173B2 (en) | 2010-06-22 |
WO2007118129A1 (en) | 2007-10-18 |
CN101466298B (zh) | 2011-08-31 |
EP2564769A1 (en) | 2013-03-06 |
EP2564769B1 (en) | 2015-06-03 |
EP2004041A1 (en) | 2008-12-24 |
JP2009536728A (ja) | 2009-10-15 |
JP5536854B2 (ja) | 2014-07-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101466298B (zh) | 用于样本的偏振敏感光频域成像的方法、装置和*** | |
JP7158283B2 (ja) | 光コヒ-レンストモグラフィを用いた高速・長深度レンジの撮像装置及び方法 | |
US9448056B2 (en) | System for fourier domain optical coherence tomography | |
US7995210B2 (en) | Devices and arrangements for performing coherence range imaging using a common path interferometer | |
TWI463177B (zh) | 使用頻率域干涉法用以執行光學成像之方法及設備 | |
AU2003210669B2 (en) | Apparatus and method for rangings and noise reduction of low coherence interferometry LCI and optical coherence tomography (OCT) signals by parallel detection of spectral bands | |
JP5917803B2 (ja) | 高速ドップラー光周波数領域撮像法のためのビーム走査パターンを放射するシステムおよび方法 | |
EP2884224B1 (en) | Sample clock generator for optical tomographic imaging apparatus, and optical tomographic imaging apparatus | |
CN104706322B (zh) | 一种基于光计算的扫频光学相干成像*** | |
CN104688188B (zh) | 一种基于光计算的光谱光学相干成像*** | |
AU2003210669A1 (en) | Apparatus and method for rangings and noise reduction of low coherence interferometry LCI and optical coherence tomography (OCT) signals by parallel detection of spectral bands | |
US20120120407A1 (en) | Optical Coherence Tomography System And Method | |
CN101370426A (zh) | 利用对光学相干断层扫描的波阵面调制来提供散斑减少的***、装置和过程 | |
US8937724B2 (en) | Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling | |
US8379220B2 (en) | Imaging and measuring apparatus for surface and internal interface of object | |
CN104983403B (zh) | 偏芯保偏光纤传感器及其oct成像装置 | |
KR100868439B1 (ko) | 편광민감 광결맞음 생체영상기기용 간섭 시스템 | |
KR100896970B1 (ko) | 결맞음 주파수영역 반사파 계측법에 기초한 광영상 시스템 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |