CN104107386A - Medicine composition for treating gosling plague and preparation method of medicine composition - Google Patents

Abstract

The invention discloses a medicine composition for treating gosling plague and a preparation method of the medicine composition. The medicine composition comprises the following medicinal raw materials: astragalus, bighead atractylodes rhizome, lucid ganoderma, semen raphani, fevervine, elaeagnus commutate, gorgon fruit, the root of kudzu vine, gynostemma pentaphylla, Rhodiola rosea, Chinese-date, lalang grass rhizome, elecampane, hairyvein agrimony, Japanese beauty-berry, Loropetalum chinense, scutellaria baicalensis, the bark of ash, sophora alopecuroide, fructus amomi, amomum kravanh, amomum tsao-ko, meadowrue root and rhizome, smoked plum, Chinese gall, humifuse euphorbia herb and pericarpium granati. The medicine composition has the beneficial effects that the medicine composition has main effects of invigorating spleen, supplementing qi, detoxifying and checking diarrhea and auxiliary effects of dispelling the wind and eliminating spasm, can strengthen the body resistance to eliminate pathogenic factors and improve the organism immunity of sick gooses, is short in course of treatment, good in curative effect and low in cost and does not have drug resistance or drug residues; the illness state can be effectively controlled, and a certain health-care effect on the body can be achieved after consumers eat the gooses.

Description

Be used for the treatment of pharmaceutical composition of gosling plague and preparation method thereof

Technical field

The present invention relates to field of veterinary, relate in particular to pharmaceutical composition of a kind of gosling plague of being used for the treatment of and preparation method thereof.

Background technology

Gosling plague is the acute or subacute septic infectious disease of one by the caused young goose of Goose Parvovirus.Clinical tired with spirit, peel off solely even, serosity nose liquid is flowed out in nostril, suffers from goose and again and again shakes the head, and draws lark or yellow green loose stool, neurological disorders, the mucosa necrosis of small intestinal posterior segment comes off and solidifies formation embolus with fibrinous exudate, shape as sausage shape be feature.Often be deteriorated blood process, M & M is very high, very big to supporting goose industry disserve to produce.

Incidence: primary disease all has generation the whole year, but multiple be born in last month of spring in winter at the beginning of, mainly encroach on the young goose of 3-20 age in days.Gaggle morbidity is outbreak of epidemic, and morbidity suddenly, is propagated rapidly, has infectiousness and the mortality rate of height.Feeding and management level is low, and brooding temperature is low, E She ground humidity, and hygienic conditions are poor, and a goose age in days is little, and its sickness rate is higher.In feedstuff, protein content is too low, lacks multivitamin and trace element, and generation and the death of primary disease all can be brought out and aggravate to the existence of intercurrent disease etc.Ill gaggle, if having mixed infection or secondary infection, its M & M is apparently higher than the Simple infection of primary disease.In recent years, the ill gaggle morbidity age in days that finds that there is indivedual geese field at the latest continue to 33 day age, but mortality rate is extremely low.Geese more than 40 ages in days only, has no generation primary disease.

Clinical symptom: primary disease incubation period is 3-5 days, upsets as main manifestations taking digestive system and central nervous system, and morbidity goose generally occurs that dysentery, mouth tell the symptom such as mucus, feed intake minimizing, and the situation of neck, tic appears turning in indivedual geese.More there is not nervous symptoms in age in days, morbidity goose shows as dysentery, feed intake reduces.

According to the length difference of the course of disease, can be faced and examine type and be divided into three kinds, acute, acute and subacute type.The multiple young goose that is born in 3-10 age in days of acute, normally loseing has any prodrome, septicemia occurs and sudden death, or present weakly there are after dull mind a few hours, and fall down to the ground and draw a lower limb, struggle several lower just dead, patient's condition is propagated rapidly, and in a few days, can propagate can group.The multiple young goose that is born in 15 age in days left and right of acute, ill young goose performance spirit is depressed, loss of appetite or absolutely useless, disorderly, head and neck shrinks feather pine, closes one's eyes slow-witted vertical, peels off and stays alone, and is reluctant to walk about, slow in action; Search for food though can do as everybody else does, the grass of adopting is not swallowed, with adopting with losing; Serosity nose liquid is flowed out in sick young goose nostril, stains around nostril, and sick goose shakes the head again and again; And then amount of drinking water increases, engender and have loose bowels, the water sample loose stool of ash discharge white or lark, often for Rice & peanut milk sample is muddy and with bubble or there is fibrous fragment, anus around tomentum stains; Beak end and web are subduing (cyanosis); There are indivedual ill young geese before to occur on one's deathbed the nervous symptoms such as cervical region torsion or tic, paralysis.According to clinical findings, most of young geese betide acute, and the course of disease is generally 2-3 days, increase with ill young goose age in days, and the course of disease gradually transfers subacute type to.The subacute type of type betides popular latter stage or young geese more than 20 ages in days conventionally, and its symptom is slight, mainly, to be slow in action, to walk about and waves, and has loose bowels, and feed intake reduces, and the mental status is slightly poor is feature.The general 4-7 days of the course of disease, or have longlyer, have the sick goose of only a few can spontaneous recovery, but young goose material feeding be undesired, growth promoter is subject to serious obstruction, becomes " stiff goose ".

Pathological change: acute case, rarely seen Duodenal Mucosa swelling hyperemia while cuing open inspection, sometimes hemorrhage as seen, be coated with in the above a large amount of faint yellow mucus; Liver enlargement hyperemia is hemorrhage, and matter is crisp frangible; Gallbladder swells, is full of bile, and the pathological changes of other organs is not obvious.

Acute case, the visible liver enlargement of when dissected, congested hemorrhage, matter is crisp; Gallbladder swells, and is full of dark green lust juice; Spleen enlargement, is kermesinus; Kidney is enlargement a little, is kermesinus, and matter is crisp frangible.Intestinal has obvious characteristic pathological change; The case that the course of disease is slightly grown, the stage casing of small intestinal and back segment, especially at the intestinal segment of yolk suspensor and ileocecus, outward appearance is expanded, intestinal mucosa hyperemia is hemorrhage, inflammation necrosis comes off, solidify with fibrinous exudate the embolus that forms (2-5 centimetre) different in size, volume increases, shape is as sausage shape, and it is solid that hands touches sausage shape place quality, cuts off visible intestinal wall attenuation after intestinal, in enteric cavity, be full of canescence or flaxen embolus shape thing (being commonly called as above the variation into sausage excrement, is gosling plague's a characteristic pathological change).Also have the sick goose small intestinal of part posterior segment to have no obviously and expand, but it is hemorrhage to see intestinal mucosa hyperemia, has a large amount of fiber disposition grumeleuse and fragment in enteric cavity, does not form solid embolus.

At present, treatment gosling plague is mainly injection goose plague vaccine and antibiotic, as gosling plague's serum, penicillin, streptomycin etc.Therapeutic scheme, medicine are all limited, do not reach desirable therapeutic effect, and treatment cost are higher.But the Chinese medicine gosling plague initial stage not only has the effects such as the antiviral of western modern medicine, also has invigorating the spleen and benefiting QI, the effect of removing toxic substances antidiarrheal, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill goose, selected natural Chinese medicines material, make drug effect directly arrive focus, the course for the treatment of is shorter, and curative effect is better, and prolonged application has no drug resistance, drug residue free, cost price is cheap, not only can effectively control the state of an illness, after edible this type of Carnis Anseris domestica of consumer, also can play to body the advantages such as certain health-care effect.

Summary of the invention

Technical problem to be solved by this invention is the pharmaceutical composition that is to provide a kind of gosling plague of being used for the treatment of, can overcome the various defects of Chinese medicine of the prior art and Western medicine, there is the effect of invigorating the spleen and benefiting QI, removing toxic substances antidiarrheal, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill goose, the course for the treatment of is shorter, curative effect is better, prolonged application has no drug resistance, drug residue free, cost price is cheap, not only can effectively control the state of an illness, after edible this type of Carnis Anseris domestica of consumer, also can play to body the advantages such as certain health-care effect.

