CN101384545A - 氘化的儿茶酚胺衍生物及包含所述化合物的药物 - Google Patents
氘化的儿茶酚胺衍生物及包含所述化合物的药物 Download PDFInfo
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- CN101384545A CN101384545A CNA2007800059126A CN200780005912A CN101384545A CN 101384545 A CN101384545 A CN 101384545A CN A2007800059126 A CNA2007800059126 A CN A2007800059126A CN 200780005912 A CN200780005912 A CN 200780005912A CN 101384545 A CN101384545 A CN 101384545A
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- Prior art keywords
- deuteriums
- amino
- dihydroxy phenyl
- physiology
- acceptable salt
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
化合物 | AUC0-t[fmol/min*min] |
L-2-氨基-3-(3,4-二羟基苯基)丙酸 | 228 |
L-2-氨基-2,3,3-三氘-3-(3,4-二羟基苯基)丙酸 | 533 |
L-2-氨基-2,3-二氘-3-(3,4-二羟基苯基)丙酸(实施例6) | 685 |
Claims (41)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006008316 | 2006-02-17 | ||
DE102006008316.4 | 2006-02-17 | ||
PCT/EP2007/001555 WO2007093450A2 (en) | 2006-02-17 | 2007-02-16 | Deuterated catecholamine derivatives and medicaments comprising said compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101384545A true CN101384545A (zh) | 2009-03-11 |
CN101384545B CN101384545B (zh) | 2014-09-03 |
Family
ID=38236462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200780005912.6A Expired - Fee Related CN101384545B (zh) | 2006-02-17 | 2007-02-16 | 氘化的儿茶酚胺衍生物及包含所述化合物的药物 |
Country Status (24)
Country | Link |
---|---|
US (2) | US8247603B2 (zh) |
EP (2) | EP3101001B1 (zh) |
JP (1) | JP5248331B2 (zh) |
KR (1) | KR101411422B1 (zh) |
CN (1) | CN101384545B (zh) |
AU (1) | AU2007214622B2 (zh) |
BR (1) | BRPI0708071A8 (zh) |
CA (1) | CA2642593C (zh) |
CY (1) | CY1117995T1 (zh) |
DK (1) | DK1991522T3 (zh) |
EA (1) | EA017983B1 (zh) |
ES (1) | ES2587368T3 (zh) |
HR (1) | HRP20161039T1 (zh) |
HU (1) | HUE028777T2 (zh) |
IL (1) | IL193102A (zh) |
LT (1) | LT1991522T (zh) |
ME (1) | ME02508B (zh) |
PL (1) | PL1991522T3 (zh) |
PT (1) | PT1991522T (zh) |
RS (1) | RS55142B1 (zh) |
SI (1) | SI1991522T1 (zh) |
UA (1) | UA97795C2 (zh) |
WO (1) | WO2007093450A2 (zh) |
ZA (1) | ZA200806568B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104968643A (zh) * | 2013-02-05 | 2015-10-07 | 伊莫菲尔股份公司 | 位置特异性的非对称氘富集儿茶酚胺衍生物和包含所述化合物的药物 |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DK2303330T4 (da) | 2008-06-06 | 2021-09-13 | Pharma Two B Ltd | Farmaceutiske sammensætninger til behandling af parkinsons sygdom |
BRPI0916769A2 (pt) | 2008-07-15 | 2017-09-26 | Theracos Inc | derivados de benzilbenzeno deuterados e métodos de uso |
EP2819656A1 (en) | 2012-02-28 | 2015-01-07 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
AU2013318182C1 (en) | 2012-09-18 | 2022-01-20 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
US9763904B2 (en) | 2013-02-05 | 2017-09-19 | Teva Pharmaceuticals International Gmbh | Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds |
WO2014174425A2 (en) * | 2013-04-24 | 2014-10-30 | Mahesh Kandula | Compositions and methods for the treatment of orthostasis and neurological diseases |
MX2016000219A (es) * | 2013-07-08 | 2016-05-31 | Auspex Pharmaceuticals Inc | Compuestos neurotransmisores de dihidroxifenilo, composiciones y metodos. |
CA2930167A1 (en) * | 2013-11-22 | 2015-05-28 | Auspex Pharmaceuticals, Inc. | Methods of treating abnormal muscular activity |
NZ720301A (en) | 2013-12-03 | 2022-01-28 | Auspex Pharmaceuticals Inc | Deuterated tetrabenazine compounds |
KR20160117596A (ko) | 2014-02-07 | 2016-10-10 | 오스펙스 파마슈티칼스, 인코포레이티드 | 신규 제약 제제 |
EP2918266A1 (en) | 2014-03-11 | 2015-09-16 | CDRD Berolina AB | Composition comprising a dopamine agonist and an L-DOPA derivative for treating Parkinson's disease |
GB201420341D0 (en) * | 2014-11-17 | 2014-12-31 | Evolution Valves Ltd | Valve arrangement |
KR20230003264A (ko) | 2015-03-06 | 2023-01-05 | 오스펙스 파마슈티칼스, 인코포레이티드 | 비정상적 불수의 운동 장애의 치료 방법 |
CN106343013A (zh) * | 2015-07-19 | 2017-01-25 | 中国科学院上海有机化学研究所 | 一种粮食储存方法 |
CN105360267B (zh) * | 2015-10-09 | 2017-11-10 | 青岛振坤食品机械有限公司 | 一种全自动穿串机 |
TW201720443A (zh) | 2015-10-09 | 2017-06-16 | 梯瓦製藥國際有限責任公司 | 用以治療帕金森氏症之經氘化左旋多巴、碳度巴、以及奧匹卡朋的組合 |
CN105862897B (zh) * | 2016-04-11 | 2018-01-16 | 江苏省华建建设股份有限公司 | 砂质泥岩地基浅基础原槽浇筑施工工法 |
