CN102940724A - Preparation method of traditional Chinese medicine compound capsule for diminishing inflammation - Google Patents
Preparation method of traditional Chinese medicine compound capsule for diminishing inflammation Download PDFInfo
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- CN102940724A CN102940724A CN2012102918697A CN201210291869A CN102940724A CN 102940724 A CN102940724 A CN 102940724A CN 2012102918697 A CN2012102918697 A CN 2012102918697A CN 201210291869 A CN201210291869 A CN 201210291869A CN 102940724 A CN102940724 A CN 102940724A
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine compound capsule for diminishing inflammation and relates to the technical field of traditional Chinese medicine preparations. The preparation method is characterized in that picriafel-terrae lour, sarcandra glabra, climbing groundsel herb, pubescent holly root and liquorice root are subjected to micronization, ultrasonic extraction, water extract concentration, alcohol precipitation, granulation and loading. The preparation method has the advantages that an active ingredient extraction ratio is high; extraction time is short; energy is saved; and human body adverse reactions caused by a drug absorption difference are eliminated to the maximum degree.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation technical field, be specifically related to a kind of preparation method of the Herbal compound capsule for antiinflammatory.
Background technology
The benzydamine capsule records " benzydamine sheet " form improvement according to " Drug Standard of Ministry of Public Health of the Peoples Republic of China " the 8th to be come.This capsule has the effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, blood circulation and channel invigorating, can effectively improve inflammation of upper respiratory tract, bronchitis, rhinitis, pharyngolaryngitis, tonsillitis, the symptoms such as bacillary dysentery and chronic cholecystitis.
The existing preparation method of benzydamine capsule is: gets Radix Picriae felterrae 100g and is ground into fine powder, cross 100 mesh sieves, and for subsequent use; Other gets Radix Picriae felterrae 450g, Herba Sarcandrae 350g, Herba Senecionis Scandentis 225g, Radix Ilicis Pubescentis 225g, Radix Glycyrrhizae 50g adds 10 times of water gagings and decocts secondary, 2 hours for the first time, 1 hour for the second time, merge first, the secondary decocting liquid filters, and it is 1.22(60 ℃ of survey that filtrate is concentrated into relative density) extractum, add ethanol and make that to contain alcohol amount be 70%, stir evenly, left standstill 24 hours, filter, it is 1.20-1.22(60 ℃ of survey that filtrate is concentrated into relative density) extractum, add Radix Picriae felterrae fine powder for subsequent use, mixing, oven dry, be ground into fine powder, add starch 20g, mixing, granulation, fill becomes 1000 capsules, and get final product.Above-mentioned preparation method is that the mode of part Radix Picriae felterrae with the common powder of crude drug joined in the preparation, makes preparation have the shortcomings such as the medical material granule is large, effect is slow, absorption difference; In addition, what the extraction method of medical material effective ingredient adopted is decocting cooking method and common concentrated, the roasting seasoning of flood, and because extract decocts, the oven dry heated time is long, some thermally labile effective ingredient easily go to pot, and effective component extraction rate is not high; For a long time heating expends the energy during the course, and contaminated environment wastes time and energy again, is difficult to realize modernization of Chinese medicine production.
Summary of the invention
The objective of the invention is for top described defective, the preparation method of the Herbal compound capsule that is used for antiinflammatory that a kind of extraction ratio is high, extraction time is short, easily be absorbed by the body is provided.
The objective of the invention is to be achieved by the following technical programs.