In order to realize foregoing invention object, the invention provides a kind of gosling plague's of being used for the treatment of pharmaceutical composition, described pharmaceutical composition comprises following raw medicinal material: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Ganoderma, Semen Raphani, fevervine, Fructus elaeagni glabrae, Semen Euryales, Radix Puerariae, Herb Gynostemmae Pentaphylli, Radix Rhodiolae, Fructus Jujubae, Rhizoma Imperatae, the Radix Aucklandiae, Herba Agrimoniae, Folium Callicarpae Formosanae, Loropetalum chinense (R. Br.) Oliv., Radix Scutellariae, Cortex Fraxini, Herba Sophorae alopecuroidis, Fructus Amomi, Fructus Amomi Rotundus, Fructus Tsaoko, Radix et Rhizoma Thalictri, Fructus Mume, Galla Chinensis, Herba Euphorbiae Humifusae and Pericarpium Granati.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Astragali 15-25 weight portion, Rhizoma Atractylodis Macrocephalae 10-15 weight portion, Ganoderma 15-25 weight portion, Semen Raphani 12-20 weight portion, fevervine 12-22 weight portion, Fructus elaeagni glabrae 10-18 weight portion, Semen Euryales 15-28 weight portion, Radix Puerariae 12-18 weight portion, Herb Gynostemmae Pentaphylli 9-18 weight portion, Radix Rhodiolae 10-17 weight portion, Fructus Jujubae 14-25 weight portion, Rhizoma Imperatae 12-21 weight portion, Radix Aucklandiae 10-19 weight portion, Herba Agrimoniae 12-19 weight portion, Folium Callicarpae Formosanae 10-18 weight portion, Loropetalum chinense (R. Br.) Oliv. 10-15 weight portion, Radix Scutellariae 15-25 weight portion, Cortex Fraxini 10-18 weight portion, Herba Sophorae alopecuroidis 8-15 weight portion, Fructus Amomi 10-14 weight portion, Fructus Amomi Rotundus 12-19 weight portion, Fructus Tsaoko 8-15 weight portion, Radix et Rhizoma Thalictri 9-15 weight portion, Fructus Mume 12-20 weight portion, Galla Chinensis 12-19 weight portion, Herba Euphorbiae Humifusae 12-19 weight portion and Pericarpium Granati 10-18 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Astragali 18 weight portions, the Rhizoma Atractylodis Macrocephalae 13 weight portions, Ganoderma 21 weight portions, Semen Raphani 16 weight portions, fevervine 17 weight portions, Fructus elaeagni glabrae 14 weight portions, Semen Euryales 21 weight portions, Radix Puerariae 15 weight portions, Herb Gynostemmae Pentaphylli 14 weight portions, Radix Rhodiolae 13 weight portions, Fructus Jujubae 18 weight portions, Rhizoma Imperatae 17 weight portions, the Radix Aucklandiae 15 weight portions, Herba Agrimoniae 15 weight portions, Folium Callicarpae Formosanae 14 weight portions, Loropetalum chinense (R. Br.) Oliv. 12 weight portions, Radix Scutellariae 21 weight portions, Cortex Fraxini 14 weight portions, Herba Sophorae alopecuroidis 11 weight portions, Fructus Amomi 12 weight portions, Fructus Amomi Rotundus 16 weight portions, Fructus Tsaoko 11 weight portions, Radix et Rhizoma Thalictri 12 weight portions, Fructus Mume 16 weight portions, Galla Chinensis 16 weight portions, Herba Euphorbiae Humifusae 16 weight portions and Pericarpium Granati 14 weight portions.

Described pharmaceutical composition also comprises Mustela eversmanni lesson., Calculus Bovis, Lumbricus, Zibethum and Nidus Vespae.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Astragali 15-25 weight portion, Rhizoma Atractylodis Macrocephalae 10-15 weight portion, Ganoderma 15-25 weight portion, Semen Raphani 12-20 weight portion, fevervine 12-22 weight portion, Fructus elaeagni glabrae 10-18 weight portion, Semen Euryales 15-28 weight portion, Radix Puerariae 12-18 weight portion, Herb Gynostemmae Pentaphylli 9-18 weight portion, Radix Rhodiolae 10-17 weight portion, Fructus Jujubae 14-25 weight portion, Rhizoma Imperatae 12-21 weight portion, Radix Aucklandiae 10-19 weight portion, Herba Agrimoniae 12-19 weight portion, Folium Callicarpae Formosanae 10-18 weight portion, Loropetalum chinense (R. Br.) Oliv. 10-15 weight portion, Radix Scutellariae 15-25 weight portion, Cortex Fraxini 10-18 weight portion, Herba Sophorae alopecuroidis 8-15 weight portion, Fructus Amomi 10-14 weight portion, Fructus Amomi Rotundus 12-19 weight portion, Fructus Tsaoko 8-15 weight portion, Radix et Rhizoma Thalictri 9-15 weight portion, Fructus Mume 12-20 weight portion, Galla Chinensis 12-19 weight portion, Herba Euphorbiae Humifusae 12-19 weight portion, Pericarpium Granati 10-18 weight portion, Mustela eversmanni lesson. 8-15 weight portion, Calculus Bovis 12-18 weight portion, Lumbricus 3-8 weight portion, Zibethum 8-15 weight portion and Nidus Vespae 8-15 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Astragali 18 weight portions, the Rhizoma Atractylodis Macrocephalae 13 weight portions, Ganoderma 22 weight portions, Semen Raphani 16 weight portions, fevervine 17 weight portions, Fructus elaeagni glabrae 14 weight portions, Semen Euryales 21 weight portions, Radix Puerariae 15 weight portions, Herb Gynostemmae Pentaphylli 14 weight portions, Radix Rhodiolae 13 weight portions, Fructus Jujubae 19 weight portions, Rhizoma Imperatae 16 weight portions, the Radix Aucklandiae 13 weight portions, Herba Agrimoniae 16 weight portions, Folium Callicarpae Formosanae 14 weight portions, Loropetalum chinense (R. Br.) Oliv. 12 weight portions, Radix Scutellariae 19 weight portions, Cortex Fraxini 14 weight portions, Herba Sophorae alopecuroidis 11 weight portions, Fructus Amomi 11 weight portions, Fructus Amomi Rotundus 16 weight portions, Fructus Tsaoko 11 weight portions, Radix et Rhizoma Thalictri 11 weight portions, Fructus Mume 16 weight portions, Galla Chinensis 15 weight portions, Herba Euphorbiae Humifusae 15 weight portions, Pericarpium Granati 14 weight portions, Mustela eversmanni lesson. 10 weight portions, Calculus Bovis 16 weight portions, Lumbricus 5 weight portions, Zibethum 12 weight portions and Nidus Vespae 11 weight portions.

In order better to realize foregoing invention object, the invention provides the preparation method of a kind of gosling plague's of being used for the treatment of pharmaceutical composition, in the time that the dosage form of pharmaceutical composition is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1～10 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 3～5 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 85%～95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill to 24～36 hours under the condition of 5 DEG C～10 DEG C, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, concentrate and be dried, and put into super micron mill at this and pulverize 40～60 minutes, the micron particles of acquisition 0.1～10 μ m volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1g～1.5g needle-use activated carbon, fully stirs 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

In the time that the dosage form of pharmaceutical composition is powder, its preparation method comprises the following steps:

The first step, Ganoderma, Semen Raphani, Herba Agrimoniae, Folium Callicarpae Formosanae, Galla Chinensis and Pericarpium Granati are mixed in described ratio, the dissolve with ethanol that to use with respect to the determining alcohol of 3～5 times of mixture quality obtaining be 85%～95%, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Sophorae alopecuroidis and Fructus Amomi Rotundus are mixed in described ratio, add the ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining, heating and refluxing extraction 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 60 DEG C～70 DEG C, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and is screened into subsequently 80～120 object fine powders, and the fine powder of acquisition is dropped in mixing and blending machine and stirred, and obtains powder.

