CN101249153A - Chinese and western drugs for curing bird bacillus coli disease and method of preparing the same - Google Patents
Chinese and western drugs for curing bird bacillus coli disease and method of preparing the same Download PDFInfo
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Abstract
The invention relates to a Chinese and western drug for treating avian escherichia coli diseases. The invention is characterized in that the Chinese and western drug comprises the components by weight parts as follows: rhubarb is 10 to 30 parts, radix scutellariae is 5 to 15 parts, coptis roots are 1 to 5 parts, radix isatidis is 1 to 5 parts, and enrofloxacin is 0.5 to 5 parts. The invention has a preparation method as follows: (1) the components are got by weight parts as follows: the rhubarb is 10 to 30 parts, the radix scutellariae is 5 to 15 parts, the radix isatidis is 1 to 5 parts, and the radix isatidis is 1 to 5 parts; (2) purified water which is 2 to 3 times the weight of the total quantity of all components is added, and concentrated solution is obtained after diacolation, evaporation and concentration, wherein, the relative density of the concentrated solution is 1.05 to 1.2; (3) the enrofloxacin which is 0.1 to 1 time the weight of the concentrated solution is added in the concentrated solution, and the purified water which is 2 to 5 the weight of the concentrated solution is added, so that the Chinese and western drug is made. The invention has strengthening efficacy after extraction and separation, effectively treats chicken escherichia infection, and reduces the economic loss of raising households. The Chinese and western drug realizes the reasonable collocation and combination by selecting various active ingredients, the cost is low, the curative effect is good, the cure rate is high, and the safety and the reliability are realized.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of poultry disease, particularly a kind of Chinese and western drugs for the treatment of fowl colibacillosis and preparation method thereof.
Background technology
Avian colibacillosis is a kind of common multiple infectious disease that is caused by Escherichia coli, comprises multiple sick type, and complicated various, is to endanger one of most important bacterial disease of aviculture at present.Ill fowl mortality rate can reach 8～10%, and ill fowl Abwehrkraft des Koepers descends, other pathogenic microorganism of easy infection, and as mycoplasma infection, viral infection, the rate that causes death increases.The drug cost that generally is used for the treatment of avian colibacillosis accounts for 10% of whole poultry farming drug cost.How aquaculture treats this disease with chemical synthetic drug such as antibiotic at present, but it is residual in the fowl body that antibiotic use can make medicine be in, cause the poultry prod downgrade, life-time service can also make escherichia coli that antibiotic is developed immunity to drugs in addition, and antibiotic antibacterial activity is descended.
Therefore, providing a kind of Chinese and western drugs for the treatment of fowl colibacillosis and preparation method thereof, effectively prevent and treat the birds colibacillosis, is one of this technical field scientific research personnel new problem of being badly in need of developing.
Summary of the invention
The objective of the invention is to overcome the weak point in the above-mentioned technology, provide that a kind of reasonable recipe, preparation are simple, Chinese and western drugs of obvious results treatment fowl colibacillosis and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object:
A kind of Chinese and western drugs for the treatment of fowl colibacillosis is characterized in that comprising by weight: 10～30 parts of Radix Et Rhizoma Rhei, 5～15 parts of Radix Scutellariaes, 1～5 part of Rhizoma Coptidis, 1～5 part of Radix Isatidis, enrofloxacin 0.5～5.
Optimization formula: Radix Et Rhizoma Rhei is that 20 parts, Radix Scutellariae are that 10 parts, Rhizoma Coptidis are 3 parts, 5 parts of Radix Isatidis, 3 parts of enrofloxacins.
A kind of preparation method for the treatment of the fowl colibacillosis Chinese and western drugs is characterized in that being undertaken by following step:
(1) gets by weight: 10～30 parts of Radix Et Rhizoma Rhei, 5～15 parts of Radix Scutellariaes, 1～5 part of Rhizoma Coptidis, 1～5 part of Radix Isatidis;
(2) add the purified water of each component total amount 2～3 times of weight, through percolation, to evaporate, be concentrated into relative density be 1.05～1.2 concentrated solution;
(3) add the enrofloxacin of 0.1～1 times of weight in the concentrated solution, and the purified water that adds concentrated solution 2～5 times of weight is made.