A kind of preparation method of the Herbal compound capsule for antiinflammatory, the five tastes raw medicinal material that comprises following weight portion: 550 parts of Radix Picriae felterrae, 350 parts of Herba Sarcandraes, 225 parts of Herba Senecionis Scandentiss, 225 parts of Radix Ilicis Pubescentiss, 50 parts in Radix Glycyrrhizae, preparation method in turn includes the following steps: 1. first the Radix Picriae felterrae of 100 parts of weight is ground into 80 order coarse powder, vacuum drying is to moisture below 3%, then doing the supersonic speed kinetic energy airflow with jet mill pulverizes, get 75 μ m, the micropowder that 200 orders are following, for subsequent use; 2. with 50 parts of 450 parts of Radix Picriae felterrae, 350 parts of Herba Sarcandraes, 225 parts of Herba Senecionis Scandentiss, 225 parts of Radix Ilicis Pubescentiss, Radix Glycyrrhizae take water as solvent, use ultrasonic extraction, get water extract filtrate; Relative density is 1.22 extractum when 3. the water extract filtrate decompression being concentrated into 60 ℃, adds ethanol and makes its solution contain amount of alcohol to be 70%, to stir evenly, left standstill 24 hours, and filtered, filtrate elder generation Recycled ethanol, relative density is the extract extractum of 1.20-1.22 when then being evaporated to 60 ℃, and is for subsequent use; 4. extract extractum adds the Radix Picriae felterrae micropowder of preparation, mixing, and oven dry is ground into fine powder, adds starch, mixing, granulation, fill becomes capsule and get final product.
1. described step shatters 100 parts of weight Radix Picriae felterrae to the coarse powder below 80 orders with medicinal material pulverizer first, at vacuum 0.85-0.95MPa, 60-70 ℃ of decompression drying to moisture less than 3%, then at 100,000 grades of environment of air cleaning, use the comminution by gas stream crusher machine, feeding quantity span 14.8-29.6kg/h, air-flow operating pressure 8.61kg/cm
2, micropowder yield 95.5%-98.5%, granule are less than 75 μ m, and 200 order micropowders are for subsequent use.
2. described step passes through 60 mesh sieve holes with 450 parts of Radix Picriae felterrae, 350 parts of Herba Sarcandraes, 225 parts of Herba Senecionis Scandentiss, 225 parts of Radix Ilicis Pubescentiss, 50 parts of coarse pulverizations of Radix Glycyrrhizae, in water, soaked 1.5-2 hour first, the consumption of water is 10-12 times of material, W/W, then under bathing warm 60-70 ℃, extract 2 times each 30-50min at 35-40kHz with ultrasonic extractor, filter afterwards filtrate for later use.
Described step 3. with water extract filtrate at vacuum 0.85-0.95MPa, 60-70 ℃ of relative density when being evaporated to 60 ℃ is 1.22 extractum, adding 95% edible ethanol makes and contains alcohol amount and reach 70%, stir evenly, left standstill 24 hours, filter, filtrate elder generation Recycled ethanol, then at vacuum 0.85-0.95MPa, being evaporated to relative density at 60-70 ℃ is 1.20-1.22,60 ℃ extract extractum.
Described step 4. extract extractum adds the Radix Picriae felterrae micropowder for preparing, mixing, and oven dry is ground into fine powder, adds starch, and making the fine powder total amount is 200 parts, mixing, granulation, fill becomes capsule, and the capsule specification is the 0.2g/ grain, and get final product.
The invention has the beneficial effects as follows: the present invention adopts supersonic extracting method, can make the rapid stripping of active ingredient in the crude drug cell, and remove the efficacy component that makes medical material under the violent condition from and destroy, reach that the active ingredient extraction ratio is high, extraction time is short, the advantage of energy savings; The Radix Picriae felterrae of part dosage is done the supersonic speed kinetic energy airflow with jet mill at low temperatures to be pulverized, obtain the following micropowder of 75 μ m, drug particles is narrower than the traditional mechanical comminuting method far away, granule is thinner, easier being absorbed by the body, the difference of eliminating to greatest extent because absorbing causes that human body is to the harmful effect of drug absorption.The present invention has overcome the deficiency of former technique, has improved product quality, reaches again and surpassed the quality standard of former technology establishment, and meets the requirement of low-carbon (LC), environmental protection and energy savings.