The invention has the beneficial effects as follows: pharmaceutical composition of the present invention is with invigorating the spleen and benefiting QI, removing toxic substances antidiarrheal master, taking suppressing liver-wind to relieve spasm as auxiliary, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill goose, the course for the treatment of is shorter, curative effect is better, have no drug resistance, drug residue free, cost price is cheap, not only can effectively control the state of an illness, after edible this type of Carnis Anseris domestica of consumer, also can play to body the advantages such as certain health-care effect.

Detailed description of the invention

Pharmaceutical composition of the present invention is followed the ultimate principle of " strengthening vital QI to eliminate pathogenic factors ", follow the principle of invigorating the spleen and benefiting QI, removing toxic substances antidiarrheal, provide one to be used for the treatment of gosling plague's pharmaceutical composition, comprised following raw medicinal material: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Ganoderma, Semen Raphani, fevervine, Fructus elaeagni glabrae, Semen Euryales, Radix Puerariae, Herb Gynostemmae Pentaphylli, Radix Rhodiolae, Fructus Jujubae, Rhizoma Imperatae, the Radix Aucklandiae, Herba Agrimoniae, Folium Callicarpae Formosanae, Loropetalum chinense (R. Br.) Oliv., Radix Scutellariae, Cortex Fraxini, Herba Sophorae alopecuroidis, Fructus Amomi, Fructus Amomi Rotundus, Fructus Tsaoko, Radix et Rhizoma Thalictri, Fructus Mume, Galla Chinensis, Herba Euphorbiae Humifusae and Pericarpium Granati; Preferably, can also comprise Mustela eversmanni lesson., Calculus Bovis, Lumbricus, Zibethum and Nidus Vespae.Wherein, Semen Raphani, fevervine, Radix Aucklandiae strengthening the spleen to promote digestion; The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Ganoderma, Semen Euryales, Herb Gynostemmae Pentaphylli, Fructus Jujubae, Radix Rhodiolae, Herba Euphorbiae Humifusae removing toxic substances, invigorating the spleen and benefiting QI; Rhizoma Imperatae, Herba Agrimoniae, Folium Callicarpae Formosanae, Loropetalum chinense (R. Br.) Oliv. removing toxic substances hemostasis; Radix Scutellariae, Cortex Fraxini, Herba Sophorae alopecuroidis, Fructus Amomi, Fructus Amomi Rotundus, Fructus Tsaoko, Radix et Rhizoma Thalictri, Fructus elaeagni glabrae, Radix Puerariae heat clearing and damp drying, removing toxic substances antidiarrheal; Fructus Mume, Galla Chinensis, Pericarpium Granati relieving diarrhea with astringents; Mustela eversmanni lesson., Calculus Bovis, Lumbricus, Zibethum and Nidus Vespae have the effect of suppressing liver-wind to relieve spasm.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Essentials of Matea Medica: " lossless can sending out, has antiperspirant to stop for the Radix Astragali, life consolidating superficial resistance; Process with invigorating middle warmer beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." " herbal justice ": " and the Radix Astragali, soil in tonification, replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and sagging person is the most suitable for clearing heat in QI system.The through people's of its skin skin table muscle, solid protection is defended sun, enriches table point, is its speciality, thus all diseases of exterior deficiency, the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali strengthens heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, protect the liver and fall hypoglycemic effect, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had to inhibitory action.The Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis.

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, there is spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cures mainly the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, QI failing to transform into body fluid, phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, and gastrointestinal function is had to regulating action.There is obvious and lasting diuresis, various animals are had to effect as rat, rabbit, Canis familiaris L..To not anaesthetizing Canis familiaris L. intravenous injection decoct 0.05-0.25g/kg, the increase of urine amount can reach more than 9 times, and medication after 5 hours still higher than normally.The Rhizoma Atractylodis Macrocephalae has obvious inhibitory action to platelet aggregation, Rhizoma Atractylodis Macrocephalae decoct 0.5g/kg gavage l-4 week, the time of energy significant prolongation rat prothrombing.The Rhizoma Atractylodis Macrocephalae has vasorelaxation action.Heart is to inhibitory action, when dosage is excessive, can causes and stop winning, anesthetized dog intravenous injection decoct 0.1g/kg, when blood pressure slightly declines 0.25g/kg, blood pressure sharply declines, and in 3-4 hour, has no recovery.

Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.

Semen Raphani: property is flat, acrid in the mouth, sweet; Return lung, spleen, stomach warp.The de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm.Cure mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen, belch, heavy after dysentery, cough with copious phlegm, dyspnea with rapid and short breath fullness in the chest.Stop up and breath with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant.Enter spleen, stomach, lung meridian, the de-swelling that can help digestion, effect is remarkable, has the title of " rush wall fall wall ".Clinical habit is used for the treatment of, and real (food, wet, stagnant) demonstrate,proved.But these product are not only the de-swellings that helps digestion, and deficiency syndrome, with it, are obtained to effect also good, because of its property peace, its abnormal smells from the patient is not high again, and what without the fraud of victory partially, can not be limited to " rush wall fall wall " says there is the suspicion (being having a surplus of flat gas actually) of dispelling the stagnated QI, and gives it up.Semen Raphani water extract has significant inhibitory action to staphylococcus and escherichia coli etc., and water extract has obvious hypotensive effect, for anesthetized rabbit, cat and dog, all can cause that animal blood pressure declines when intravenous injection.

Fevervine: property is flat, sweet in the mouth, micro-hardship." the SHENGCAO property of medicine is standby to be wanted ": " its head is controlled new internal injury, and pot is carnivorous, and tonify deficiency kidney tonifying, except fire is enriched blood; Wash skin ulcer pain relieving, the loose poison of the heat that disappears.Its leaf is beaten rice with confectionery, dysentery relieving." " Zhiwu Mingshi Tukao ": " be wash, removing toxic substances, removes wind, heat clearing away, cold expelling.Apply innominate toxic swelling, and mend muscles and bones." expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.Fevervine total alkaloids lumbar injection can suppress mice voluntary activity, extends pentobarbital sodium length of one's sleep, has certain sedation.Fevervine total alkaloids can suppress myenteron and shrink, and can antagonism myenteron contracture due to acetylcholine.Fevervine decoct has inhibitory action to external staphylococcus aureus and Fu Shigella flexneri, and extractum also has bacteriostasis to staphylococcus aureus and streptococcus pneumoniae.

Fructus elaeagni glabrae: acid; Flat.Return large intestine channel.Function cures mainly: astringing to arrest diarrhea; Dysentery relieving.Main intestinal inflammation; Diarrhoea; Dysentery.

Semen Euryales: sweet in the mouth, puckery, property is flat.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, insufficiency of the spleen nebulousurine, is with inferior card.

Radix Puerariae: sweet, pungent, cool.Return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, and rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.

Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature; Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.After small number of patients is taken medicine, there is the symptoms such as nausea and vomiting, abdominal distention diarrhoea (or constipation), dizziness, dim eyesight, tinnitus.Take after Herb Gynostemmae Pentaphylli, enterogastric peristalsis is accelerated, and it is long that appetite increases the resistance to time of hungering and thirst, and not only treats constipation but also control loose stool.Reaction excited to cerebral cortex and that suppress can keep suitable balance, and nervus centralis is had to dual regulation.There is good analgesia, sleep peacefully, antitonic effect.Reducing myocardial wall anxiety, relaxing on the basis of cerebrovascular and peripheral vascular resistance, can strengthen heart and brain vigor, strengthen coronary flow, relax arteriosclerosis, impel entirety circulation more vigorous and smooth.Experiment showed, not that diet is rich and take Herb Gynostemmae Pentaphylli group, and avoid meat and refuse to obey Herb Gynostemmae Pentaphylli group, make regular check on comparison, body inner bag is solid close with neutral fat content.Herb Gynostemmae Pentaphylli has optimum conversion regulating action to body fat mass in human body as can be seen here.Take the mouse comparison of Herb Gynostemmae Pentaphylli and disobedience, the approximately long 31-57% of its swimming time, and antisecosis is also faster, people takes after Herb Gynostemmae Pentaphylli, and physical energy is more abundant, and even indefatigability be also easy to recover tired, thereby work efficiency increases.Human body part function weakness, can produce allergy to Cucumber, and forms the diseases such as bronchus is panted, skin rashes, arthralgia, and Herb Gynostemmae Pentaphylli is rather good to these sick effects.

Radix Rhodiolae: sweet, hardship, flat; Return lung, heart channel.Radix Rhodiolae is dry root and the rhizome of crassulaceae plants Radix Rhodiolae, and effect of Radix Rhodiolae and effect are can the kidney invigorating, regulate the flow of vital energy and nourish blood, and have promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and effect under leukorrhagia stopping, and the side effect of Radix Rhodiolae is not temporarily found.Radix Rhodiolae can improve sleep, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyreticly bring down a fever, nourish the effects such as vigour; Be used for the treatment of traumatic injury and burn and scald outward.Research points out that Oxidation, in a lot of advancing of disease processes, playing the part of very important role, such as cancer, cardiovascular diseases, diabetes, nerve degeneration and rheumatoid arthritis etc.In traditional medicine, Radix Rhodiolae is also for treating diabetes.Relevant experiment utilizes mouse to make object, and test Radix Rhodiolae is to controlling glycemic index, ferment and some antioxidative activities of type-II diabetes.

Fructus Jujubae: there is immunosuppressive action, the ethanol extract of Fructus Jujubae with every day 100mg to rat oral gavage, show Fructus Jujubae there is same immunosuppressant with azathioprine; Can suppress the generation of antibody to atopic diseases.Fructus Jujubae ethanol extract may have inhibitory action to rat reactive antibody, and non-reacted antibody is not produced to other effects of inhibitory action: the two glucoside A of flavone in Fructus Jujubae, pharmacological evaluation proves to have calmness, hypnosis and hypotensive effect, Fructus Jujubae to have the effect that increases cAMP in leukocyte.Fructus Jujubae decoct can reduce the damage of CCl4 to Rabbit Liver.Can extend the swimming time of mice.Report Fructus Jujubae has the proliferation function of anticancer recently.

Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, urinary bladder channel." Bencao Tujing ": " Rhizoma Imperatae, the present has it everywhere.Spring sprouts, and cloth ground is as pin, and the thatch pin of calling between custom, also can eat, very beneficial children's.Xia Sheng spends in vain, and fine so to the autumn, and withered, its root is extremely pure white, also very sweet and refreshing, adopts root June and uses." Compendium of Material Medica: " emesis all blood of being defeated in battle, typhoid fever hiccup, lung-heat dyspnea with rapid respiration, edema, jaundice, alcoholic intoxication." have the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis, being mainly used in lung stomach has haematemesis, the hemoptysis of accumulated heat, and damp invasion of lower energizer pents up the hematuria of bladder, calentura excessive thirst taking fluids profusely, gastropyretic vomiting, the cards such as jaundice due to damp-heat.Rhizoma Imperatae decoct and water logging agent gavage, and normal rabbits is had to diuresis, administration 5-10 days, and diuresis is the most obvious.Rhizoma Imperatae decoct has obvious inhibitory action to Fu Shi and sonne bacillus in vitro, but to will Hayes and the effect of easypro Shigella flexneri nothing.Contraction and the metabolism of the contained Coixol of Rhizoma Imperatae to skeletal muscle has inhibitory action.

The Radix Aucklandiae: pungent, bitter, temperature.Return spleen, stomach, large intestine, three warmers, gallbladder meridian.Function cures mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).Stomachache is used for having loose bowels.

Herba Agrimoniae: bitter in the mouth, puckery, property is flat, GUIXIN, Liver Channel, " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control married woman's menstruation or before or after, leucorrhea with red and white discharge, the cold stomachache of face, with the passing of time red white dysentery." " BAICAO mirror ": " therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness; Traumatic injury is spitted blood, metrorrhagia, dysentery, discharging fresh blood stool." astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage cards, for example: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.

Folium Callicarpae Formosanae: pungent, bitter, flat.Return liver, spleen, stomach warp.Dissipating blood stasis hemostasis, reducing swelling and alleviating pain.Leaf: for spitting blood, spitting of blood, epistaxis, has blood in stool; External curing traumatic hemorrhage.Root: treating swelling and pain by traumatic injury, rheumatic ostalgia.Supplement to the Herbal: " separate all poisonous substances, carbuncle, sore throat, poison is swollen, lower flaccidity, Serpentis a poisonous snake mentioned in ancient books is bugbite, mad dog poison, and liquor clothes; Also it is swollen that liquor is washed skin ulcer, the long skin of dehematize." " middle traditional Chinese medicines are planted illustrated handbook ": " and hemorrhage to esophageal vein, intestine gastric ulcer is hemorrhage, epistaxis, and wound hinders, pneumorrhagia and the hemorrhage good effect that all has of having tooth pulled out." Folium Callicarpae Formosanae has the effect of blood coagulation of promotion, intestinal blood vessel there is is direct contraction and indirectly plays anastalsis by the stifled resistance of intestinal tube contracture compressing blood vessel.Folium Callicarpae Formosanae all has inhibitory action in various degree to escherichia coli, shigella flexneri, staphylococcus aureus, Hemolytic streptococcus etc.Folium Callicarpae Formosanae can make bleeding time and clotting time shorten, and its hemostasis principle may be that it makes vasoconstriction and platelet count is increased.

Loropetalum chinense (R. Br.) Oliv.: bitter, puckery, flat.Return liver, stomach, large intestine channel.Astringing to arrest bleeding, heat-clearing and toxic substances removing, antidiarrheal.Root, leaf, flower, fruit are used as medicine, can be antipyretic, hemostasis, dredge the meridian passage; Timber is solid durable; Core and leaf, containing tannin, can be carried mimosa extract.This product is puckery to be restrained, and has good astringing to arrest bleeding effect, can be used for multiple hemorrhagic condition.This product can hemostasia and promoting granulation, again can heat-clearing and toxic substances removing, and the available burn due to hot liquid or fire of controlling.This product bitterness, function astringing to arrest diarrhea, cure mainly have loose bowels, dysentery.The mixture of leaf and cured leaf powder all have anastalsis; Contained flavone can strengthen coronary flow, and has heart tonifying, the effect of expansion peripheral blood vessel; Experiment in vitro shows, this product all has inhibitory action to streptococcus, staphylococcus, typhoid fever and escherichia coli.

Radix Scutellariae: property hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and Radix Bupleuri the best, so can not reach table by cool flesh without Radix Scutellariae.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so gives up Radix Scutellariae and can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with removing toxic substances and promoting granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, agent also first of Ci Gaizhu section half exterior and half interior." can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.That Radix Scutellariae has is antipyretic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppress the effects such as intestinal tube wriggling, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, newcastle, bacillus pyocyaneus are had to certain inhibitory action, upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc. are had to good curative effect.

