CN105031062A - Freckle removing medicinal liquid - Google Patents
Freckle removing medicinal liquid Download PDFInfo
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- CN105031062A CN105031062A CN201510534958.3A CN201510534958A CN105031062A CN 105031062 A CN105031062 A CN 105031062A CN 201510534958 A CN201510534958 A CN 201510534958A CN 105031062 A CN105031062 A CN 105031062A
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Abstract
The invention relates to a freckle removing medicinal liquid. The freckle removing medicinal liquid has the effects of dispelling wind, activating blood, nourishing blood, moistening dryness, removing stasis, removing freckles, restoring the skin pigment and the like. After the medicinal liquid is soaked into alcohol, all or most of useful components such as freckle removing components contained in the medicinal liquid are dissolved into the alcohol, and the original effects of all the components are kept, so that the freckle removing medicinal liquid is formed. After the face is wiped by using the medicinal liquid, dust on the face and metabolic wastes in pores are effectively removed by virtue of the drug efficacy, the medicinal liquid is permeated into the skin to destroy various pigment cells, inhibit the activities of tyrosine and tyrosinase, inhibit the formation of various pigment granules and change the structures of the pigment granules, and thus, toxins in the cells are removed, the microcirculation of a skin layer is smoothened, and skin pigment deposition is effectively prevented and relieved. The freckle removing medicinal liquid can be used for dissolving freckles, relieving freckles, slowly shortening and attenuating pores, whitening the skin color of the face and ensuring that the face becomes smooth and elastic, and finally, the freckles on the face are thoroughly removed. The medicinal liquid disclosed by the invention has no side effects and is remarkable in freckle removing effect, stable in effect and free of rebound.
Description
Technical field
The invention belongs to the Chinese medicine beauty and skin care field of speckle dispelling, particularly be a kind of speckle dispelling liquid medicine being raw material with pure plant.
Background technology
From the angle of the traditional Chinese medical science, speckle refers to the redness or purplish red, light red, black, sepia speckle sent out in skin surface, a little bigger then slabbing that is connected.Speckle many genus heat syndrome, excess syndrome, because the reason difference formed can be divided into freckle, chloasma, cyasma, black speck, senile plaque, sunburn, coffee speckle, tinea versicolor etc., some speckles are more and more serious with advancing age, even develop into whole face all, speckle not only has a strong impact on the attractive in appearance of people, and allows people feel oneself inferior, it is a kind of able-bodied dermatosis having a strong impact on people, but the improper speckle that can allow again of speckle dispelling increases the weight of, and even occur other side effect, therefore safe speckle dispelling is the unremitting pursue of liking beauty always.
The reason of the long speckle of skin is generally divided into endogenous cause of ill and exopathogenic factor, wherein,
Internal factor is:
1), pressure: when people is under pressure, will epinephrine being secreted, preparing for tackling pressure.If be under pressure for a long time, the balance of human metabolism will be destroyed, and the nutrition supply needed for skin is tending towards slow, and chromoplast will become very active.
2), hormone imbalance: estrogen estrogen contained in contraceptive, the secretion of Mai Laning cell can be stimulated and form uneven speckle, the speckle formed because of contraceptive, can stop although having no progeny in taking medicine, but still can stop a very long time on skin.Because of the estrogenic increase of estrogen in pregnancy, easily can there is speckle from conceived 4-5 month, the speckle at this time occurred puerperal major part can disappear., metabolism is abnormal, skin is exposed the reason such as to be under pressure under strong ultraviolet, mentally, and speckle all can be made to deepen.Have the stylish speckle grown, puerperal also can not disappear, so need more to note.
3), sluggish metabolism: also there will be speckle during the abnormal or hypo-ovaria of the metabolic function of liver.Because under metabolism has some setbacks or endocrine disturbance's health is in sensitiveness, make pigment problem aggravate.Constipation can form speckle, is exactly that endocrine disturbance causes allergic constitution to be formed in fact.Time condition is abnormal, ultraviolet irradiation also can accelerate the formation of speckle.
4), mistake make apply some make up: employ the cosmetics being not suitable for oneself skin, cause skin allergy, if excessive exposure is to ultraviolet in the process for the treatment of, skin can in order to resist extraneous infringement, there being the position of inflammation to assemble Mai Laning pigment, there will be Pigmented problem like this.
External factor is:
1), ultraviolet: when irradiation ultraviolet radiation, human body, in order to protect skin, can produce a lot of Mai Laning pigment at basal layer.So in order to protect skin can assemble more pigment at sensitive part.Often exposedly under strong sunlight, not only promote the aging of skin, also can cause the Pigmented dermatopathy such as black speck, freckle.
