JP5053845B2 - 光学コヒーレンス断層撮影法を使用して試料中の少なくとも1つの位置を決定するための方法、システムおよびソフトウェア装置 - Google Patents
光学コヒーレンス断層撮影法を使用して試料中の少なくとも1つの位置を決定するための方法、システムおよびソフトウェア装置 Download PDFInfo
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Description
本出願は2004年8月6日に出願された、米国特許出願第60/599,809号からの優先権を主張するものであり、その全体の開示はここに参照により組み込まれたものとする。本出願はまた、米国特許公開公報第2000/0198457号にも関連し、その全体の開示はここに参照により組み込まれたものとする。
発明の分野
本発明は一般的には、光学コヒーレンス断層撮影法(「OCT」)を使用する撮像に関し、特に、OCT技術を使用して試料中の少なくとも1つの位置を決定できる方法(処理)、システム、およびソフトウェア装置に関する。
光学コヒーレンス断層撮影法(「OCT」)は、光の基準ビームと、試料から反射された検出ビームの間の干渉を測定可能な撮像技術である。従来の時間領域OCTの詳細なシステムの記述は、Huangその他による、「光学コヒーレンス断層撮影法(Optical coherence tomography)」 Science 254(5035),1178−81(1991)に開示されている。光学コヒーレンス断層撮影法(「OCT」)のスペクトル領域変形例は、スペクトル領域光学コヒーレンス断層撮影法(「SD−OCT」)と呼ばれるが、超高解像度の眼病用撮像用に適している技術である。この技術は、Cense,B.その他による、「スペクトル領域光学コヒーレンス断層撮影法を使用する超高解像度高速網膜撮像法(Ultrahigh−resolution high−speed retinal imaging using spectral−domain optical coherence tomography)」,Optics Express,2004および国際特許公開(International Patent Publication)WO 03/062802号に記載されている。更に、2002年10月16日に出願された米国特許出願第10/272,171号の、Wojtkowskiその他による、「フーリエ領域光学コヒーレンス断層撮影法による試験管内の人間の網膜撮像(In Vivo Human Retinal Imaging by Fourier Domain Optical Coherence Tomography)」,Journal of Biomedical Optics,2002,7(3),pp.457−463,Nassifその他による「超高速スペクトル領域光学コヒーレンス断層撮影法による生体内における人間の網膜撮像(In Vivo Human Retinal Imaging by Utrahigh−Speed Spectral Domain Optical Coherence Tomography)」,Optics Letters,2004,29(5),pp.480−482もまたこの主題事項に関連している。また、光学周波数領域干渉計使用法(OFDI)設定(Yun,S.H.その他による「高速光学周波数領域撮像(High−Speed Optical Frequency−Domain Imaging)」,Optics Express,2003,11(22),pp.
2953−2963に記載されているように)や、国際公開WO 03/062802号、および2004年10月27日に出願された米国特許出願第60/514,769号は更に、本発明の主題事項に関連している。
この値は、第1オフセット電圧に加えることができ、更新された値は、データのまとまりの取得の間に、RSODに送信される。式(2)は、バネを律するフックの法則に類似しており、ここで、Rはバネ定数に等しいとすることができる。Rが取得中に動的に制御できるという事実により、患者の動きを最適に抑えるための適切なパラメータの決定が可能となる。範囲測定手順は、チェックマーク制御が停止されるまで各データのまとまりに対して継続され、ソフトウェアはそれが再度起動されたときにその新しい場所で再固定する。
(態様1)
光学コヒーレンス断層撮影法を用いて、試料の少なくとも一部分の少なくとも1つの位置を決定するシステムであって、
前記試料から受ける第1電磁放射と基準から受ける第2電磁放射を含む干渉信号に関連している前記試料の少なくとも一部分に関連している情報を得るように構成されるコンピュータ処理装置を備え、前記コンピュータ処理装置は更に、