Cortex Fraxini: bitter in the mouth, cold; Return Liver Channel, gallbladder meridian, large intestine channel." book on Chinese herbal medicine converges and says ": " Cortex Fraxini, bitter in the mouth is puckery and hard, can restrain the vital essence of wandering away.Therefore Zhong Jing Radix Pulsatillae Decoction, controls the inferior burnt deficiency-heat and sharp person with this, get bitter with puckery meaning also." Compendium of Material Medica: “ Ash skin, color clearing heat in QI system is cold, and bitter in the mouth is puckery, is faint cloudy liver, few positive gallbladder meridian medicine also.Therefore control order disease, infantile convulsion, get its flat wood also; Control the inferior dysentery, metrorrhagia and leukorrhagia, get its astringent therapy also; Can control again the few essence of man, beneficial essence has son, all gets that it is puckery and have benefit also." Shennong's Herbal: " heat extraction, blue or green nebula tunica albuginea in order." function heat clearing and damp drying, liver heat removing and eyesight improving, astringent therapy dysentery relieving, leukorrhagia stopping.For pyretic toxicity dysentery, leukorrhagia pudendal pruritus, liver-heat conjunctival congestion and swelling pain, the raw cataracta of order.

Herba Sophorae alopecuroidis: nature and flavor hardship, cold, poisonous.Heat clearing and damp drying, pain relieving, parasite killing.Cure mainly the damp and hot dysentery of letting out, leukorrhagia, ulcer etc.The effects such as the total alkaloid of sophora alopecuroide extracting from herb has antiinflammatory, anticancer, antiallergic action, anti-arrhythmia, antiulcer, leukocyte increasing, relievings asthma, antipyretic, parasite killing, calmness, analgesia, antiviral.The pharmacological action of Alkaloids From Sophora Alopecuroides L: the 1. effect to central nervous system, is embodied in tranquilizing soporific, analgesia and cooling; 2. the effect to cardiovascular system, is embodied in arrhythmia, positive inotropic action, and blood pressure lowering and reduction heart rate function, to the protective effect of myocardial ischemia and infraction, effect for reducing blood fat; 3. antiviral, antiinflammatory and immunosuppressive action, Radix Sophorae Flavescentis total alkaloids can suppress multiple virus breeding. strengthen immunoloregulation function and immunologic enhancement; 4. antitumor action, obvious to hepatoma carcinoma cell inhibitory action, cervical cancer, lymphosarcoma, pulmonary carcinoma are also had to inhibitory action; 5. the effect to smooth muscle, total alkali and some monosomic alkali all can resist the Contraction of The Ileum From A White of being induced by inflammatory mediator, and bronchial smooth muscle is had to relexation, and block mold is also had to effect.

Fructus Amomi: acrid in the mouth, warm in nature; Return spleen channel, stomach warp, kidney channel.Materia Medica of Decoction: " contracting sand for making to enter lung, for making to enter spleen, for making to enter kidney, enters large and small intestinal with red, Kaolin for making with Cortex Phellodendri, Poria with Radix Ginseng, Fructus Alpiniae Oxyphyllae with Symplocoris Paniculatae, Fructus Amomi Rotundus." " Japan hanako materia medica ": " control all gas, cramp caused by acute vomiting and diarrhea, cardiac and abdominal pain." function removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.The pungent loose temperature of these product is logical, abnormal smells from the patient fragrance, and its removing dampness is amusing, and the effect of circulation of qi promoting warming middle-JIAO is all good, and ancients say it: " adjust stomach key medicine for being amusing." therefore all cards of incoordination between the spleen and stomach such as the abdominal distention due to all dampness or the stagnation of QI are conventional, especially cold-damp stagnation of QI person is the most suitable.

Fructus Amomi Rotundus: acrid in the mouth, hardship, warm in nature, enter spleen, stomach, large intestine channel, there is the effect of warming middle-JIAO astringing intestine to stop diarrhea, promote qi circulation digestion promoting, for diarrhea of deficiency type, cold-dysentery, abdominal distention, lack of appetite vomiting, the dyspepsia card such as do not disappear.Methyleugenol in this product volatile oil and elemicine, to mice, rabbit, cat and Canis familiaris L., have anesthetic action after iv administration.Mouse Uterus cancer and cutaneous papilloma that Semen Myristicae brings out MCA and DMBA have inhibitory action.The contained volatile oil of these product has stimulation to gastrointestinal tract, and has the effect of dispeling the wind.Myristicin has hallucinogenic action to normal person, and people's brain is had to moderate excitation.Semen Myristicae and myristicin all can strengthen the effect of tryptamines.

Fructus Tsaoko: acrid in the mouth, warm in nature, nontoxic; Enter spleen channel, stomach warp.Compendium of Material Medica: " Fructus Tsaoko, with the same use of the Rhizoma Anemarrhenae, controls subtertian malaria cold and heat, gets the evil of its monoyin and monoyang without inclined to one side victory, and it is cold that lid Fructus Tsaoko is controlled lunar only victory, and the fire of the only victory of Rhizoma Anemarrhenae Zhi Yangming also." " herbal classic is met former ": " and except cold, dampness, dissipating depression of QI, relieving dyspepsia, expectorant on sharp diaphragm, separates wheaten food, fish, all poison of meat." dampness is except cold, the preventing the attack (or recurrence) of malaria that eliminates the phlegm, relieving dyspepsia helps digestion.Cure mainly malaria, phlegm retention feeling of fullness, coldness and pain in the epigastrium, regurgitation, vomiting, dysentery, food stagnation.Join the Rhizoma Anemarrhenae, there are tune cold and heat, and the merit of the exterior and the interior, kind treating malaria card.

Radix et Rhizoma Thalictri: nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication.Control damp-heat dysentery, jaundice, calentura agitation, cough due to lung-heat, carbuncle pyogenic infections from tumour or sore, conjunctival congestion and swelling pain.Be applied to now enteritis, infectious hepatitis, flu, measles, carbuncle furuncle, conjunctivitis.Fetidine has hypotensive effect, and its crude preparation by using can be controlled hypertension.Magnoflorine, berberine, jateorhizine etc. are referring to Radix Aristolochiae, Rhizoma Coptidis bar.Congener Radix thalictri petaloidei Thalictrumpetaloideum or T.simplex T.simplex are containing thalcimine (Thalsimine), animal is had to antiinflammatory, analgesia, cooling effect. purple meadowrue (Thalictrum dasycarpum) T.Dasycarpum is containing Thalictrum aquilegifolium L. var. sibiricum Regel card product alkali (Thalicarpine), purple meadowrue (Thalictrum dasycarpum) alkali (Thalidasine), thalfetidine, effective to rat watt g cancer 1 and Mice Bearing Lewis Lung Cancer.Thalictrum aquilegifolium L. var. sibiricum Regel card product alkali also has weak hypotensive effect.

Fructus Mume: bitter in the mouth, acid, puckery, warm in nature, enter liver, lung, spleen, large intestine channel, supplement to the Herbal: " remove expectorant, main malaria miasma, quenches the thirst in tune, and except cold and hot dysentery, emesis is contrary." " Japan hanako materia medica ": " and except labor, control hectic fever due to YIN-deficiency, go unhappiness, relieving dysentery with astringents, the alcoholism that disappears, controls hemiplegia skin paralysis, and de-black point, makes us to such an extent that sleep.Enter to build again tea, Rhizoma Zingiberis is ball, only chronic dysentery with frequent relapse." have and astringe the lung, astringing intestine to stop diarrhea, hemostasis, the effect of promoting the production of body fluid, is used for the treatment of chronic dysentery more than, and damp-heat dysentery is had blood in stool, the card such as hematuria, snowslide.Fructus Mume has the function of sterilization, also prevents that food from degenerating in the intestines and stomach.Malic acid in Fructus Mume directs into large intestine appropriate moisture, forms feces and excreting.In the time of blood purification, metabolism just strengthens, and health can recover energy naturally.Citric acid in Fructus Mume helps to absorb vitamin and ferment, and also having can prevent disease and allaying tiredness.

