CN106619223A - Natural anti-aging cosmetic and preparation method thereof - Google Patents

Natural anti-aging cosmetic and preparation method thereof Download PDF

Info

Publication number
CN106619223A
CN106619223A CN201611237337.XA CN201611237337A CN106619223A CN 106619223 A CN106619223 A CN 106619223A CN 201611237337 A CN201611237337 A CN 201611237337A CN 106619223 A CN106619223 A CN 106619223A
Authority
CN
China
Prior art keywords
component
skin
genistein
natural anti
aging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201611237337.XA
Other languages
Chinese (zh)
Other versions
CN106619223B (en
Inventor
李凌霞
祁永华
季顺欣
张艳红
蔺振林
李桐
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heilongjiang University of Chinese Medicine
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201611237337.XA priority Critical patent/CN106619223B/en
Publication of CN106619223A publication Critical patent/CN106619223A/en
Application granted granted Critical
Publication of CN106619223B publication Critical patent/CN106619223B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365Hydroxycarboxylic acids; Ketocarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/604Alkylpolyglycosides; Derivatives thereof, e.g. esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8158Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention provides a natural anti-aging cosmetic and a preparation method thereof. The cosmetic is prepared from the following raw materials: component A: jojoba oil, isopropyl palmitate, polyacrylamide, bisabolol, azone, hexadecyl glucoside and glyceryl monostearate; component B: sodium hyaluronate, a methylparaben amino acid moisturizer, 1,3-dihydroxylmethyl-5,5-dimethylhydantoin; component C: genistein, ferulic acid, ligustilide and glycerol; the balance of deionized water, and the total weight percentage of the raw materials is 100%. The natural anti-aging cosmetic is applicable to postmenopausal women, and fundamentally delays the senescence of the postmenopausal women by adding genistein as an effective ingredient of soybean isoflavones as well as ferulic acid and ligustilide; genistein is used in combination with ferulic acid and ligustilide and can play a more synergistic role.