The invention has the beneficial effects as follows: the present invention through extract with separates after, drug effect is strengthened, and can effectively treat chicken colibacillosis and infect, minimizing raiser's economic loss.The present invention chooses various effective ingredient and is reasonably combined, and cost is low, good effect, cure rate height, safe and reliable.
The specific embodiment
Below in conjunction with embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of Chinese and western drugs for the treatment of fowl colibacillosis comprises: Radix Et Rhizoma Rhei is 20 parts, and Radix Scutellariae is 10 parts, and Rhizoma Coptidis is 3 parts, and Cortex Phellodendri is 3 parts, 2 parts of Radix Isatidis, 6 parts of enrofloxacins.
Embodiment 2
A kind of Chinese and western drugs for the treatment of fowl colibacillosis comprises: 10 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Scutellariaes, 1 part of Rhizoma Coptidis, 1 part of Cortex Phellodendri, 3 parts of Radix Isatidis, 3 parts of enrofloxacins.
Embodiment 3
A kind of Chinese and western drugs for the treatment of fowl colibacillosis comprises: 30 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 5 parts of Cortex Phellodendris, 3 parts of Radix Isatidis, 15 parts of enrofloxacins.
Embodiment 4
A kind of Chinese and western drugs for the treatment of fowl colibacillosis comprises: Radix Et Rhizoma Rhei is 20 parts, and Radix Scutellariae is 10 parts, Rhizoma Coptidis is 3 parts, and Cortex Phellodendri is 3 parts, 4 parts of Radix Isatidis, 10 parts of enrofloxacins, the Radix Pulsatillae is 10 parts, and Herba Andrographis is 10 parts, and Folium Isatidis is 10 parts, Flos Lonicerae is 10 parts, and Foliumet Ramulus Evodiae is 10 parts, and Herba Polygoni hydropiperis is 100 parts, Radix Gentianae is 30 parts, Cortex Cinnamomi is 3 parts, and Fructus Foeniculi is 3 parts, and Borneolum Syntheticum is 0.3 part.
Embodiment 5
A kind of Chinese and western drugs for the treatment of fowl colibacillosis, comprise: 10 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Scutellariaes, 1 part of Rhizoma Coptidis, 1 part of Cortex Phellodendri, 1 part of Radix Isatidis, 3 parts of enrofloxacins, 15 parts of the Radix Pulsatillaes, 15 parts of Herba Andrographis, 5 parts of Folium Isatidiss, 15 parts of Flos Loniceraes, 15 parts of Foliumet Ramulus Evodiae, 150 parts of Herba Polygoni hydropiperiss, 20 parts of Radix Gentianae, 1 part of Cortex Cinnamomi, 5 parts of Fructus Foeniculi, 0.1 part of Borneolum Syntheticum.
Embodiment 6
A kind of Chinese and western drugs for the treatment of fowl colibacillosis, comprise: 30 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 5 parts of Cortex Phellodendris, 4 parts of Radix Isatidis, 10 parts of enrofloxacins, 5 parts of the Radix Pulsatillaes, 5 parts of Herba Andrographis, 15 parts of Folium Isatidiss, 5 parts of Flos Loniceraes, 5 parts of Foliumet Ramulus Evodiae, 50 parts of Herba Polygoni hydropiperiss, 40 parts of Radix Gentianae, 5 parts of Cortex Cinnamomis, 1 part of Fructus Foeniculi, 0.4 part of Borneolum Syntheticum.