Galla Chinensis: sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, Compendium of Material Medica: " cough-relieving is coughed; quench one's thirst for the pathogenic fire reducing of astringing the lung, the drink that reduces phlegm, night sweat, and vomiting, loses blood, chronic dysentery, jaundice; cardiac and abdominal pain, the nocturnal fretfulness in infants, controls eye red wet rotten, and detumescence poison, sore throat, hold back routed skin ulcer, incised wound, receives under proctoptosis, sub-intestinal pendant." there is the hidroschesis of astringing the lung, astringing intestine to stop diarrhea controlling nocturnal emission with astringent drugs, effect of hemostasis removing toxic substances, cures mainly the card such as chronic cough of deficiency lung, spontaneous sweating, chronic dysentery chronic diarrhea, proctoptosis, seminal emission, nebulousurine, various hemorrhage, carbuncle furuncle.Because wherein contained tannic acid has Galla Chinensis precipitation to protein, after skin, mucosa, ulcer contact tannic acid, its tissue protein is solidified, and causes one deck tunicle and is astriction, simultaneously also oppressed contraction of little blood vessel, blood clotting and play hemostasia effect.In vitro tests all has significantly antibacterial or bactericidal action to staphylococcus aureus, streptococcus, streptococcus pneumoniae and typhoid fever, paratyphoid fever, dysentery, anthrax, diphtheria, bacillus pyocyaneus etc.Tannic acid can form insoluble complex with a lot of heavy metal ion, alkaloid and glycoside, therefore can be used as chemical antidote.

Herba Euphorbiae Humifusae: pungent, flat.Return liver, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis.For dysentery, have loose bowels, hemoptysis, hematuria, has blood in stool, metrorrhagia, furuncle carbuncle.

Pericarpium Granati: sour in the mouth is puckery, warm in nature; Enter large intestine, kidney channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control with the passing of time watery diarrhea, simmer clothes with frying Saccharum Sinensis Roxb., control again dysentery pus and blood, large intestine hematochezia.Decoct and control children's's infantile malnutrition worm with Fructus Aristolochiae.And wash bladder." " detailed outline ": " antidiarrheal dysentery, hematochezia, proctoptosis, metrorrhagia leukorrhagia." there is relieving diarrhea with astringents, effect of hemostasis parasite killing, for chronic diarrhea chronic dysentery, discharging fresh blood stool, bleeding not during menses, the cards such as abdominal pain due to worm stagnation, Pericarpium Granati has stronger inhibitory action to escherichia coli.Pericarpium Granati after they contact with mucosa, wound surface etc., can precipitate or solidify local protein containing mixing matter containing many, makes to form comparatively fine and close protective layer on surface, contributes to local woanded surface healing or protection part to avoid stimulating.The matter of mixing is the effective ingredient of the anti-genitals herpus vivus of Pericarpium Granati, and its feature not only can suppress virus in intracellular propagation, and what is more important shows stronger direct kill virus and the effect of prevention and adherent cell.

Mustela eversmanni lesson.: sweet in the mouth; Warm in nature.GUIXIN; Liver Channel.Function cures mainly: dispel the wind; Spasmolytic; Promoting blood circulation to remove obstruction in the collateral.Main epilepsy; Paralysis; Hemiplegia.

Calculus Bovis: sweet, cool.GUIXIN, Liver Channel.Function cures mainly: clear away heart-fire, eliminating phlegm, has one's ideas straightened out, cool liver, endogenous wind stopping, removing toxic substances.For calentura coma, middle wind-phlegm fan, infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.

Lumbricus: salty, cold.Enter liver, spleen, lung meridian.Enter liver, spleen, lung three warps.Function cures mainly: heat clearing away, suppressing the hyperactive liver, Zhichuan, dredging collateral.Control height fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula.Mumps, skin infection.

Zibethum: pungent, temperature.Function cures mainly: spasmolytic, analgesia, calms the nerves.Cure mainly colic, stomachache, hysteropathy punching contrary (wiping umbilical part with fragrant liquid effective).And the circulation of qi promoting of can having one's ideas straightened out, the meridian dredging, flesh bone thoroughly, subduing inflammation.

Nidus Vespae: sweet, flat.Return stomach warp.Function cures mainly: dispels the wind, and merit poison, parasite killing, pain relieving.For toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 pharmaceutical composition 1

The embodiment of the present invention provides a kind of gosling plague's of being used for the treatment of pharmaceutical composition, raw medicinal material by following parts by weight is made: the Radix Astragali 18 weight portions, the Rhizoma Atractylodis Macrocephalae 13 weight portions, Ganoderma 21 weight portions, Semen Raphani 16 weight portions, fevervine 17 weight portions, Fructus elaeagni glabrae 14 weight portions, Semen Euryales 21 weight portions, Radix Puerariae 15 weight portions, Herb Gynostemmae Pentaphylli 14 weight portions, Radix Rhodiolae 13 weight portions, Fructus Jujubae 18 weight portions, Rhizoma Imperatae 17 weight portions, the Radix Aucklandiae 15 weight portions, Herba Agrimoniae 15 weight portions, Folium Callicarpae Formosanae 14 weight portions, Loropetalum chinense (R. Br.) Oliv. 12 weight portions, Radix Scutellariae 21 weight portions, Cortex Fraxini 14 weight portions, Herba Sophorae alopecuroidis 11 weight portions, Fructus Amomi 12 weight portions, Fructus Amomi Rotundus 16 weight portions, Fructus Tsaoko 11 weight portions, Radix et Rhizoma Thalictri 12 weight portions, Fructus Mume 16 weight portions, Galla Chinensis 16 weight portions, Herba Euphorbiae Humifusae 16 weight portions and Pericarpium Granati 14 weight portions.

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 4 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill to 30 hours under the condition of 9 DEG C, adopt the speed slowly percolation of percolation with 2ml per minute, collect percolate, concentrate and be dried, and put into super micron mill at this and pulverize 50 minutes, obtain the mixed powder that the micron particles of 4 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets the mixed powder 15g that second step obtains, and adds propylene glycol 40g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μ m filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 2 pharmaceutical compositions 2

The embodiment of the present invention provides a kind of gosling plague's of being used for the treatment of pharmaceutical composition, raw medicinal material by following parts by weight is made: the Radix Astragali 18 weight portions, the Rhizoma Atractylodis Macrocephalae 13 weight portions, Ganoderma 22 weight portions, Semen Raphani 16 weight portions, fevervine 17 weight portions, Fructus elaeagni glabrae 14 weight portions, Semen Euryales 21 weight portions, Radix Puerariae 15 weight portions, Herb Gynostemmae Pentaphylli 14 weight portions, Radix Rhodiolae 13 weight portions, Fructus Jujubae 19 weight portions, Rhizoma Imperatae 16 weight portions, the Radix Aucklandiae 13 weight portions, Herba Agrimoniae 16 weight portions, Folium Callicarpae Formosanae 14 weight portions, Loropetalum chinense (R. Br.) Oliv. 12 weight portions, Radix Scutellariae 19 weight portions, Cortex Fraxini 14 weight portions, Herba Sophorae alopecuroidis 11 weight portions, Fructus Amomi 11 weight portions, Fructus Amomi Rotundus 16 weight portions, Fructus Tsaoko 11 weight portions, Radix et Rhizoma Thalictri 11 weight portions, Fructus Mume 16 weight portions, Galla Chinensis 15 weight portions, Herba Euphorbiae Humifusae 15 weight portions, Pericarpium Granati 14 weight portions, Mustela eversmanni lesson. 10 weight portions, Calculus Bovis 16 weight portions, Lumbricus 5 weight portions, Zibethum 12 weight portions and Nidus Vespae 11 weight portions.