Description

A kind of natural anti-aging cosmetics and preparation method thereof
Technical field
The present invention relates to cosmetic field, more particularly to a kind of natural anti-aging cosmetics and preparation method thereof.
Background technology
With advancing age, must all there are a series of retrogressions in terms of morphosis and physiological function in body Change, here it is usually said " aging ".Skin senescence is an important component part of body aging, especially to postclimacteric For women, the change of skin is huge, and the change of skin collagen causes skin elasticity reduction, effect of elastic resistance to weaken, therefore, The beauty skin care product of various preventions and delay skin aging is increasingly subject to people's attention.
In view of injury of the chemistry skin care item to skin at present, people turn to sight has good safety, stability, effect Fruit substantially and the high natural anti-aging cosmetics of cost performance, such as various Chinese medicine cosmetics.Application in TCM has in beautifying skin Efficacy stability, persistently, to skin action temperature and, excitant it is little, safe, it is evident in efficacy the features such as.Patent 201510173817.3 disclose it is a kind of with whitening and anti-aging, remove wrinkle, the cosmetic composition of spot-removing function and cosmetics, The function adding ingredient of this cosmetics have oat extract, Ginseng extract, arabo-ascorbic acid, Ma Zhi look for extract, glucan, Reed fragrant plant oil, aloe extract, lemon yellow Jojoba coloured silk particle, ginseng one, whitening effect is good, goes wrinkle effect good, nti-freckle ability It is remarkable.But the shortcoming of the present invention has:(1) containing various natural extracts, species is more so that extraction process is more complicated, while Due to complicated component, it is difficult to determine the anti-ageing, whitening of performance, remove wrinkle, the concrete composition of nti-freckle and specific mechanism of action;(2) nothing Method determines ratio standard when making, because different sources, the same medicine of different cultivars, its composition and content have difference, Therefore the constituent structure of extract can be affected;(3) this cosmetics function is numerous, whitening and anti-aging, go wrinkle, nti-freckle, it can be difficult to Determine that what its effect for accounting for main advantage is;(4) plurality of Chinese extract component is mixed and chemical matrix is blended in After together, if unknown reaction can be played, the characteristic and function of cosmetics is affected.
Patent 201510165517.0 discloses a kind of skin care item formula of delay skin aging, fills a prescription by parts by weight 1 part of Aloe Vera Gel, 1 part of body lotion, 1 part of olive oil, 1 part of vitamin are made.The present invention can be disposed and cause Skin Cell aging Free radical, can provide nutrient necessary to skin, and energy nourishes rough skin while skin surface free radical is removed, delaying skin declines Always, cell senescence and the melanin deposition caused due to ultraviolet radiation can also be alleviated, is reached while delay skin aging To the effect of skin whitening.But the present invention is the nourishing and protection on surface, activation and again can not be played to the functional layer of skin Raw effect, it is impossible to the fundamentally aging of delaying skin.
Skin senescence is endogenous physiological aging and the coefficient result of exogenous environmental factor, and endogenous aging is root This, environmental factor plays acceleration or retarding action on the basis of endogenous aging, therefore can solve in postmenopausal women for research The natural cosmetics tool significance of source property aging.
The content of the invention
The purpose of the present invention is mainly to provide a kind of natural anti-aging cosmetics suitable for postmenopausal women and its preparation Method, by the active ingredient genistein for adding plant estrogen isoflavones, fundamentally delays postmenopausal women Aging.
The technical solution used in the present invention is as follows:
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2-8%, isopropyl palmitate 0.5-4%, polyacrylamide 0.2-4%, bisabolol 0.01-0.5%, azone 0.01-0.5%, Alkyl Polyglycoside of Hexadecyl 1-6%, glycerin monostearate 1-7%;
B component:Sodium Hyaluronate 1-5%, methyl hydroxybenzoate 0.2-0.4%, amino acid humectant 0.5-5%, 1,3- bis- Methylol -5,5- dimethyl hydantoin 0.2-0.5%;
Component C:Genistein 0.1-0.4%, forulic acid 0.01-0.05%, ligustilide 0.01-0.05%, glycerine 1- 7%;
Balance of deionized water, adds up to 100%;
Preferably, the natural anti-aging cosmetics are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, nitrogen Ketone 0.1%, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyls- 5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, forulic acid 0.02%, ligustilide 0.02%, glycerine 3.0%;
Balance of deionized water, adds up to 100%.
Main functional component is genistein in technical scheme, and genistein is mainly having for isoflavones Effect composition, with antioxidation, with estrogen and antiestrogenic property, can suppress the activity for opening up analysis foreign matter enzyme II, can press down The activity of LCK PTK processed.Its molecular weight is relatively low, can be dissolved in matrix and can absorbing transmission from skin, with The ERs combination of skin of face, promotes skin collagen synthesis, stimulates epidermal cell proliferation, affects dividing for sebaceous glands Secrete, delay cuticula atrophy and epidermis thinning, keep skin elasticity, reduce wrinkle, play estrogen-like action, meanwhile, may be used also With by anti-oxidant come delay skin aging.