Embodiment 7
A kind of preparation method for the treatment of the Chinese and western drugs of fowl colibacillosis, form by following step:
(1) takes by weighing: Radix Et Rhizoma Rhei 20Kg, Radix Scutellariae 10Kg, Rhizoma Coptidis 3Kg, Cortex Phellodendri 3Kg, Radix Isatidis 3Kg;
(2) rinsing drying: routinely that the various raw material rinsings of component are clean, it was kept dry in 60 ℃ of temperature, 2 hours time;
(3) crushing screening: adopt Universalpulverizer with raw material pulverizing, cross sieve No. 3;
(4) soak into extraction: the raw material after the pulverizing soaked in purified water 4 hours, and quantity of solvent is 2 times of component total amount;
(5) pressurization percolation: adopt pressurization percolation method extraction fast, the time is 1.5 hours, and pressure is 200pa;
(6) flocculating sedimentation: the flocculating setting agent of employing is the ZTC1-1 natural clarifying agent, and the flocculating setting agent adding proportion is 1% of an extract total amount;
(7) filter: adopt ultrafiltration membrance filter, cross 350 purpose films, remove impurity such as destarching, protein, resin, tannin;
(8) concentrate: be concentrated into relative density and be 1.05 concentrated solution;
(9) add 1 times of weight enrofloxacin in the concentrated solution, the purified water that adds 4 times of weight is again made.
Under vacuum state, in regulating the suction vaporization chamber, the influencing meridian effusion meter concentrates.The evaporation gas cools off to flow to through high-performance heat exchanger and reclaimed by flow container, and basin before solvent pump is input to extractor again can enter fresh solvent continuously and discharge extractum continuously, the continuous concentrate that gets, and the leaching medical material so moves in circles.
This medicine can be treated avian colibacillosis etc. effectively.Raw materials used resources of Chinese medicinal herb is extensive, and production technology is simple; Enrofloxacin alcohol drug residue hangs down and waits side effect.This compound medicine noresidue has no side effect.
Composition principle:
This product prescription compiles monarch, minister, helps, makes, and fully worships the principle of Chinese medicine " organic conception " and " dialectical executing controlled ", the treating both the principal and secondary aspects of a disease function of performance Chinese medicine, and its concrete function is summarized as follows with curing mainly:
1, intestinal tract cleaning, anti-inflammation: the active ingredient in this product has powerful adsorption function, the toxin adsorbable and discharge antibacterial, virus produce in intestinal, reach the purpose of cleaning intestinal rubbish, simultaneously to causing the various bacteria of enteritis, as escherichia coli, dysentery bacterium powerful inhibitory or killing effect is arranged, active ingredient in the Chinese medicine simultaneously has repair to impaired intestinal mucosa, thereby eliminates enteritis fast.
2, the function that has heat clearing and damp drying, promoting the circulation of QI to relieve pain, dysentery relieving stopping leak.Active ingredient in the side can suppress enterokinesia, delay content discharges, and has powerful anti-diarrhea effect, thereby can be used for treating the red blood dysentery that various bacteria causes, diseases such as enteritis, diarrhea are particularly useful for the enteritis dysentery of commercial meat bird middle and late stage and laying cycle of laying hens.Eliminate the poultry intractable dysentery that unknown cause causes rapidly.
3, enrofloxacin has another name called ethyl ciprofloxacin, enrofloxacin.This product is the animal specific medicine.The absorption of for oral administration and intramuscular injection rapidly and more complete, blood medicine degree reached the peak in 0.5～2 hour.This product is the broad-spectrum sterilization medicine, and mycoplasma is had specially good effect.Escherichia coli, klebsiella bacillus, Salmonella, Bacillus proteus, bacillus pyocyaneus, haemophilus, pasteurella multocida, pasteurella haemolytica, golden Portugal bacterium, streptococcus etc. all there is sterilization effectiveness.It has advantages such as drug residue is low.