Its preparation method is as follows:

The first step, mixes Ganoderma, Semen Raphani, Herba Agrimoniae, Folium Callicarpae Formosanae, Galla Chinensis and Pericarpium Granati in described ratio, the dissolve with ethanol that to use with respect to the determining alcohol of 4 times of mixture quality obtaining be 90%, and reflux was extracted after 3 hours, and filtration, obtains the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 90% of 2 times of the mixture quality obtaining again, and reflux was extracted after 2 hours, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Sophorae alopecuroidis and Fructus Amomi Rotundus are mixed in described ratio, add the ethanol with respect to the determining alcohol 90% of 3 times of the mixture quality obtaining, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 65 DEG C, relative density is 1.22, the mastic after concentrated is dried to powder with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 3 hours, filters; Filtering residue is used to the water dissolution of 1.5 times with respect to the mixture quality obtaining again, and heating decocts 1.5 hours again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and is screened into subsequently 100 object fine powders, and the fine powder of acquisition is dropped in mixing and blending machine and stirred, and obtains powder.

The toxicity test of pharmaceutical composition:

1, trial drug

Choose Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 13g, Ganoderma 21g, Semen Raphani 16g, fevervine 17g, Fructus elaeagni glabrae 14g, Semen Euryales 21g, Radix Puerariae 15g, Herb Gynostemmae Pentaphylli 14g, Radix Rhodiolae 13g, Fructus Jujubae 18g, Rhizoma Imperatae 17g, Radix Aucklandiae 15g, Herba Agrimoniae 15g, Folium Callicarpae Formosanae 14g, Loropetalum chinense (R. Br.) Oliv. 12g, Radix Scutellariae 21g, Cortex Fraxini 14g, Herba Sophorae alopecuroidis 11g, Fructus Amomi 12g, Fructus Amomi Rotundus 16g, Fructus Tsaoko 11g, Radix et Rhizoma Thalictri 12g, Fructus Mume 16g, Galla Chinensis 16g, Herba Euphorbiae Humifusae 16g and Pericarpium Granati 14g and mix, be ground into powder; Acquisition powder is added in 1400g cold water and soaked 25 hours, and with slow fire boiling, decocting time is 1.5 hours, and decoction liquor is filtered, and obtains the first filtrate, collects filtering residue; Again add in 1400g cold water filtering the filtering residue obtaining, with slow fire boiling 3 times, decoct 1 hour at every turn, filter and merge filtrate, obtain the second filtrate; Merge filtrate twice, concentrating under reduced pressure remove portion water, obtains decoction, and the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal for 2 weeks.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and matched group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range, between group without significant difference; Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.

Contrast test

Liaocheng of Shandong Province Mou E plant, in by the end of December, 2012, finds that inappetence, down in spirits, the random phenomenon of feather pine in various degree appears in 450 young geese nearly, flow out serosity nose liquid with nostril, draw lark loose stool, even occur dead young goose, young death goose is dissected to visible liver enlargement, be kermesinus, matter is crisp frangible, at the little intestinal segment of yolk suspensor and ileocecus, outward appearance is expanded, intestinal mucosa hyperemia, inflammation necrosis comes off, and solidifies the embolus into about 3cm with fibrinous exudate.Be diagnosed as gosling plague according to above-mentioned epidemiology with analysing.

Choose 180 of the ill young geese of making a definite diagnosis 2 week age, 180 ill geese are divided into three groups at random, be respectively embodiment group 1, embodiment group 2 and matched group, the ill goose of three groups all without significant difference, has comparability at the aspect such as body weight, the state of an illness.Embodiment group 1, embodiment group 2 and matched group use respectively the injectable powder of the embodiment of the present invention 1, powder and the conventional medicament of embodiment 2 to treat; Wherein, injectable powder adopts subcutaneous injection, and each 2g, once a day, injects 7 days continuously; The using method of powder be by powder according in the part by weight conventional feed of 3:100, feed continuously 7 days; Conventional medicament is 0.2 milliliter of subcutaneous injection hyper-immune serum, the conventional feed of feeding.Be 7 days experimental period, before and after experiment, takes respectively each group of ill goose body weight, records during this time recovery from illness situation and the death toll of ill goose, calculates average daily gain and cure rate, and result as shown in Table 1 and Table 2.Wherein, cure: spirit is normal, the drinking-water of searching for food is normal, and feces is normal, bouncing, and it is normal that the histoorgans such as inspection liver, intestinal, fabricius bursa, pancreas are cutd open in sampling; Invalid: clinical symptoms is not improved and even increased the weight of or death.

The young goose average weight of table 1 liang experimental group synopsis

Data from table 1: compared with matched group, use the ill goose of Drug therapy of the present invention, during to 3 week age of young goose, its average weight exceeds respectively 60.2g and 90g than the young goose of traditional therapy treatment, and average daily gain exceeds respectively 8.6g/d and 12.88g/d.

The therapeutic effect synopsis of the young goose of table 2 liang experimental group

Data from table 2: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 has advantage evident in efficacy, cheap, that have no side effect aspect treatment gosling plague.

Known by contrast test: compared with conventional medicament, the pharmaceutical composition of the embodiment of the present invention 1 and 2 has toxic and side effects advantage little, evident in efficacy aspect treatment gosling plague, but also can be good at ensureing the normal growth of young goose.

Model case:

The young goose of 300 14 ages in days of in January, 2014 Taian Shandong Mou Yang goose specialist raising, nearly 100 young geese there is down in spirits, be slow in action, the symptom such as loss of appetite, defecation yellow green loose stool, select a wherein seriously ill young goose to dissect, find to be full of linen embolus shape thing in small intestinal.Get the pathological material of diseases such as the heart, liver, spleen of ill young goose and shred grinding, do to be diluted to suspension at 1: 5 with sterile saline, after adding penicillin and streptomycin to process, be inoculated in the goose embryo fine hair allantoic cavity of 14 ages in days every goose embryonic breeding kind 0.5ml, after 3-5 days, the death of goose embryo, cuts open the dead goose embryo of inspection, finds goose idiosome villous allantoic cavity edema, whole skin hyperemia, hemorrhage and edema, be diagnosed as acute gosling plague.Immediately the young goose that does not occur symptom is isolated and raise place.Choose 50 ill young geese wherein, start to feed and be added with the feedstuff of the embodiment of the present invention 2 powders, powder is sneaked in conventional feed according to 3:100 weight ratio, feed 7 days, within the 2nd day, ill young goose symptom is obviously improved, and within the 3rd day, 50 young geese are all fully recovered, and continue to feed after 4 days, compared with the young goose of health, average weight is basic identical.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (10)

1. be used for the treatment of gosling plague's pharmaceutical composition, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Ganoderma, Semen Raphani, fevervine, Fructus elaeagni glabrae, Semen Euryales, Radix Puerariae, Herb Gynostemmae Pentaphylli, Radix Rhodiolae, Fructus Jujubae, Rhizoma Imperatae, the Radix Aucklandiae, Herba Agrimoniae, Folium Callicarpae Formosanae, Loropetalum chinense (R. Br.) Oliv., Radix Scutellariae, Cortex Fraxini, Herba Sophorae alopecuroidis, Fructus Amomi, Fructus Amomi Rotundus, Fructus Tsaoko, Radix et Rhizoma Thalictri, Fructus Mume, Galla Chinensis, Herba Euphorbiae Humifusae and Pericarpium Granati.

2. the pharmaceutical composition that is used for the treatment of gosling plague according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Astragali 15-25 weight portion, Rhizoma Atractylodis Macrocephalae 10-15 weight portion, Ganoderma 15-25 weight portion, Semen Raphani 12-20 weight portion, fevervine 12-22 weight portion, Fructus elaeagni glabrae 10-18 weight portion, Semen Euryales 15-28 weight portion, Radix Puerariae 12-18 weight portion, Herb Gynostemmae Pentaphylli 9-18 weight portion, Radix Rhodiolae 10-17 weight portion, Fructus Jujubae 14-25 weight portion, Rhizoma Imperatae 12-21 weight portion, Radix Aucklandiae 10-19 weight portion, Herba Agrimoniae 12-19 weight portion, Folium Callicarpae Formosanae 10-18 weight portion, Loropetalum chinense (R. Br.) Oliv. 10-15 weight portion, Radix Scutellariae 15-25 weight portion, Cortex Fraxini 10-18 weight portion, Herba Sophorae alopecuroidis 8-15 weight portion, Fructus Amomi 10-14 weight portion, Fructus Amomi Rotundus 12-19 weight portion, Fructus Tsaoko 8-15 weight portion, Radix et Rhizoma Thalictri 9-15 weight portion, Fructus Mume 12-20 weight portion, Galla Chinensis 12-19 weight portion, Herba Euphorbiae Humifusae 12-19 weight portion and Pericarpium Granati 10-18 weight portion.