In the technical program, also added active ingredient forulic acid and ligustilide, both of which from angelica extract, Forulic acid has antioxidation, by directly eliminating free radical, suppresses the membrane lipid peroxidatio reaction that superoxide radical causes And radical reaction, and the infringement with various mechanism antagonism free radicals such as biological film phospholipid join protection membrane lipid to organizing, Gloomy or not magnificent to the complexion caused by free radical retardance or raw sore swells, there is special efficacy.Additionally, forulic acid also has anti-inflammatory, pain relieving Effect, while also good Transdermal absorption function is permeated with Transdermal absorption function, the absorption that can promote genistein is promoted;Ligusticum sinense oliver Lactone is the main component of Chinese angelica volatile oil, with effect that is promoting blood circulation and removing blood stasis, improving skin microcirculation, can keep the life of skin State is balanced, and prevents skin from abnormal change occurring, and controls deposition of the lipid metabolite in skin, prevention skin aging and senile plaque expelling Generation.
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2-8%, isopropyl palmitate 0.5-4%, polyacrylamide 0.2-4%, bisabolol 0.01-0.5%, azone 0.01-0.5%, Alkyl Polyglycoside of Hexadecyl 1-6%, glycerin monostearate 1-7%;
B component:Sodium Hyaluronate 1-5%, methyl hydroxybenzoate 0.2-0.4%, amino acid humectant 0.5-5%, 1,3- bis- Methylol -5,5- dimethyl hydantoin 0.2-0.5%;
Component C:Genistein 0.1-0.4%, angelica extract 0.5-2.0%, glycerine 1-7%;
Balance of deionized water, adds up to 100%;
Containing forulic acid and ligustilide wherein in angelica extract.
Preferably, the natural anti-aging cosmetics are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, nitrogen Ketone 0.1%, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyls- 5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, angelica extract 2.0%, glycerine 3.0%;
Balance of deionized water, adds up to 100%;
Containing forulic acid and ligustilide wherein in angelica extract.
In the technical program, pure forulic acid and ligustilide is replaced using angelica extract, not only reduce production Cost, it is even more important that angelica extract in addition to containing forulic acid and ligustilide, also containing amino acid, trace element and Other organic principles, therefore angelica extract not only has the function of forulic acid and ligustilide, also with other functions, such as Angelica extract has abundant moisture-keeping functions, stores after skin absorption and is contained in epidermis, makes keratoderma keep the aqueous of abundance Amount, plays " direct moisturizing " mechanism.Angelica extract also has removes free radical and complexing ferrous ion ability and to junket ammonia Sour enzyme has rejection ability, plays anti-aging and whitening function.
Further, the cosmetics are primarily adapted for use in postclimacteric old women.
A kind of preparation method of above-mentioned anti-aging cosmetics, comprises the following steps:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved Obtain II phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stir to It is well mixed.
The present invention shares genistein with angelica extract with forulic acid and ligustilide or genistein, can play more Good collaboration facilitation, so that its delay skin aging, keeps skin of face elasticity, reduces wrinkle, promotes face blood Circulation, keeps having rosy cheeks, and suppresses the formation of dermal melanin, also acts as skin whitening effect.Plant can also be promoted female sharp simultaneously The Transdermal absorption of element, drug extract itself can play the good anti-oxidant effect of guaranteeing the quality again.
The present invention anti-aging cosmetics be primarily adapted for use in women after menopause, to solve menopause after women endogenous physiological For the purpose of aging, pure white fine and smooth, the pure and fresh simple and elegant, sense organ of smell of color and luster comfortably moistens, non-greasy, good permeability, sooner or later can Use, and without essence and preservative, it is little to skin irritation, have no toxic side effect, it is safe and reliable.
Specific embodiment
The principle and feature of the present invention are described below, example is served only for explaining the present invention, is not intended to limit Determine the scope of the present invention.
The part material source arrived used in following examples is as follows:Genistein (purity 98wt%) is purchased from Yuquan monomer Storehouse;Forulic acid (purity >=98wt%), ligustilide (purity >=98wt%) are purchased from Shanghai experiment reagent consumptive material home office;Radix Angelicae Sinensis is carried Take thing to converge purchased from natural material.
Embodiment 1
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, nitrogen Ketone 0.1%, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyls- 5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, forulic acid 0.02%, ligustilide 0.02%, glycerine 3.0%;
Balance of deionized water, adds up to 100%;
The preparation process of the natural anti-aging cosmetics is as follows:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved Obtain II phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stir to It is well mixed.
Embodiment 2