In recent years, the Chinese and Western veterinary drug especially herbal medicine combine the report of the bacterial disease that is used to prevent and treat poultry, virosis, mycoplasma, frequently-occurring disease, commonly encountered diseases with the classes of anti-infective Western medicine more and more.Especially some are used the not obvious or invalid disease of classes of anti-infective western medicine result separately, it is evident in efficacy after being used in combination the Chinese and Western veterinary drug.In the present invention, cooperate the Chinese medicine and western medicine compound recipe of enrofloxacin preparation in the Chinese herbal medicine such as Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis, Radix Isatidis, can effectively prevent and treat colibacillosis; This Chinese medicine and western medicine compound effect obviously is better than using separately the enrofloxacin Western medicine; The Chinese and Western veterinary drug compound preparation that TMP utilizes Chinese medicine such as Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Isatidis and the compound compatibility of Western medicine enrofloxacin to produce, the colibacillosis effect of treatment fowl is fine, applies the welcome that is subjected to very much the raiser.The Chinese medicine and western medicine compound recipe adopts antibiotics to take stopgap measures, and the herbal medicine with heat-clearing and toxic substances removing effects a permanent cure again, the clinical curative effect preferably that obtained.Especially in good time inactive Western medicine of banning drugs phase, carry out the fowl disease control with Chinese medicine, promote that more the back fertility performance is brought into play, it is residual effectively to reduce the intravital medicine of pig chicken, satisfies the food safety needs of increasingly stringent.
The herbal medicine toxic and side effects is little, can not produce drug resistance, emphasizes to regulate allomeric function during application, improves the immunocompetence of body self, and prolonged application is safe and reliable.Western medicine (especially antibiotic Western medicine) has fast, the characteristics such as effect is strong, easy to use of producing effects.Both combine, then can learn from other's strong points to offset one's weaknesses, inside and outside lay equal stress on, whole lay equal stress on the part, play the effect that brings out the best in each other.The combination of Chinese medicine and western medicine is the important behave of development motherland medicine and pharmacology.In recent years, Chinese herbal medicine worldwide more and more comes into one's own, and excellent curative is used and obtained to Chinese medicine and western medicine in conjunction with using for most veterinary work persons.
Embodiment 8
A kind of preparation method for the treatment of the Chinese and western drugs of fowl colibacillosis, form by following step:
(1) takes by weighing: Radix Et Rhizoma Rhei 10Kg, Radix Scutellariae 15Kg, Rhizoma Coptidis 1Kg, Cortex Phellodendri 1Kg, Radix Isatidis 1Kg;
(2) rinsing drying: routinely that the various raw material rinsings of component are clean, it was kept dry in 120 ℃ of temperature, 1 hour time;
(3) crushing screening: adopt Universalpulverizer with raw material pulverizing, cross sieve No. 4;
(4) soak into extraction: the raw material after the pulverizing soaked in purified water 2 hours, and quantity of solvent is 3 times of component total amount;
(5) pressurization percolation: adopt pressurization percolation method extraction fast, the time is 2 hours, and pressure is 100pa;
(6) flocculating sedimentation: the flocculating setting agent of employing is the ZTC1-1 natural clarifying agent, and the flocculating setting agent adding proportion is 0.5% of an extract total amount;
(7) filter: adopt ultrafiltration membrance filter, cross 200 purpose films, remove impurity such as destarching, protein, resin, tannin;
(8) concentrate: be concentrated into relative density and be 1.05 concentrated solution;
(9) add 0.5 times of weight enrofloxacin in the concentrated solution, the purified water that adds 3 times of weight is again made.