3. the pharmaceutical composition that is used for the treatment of gosling plague according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Astragali 18 weight portions, the Rhizoma Atractylodis Macrocephalae 13 weight portions, Ganoderma 21 weight portions, Semen Raphani 16 weight portions, fevervine 17 weight portions, Fructus elaeagni glabrae 14 weight portions, Semen Euryales 21 weight portions, Radix Puerariae 15 weight portions, Herb Gynostemmae Pentaphylli 14 weight portions, Radix Rhodiolae 13 weight portions, Fructus Jujubae 18 weight portions, Rhizoma Imperatae 17 weight portions, the Radix Aucklandiae 15 weight portions, Herba Agrimoniae 15 weight portions, Folium Callicarpae Formosanae 14 weight portions, Loropetalum chinense (R. Br.) Oliv. 12 weight portions, Radix Scutellariae 21 weight portions, Cortex Fraxini 14 weight portions, Herba Sophorae alopecuroidis 11 weight portions, Fructus Amomi 12 weight portions, Fructus Amomi Rotundus 16 weight portions, Fructus Tsaoko 11 weight portions, Radix et Rhizoma Thalictri 12 weight portions, Fructus Mume 16 weight portions, Galla Chinensis 16 weight portions, Herba Euphorbiae Humifusae 16 weight portions and Pericarpium Granati 14 weight portions.

4. according to the pharmaceutical composition that is used for the treatment of gosling plague described in claim 1-3 any one, it is characterized in that, described pharmaceutical composition also comprises Mustela eversmanni lesson., Calculus Bovis, Lumbricus, Zibethum and Nidus Vespae.

5. according to the pharmaceutical composition that is used for the treatment of gosling plague described in claim 1-4 any one, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Astragali 15-25 weight portion, Rhizoma Atractylodis Macrocephalae 10-15 weight portion, Ganoderma 15-25 weight portion, Semen Raphani 12-20 weight portion, fevervine 12-22 weight portion, Fructus elaeagni glabrae 10-18 weight portion, Semen Euryales 15-28 weight portion, Radix Puerariae 12-18 weight portion, Herb Gynostemmae Pentaphylli 9-18 weight portion, Radix Rhodiolae 10-17 weight portion, Fructus Jujubae 14-25 weight portion, Rhizoma Imperatae 12-21 weight portion, Radix Aucklandiae 10-19 weight portion, Herba Agrimoniae 12-19 weight portion, Folium Callicarpae Formosanae 10-18 weight portion, Loropetalum chinense (R. Br.) Oliv. 10-15 weight portion, Radix Scutellariae 15-25 weight portion, Cortex Fraxini 10-18 weight portion, Herba Sophorae alopecuroidis 8-15 weight portion, Fructus Amomi 10-14 weight portion, Fructus Amomi Rotundus 12-19 weight portion, Fructus Tsaoko 8-15 weight portion, Radix et Rhizoma Thalictri 9-15 weight portion, Fructus Mume 12-20 weight portion, Galla Chinensis 12-19 weight portion, Herba Euphorbiae Humifusae 12-19 weight portion, Pericarpium Granati 10-18 weight portion, Mustela eversmanni lesson. 8-15 weight portion, Calculus Bovis 12-18 weight portion, Lumbricus 3-8 weight portion, Zibethum 8-15 weight portion and Nidus Vespae 8-15 weight portion.

6. according to the pharmaceutical composition that is used for the treatment of gosling plague described in claim 1-5 any one, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Astragali 18 weight portions, the Rhizoma Atractylodis Macrocephalae 13 weight portions, Ganoderma 22 weight portions, Semen Raphani 16 weight portions, fevervine 17 weight portions, Fructus elaeagni glabrae 14 weight portions, Semen Euryales 21 weight portions, Radix Puerariae 15 weight portions, Herb Gynostemmae Pentaphylli 14 weight portions, Radix Rhodiolae 13 weight portions, Fructus Jujubae 19 weight portions, Rhizoma Imperatae 16 weight portions, the Radix Aucklandiae 13 weight portions, Herba Agrimoniae 16 weight portions, Folium Callicarpae Formosanae 14 weight portions, Loropetalum chinense (R. Br.) Oliv. 12 weight portions, Radix Scutellariae 19 weight portions, Cortex Fraxini 14 weight portions, Herba Sophorae alopecuroidis 11 weight portions, Fructus Amomi 11 weight portions, Fructus Amomi Rotundus 16 weight portions, Fructus Tsaoko 11 weight portions, Radix et Rhizoma Thalictri 11 weight portions, Fructus Mume 16 weight portions, Galla Chinensis 15 weight portions, Herba Euphorbiae Humifusae 15 weight portions, Pericarpium Granati 14 weight portions, Mustela eversmanni lesson. 10 weight portions, Calculus Bovis 16 weight portions, Lumbricus 5 weight portions, Zibethum 12 weight portions and Nidus Vespae 11 weight portions.

7. according to the pharmaceutical composition that is used for the treatment of gosling plague described in claim 1-6 any one, it is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1～10 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 3～5 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 85%～95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill to 24～36 hours under the condition of 5 DEG C～10 DEG C, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, concentrate and be dried, and put into super micron mill at this and pulverize 40～60 minutes, the micron particles of acquisition 0.1～10 μ m volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1g～1.5g needle-use activated carbon, fully stirs 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

8. according to the pharmaceutical composition that is used for the treatment of gosling plague described in claim 1-6 any one, it is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, Ganoderma, Semen Raphani, Herba Agrimoniae, Folium Callicarpae Formosanae, Galla Chinensis and Pericarpium Granati are mixed in described ratio, the dissolve with ethanol that to use with respect to the determining alcohol of 3～5 times of mixture quality obtaining be 85%～95%, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Sophorae alopecuroidis and Fructus Amomi Rotundus are mixed in described ratio, add the ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining, heating and refluxing extraction 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 60 DEG C～70 DEG C, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and is screened into subsequently 80～120 object fine powders, and the fine powder of acquisition is dropped in mixing and blending machine and stirred, and obtains powder.

9. a preparation method for the pharmaceutical composition that is used for the treatment of gosling plague as described in claim 1-6 any one, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1～10 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 3～5 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 85%～95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill to 24～36 hours under the condition of 5 DEG C～10 DEG C, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, concentrate and be dried, and put into super micron mill at this and pulverize 40～60 minutes, the micron particles of acquisition 0.1～10 μ m volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1g～1.5g needle-use activated carbon, fully stirs 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

10. a preparation method for the pharmaceutical composition that is used for the treatment of gosling plague as described in claim 1-6 any one, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, Ganoderma, Semen Raphani, Herba Agrimoniae, Folium Callicarpae Formosanae, Galla Chinensis and Pericarpium Granati are mixed in described ratio, the dissolve with ethanol that to use with respect to the determining alcohol of 3～5 times of mixture quality obtaining be 85%～95%, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Sophorae alopecuroidis and Fructus Amomi Rotundus are mixed in described ratio, add the ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining, heating and refluxing extraction 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 60 DEG C～70 DEG C, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and is screened into subsequently 80～120 object fine powders, and the fine powder of acquisition is dropped in mixing and blending machine and stirred, and obtains powder.