CN101284120A - Process for preparing Pingxiao preparation - Google Patents
Process for preparing Pingxiao preparation Download PDFInfo
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- CN101284120A CN101284120A CNA2008101098410A CN200810109841A CN101284120A CN 101284120 A CN101284120 A CN 101284120A CN A2008101098410 A CNA2008101098410 A CN A2008101098410A CN 200810109841 A CN200810109841 A CN 200810109841A CN 101284120 A CN101284120 A CN 101284120A
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Abstract
The invention relates to a preparation method of the prior Chinese traditional medicine, particularly a preparation method of Canelim preparation. The preparation method comprises extracting turmeric root tuber to obtain volatile oil, percolating, decocting, mixing the decoctions, mixing, vacuum concentrating into thick paste, drying at low temperature, pulverizing into fine powder, adding vomic nut powder, and appropriate amount of dried lacquer, faeces trogopterorum, white alum, niter fine powder and adjuvants, mixing completely, adding the primary filtrate, granulating, drying at low temperature, spraying volatile oil, sealing for 30-60 minutes, mixing intensively, preparing into tablet, and coating with sugarcoat or film coat. The preparation method has reasonable process, greatly increases effective component content in the Canelim preparation, and improves curative effect of Chinese patent medicine Canelim preparation.
Description
Technical field
The present invention relates to a kind of preparation method of existing preparation method of Chinese medicine, particularly flat oral preparation for eliminating.
Background technology
Flat oral preparation for eliminating comprises tablet, capsule, is a kind of antineoplastic Chinese traditional medicine commonly used.In the 20 in the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation, the 71st～72 page of WS
2In-B-3798-98 the standard, its prescription, method for making, character, discriminating, inspection, assay etc. have been made specified in more detail.Wherein, its method for making is: Resina Toxicodendri, Oletum Trogopterori, Alumen, Sal Nitri are ground into fine powder; Radix Curcumae, Fructus Aurantii are ground into coarse powder, according to the percolation (appendix IO) under fluid extract and the extractum item, are solvent with 70% ethanol, carry out percolation, the collection percolate; Medicinal residues and Herba Agrimoniae decoct with water secondary, and collecting decoction filters, and after percolate reclaims ethanol, merge with above-mentioned filtrate, concentrating under reduced pressure becomes thick paste, and dry back adds Semen Strychni Pulveratum, above-mentioned fine powder and right amount of auxiliary materials, and mixing is granulated, drying, compacting is in blocks, sugar coating or film-coat, promptly.
In the prescription of above-mentioned preparation, Radix Curcumae is a monarch drug, and its main component volatile oil is in above-mentioned prepared, a large amount of volatilization losses, and produce in the process whole, the effective ingredient of part medical material is not fully utilized, and causes the clinical efficacy of this medicine not bring into play optimum efficiency.
Summary of the invention
The objective of the invention is to overcome above-mentioned the deficiencies in the prior art, provide a kind of and can fully extract the volatile oil in the Radix Curcumae and the effective ingredient of other medical material, preparation technology is more reasonable simultaneously, has guaranteed the preparation method of the active constituent content in the flat oral preparation for eliminating.
For achieving the above object, technical scheme of the present invention is: a kind of preparation method of flat oral preparation for eliminating:
The extraction of a, Radix Curcumae volatile oil: after turmeric powder is broken into coarse powder, extract volatile oil, medicinal residues are stand-by;
B, percolation: with the coarse powder of the Radix Curcumae medicinal residues behind the said extracted volatile oil and Fructus Aurantii, be solvent with 70% ethanol, carry out percolation, collect just filtrate and subsequent filtrate respectively, the medicinal residues behind the percolation are stand-by;
C, decoction: medicinal residues behind the above-mentioned percolation and Herba Agrimoniae are decocted with water secondary, collecting decoction, after the filtration, filtrate is stand-by;
D, the filtrate that the subsequent filtrate of step b is reclaimed behind the ethanol with step c merge, concentrating under reduced pressure becomes thick paste, after the cold drying, be ground into fine powder, add Semen Strychni Pulveratum and Resina Toxicodendri, Oletum Trogopterori, Alumen, Sal Nitri fine powder and right amount of auxiliary materials then, behind the mixing, add the first filtrate of step b, stand-by after granulation, the cold drying as raw material;
E, film-making agent: in the raw material of steps d, spray into step a and extract volatile oil, airtight 30-60 minute, behind the mixing, be pressed into tablet, sugar coating or film-coat get product.