Embodiment 9
A kind of preparation method for the treatment of the Chinese and western drugs of fowl colibacillosis, form by following step:
(1) takes by weighing: Radix Et Rhizoma Rhei 30Kg, Radix Scutellariae 5Kg, Rhizoma Coptidis 5Kg, Cortex Phellodendri 5Kg, 5 parts of Radix Isatidis;
(2) rinsing drying: routinely that the various raw material rinsings of component are clean, it was kept dry in 90 ℃ of temperature, 2 hours time;
(3) crushing screening: adopt Universalpulverizer with raw material pulverizing, cross sieve No. 2;
(4) soak into extraction: the raw material after the pulverizing soaked in purified water 3 hours, and quantity of solvent is 3 times of component total amount;
(5) pressurization percolation: adopt pressurization percolation method extraction fast, the time is 1.5 hours, and pressure is 100pa;
(6) flocculating sedimentation: the flocculating setting agent of employing is the ZTC1-1 natural clarifying agent, and the flocculating setting agent adding proportion is 0.5% of an extract total amount;
(7) filter: adopt ultrafiltration membrance filter, cross 300 purpose films, remove impurity such as destarching, protein, resin, tannin;
(8) concentrate: be concentrated into relative density and be 1.05 concentrated solution;
(9) add 1 times of weight enrofloxacin in the concentrated solution, the purified water that adds concentrated solution 3 times of weight is again made.
Embodiment 10
A kind of preparation method for the treatment of the Chinese and western drugs of fowl colibacillosis, form by following step:
(1) gets 20 parts of Radix Et Rhizoma Rhei, 10 parts of Radix Scutellariaes, 3 parts of Rhizoma Coptidis, 3 parts of Cortex Phellodendris, 4 parts of Radix Isatidis, 10 parts of the Radix Pulsatillaes, 10 parts of Herba Andrographis, 10 parts of Folium Isatidiss, 10 parts of Flos Loniceraes, 10 parts of Foliumet Ramulus Evodiae, 100 parts of Herba Polygoni hydropiperiss, 30 parts of Radix Gentianae, 3 parts of Cortex Cinnamomis, 3 parts of Fructus Foeniculi, 0.3 part of Borneolum Syntheticum;
Step (2)-(9) are with embodiment 7.
Embodiment 11
A kind of preparation method for the treatment of the Chinese and western drugs of fowl colibacillosis, form by following step:
(1) gets: 10 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Scutellariaes, 1 part of Rhizoma Coptidis, 1 part of Cortex Phellodendri, 4 parts of Radix Isatidis, 15 parts of the Radix Pulsatillaes, 15 parts of Herba Andrographis, 5 parts of Folium Isatidiss, 15 parts of Flos Loniceraes, 15 parts of Foliumet Ramulus Evodiae, 150 parts of Herba Polygoni hydropiperiss, 20 parts of Radix Gentianae, 1 part of Cortex Cinnamomi, 5 parts of Fructus Foeniculi, 0.1 part of Borneolum Syntheticum;
Step (2)-(9) are with embodiment 8.
Embodiment 12
A kind of preparation method for the treatment of the Chinese and western drugs of fowl colibacillosis, form by following step:
(1) gets: 30 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 5 parts of Cortex Phellodendris, 4 parts of Radix Isatidis, 5 parts of the Radix Pulsatillaes, 5 parts of Herba Andrographis, 15 parts of Folium Isatidiss, 5 parts of Flos Loniceraes, 5 parts of Foliumet Ramulus Evodiae, 50 parts of Herba Polygoni hydropiperiss, 40 parts of Radix Gentianae, 5 parts of Cortex Cinnamomis, 1 part of Fructus Foeniculi, 0.4 part of Borneolum Syntheticum;
Step (2)-(9) are with embodiment 9.
Embodiment 12
Clinical experiment:
After the white plumage broiler inoculation of 12～15 ages in days birds escherichia coli virus, adopt respectively the Chinese and western drugs of this treatment fowl colibacillosis of the embodiment of the invention 7 preparation divide high (1.0ml/kg mixes drink), in (0.5ml/kg mixes drink), low dosage (0.25ml/kg mixes and drinks), JILILING SAN (0.7g/ mixed feeding, medicine matched group) treat according to the amount of stipulating in the testing program.Clinical efficacy experiment through this test shows, mortality rate, medicine effective percentage and cure rate of this medicine group chickling of the embodiment of the invention 7 preparations and the poor heteropole of infected group be (P＜0.01) significantly, and this Chinese and western drugs that just shows this treatment fowl colibacillosis has better curative effect to the birds escherichia coli.