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2%, isopropyl palmitate 0.6%, polyacrylamide 0.3%, bisabolol 0.05%, nitrogen Ketone 0.05%, Alkyl Polyglycoside of Hexadecyl 1.5%, glycerin monostearate 7%;
B component:Sodium Hyaluronate 2.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 1.0%, 1,3- dihydroxymethyls- 5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, forulic acid 0.02%, ligustilide 0.02%, glycerine 2.0%;
Balance of deionized water, adds up to 100%;
The preparation process of the natural anti-aging cosmetics is as follows:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved Obtain II phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stir to It is well mixed.
Embodiment 3
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, nitrogen Ketone 0.1%, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyls- 5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, angelica extract 2%, glycerine 3.0%;
Balance of deionized water, adds up to 100%;
The preparation process of the natural anti-aging cosmetics is as follows:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved Obtain II phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stir to It is well mixed.
Embodiment 4
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2%, isopropyl palmitate 0.6%, polyacrylamide 0.3%, bisabolol 0.05%, nitrogen Ketone 0.05%, Alkyl Polyglycoside of Hexadecyl 1.5%, glycerin monostearate 7%;
B component:Sodium Hyaluronate 2.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 1.0%, 1,3- dihydroxymethyls- 5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, angelica extract 0.5%, glycerine 2.0%;
Balance of deionized water, adds up to 100%;
The preparation process of the natural anti-aging cosmetics is as follows:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved Obtain II phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stir to It is well mixed.
The following is the anti-aging performance test to product:
1st, test object
In Kiamusze City the age physiological menopause in -75 years old 55 years old women, without major disease, without skin disease and allergy History, do not apply some make up at ordinary times and go out at ordinary times less, without the strong Exposure to Sunlight of long-time, without habits of smoking and alcohol drinking person, test number is 40 People.
2nd, method of testing
(1) skin elasticity test
Sooner or later each to wipe once in tester's forehead, canthus and cheekbone portion as test zone, left side face wipes control sample, Right side face wipes test sample, and genistein, forulic acid and Ligustilide, other components and embodiment 1 are not contained in control sample Identical, test sample adopts the formula of embodiment 1, and using method is Blind Test (do not tell tester two kinds and wipe the white difference of faces). Diet keeps light, rule during test, and the product of pungent stimulation and cold and cool raw food are eaten less, and the sleep for keeping rule sufficient is not long Time strong Exposure to Sunlight, keeps the happiness that is in a light hearted mood, period not to wipe other cosmetics as far as possible.Using after two months, adopt Cutometer MPA580 skin elasticities instrument tests the skin elasticity of wiped area, and test result is as shown in table 1.It is tested during test Person loosens facial muscle groups, gently closes eyes, avoids speaking and various expressions in measurement process, and test environment phase is kept in measurement To stable, light, sound interference are avoided;Probe positions are correct during skin surface direct measurement, should be same to same position One tested region is carried out;Using firmly wanting uniform during probe, the pressure of applying should continued for constant.In order to preferably evaluate gained Data, introduce parameter R2, R5 and R7, these three parameters represent the ability that original position is returned to after skin deformation, they Value be closer to 1, skin elasticity is better.Wherein R2 indicates that the springback capacity Ua without skin during negative pressure draws with there is maximum during negative pressure The ratio of the amount of stretching Uf;R5 for skin test first time cyclic process in skin recovery process elastic part Ur with plus negative pressure process Elastic part Ue ratio;R7 for skin test first time cyclic process in skin recovery process elastic part Ur with it is current The ratio of maximum tension amount Uf of skin in cyclic process.
(2) dermatoglyph test
Sooner or later each to wipe once in tester's forehead, canthus and cheekbone portion as test zone, left side face wipes control sample, Right side face wipes test sample, and genistein, forulic acid and Ligustilide, other components and embodiment 1 are not contained in control sample Identical, test sample adopts the formula of embodiment 1, and using method is Blind Test (do not tell tester two kinds and wipe the white difference of faces). Diet keeps light, rule during test, and the product of pungent stimulation and cold and cool raw food are eaten less, and the sleep for keeping rule sufficient is not long Time strong Exposure to Sunlight, keeps the happiness that is in a light hearted mood, period not to wipe other cosmetics as far as possible.Using after two months, using VC98 Viable skin surface analysis system tests the dermatoglyph of wiped area, and test result is as shown in table 2.Dermatoglyph test result Evaluated using following four parameter:
Sesc:Show the peeling degree of keratoderma, drawn by the ratio for calculating bright pixel, value is less, and cuticula contains The water yield is higher, and skin is more smooth;
Ser:Show skin roughness, drawn by the ratio for calculating dark pixel, value is higher, represents skin more coarse;