I. 前記試料の前記少なくとも一部分の深度情報または側方情報の少なくとも1つを取得し、
II. 少なくとも1つの重み関数を、前記深度情報または前記側方情報の前記少なくとも1つに適用して、結果情報を生成し、
III. 前記結果情報に基づいて、前記試料の前記少なくとも一部分の表面位置、側方位置、または深度位置の少なくとも1つにおける変化である特別情報を突き止め、
IIIA. 前記特別情報に基づいて、前記基準の長さを修正するように構成されるシステム。
(態様25)
光学コヒーレンス断層撮影法を用いて、試料の少なくとも一部分の少なくとも1つの位置を決定する方法であって、
前記試料から受ける第1電磁放射と、基準から受ける第2電磁放射を含む干渉信号に関連している前記試料の少なくとも一部分に関連する情報を取得し、
前記試料の前記少なくとも一部分の深度情報または側方情報の少なくとも1つを取得し、
少なくとも1つの重み関数を、前記深度情報または前記側方情報の前記少なくとも1つに適用して、結果情報を生成し、
前記結果情報に基づいて、前記試料の前記少なくとも一部分の表面位置、側方位置、または深度位置の少なくとも1つにおける変化である特別情報を突き止め、
前記特別情報に基づいて、前記基準の長さを修正する、方法。
(態様26)
光学コヒーレンス断層撮影法を用いて、処理装置に実行させて試料の少なくとも一部分の少なくとも1つの位置を決定させるプログラムであって、
前記試料から受ける第1電磁放射と、基準から受ける第2電磁放射を含む干渉信号に関連している前記試料の少なくとも一部分に関連する情報を得る命令の第1セットと、
前記試料の前記少なくとも一部分の深度情報または側方情報の少なくとも1つを得る命令の第2セットと、
少なくとも1つの重み関数を、前記深度情報または前記側方情報の前記少なくとも1つに適用して、結果情報を生成する命令の第3セットと、
前記結果情報に基づいて、前記試料の前記少なくとも一部分の表面位置、側方位置、または深度位置の少なくとも1つにおける変化である特別情報を突き止める命令の第4セットと、
前記特別情報に基づいて、前記基準の長さを修正する命令の第5セットと、を備えるプログラム。
Claims (26)
- 光学コヒーレンス断層撮影法を用いて、試料の少なくとも一部分の少なくとも1つの位置を決定するシステムであって、
前記試料から受ける第1電磁放射と基準から受ける第2電磁放射を含む干渉信号に関連している前記試料の少なくとも一部分に関連している情報を得るように構成されるコンピュータ処理装置を備え、前記コンピュータ処理装置は更に、
I. 前記試料の前記少なくとも一部分の深度情報または側方情報の少なくとも1つを取得し、
II. 少なくとも1つの重み関数を、前記深度情報または前記側方情報の前記少なくとも1つに適用して、結果情報を生成し、
III. 前記結果情報に基づいて、前記試料の前記少なくとも一部分の表面位置、側方位置、または深度位置の少なくとも1つにおける時間的な変化である特別情報を突き止め、
IIIA. 前記特別情報に基づいて、前記基準の長さを修正するように構成されるシステム。 - 前記深度情報または前記側方情報の少なくとも1つは、前記試料の前記少なくとも一部分内の流れ情報を含む請求項1に記載のシステム。
- 前記深度情報または前記側方情報の少なくとも1つは、前記試料の前記少なくとも一部分に関連する複屈折情報および偏光情報の少なくとも1つを含む請求項1又は2に記載のシステム。
- 前記深度情報または前記側方情報の少なくとも1つは、前記試料の前記少なくとも一部分の分光情報を含む請求項1から3の何れか一項に記載のシステム。
- 前記特別情報を突き止めた後、前記処理装置は更に、
IV. 前記表面情報、前記側方情報、および前記深度情報の少なくとも更に1つを、前記特別情報の関数として推定または予測の少なくともどちらかを行うように構成されている請求項1から4の何れか一項に記載のシステム。 - 前記処理装置は更に、
V. 前記手順(I)−(IIIA)の少なくとも1つを実行して、前記特別情報に関連するデータセットを取得し、
VI. 前記データセットに基づいて前記手順(IV)を実行するように構成されている請求項5に記載のシステム。 - 前記深度情報または前記側方情報の少なくとも1つは、前記試料の前記少なくとも一部分の強度情報を含む請求項1から6の何れか一項に記載のシステム。
- 更に前記試料および前記基準の少なくとも1つに関連する遅延装置を更に備え、その中の可変透過光学経路を促進する請求項1から7の何れか一項に記載のシステム。
- 前記試料および前記基準の少なくとも1のある特別経路の少なくとも一部は、非相互的である請求項1から8の何れか一項に記載のシステム。
- 前記基準は、それに沿って前記基準から放射が送信される経路とは異なる経路を介して前記放射を受ける請求項1から9の何れか一項に記載のシステム。