F, capsule: in the raw material of steps d, spray into step a and extract volatile oil, airtight 30-60 minute, behind the mixing, in incapsulating, promptly get the capsule finished product.
The temperature of above-mentioned cold drying is lower than 70 ℃.
It is reasonable that the present invention has technology, improved active constituent content in the flat oral preparation for eliminating of existing Chinese patent medicine.The present invention is on existing preparation technology's basis, at first the volatile oil in the Radix Curcumae is extracted in advance, simultaneously the percolation process in the existing technology is improved, first filtrate behind the percolation is added before granulation, make binding agent usefulness, simultaneously before film-making or capsule, add the volatile oil in the Radix Curcumae, volatile oil in tablet or the capsule is fully kept, the content of effective of monarch drug in the flat oral preparation for eliminating is improved greatly, thereby improve the curative effect of flat oral preparation for eliminating.
The specific embodiment
To produce 1000 PINGXIAO PIAN is example, and it is as follows that the present invention will be described:
Get Radix Curcumae 56g, be ground into coarse powder after, extract volatile oil.The extraction of volatile oil can be adopted existing steam distillation or supercritical CO
2Mature technologies such as fluid extraction method.Preserve the volatile oil that extracts stand-by.With the coarse powder 90g of Radix Curcumae medicinal residues and Fructus Aurantii that extracts behind the volatile oil, after the mixing, the employing percolation is a solvent with 70% ethanol, carries out percolation; Collect just filtrate and subsequent filtrate respectively, medicinal residues behind the percolation and Herba Agrimoniae 54g, decoct with water secondary, collecting decoction, to merge with above-mentioned collecting decoction behind the above-mentioned subsequent filtrate recovery ethanol, concentrating under reduced pressure becomes thick paste, be lower than under 70 ℃ the temperature after the drying, be ground into fine powder, add fine powder and the right amount of auxiliary materials of Semen Strychni Pulveratum 36g and Resina Toxicodendri 18g, Oletum Trogopterori 54g, Alumen 54g, Sal Nitri 54g then, behind the mixing, add first filtrate as binding agent, after the granulation,, stand-by as raw material being lower than under 60 ℃ the temperature after the drying;
Utilize above-mentioned raw materials film-making agent: in above-mentioned raw materials, spray into the Radix Curcumae volatile oil of extraction, airtight about 40 minutes, volatile oil is fully absorbed by above-mentioned raw materials, behind the mixing, can be pressed into tablet simultaneously, sugar coating or film-coat get product 1000.
Utilize above-mentioned raw materials glue wafer: in above-mentioned raw materials, spray into the Radix Curcumae volatile oil of extraction, airtight about 50 minutes, volatile oil is fully absorbed by above-mentioned raw materials, behind the mixing, in incapsulating, promptly get the capsule finished product simultaneously.
Spray into the airtight time of the raw material of Radix Curcumae volatile oil, can be controlled in 30-60 minute according to the difference of equipment or the method difference of batch mixing.Its main purpose is that volatile oil is fully absorbed by raw material.
The raw material of method for preparing also can be used as the raw material of making granule or drop pill.
Claims (2)
1, a kind of preparation method of flat oral preparation for eliminating:
The extraction of a, Radix Curcumae volatile oil: after turmeric powder is broken into coarse powder, extract volatile oil, medicinal residues are stand-by;
B, percolation: with the coarse powder of the Radix Curcumae medicinal residues behind the said extracted volatile oil and Fructus Aurantii, be solvent with 70% ethanol, carry out percolation, collect just filtrate and subsequent filtrate respectively, the medicinal residues behind the percolation are stand-by;
C, decoction: medicinal residues behind the above-mentioned percolation and Herba Agrimoniae are decocted with water secondary, collecting decoction, after the filtration, filtrate is stand-by;
D, the filtrate that the subsequent filtrate of step b is reclaimed behind the ethanol with step c merge, concentrating under reduced pressure becomes thick paste, after the cold drying, be ground into fine powder, add Semen Strychni Pulveratum and Resina Toxicodendri, Oletum Trogopterori, Alumen, Sal Nitri fine powder and right amount of auxiliary materials then, behind the mixing, add the first filtrate of step b, stand-by after granulation, the cold drying as raw material;
E, film-making agent: in the raw material of steps d, spray into step a and extract volatile oil, airtight 30-60 minute, behind the mixing, be pressed into tablet, sugar coating or film-coat get product.