Sew:Show wrinkle of skin degree, proportional to the quantity of wrinkle and depth, wrinkle of skin is more, its value is higher;
Sesm:Show the smoothness of skin, proportional to the depth of wrinkle and form, value is bigger, and skin is more smooth.
(3) statistical method
Each being described property of parameter is analyzed using statistical package, skin elasticity, texture compare to be checked using t. Inspection level α=0.05.
(4) test result
Before and after the control sample of table 1 and test sample are wiped, the coefficient of skin elasticity of different parts
In table 1, the value of R2, R5 and R7 before and after sample is used by contrast, using control sample and test sample Afterwards, the value of R2, R5 and R7 increases, and difference is respectively provided with statistical significance (P ﹤ 0.05);Test sample is to skin elasticity Effect compares with control sample, and difference has statistical significance (P ﹤ 0.05), and test sample effect is better than control sample, illustrates this Product is really with the effect for improving old women skin elasticity after menopause more more preferable than control sample.
Before and after the control sample of table 2 and test sample are wiped, the texture parameter values of skin different parts
In table 2, by contrast using each dermatoglyph parameter before and after sample, using control sample and test specimens After product, Ser, Sew, Sesc value decreases, and Sesm values increase, statistically significant (the P ﹤ of numerical value difference 0.05);Test sample compares the effect of dermatoglyph with control sample, and difference has statistical significance (P ﹤ 0.05), test Sample effect is better than control sample, illustrates that the product for adding active component improves ratio without active component to dermatoglyph Product is bigger, is more beneficial for post menopausal old women skin smooth and moistens, and texture is reduced.
(5) discuss
Skin elasticity goes down, texture increases and deepens the key character for being skin senescence.These skin surface characteristics are entered Row quantifies, evaluates, and is that cosmetic dermatology studies commonly used important means.
The anti-wrinkle effect of the present invention is also adopted by skin elasticity, dermatoglyph tester and is evaluated.Test skin elasticity Principle is based on suction and stretching principle.Test result shows that post menopausal all ages and classes female skin elasticity is using test specimens There is notable difference after product, the age is bigger, coefficient of skin elasticity value is lower, and skin elasticity is poorer.It is ultraviolet except outdoor activities Line irradiation is outer, and age growth is to cause skin aging, the main cause of elasticity attenuation.Skin fine structure shows, collagenous fibres Density increases with the age and increases, misaligned, and elastic fibers then increases with the age and weares and teares, and these changes cause skin Elasticity is reduced.In face, canthus skin elasticity is most obvious with change of age, is the portion that facial skin aging occurs changing earliest Position, is look-out station that optimum is elected to be anti-ageing cosmetics curative effect, next to that forehead and cheekbone portion.
Dermatoglyph change is also the important indicator of skin aging, dermatoglyph is quantified using dermatoglyph measuring instrument examine Survey, also play an important role in terms of cosmetics and skincare product evaluation of effect.Dermatoglyph measuring instrument VC98 that this test is used, is to adopt With optical principle, measuring head is contained within a digital camera, with the texture image of its shooting skin surface under UVA light sources, it Afterwards again with software kit to graphical analysis, the corresponding parametric values of roughness are drawn.Experimental result shows, different parts skin Be present significant difference in SESC, SER, SEW and SESM value dermatoglyph after using test sample, as a result anticipate with statistics Justice.Showing that the age is bigger using each parameter of test sample rear face, its numerical value change value is bigger, illustrates that the age is bigger, skin Texture and Flexible change are more prominent, also more obvious to the action-reaction of phytoestrogen.Because except time course is aging and light Aging outer, the decline of postmenopausal estrogen level is also the key factor of skin aging.Decrease in estrogen can be made in skin Collagen content is reduced, collagenous fibres quantity, is arranged and morphologic change, and epidermis is thinning, and water content is reduced, and skin elasticity occurs Decline, wrinkle increases the aging performances such as intensification.Estrogen replacement increases elasticity, reduces wrinkle to improving old women skin senescence Line has definite curative effect, but is to prohibit the use of hormone to add for safety in cosmetics adding ingredient operating specification 's.And the material with estrogen active extracted in plant, the gentle effect of natural disposition slowly, make by pair nontoxic to body to skin With the monomer molecule amount of extraction is little, can fully be absorbed by the skin, and with skin and subcutaneous estrogen receptor binding reparation skin is reached Skin structure, recovers elasticity, reduces the effect of wrinkle, makes aging skin recapture young life.
The foregoing is only presently preferred embodiments of the present invention, not to limit the present invention, all spirit in the present invention and Within principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.