The specific embodiment
Implementation example:Press crude drug formulation weight mark, get Radix Picriae felterrae 5.5Kg, Herba Sarcandrae 3.5Kg, a thousand li
Light 2.25Kg, Radix Ilicis Pubescentis 2.25Kg, Radix Glycyrrhizae 0.5Kg.
The micropowder preparation:Chinese medicine Radix Picriae felterrae 1.0 Kg are crushed to coarse powder below 80 orders, vacuum 0.85～
0.95Mpa, 60～70 ℃ of vacuum dryings to moisture less than 3%.Then pulverize with jet mill, under 100,000 grades of environment of air cleaning, feeding quantity span 14.8～29.6kg/h, air-flow operating pressure 8.61kg/cm
2Receive to get micropowder 0.97Kg yield 97%, micro powder granule is less than 75 μ m(200 orders), for subsequent use.
Ultrasonic extraction:Get Chinese crude drug Radix Picriae felterrae 4.5Kg, Herba Sarcandrae 3.5Kg, Herba Senecionis Scandentis 2.25Kg, Radix Ilicis Pubescentis 2.25Kg, Radix Glycyrrhizae 0.5Kg, coarse pulverization is by 60 mesh sieve holes.Use first the 156Kg water soaking 2 hours, and then bathing under warm 70 ℃, extracted 50min with ultrasonic extractor at 40kHz, filter afterwards, get first-time filtrate.Filtering residue adds water 130Kg again, bathing under warm 60 ℃, extracts 30min with ultrasonic extractor at 35kHz, filters, and gets secondary filtrate; Merge extracted twice liquid, for subsequent use.
Aqueous extract is concentrated, precipitate with ethanol:With water extract filtrate at vacuum 0.85～0.95Mpa, 60～70 ℃ of pressures are concentrated into relative density and are about 1.22(60 ℃ of survey) extractum, anti-cold, add 95% edible ethanol and make and contain alcohol amount and reach 70%, stir evenly, left standstill 24 hours, filter, filtrate elder generation Recycled ethanol is then at vacuum 0.85～0.95Mpa, 60～70 ℃ are evaporated to relative density and are about 1.20～1.22(60 ℃ of survey) extract equivalent extract 1.7Kg, for subsequent use.
Granulation, fill:Get extract equivalent extract 1.7Kg, add the Radix Picriae felterrae micropowder 0.97Kg of comminution by gas stream, mixing is at vacuum 0.85～0.95Mpa, 60～70 ℃ of oven dry are arrived moisture less than 5%, be ground into fine powder 1.8Kg, add suitable weight starch again, making its total amount is 2.0Kg, mixing, granulation, fill become 10000 capsules (0.2g/ grain), and packing gets product.
Finished product requires to test according to the quality standard of former technology establishment, and the result is as follows.
[character]This product is capsule, and content is brownish black granule and powder; Bitter in the mouth.
[inspection]This product should meet (appendix IL of Chinese Pharmacopoeia version in 2010) relevant every regulation under the capsule item.The results are shown in Table 1.
Table 1 check result.
[
Differentiate]
(1) differentiates with Radix Picriae felterrae control medicinal material thin layer: according to thin layer chromatography (" 2010 editions appendix VIB of Chinese pharmacopoeia) test.As a result in the test sample thin layer chromatography, with control medicinal material chromatograph relevant position on, aobvious same color speckle.
(2) differentiate with Herba Sarcandrae control medicinal material thin layer: according to thin layer chromatography (" 2010 editions appendix VIB of Chinese pharmacopoeia) test.As a result in the test sample thin layer chromatography, with control medicinal material chromatograph relevant position on, aobvious same color speckle.
(3) differentiate with Herba Senecionis Scandentis control medicinal material thin layer: according to thin layer chromatography (" 2010 editions appendix VIB of Chinese pharmacopoeia) test.As a result in the test sample thin layer chromatography, with control medicinal material chromatograph relevant position on, aobvious same color speckle.