2), bad clean custom: because strong clean custom makes skin become responsive, understand oneself chafe like this.When skin sensitivity, human body is in order to protect skin, and melanocyte can secrete a lot of Mai Laning pigment, has just occurred the problem of the cutaneous pigmentation such as speckle, flaw when pigment is superfluous.
3), gene: have long speckle in father and mother, then the probability of my long speckle is just very high, and this situation just can judge to a certain extent is genetic effect.So family particularly elder have the people of long speckle, note avoiding the ultraviolet radiation causing one of speckle key factor.This is that pre-antiplaque must be noted that.
At present, the speckle dispelling product occurred on the market is varied, but seldom has and can reach radical cure and preventive effect.And chemical composition is more, side effect is large, and relapse rate is high.
Summary of the invention
The problem to be solved in the present invention is for above problem, provides a kind of speckle dispelling liquid medicine that a kind of cure rate is high, side effect is little, relapse rate is low.
For solving the problem, the technical solution adopted in the present invention is:
A kind of speckle dispelling liquid medicine, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, it is characterized in that:
The component of described principal agent and weight are:
Folium Isatidis 10-20 gram, Fructus Mume 10-20 gram, Flos Trollii 10-20 gram, Herba Lycopi 5-15 gram, Herba Leonuri 5-10 gram, Radix Salviae Miltiorrhizae 3-8 gram, purple rugose rose (Rosa rugosa var typica) 5-10 gram, Flos Chrysanthemi 3-8 gram, Spica Prunellae 5-15 gram, Magnolia denudata Desr. 3-8 gram, Serissa foetida 3-8 gram, Fructus Lycii 5-15 gram, Fructus Chaenomelis silk 5-10 gram, Radix Oenotherae erythrosepalae 5-10 gram, Cortex Dictamni 3-8 gram, Radix Clematidis 5-10 gram, Radix Isatidis 3-8 gram, Flos Carthami 5-10 gram;
The component of described accessory drugs and weight are:
Fructus Forsythiae 3-8 gram, Fructus Cannabis 3-8 gram, Bombyx Batryticatus 3-8 gram, Periostracum Cicadae 5-10 gram, Concha Margaritifera 3-8 gram, Semen Benincasae 5-10 gram, Fructus Gleditsia 3-8 gram, Bulbus Fritillariae Thunbergii 3-8 gram, Semen Lablab Album 3-8 gram.
As a kind of prioritization scheme:
The component of described principal agent and weight are:
Folium Isatidis 10 grams, Fructus Mume 10 grams, Flos Trollii 10 grams, Herba Lycopi 5 grams, Herba Leonuri 5 grams, Radix Salviae Miltiorrhizae 3 grams, purple rugose rose (Rosa rugosa var typica) 5 grams, Flos Chrysanthemi 3 grams, Spica Prunellae 5 grams, Magnolia denudata Desr. 3 grams, Serissa foetida 3 grams, Fructus Lycii 5-gram, Fructus Chaenomelis silk 5 grams, Radix Oenotherae erythrosepalae 5 grams, Cortex Dictamni 3 grams, Radix Clematidis 5 grams, Radix Isatidis 3 grams, 5 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 3 grams, Fructus Cannabis 3 grams, Bombyx Batryticatus 3 grams, Periostracum Cicadae 5 grams, Concha Margaritifera 3 grams, Semen Benincasae 5 grams, Fructus Gleditsia 3 grams, Bulbus Fritillariae Thunbergii 3 grams, Semen Lablab Album 3 grams.
As a kind of prioritization scheme:
The component of described principal agent and weight are:
Folium Isatidis 20 grams, Fructus Mume 20 grams, Flos Trollii 20 grams, Herba Lycopi 15 grams, Herba Leonuri 10 grams, Radix Salviae Miltiorrhizae 8 grams, purple rugose rose (Rosa rugosa var typica) 10 grams, Flos Chrysanthemi 8 grams, Spica Prunellae 15 grams, Magnolia denudata Desr. 8 grams, Serissa foetida 8 grams, Fructus Lycii 15 grams, Fructus Chaenomelis silk 10 grams, Radix Oenotherae erythrosepalae 10 grams, Cortex Dictamni 8 grams, Radix Clematidis 10 grams, Radix Isatidis 8 grams, 10 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 8 grams, Fructus Cannabis 8 grams, Bombyx Batryticatus 8 grams, Periostracum Cicadae 10 grams, Concha Margaritifera 8 grams, Semen Benincasae 10 grams, Fructus Gleditsia 8 grams, Bulbus Fritillariae Thunbergii 8 grams, Semen Lablab Album 8 grams.