Claims (6)

1. a kind of natural anti-aging cosmetics, it is characterised in that be prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2-8%, isopropyl palmitate 0.5-4%, polyacrylamide 0.2-4%, bisabolol 0.01- 0.5%th, azone 0.01-0.5%, Alkyl Polyglycoside of Hexadecyl 1-6%, glycerin monostearate 1-7%;
B component:Sodium Hyaluronate 1-5%, methyl hydroxybenzoate 0.2-0.4%, amino acid humectant 0.5-5%, 1,3- dihydroxy first Base -5,5- dimethyl hydantoin 0.2-0.5%;
Component C:Genistein 0.1-0.4%, forulic acid 0.01-0.05%, ligustilide 0.01-0.05%, glycerine 1-7%;
Balance of deionized water, adds up to 100%.
2. natural anti-aging cosmetics according to claim 1, it is characterised in that by the raw material system of following percentage by weight It is standby to form:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, azone 0.1%th, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyl -5,5- Dimethyl hydantoin 0.1%;
Component C:Genistein 0.2%, forulic acid 0.02%, ligustilide 0.02%, glycerine 3.0%;
Balance of deionized water, adds up to 100%.
3. a kind of natural anti-aging cosmetics, it is characterised in that be prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2-8%, isopropyl palmitate 0.5-4%, polyacrylamide 0.2-4%, bisabolol 0.01- 0.5%th, azone 0.01-0.5%, Alkyl Polyglycoside of Hexadecyl 1-6%, glycerin monostearate 1-7%;
B component:Sodium Hyaluronate 1-5%, methyl hydroxybenzoate 0.2-0.4%, amino acid humectant 0.5-5%, 1,3- dihydroxy first Base -5,5- dimethyl hydantoin 0.2-0.5%;
Component C:Genistein, 0.1-0.4%, angelica extract 0.5-2.0%, glycerine 1-7%;
Balance of deionized water, adds up to 100%;
Containing forulic acid and ligustilide wherein in angelica extract.
4. natural anti-aging cosmetics according to claim 3, it is characterised in that by the raw material system of following percentage by weight It is standby to form:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, azone 0.1%th, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyl -5,5- Dimethyl hydantoin 0.1%;
Component C:Genistein 0.2%, angelica extract 2.0%, glycerine 3.0%;
Balance of deionized water, adds up to 100%.
5. natural anti-aging cosmetics according to any one of claim 1-4, it is characterised in that the cosmetics are mainly fitted For postclimacteric old women.
6. a kind of preparation method of the natural anti-aging cosmetics as described in any one of claim 1-4, it is characterised in that include Following steps:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved and is obtained II Phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stirs to mixing It is uniform.
CN201611237337.XA 2016-12-28 2016-12-28 A kind of natural anti-aging cosmetics and preparation method thereof Active CN106619223B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611237337.XA CN106619223B (en) 2016-12-28 2016-12-28 A kind of natural anti-aging cosmetics and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201611237337.XA CN106619223B (en) 2016-12-28 2016-12-28 A kind of natural anti-aging cosmetics and preparation method thereof