[isofraxidin assay]Measure according to high performance liquid chromatography (an appendix VI of Chinese Pharmacopoeia version in 2010 D).Require every of this product to contain Herba Sarcandrae with isofraxidin (C
11H
10O
5) meter, should be no less than 0.04mg.
Measurement result:Every of this product contains isofraxidin (C
11H
10O
5) average out to 0.072 mg.
Testing result shows the benzydamine capsule of new technology preparation, and indices all meets the quality index regulation of former process stipulation, and some indexs surpass the requirement that is better than former regulation.
Claims (5)
1. preparation method that is used for the Herbal compound capsule of antiinflammatory, the five tastes raw medicinal material that comprises following weight portion: 550 parts of Radix Picriae felterrae, 350 parts of Herba Sarcandraes, 225 parts of Herba Senecionis Scandentiss, 225 parts of Radix Ilicis Pubescentiss, 50 parts in Radix Glycyrrhizae, preparation method in turn includes the following steps: 1. first the Radix Picriae felterrae of 100 parts of weight is ground into 80 order coarse powder, vacuum drying is to moisture below 3%, then doing the supersonic speed kinetic energy airflow with jet mill pulverizes, get 75 μ m, the micropowder that 200 orders are following, for subsequent use; 2. with 50 parts of 450 parts of Radix Picriae felterrae, 350 parts of Herba Sarcandraes, 225 parts of Herba Senecionis Scandentiss, 225 parts of Radix Ilicis Pubescentiss, Radix Glycyrrhizae take water as solvent, use ultrasonic extraction, get water extract filtrate; Relative density is 1.22 extractum when 3. the water extract filtrate decompression being concentrated into 60 ℃, adds ethanol and makes its solution contain amount of alcohol to be 70%, to stir evenly, left standstill 24 hours, and filtered, filtrate elder generation Recycled ethanol, relative density is the extract extractum of 1.20-1.22 when then being evaporated to 60 ℃, and is for subsequent use; 4. extract extractum adds the Radix Picriae felterrae micropowder of preparation, mixing, and oven dry is ground into fine powder, adds starch, mixing, granulation, fill becomes capsule and get final product.
2. the preparation method of a kind of Herbal compound capsule for antiinflammatory according to claim 1, it is characterized in that: 1. described step shatters 100 parts of weight Radix Picriae felterrae to the coarse powder below 80 orders with medicinal material pulverizer first, at vacuum 0.85-0.95MPa, 60-70 ℃ of decompression drying to moisture less than 3%, then at 100,000 grades of environment of air cleaning, use the comminution by gas stream crusher machine, feeding quantity span 14.8-29.6kg/h, air-flow operating pressure 8.61kg/cm
2, micropowder yield 95.5%-98.5%, granule are less than 75 μ m, and 200 order micropowders are for subsequent use.
3. the preparation method of a kind of Herbal compound capsule for antiinflammatory according to claim 1, it is characterized in that: 2. described step passes through 60 mesh sieve holes with 450 parts of Radix Picriae felterrae, 350 parts of Herba Sarcandraes, 225 parts of Herba Senecionis Scandentiss, 225 parts of Radix Ilicis Pubescentiss, 50 parts of coarse pulverizations of Radix Glycyrrhizae, in water, soaked 1.5-2 hour first, the consumption of water is 10-12 times of material, and W/W is then under bathing warm 60-70 ℃, extract 2 times at 35-40kHz with ultrasonic extractor, each 30-50min filters filtrate for later use afterwards.
4. the preparation method of a kind of Herbal compound capsule for antiinflammatory according to claim 1, it is characterized in that: described step 3. with water extract filtrate at vacuum 0.85-0.95MPa, 60-70 ℃ of relative density when being evaporated to 60 ℃ is 1.22 extractum, adding 95% edible ethanol makes and contains alcohol amount and reach 70%, stir evenly, left standstill 24 hours, filter, filtrate elder generation Recycled ethanol, then at vacuum 0.85-0.95MPa, being evaporated to relative density at 60-70 ℃ is 1.20-1.22,60 ℃ extract extractum.