Experimental technique:
| Numbering | Group | Quantity/only | Usage and consumption | Drug treatment |
| A | Normal healthy controls (not infecting) group | 40 | Do not infect not administration, sufficient drinking-water | ------ |
| B | Infect matched group | 40 | Infect not administration, sufficient drinking-water | ------ |
| C | Embodiment 7 high dose group | 40 | 1.0ml/kg/24h mix drink | 6 days |
| D | Dosage group among the embodiment 7 | 40 | 0.50ml/kg/24h mix drink | 6 days |
| E | Embodiment 7 low dose group | 40 | 0.25ml/kg/24h mix drink | 6 days |
| F | JILILING SAN group (medicine matched group) | 40 | 0.7g/ only/the 24h mixed feeding | 6 days |
Experimental result:
| Numbering | Group | Mortality rate/% | Inefficiency % | Effective percentage % | Cure rate % | Symptom Caput Gallus domesticus number is arranged during end | The relative weight gain rate % |
| A | Normal healthy controls (not infecting) | 0 | 0 | 100 | 100 | 0 | 100 |
| B | Infect contrast | 22.7 | 27.5 | 72.5 | 68.3 | 1 | 68.2 |
| C | Embodiment 7 high doses | 8.7 | 4.5 | 95.5 | 95.4 | 4 | 95.0 |
| D | Dosage among the embodiment 7 | 9.9 | 8.4 | 91.6 | 88.6 | 3 | 87.1 |
| E | Embodiment 7 low dosages | 12.5 | 17.3 | 82.7 | 81.7 | 6 | 84.2 |
| F | JILILING SAN group (medicine matched group) | 17.5 | 22 | 78 | 66.7 | 8 | 88.3 |
This result of the test shows that a kind of Chinese and western drugs for the treatment of fowl colibacillosis is used for the treatment of the birds coli-infection obvious effects.Curative effect statistics and X
2Assay shows that the therapeutic effect difference of this medicine height, middle dosage group and JILILING SAN group is (P＜0.01) extremely significantly.
Embodiment 13
A kind of application of Chinese and western drugs aspect a chicken colibacillosis and the treatment of necrotic enteritis mixed infection case for the treatment of fowl colibacillosis.
1000 of area, Hebei one raiser Ai Wei mattress raising layers are fallen ill in 31 ages in days.Respiratory symptom appears in the initial stage, and snore, ataxia have indivedual chicken essence god depressed, slow-witted upright, arrange white loose stool, have paralysed chicken to occur.Do not see after 3 days by respiratory tract disease treatment and to be clearly better.
Cut open inspection: dissect 6 chickens, sick chicken outward appearance feather pine is random, and the anus place is stained with rare white excrement, toughness secretions in the trachea, and heart and liver are wrapped up by cheesy thing, the air bag muddiness, intraperitoneal has cheesy thing.Duodenum and each section of small intestinal all occur downright bad, and content rots, and is escherichia coli and necrotic enteritis mixed infection according to disease symptom, pathological change, tentative diagnosis.
Drug therapy:
1, at first should strengthen feeding and management, add in the drinking-water in " multidimensional electrolyte ".
2, a kind of Chinese and western drugs (embodiment 9) 400ml/1000 every day for the treatment of fowl colibacillosis, concentrate and once drink the morning.(150ml/1000 only), concentrate and once drink afternoon.
3, add the Concentrated Cod-liver Oil powder in the feedstuff.
Medication 4 days was paid a return visit on the 5th day, and chicken mines massively to eat to be increased, and is almost recovered.
Embodiment 14
A kind of application of Chinese and western drugs aspect doubtful Salmonella of a chicken and the treatment of intestinal poison syndrome mixed infection case for the treatment of fowl colibacillosis.
