CN101319234B - 截短侧耳素的发酵方法 - Google Patents
截短侧耳素的发酵方法 Download PDFInfo
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- CN101319234B CN101319234B CN200810022973XA CN200810022973A CN101319234B CN 101319234 B CN101319234 B CN 101319234B CN 200810022973X A CN200810022973X A CN 200810022973XA CN 200810022973 A CN200810022973 A CN 200810022973A CN 101319234 B CN101319234 B CN 101319234B
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- liquid
- fermentor tank
- fermentation
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- tank liquid
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- 238000000855 fermentation Methods 0.000 title claims abstract description 40
- 230000004151 fermentation Effects 0.000 title claims abstract description 40
- 238000000034 method Methods 0.000 title abstract description 7
- ZRZNJUXESFHSIO-BKUNHTPHSA-N 3de4a80mz1 Chemical compound C([C@H]([C@@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-BKUNHTPHSA-N 0.000 title 1
- 229950009961 pleuromulin Drugs 0.000 title 1
- ZRZNJUXESFHSIO-UHFFFAOYSA-N Pleuromutilin Natural products CC1C(O)C(C)(C=C)CC(OC(=O)CO)C2(C)C(C)CCC31C2C(=O)CC3 ZRZNJUXESFHSIO-UHFFFAOYSA-N 0.000 claims abstract description 11
- ZRZNJUXESFHSIO-VYTKZBNOSA-N pleuromutilin Chemical compound C([C@H]([C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-VYTKZBNOSA-N 0.000 claims abstract description 11
- 238000010899 nucleation Methods 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims description 88
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 40
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000008103 glucose Substances 0.000 claims description 13
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 claims description 12
- 244000068988 Glycine max Species 0.000 claims description 10
- 235000010469 Glycine max Nutrition 0.000 claims description 10
- 240000008042 Zea mays Species 0.000 claims description 9
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 9
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 9
- 230000001580 bacterial effect Effects 0.000 claims description 9
- 235000005822 corn Nutrition 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 230000009514 concussion Effects 0.000 claims description 4
- 238000011081 inoculation Methods 0.000 claims description 4
- 241000974485 Aricia shasta Species 0.000 claims description 3
- 238000004043 dyeing Methods 0.000 claims description 3
- 239000002054 inoculum Substances 0.000 claims description 3
- 241000221198 Basidiomycota Species 0.000 claims description 2
- 241000589516 Pseudomonas Species 0.000 claims description 2
- 210000005069 ears Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 4
- 239000003513 alkali Substances 0.000 description 3
- 238000007664 blowing Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000222350 Pleurotus Species 0.000 description 1
- 241001052560 Thallis Species 0.000 description 1
- 230000037358 bacterial metabolism Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000006052 feed supplement Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 238000009923 sugaring Methods 0.000 description 1
- LLYYNOVSVPBRGV-MVNKZKPCSA-N valnemulin Chemical compound CC(C)[C@@H](N)C(=O)NCC(C)(C)SCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@@H]2C(=O)CC3 LLYYNOVSVPBRGV-MVNKZKPCSA-N 0.000 description 1
- 229950008166 valnemulin Drugs 0.000 description 1
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200810022973XA CN101319234B (zh) | 2008-07-04 | 2008-07-04 | 截短侧耳素的发酵方法 |
Applications Claiming Priority (1)
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CN200810022973XA CN101319234B (zh) | 2008-07-04 | 2008-07-04 | 截短侧耳素的发酵方法 |
Publications (2)
Publication Number | Publication Date |
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CN101319234A CN101319234A (zh) | 2008-12-10 |
CN101319234B true CN101319234B (zh) | 2011-02-16 |
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Application Number | Title | Priority Date | Filing Date |
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CN200810022973XA Expired - Fee Related CN101319234B (zh) | 2008-07-04 | 2008-07-04 | 截短侧耳素的发酵方法 |
Country Status (1)
Country | Link |
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CN (1) | CN101319234B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101659970B (zh) * | 2009-07-30 | 2012-07-04 | 浙江升华拜克生物股份有限公司 | 阿维菌素发酵废水和侧耳素发酵废水循环处理方法 |
CN101838199B (zh) * | 2010-05-21 | 2013-01-30 | 西南大学 | 截短侧耳素的溶剂提取工艺 |
CN103734022B (zh) * | 2012-10-16 | 2017-09-05 | 中国科学院天津工业生物技术研究所 | 生产麦角硫因的菌株及制备麦角硫因的方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4107434A (en) * | 1976-01-15 | 1978-08-15 | Sandoz Ltd. | Process for making pleuromutilins |
CN1671663A (zh) * | 2002-07-24 | 2005-09-21 | 桑多斯股份公司 | 截短侧耳素 |
CN1775755A (zh) * | 2005-12-06 | 2006-05-24 | 江苏赛奥生化有限公司 | 泰妙菌素合成过程中用的截短侧耳素原料的制备方法 |
CN1814765A (zh) * | 2005-12-06 | 2006-08-09 | 江苏赛奥生化有限公司 | 生产泰妙菌素过程中含截短侧耳素的原料的制备方法 |
-
2008
- 2008-07-04 CN CN200810022973XA patent/CN101319234B/zh not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4107434A (en) * | 1976-01-15 | 1978-08-15 | Sandoz Ltd. | Process for making pleuromutilins |
CN1671663A (zh) * | 2002-07-24 | 2005-09-21 | 桑多斯股份公司 | 截短侧耳素 |
CN1775755A (zh) * | 2005-12-06 | 2006-05-24 | 江苏赛奥生化有限公司 | 泰妙菌素合成过程中用的截短侧耳素原料的制备方法 |
CN1814765A (zh) * | 2005-12-06 | 2006-08-09 | 江苏赛奥生化有限公司 | 生产泰妙菌素过程中含截短侧耳素的原料的制备方法 |
Non-Patent Citations (2)
Title |
---|
黄宇琪 等.截短侧耳素产生菌的鉴定及发酵培养基初筛.《四川大学学报(自然科学版)》.2008,第45卷(第3期), |
黄宇琪等.截短侧耳素产生菌的鉴定及发酵培养基初筛.《四川大学学报(自然科学版)》.2008,第45卷(第3期), * |
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CN101319234A (zh) | 2008-12-10 |
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Effective date of registration: 20210826 Address after: 310000 block a, 9 / F, building a, Paradise Software Park, No. 3, xidoumen Road, Xihu District, Hangzhou City, Zhejiang Province Patentee after: Hangzhou Shangni Biotechnology Co.,Ltd. Address before: 310000 Room F, 9/F, Building A, Paradise Software Park, No. 3 Xidoumen Road, Xihu District, Hangzhou City, Zhejiang Province Patentee before: ZHEJIANG ZHEJIANG UNIVERSITY SUNSHINE TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20211111 Address after: 226000 Building 2, No. 128, Changhe Road, Nantong, Jiangsu Province Patentee after: JIANGSU SEL BIOCHEMISTRY Co.,Ltd. Address before: 310000 block a, 9 / F, building a, Paradise Software Park, No. 3, xidoumen Road, Xihu District, Hangzhou City, Zhejiang Province Patentee before: Hangzhou Shangni Biotechnology Co.,Ltd. |
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