5. the preparation method of a kind of Herbal compound capsule for antiinflammatory according to claim 1, it is characterized in that: described step 4. extract extractum adds the Radix Picriae felterrae micropowder for preparing, mixing, oven dry, be ground into fine powder, add starch, making the fine powder total amount is 200 parts, mixing, granulation, fill becomes capsule, and the capsule specification is the 0.2g/ grain, and get final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012102918697A CN102940724A (en) | 2012-08-16 | 2012-08-16 | Preparation method of traditional Chinese medicine compound capsule for diminishing inflammation |
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| CN2012102918697A CN102940724A (en) | 2012-08-16 | 2012-08-16 | Preparation method of traditional Chinese medicine compound capsule for diminishing inflammation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106539927A (en) * | 2016-10-26 | 2017-03-29 | 赵良 | Xiaoyan San |
| CN107519293A (en) * | 2017-08-14 | 2017-12-29 | 海南葫芦娃药业集团股份有限公司 | A kind of benzydamine micropill and preparation method thereof |
| CN108992528A (en) * | 2018-09-30 | 2018-12-14 | 广西维威制药有限公司 | Xiaoyanling Tablet and preparation method thereof |
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|---|---|---|---|---|
| EP0568001A2 (en) * | 1992-04-27 | 1993-11-03 | Showa Shell Sekiyu Kabushiki Kaisha | Antiviral agent containing crude drug |
| CN101618146A (en) * | 2009-07-17 | 2010-01-06 | 南宁市维威制药有限公司 | Complex traditional Chinese medicine preparation for treating upper respiratory tract infection and preparation method thereof |
| RU2413527C1 (en) * | 2009-08-21 | 2011-03-10 | Учреждение Российской Академии Наук Институт общей и экспериментальной биологии Сибирского отделения РАН | Anti-inflammatory and antibacterial drug |
| WO2012073191A1 (en) * | 2010-11-30 | 2012-06-07 | Ricerfarma S.R.L. | Topical compositions for preserving or restoring the integrity of mucosae |
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2012
- 2012-08-16 CN CN2012102918697A patent/CN102940724A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0568001A2 (en) * | 1992-04-27 | 1993-11-03 | Showa Shell Sekiyu Kabushiki Kaisha | Antiviral agent containing crude drug |
| CN101618146A (en) * | 2009-07-17 | 2010-01-06 | 南宁市维威制药有限公司 | Complex traditional Chinese medicine preparation for treating upper respiratory tract infection and preparation method thereof |
| RU2413527C1 (en) * | 2009-08-21 | 2011-03-10 | Учреждение Российской Академии Наук Институт общей и экспериментальной биологии Сибирского отделения РАН | Anti-inflammatory and antibacterial drug |
| WO2012073191A1 (en) * | 2010-11-30 | 2012-06-07 | Ricerfarma S.R.L. | Topical compositions for preserving or restoring the integrity of mucosae |
Non-Patent Citations (2)
| Title |
|---|
| 张兆旺: "《中药药剂学》", 31 January 2003, 中国中医药出版社 * |
| 葛晓陵: "中药的超细加工及其应用的探讨", 《中成药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106539927A (en) * | 2016-10-26 | 2017-03-29 | 赵良 | Xiaoyan San |
| CN107519293A (en) * | 2017-08-14 | 2017-12-29 | 海南葫芦娃药业集团股份有限公司 | A kind of benzydamine micropill and preparation method thereof |
| CN108992528A (en) * | 2018-09-30 | 2018-12-14 | 广西维威制药有限公司 | Xiaoyanling Tablet and preparation method thereof |
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Application publication date: 20130227 |