- 前記基準は、透過型基準である請求項9に記載のシステム。
- 前記処理装置は更に、前記表面位置および前記深度位置の少なくとも1つに基づいて、前記基準の長さを修正できる請求項1から11の何れか一項に記載のシステム。
- 前記長さを修正後、前記処理装置は更に、前記基準の新しい位置に基づいて前記手順(I)−(III )の少なくとも1つを実行するように構成されている請求項12に記載のシステム。
- 前記処理装置は、制御可能パラメータを使用して、前記基準の前記長さを修正できる請求項12に記載のシステム。
- 前記制御可能パラメータは、前記基準の前記長さの修正レベルを動的に制御するために使用される応答パラメータである請求項14に記載のシステム。
- 前記少なくとも一部分は、前記試料の特徴を含み、前記処理装置は、前記特徴の前記側方位置を決定できる請求項1から15の何れか一項に記載のシステム。
- 前記側方情報は、前記試料の前記少なくとも一部分内に流れ情報を含む請求項1から16の何れか一項に記載のシステム。
- 前記側方情報は、前記試料の前記少なくとも一部分に関連する複屈折情報および偏光情報の少なくとも1つを含む請求項1から17の何れか一項に記載のシステム。
- 前記側方情報は、前記試料の前記少なくとも一部分の分光情報を含む請求項1から18の何れか一項に記載のシステム。
- 前記側方情報は、前記試料の前記少なくとも一部分の強度情報を含む請求項1から19の何れか一項に記載のシステム。
- 前記処理装置は更に、前記側方位置に基づいて、前記試料の側方走査範囲を修正できる請求項1から20の何れか一項に記載のシステム。
- 前記側方走査範囲を修正後、前記処理装置は更に、新しい側方走査範囲に基づいて前記手順(I)−(III )の少なくとも1つを実行するように構成されている請求項21に記載のシステム。
- 前記処理装置は、制御可能パラメータを使用して、前記試料の側方走査範囲を修正できる請求項15に記載のシステム。
- 前記制御可能パラメータは、前記側方走査範囲の修正レベルを動的に制御するために使用される応答パラメータである請求項23に記載のシステム。
- 光学コヒーレンス断層撮影法を用いて、試料の少なくとも一部分の少なくとも1つの位置を決定する方法であって、
前記試料から受ける第1電磁放射と、基準から受ける第2電磁放射を含む干渉信号に関連している前記試料の少なくとも一部分に関連する情報を取得し、
前記試料の前記少なくとも一部分の深度情報または側方情報の少なくとも1つを取得し、
少なくとも1つの重み関数を、前記深度情報または前記側方情報の前記少なくとも1つに適用して、結果情報を生成し、
前記結果情報に基づいて、前記試料の前記少なくとも一部分の表面位置、側方位置、または深度位置の少なくとも1つにおける時間的な変化である特別情報を突き止め、
前記特別情報に基づいて、前記基準の長さを修正する、方法。 - 光学コヒーレンス断層撮影法を用いて、処理装置に実行させて試料の少なくとも一部分の少なくとも1つの位置を決定させるプログラムであって、
前記試料から受ける第1電磁放射と、基準から受ける第2電磁放射を含む干渉信号に関連している前記試料の少なくとも一部分に関連する情報を得る命令の第1セットと、
前記試料の前記少なくとも一部分の深度情報または側方情報の少なくとも1つを得る命令の第2セットと、
少なくとも1つの重み関数を、前記深度情報または前記側方情報の前記少なくとも1つに適用して、結果情報を生成する命令の第3セットと、
前記結果情報に基づいて、前記試料の前記少なくとも一部分の表面位置、側方位置、または深度位置の少なくとも1つにおける時間的な変化である特別情報を突き止める命令の第4セットと、
前記特別情報に基づいて、前記基準の長さを修正する命令の第5セットと、を備えるプログラム。
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EP1782020B1 (en) | 2012-10-03 |
US8081316B2 (en) | 2011-12-20 |
US20060039004A1 (en) | 2006-02-23 |
KR20070062513A (ko) | 2007-06-15 |
WO2006017837A2 (en) | 2006-02-16 |
WO2006017837A3 (en) | 2006-04-27 |
EP1782020A2 (en) | 2007-05-09 |
US20120127476A1 (en) | 2012-05-24 |
JP2008509403A (ja) | 2008-03-27 |
US9226660B2 (en) | 2016-01-05 |
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