SG11202105545QA (en) * | 2018-12-06 | 2021-06-29 | Senda Biosciences Inc | Quaternary ammonium salts as inhibitors of trimethylamine production |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3699158A (en) | 1969-08-25 | 1972-10-17 | Merck & Co Inc | Selective deuteration of tyrosine, aspartic and glutamic acids |
DE2049807A1 (en) | 1970-10-10 | 1972-04-13 | Hartmeyer H | Conversion of closed cell plastics foam to - open cell structure |
DE2049115C3 (de) | 1970-10-06 | 1981-07-30 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo | Verwendung von Calcium-5-butylpicolinat und/oder Calcium-5-pentylpicolinat bei der Bekämpfung des Parkinsonismus mit 3-(3,4-Dihydroxyphenyl)-L-alanin (L-Dopa) |
ATE76747T1 (de) * | 1986-06-10 | 1992-06-15 | Chiesi Farma Spa | Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen. |
IT1226902B (it) | 1988-07-12 | 1991-02-21 | Mini Ricerca Scient Tecnolog | Processo per la sintesi del levodopa |
US5354885A (en) * | 1992-12-24 | 1994-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Process for preparing ethyl ester of L-DOPA |
US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
DK1104760T3 (da) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler |
DE10261808A1 (de) * | 2002-12-19 | 2004-07-08 | Turicum Drug Development Ag | Verwendung von L-DOPA, seiner Derivate und diese Verbindungen enthaltender Arzneimittel zur Prophylaxe psychotischer Erkrankungen |
DE10261807A1 (de) * | 2002-12-19 | 2004-07-01 | Turicum Drug Development Ag | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
-
2007
- 2007-02-16 SI SI200731819A patent/SI1991522T1/sl unknown
- 2007-02-16 EP EP16170031.5A patent/EP3101001B1/en active Active
- 2007-02-16 PL PL07703542T patent/PL1991522T3/pl unknown
- 2007-02-16 LT LTEP07703542.6T patent/LT1991522T/lt unknown
- 2007-02-16 HU HUE07703542A patent/HUE028777T2/en unknown
- 2007-02-16 WO PCT/EP2007/001555 patent/WO2007093450A2/en active Application Filing
- 2007-02-16 RS RS20160674A patent/RS55142B1/sr unknown
- 2007-02-16 UA UAA200811184A patent/UA97795C2/uk unknown
- 2007-02-16 DK DK07703542.6T patent/DK1991522T3/en active
- 2007-02-16 EP EP07703542.6A patent/EP1991522B1/en active Active
- 2007-02-16 PT PT77035426T patent/PT1991522T/pt unknown
- 2007-02-16 US US12/224,120 patent/US8247603B2/en not_active Ceased
- 2007-02-16 BR BRPI0708071A patent/BRPI0708071A8/pt not_active Application Discontinuation
- 2007-02-16 ME MEP-2016-167A patent/ME02508B/me unknown
- 2007-02-16 KR KR1020087022011A patent/KR101411422B1/ko active IP Right Grant
- 2007-02-16 US US14/464,568 patent/USRE46555E1/en active Active
- 2007-02-16 JP JP2008554702A patent/JP5248331B2/ja not_active Expired - Fee Related
- 2007-02-16 AU AU2007214622A patent/AU2007214622B2/en not_active Ceased
- 2007-02-16 ES ES07703542.6T patent/ES2587368T3/es active Active
- 2007-02-16 CA CA2642593A patent/CA2642593C/en active Active
- 2007-02-16 EA EA200801826A patent/EA017983B1/ru not_active IP Right Cessation
- 2007-02-16 CN CN200780005912.6A patent/CN101384545B/zh not_active Expired - Fee Related
-
2008
- 2008-07-28 ZA ZA200806568A patent/ZA200806568B/xx unknown
- 2008-07-29 IL IL193102A patent/IL193102A/en active IP Right Grant
-
2016
- 2016-08-17 CY CY20161100808T patent/CY1117995T1/el unknown
- 2016-08-17 HR HRP20161039TT patent/HRP20161039T1/hr unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104968643A (zh) * | 2013-02-05 | 2015-10-07 | 伊莫菲尔股份公司 | 位置特异性的非对称氘富集儿茶酚胺衍生物和包含所述化合物的药物 |
CN104968643B (zh) * | 2013-02-05 | 2020-03-03 | 梯瓦制药国际有限责任公司 | 位置特异性的非对称氘富集儿茶酚胺衍生物和包含所述化合物的药物 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160304 Address after: Berlin Patentee after: Imoffel AG Address before: Berlin Patentee before: BIRDS PHARMA GMBH BEROLINA INNOVATIVE RESEARCH & DEVELOPMENT SERVICES |
|
TR01 | Transfer of patent right |
Effective date of registration: 20170527 Address after: Switzerland Jonathan Patentee after: Teva Pharmaceuticals International GmbH Address before: Ulm Patentee before: Weisuo Fan Co.,Ltd. Effective date of registration: 20170527 Address after: Ulm Patentee after: Weisuo Fan Co.,Ltd. Address before: Berlin Patentee before: Imoffel AG |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140903 Termination date: 20210216 |