F, capsule: in the raw material of steps d, spray into step a and extract volatile oil, airtight 30-60 minute, behind the mixing, in incapsulating, promptly get the capsule finished product.
2, the preparation method of flat oral preparation for eliminating according to claim 1 is characterized in that the temperature of above-mentioned cold drying is lower than 70 ℃.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101098410A CN101284120A (en) | 2008-05-29 | 2008-05-29 | Process for preparing Pingxiao preparation |
| CN2009102034976A CN101574506B (en) | 2008-05-29 | 2009-05-27 | Method for preparing pingxiao preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101098410A CN101284120A (en) | 2008-05-29 | 2008-05-29 | Process for preparing Pingxiao preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101284120A true CN101284120A (en) | 2008-10-15 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101098410A Pending CN101284120A (en) | 2008-05-29 | 2008-05-29 | Process for preparing Pingxiao preparation |
| CN2009102034976A Expired - Fee Related CN101574506B (en) | 2008-05-29 | 2009-05-27 | Method for preparing pingxiao preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102034976A Expired - Fee Related CN101574506B (en) | 2008-05-29 | 2009-05-27 | Method for preparing pingxiao preparation |
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| Country | Link |
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| CN (2) | CN101284120A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566282A (en) * | 2012-07-27 | 2014-02-12 | 西安正大制药有限公司 | Traditional Chinese medicine composition with anti-tumor effect and preparation method thereof |
| CN106421630A (en) * | 2016-06-29 | 2017-02-22 | 宁夏金太阳药业有限公司 | Radix Curcumae Aromaticae extract product, and preparation method and application thereof |
| CN116492436A (en) * | 2023-03-02 | 2023-07-28 | 济南市中心医院 | Preparation method of Pingxiao preparation |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566281B (en) * | 2012-07-27 | 2016-12-21 | 西安正大制药有限公司 | A kind of Traditional Chinese medicine composition with anti-tumor effect and preparation method |
| CN106039209A (en) * | 2016-06-29 | 2016-10-26 | 宁夏金太阳药业有限公司 | Traditional Chinese medicine extract for treating hyperplasia of mammary glands, as well as preparation method and application thereof |
| CN106110173A (en) * | 2016-06-29 | 2016-11-16 | 宁夏金太阳药业有限公司 | A kind of Chinese medicine extract treating cyclomastopathy and extracting method thereof and application |
| CN106039210A (en) * | 2016-06-29 | 2016-10-26 | 宁夏金太阳药业有限公司 | Traditional Chinese medicinal composition for treating hyperplasia of mammary glands as well as preparation method and application thereof |
| CN106389872A (en) * | 2016-09-26 | 2017-02-15 | 魏庆 | Traditional Chinese medicine composition for preventing and treating tumors and preparation method of traditional Chinese medicine composition for preventing and treating tumors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1268324C (en) * | 2004-04-30 | 2006-08-09 | 甘肃独一味生物制药有限责任公司 | Chinese medicinal soft capsule and preparing process thereof |
-
2008
- 2008-05-29 CN CNA2008101098410A patent/CN101284120A/en active Pending
-
2009
- 2009-05-27 CN CN2009102034976A patent/CN101574506B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566282A (en) * | 2012-07-27 | 2014-02-12 | 西安正大制药有限公司 | Traditional Chinese medicine composition with anti-tumor effect and preparation method thereof |
| CN106421630A (en) * | 2016-06-29 | 2017-02-22 | 宁夏金太阳药业有限公司 | Radix Curcumae Aromaticae extract product, and preparation method and application thereof |
| CN116492436A (en) * | 2023-03-02 | 2023-07-28 | 济南市中心医院 | Preparation method of Pingxiao preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101574506A (en) | 2009-11-11 |
| CN101574506B (en) | 2010-12-29 |
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