Quay town, Wudi County, Shandong Province raiser has 1256 of 150 days laying hens, opens product certainly and does not go up the peak of laying eggs so far, and brood and disease does not all take place finishing period.Certain company's premix material of feeding.
Chicken group symptom mainly be draw that feedstuff is just serious, the chicken mass-sending educates normally substantially, the eggshell color is normal, rare white shell egg, search for food normal, laying rate is fluctuated.
Select in two cages not laying hen, cuing open inspection changes: phalanx spacing and breastbone and phalanx spacing are all less, cockscomb is swung to a side, follicle degeneration, necrosis, hemorrhage or liquefaction, fallopian tube ateliosis, small intestinal especially duodenum, intestinal mucosa thicken, intestinal wall swelling, cut off and turn up, be full of foam or wheat bran shape material in the enteric cavity, other internal organs are good.
Is Salmonella and the mixed sense of intestinal poison according to clinical symptoms with cuing open the preliminary suspection of inspection variation.
The suggestion processing scheme is: a kind of Chinese and western drugs (embodiment 9) for the treatment of fowl colibacillosis
1 bottle/day (250ml/1000 only) drinks;
1 bag/day in Concentrated Cod-liver Oil powder, the whole day spice;
Logotype 3 days, through paying a return visit, symptom fades away, the rising of laying eggs.
Above-mentioned detailed description of Chinese and western drugs of this treatment fowl colibacillosis and preparation method thereof being carried out with reference to embodiment; be illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1, a kind of Chinese and western drugs for the treatment of fowl colibacillosis is characterized in that comprising by weight: 10～30 parts of Radix Et Rhizoma Rhei, 5～15 parts of Radix Scutellariaes, 1～5 part of Rhizoma Coptidis, 1～5 part of Radix Isatidis, enrofloxacin 0.5～5.
2, the Chinese and western drugs of treatment fowl colibacillosis according to claim 1 is characterized in that optimization formula: Radix Et Rhizoma Rhei is that 20 parts, Radix Scutellariae are that 10 parts, Rhizoma Coptidis are 3 parts, 5 parts of Radix Isatidis, 3 parts of enrofloxacins.
3, a kind of preparation method of treatment fowl colibacillosis Chinese and western drugs according to claim 1 is characterized in that being undertaken by following step:
(1) gets by weight: 10～30 parts of Radix Et Rhizoma Rhei, 5～15 parts of Radix Scutellariaes, 1～5 part of Rhizoma Coptidis, 1～5 part of Radix Isatidis;
(2) add the purified water of each component total amount 2～3 times of weight, through percolation, to evaporate, be concentrated into relative density be 1.05～1.2 concentrated solution;
(3) add the enrofloxacin of 0.1～1 times of weight in the concentrated solution, and the purified water that adds concentrated solution 2～5 times of weight is made.
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| CNA2008100526628A CN101249153A (en) | 2008-04-08 | 2008-04-08 | Chinese and western drugs for curing bird bacillus coli disease and method of preparing the same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239544A (en) * | 2013-05-29 | 2013-08-14 | 北京大北农动物保健科技有限责任公司 | Fishery Chinese and western compound medicine composition as well as premix compound, batch mixture and application thereof |
| CN103784858A (en) * | 2012-11-01 | 2014-05-14 | 天津中敖生物科技有限公司 | Traditional Chinese medicine composition for treating escherichia coli disease of poultry |
-
2008
- 2008-04-08 CN CNA2008100526628A patent/CN101249153A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784858A (en) * | 2012-11-01 | 2014-05-14 | 天津中敖生物科技有限公司 | Traditional Chinese medicine composition for treating escherichia coli disease of poultry |
| CN103239544A (en) * | 2013-05-29 | 2013-08-14 | 北京大北农动物保健科技有限责任公司 | Fishery Chinese and western compound medicine composition as well as premix compound, batch mixture and application thereof |
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Open date: 20080827 |