Publications (2)

Publication Number Publication Date
CN106619223A true CN106619223A (en) 2017-05-10
CN106619223B CN106619223B (en) 2019-11-29

Family

ID=58831994

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201611237337.XA Active CN106619223B (en) 2016-12-28 2016-12-28 A kind of natural anti-aging cosmetics and preparation method thereof

Country Status (1)

Country Link
CN (1) CN106619223B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108309848A (en) * 2018-03-27 2018-07-24 上海清轩生物科技有限公司 The preparation method and its anti-apolexis composition of chlorella extract
CN108338950A (en) * 2018-03-27 2018-07-31 上海清轩生物科技有限公司 With stablizing the anti-apolexis composition and application thereof for being adhered effect between epidermis and corium
CN108652991A (en) * 2018-05-25 2018-10-16 珀莱雅化妆品股份有限公司 A kind of preparation method of the composition with smooth skin effect
CN109646317A (en) * 2018-12-29 2019-04-19 肇庆巧巧日用化工有限公司 Preparation method of moisturizing cream for chest skin

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101234132A (en) * 2007-01-31 2008-08-06 成都彩子化妆品有限公司 New use of angelica sinensis or its extract in preparing skin care products
CN104107159A (en) * 2014-06-27 2014-10-22 陈海 Cosmetic and preparation method thereof
CN105106071A (en) * 2015-09-15 2015-12-02 湖北穆兰同大科技有限公司 Anti-wrinkle skin care product and preparation method thereof
CN105193653A (en) * 2015-09-15 2015-12-30 湖北穆兰同大科技有限公司 Angelica sinensis anti-wrinkle cream and preparation method thereof
CN105687031A (en) * 2016-02-01 2016-06-22 东莞品派实业投资有限公司 Total-effect multifunctional moisturizing cream and preparation method thereof
CN105832568A (en) * 2016-03-26 2016-08-10 佛山市芊茹化妆品有限公司 Solid micro-emulsion, preparation method and application thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101234132A (en) * 2007-01-31 2008-08-06 成都彩子化妆品有限公司 New use of angelica sinensis or its extract in preparing skin care products
CN104107159A (en) * 2014-06-27 2014-10-22 陈海 Cosmetic and preparation method thereof
CN105106071A (en) * 2015-09-15 2015-12-02 湖北穆兰同大科技有限公司 Anti-wrinkle skin care product and preparation method thereof
CN105193653A (en) * 2015-09-15 2015-12-30 湖北穆兰同大科技有限公司 Angelica sinensis anti-wrinkle cream and preparation method thereof
CN105687031A (en) * 2016-02-01 2016-06-22 东莞品派实业投资有限公司 Total-effect multifunctional moisturizing cream and preparation method thereof
CN105832568A (en) * 2016-03-26 2016-08-10 佛山市芊茹化妆品有限公司 Solid micro-emulsion, preparation method and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
高斌等: "大豆异黄酮与皮肤美容", 《中国化妆品》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108309848A (en) * 2018-03-27 2018-07-24 上海清轩生物科技有限公司 The preparation method and its anti-apolexis composition of chlorella extract
CN108338950A (en) * 2018-03-27 2018-07-31 上海清轩生物科技有限公司 With stablizing the anti-apolexis composition and application thereof for being adhered effect between epidermis and corium
CN108338950B (en) * 2018-03-27 2020-04-24 上海清轩生物科技有限公司 Anti-aging composition with function of stabilizing adhesion between epidermis and dermis and application thereof
CN108309848B (en) * 2018-03-27 2020-08-04 上海清轩生物科技有限公司 Preparation method of chlorella extract and anti-aging composition thereof
CN108652991A (en) * 2018-05-25 2018-10-16 珀莱雅化妆品股份有限公司 A kind of preparation method of the composition with smooth skin effect
CN109646317A (en) * 2018-12-29 2019-04-19 肇庆巧巧日用化工有限公司 Preparation method of moisturizing cream for chest skin

Also Published As

Publication number Publication date
CN106619223B (en) 2019-11-29

Similar Documents

Publication Publication Date Title
CN111529417B (en) Repairing eye cream with blue light resisting effect and preparation method thereof
CN106619223B (en) A kind of natural anti-aging cosmetics and preparation method thereof
CN105534796B (en) A kind of antiallergy toner containing Folium Artemisiae Argyi extract and preparation method thereof
TW200812638A (en) Compositions comprising kakadu plum extract or acai berry extract
CN110279599B (en) Whitening composition, set containing whitening composition and preparation method of set
CN105168054A (en) Mask capable of supplementing water, whitening and removing wrinkles and preparation method of mask
CN107308057B (en) Nontoxic hair softening cream capable of softening and nourishing hair and preparation method thereof
CN105662899A (en) Skincare product having functions of repairing scar and resisting wrinkle and preparation method thereof
CN114376949B (en) Essence mask and preparation method and application thereof
CN103494719B (en) Preparation method of anti-aging cream
CN113576975A (en) Easily-absorbed anti-aging composition and preparation method and application thereof
CN110721148A (en) Multidirectional pulling and tightening polypeptide essence and preparation method thereof
CN114306165A (en) Moisturizing composition and preparation method thereof
CN113413355A (en) Eye cream with instant brightening and wrinkle reducing effects and preparation method thereof
CN109044941A (en) A kind of skin-tightening nourishes moisture-keeping composition and its preparation method and application
CN108354863A (en) A kind of Shu Min remediation compositions
CN113171309B (en) Whitening and moisturizing cosmetic composition containing phloretin as well as preparation and application thereof
CN110664643A (en) Polypeptide essence with multiple-effect whitening effect and preparation method thereof
CN110433123A (en) A kind of composite skin care product for having effects that repair
CN110559195A (en) Mask powder with whitening and anti-aging functions and preparation method thereof
CN110302128A (en) A kind of whitening antiallergic rich in natural product extraction ingredient is releived sleep mask and preparation method thereof
CN112516066B (en) Oil control composition and application thereof in cosmetics
CN104188859B (en) A kind of crease-resistant skin care emulsion containing natural component extract and preparation method thereof
CN107854358A (en) A kind of anti-apolexis composition and the skin care item containing said composition
CN109260086B (en) Anti-wrinkle essence, preparation method and application thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20190214

Address after: 150040 24 Heping Road, Xiangfang District, Harbin, Heilongjiang.

Applicant after: Heilongjiang University of Chinese Medicine

Address before: 154007 Guanghua Street, Qianjin District, Jiamusi, Heilongjiang 39

Applicant before: Li Lingxia

GR01 Patent grant
GR01 Patent grant