As a kind of prioritization scheme:
The component of described principal agent and weight are:
Folium Isatidis 15 grams, Fructus Mume 15 grams, Flos Trollii 15 grams, Herba Lycopi 10 grams, Herba Leonuri 8 grams, Radix Salviae Miltiorrhizae 5 grams, purple rugose rose (Rosa rugosa var typica) 8 grams, Flos Chrysanthemi 6 grams, Spica Prunellae 10 grams, Magnolia denudata Desr. 5 grams, Serissa foetida 6 grams, Fructus Lycii 10 grams, Fructus Chaenomelis silk 8 grams, Radix Oenotherae erythrosepalae 7 grams, Cortex Dictamni 5 grams, Radix Clematidis 8 grams, Radix Isatidis 5 grams, 7 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 5 grams, Fructus Cannabis 5 grams, Bombyx Batryticatus 6 grams, Periostracum Cicadae 7 grams, Concha Margaritifera 5 grams, Semen Benincasae 7 grams, Fructus Gleditsia 6 grams, Bulbus Fritillariae Thunbergii 5 grams, Semen Lablab Album 6 grams.
As a kind of prioritization scheme:
The component of described principal agent and weight are:
Folium Isatidis 10 grams, Fructus Mume 10 grams, Flos Trollii 10 grams, Herba Lycopi 5 grams, Herba Leonuri 5 grams, Radix Salviae Miltiorrhizae 3 grams, purple rugose rose (Rosa rugosa var typica) 5 grams, Flos Chrysanthemi 3 grams, Spica Prunellae 5 grams, Magnolia denudata Desr. 3 grams, Serissa foetida 8 grams, Fructus Lycii 15 grams, Fructus Chaenomelis silk 10 grams, Radix Oenotherae erythrosepalae 10 grams, Cortex Dictamni 8 grams, Radix Clematidis 10 grams, Radix Isatidis 8 grams, 10 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 3 grams, Fructus Cannabis 3 grams, Bombyx Batryticatus 3 grams, Periostracum Cicadae 5 grams, Concha Margaritifera 3 grams, Semen Benincasae 10 grams, Fructus Gleditsia 8 grams, Bulbus Fritillariae Thunbergii 8 grams, Semen Lablab Album 8 grams.
As a kind of prioritization scheme:
The component of described principal agent and weight are:
Folium Isatidis 20 grams, Fructus Mume 20 grams, Flos Trollii 20 grams, Herba Lycopi 15 grams, Herba Leonuri 10 grams, Radix Salviae Miltiorrhizae 8 grams, purple rugose rose (Rosa rugosa var typica) 10 grams, Flos Chrysanthemi 8 grams, Spica Prunellae 15 grams, Magnolia denudata Desr. 8 grams, Serissa foetida 3 grams, Fructus Lycii 5 grams, Fructus Chaenomelis silk 5 grams, Radix Oenotherae erythrosepalae 5 grams, Cortex Dictamni 3 grams, Radix Clematidis 5 grams, Radix Isatidis 3 grams, 5 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 8 grams, Fructus Cannabis 8 grams, Bombyx Batryticatus 8 grams, Periostracum Cicadae 10 grams, Concha Margaritifera 8 grams, Semen Benincasae 5 grams, Fructus Gleditsia 3 grams, Bulbus Fritillariae Thunbergii 3 grams, Semen Lablab Album 3 grams.
As a kind of prioritization scheme:
The component of described principal agent and weight are:
Folium Isatidis 10 grams, Fructus Mume 10 grams, Flos Trollii 10 grams, Herba Lycopi 5 grams, Herba Leonuri 10 grams, Radix Salviae Miltiorrhizae 8 grams, purple rugose rose (Rosa rugosa var typica) 10 grams, Flos Chrysanthemi 8 grams, Spica Prunellae 5 grams, Magnolia denudata Desr. 3 grams, Serissa foetida 3 grams, Fructus Lycii 5 grams, Fructus Chaenomelis silk 10 grams, Radix Oenotherae erythrosepalae 10 grams, Cortex Dictamni 8 grams, Radix Clematidis 10 grams, Radix Isatidis 3 grams, 5 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 3 grams, Fructus Cannabis 3 grams, Bombyx Batryticatus 8 grams, Periostracum Cicadae 10 grams, Concha Margaritifera 3 grams, Semen Benincasae 5 grams, Fructus Gleditsia 8 grams, Bulbus Fritillariae Thunbergii 8 grams, Semen Lablab Album 3 grams.
Wherein: expelling wind and activating blood circulation, blood enriching and dryness moistening, eliminating stagnation are moved back speckle, recovered skin pigment
Folium Isatidis bitter in the mouth, cold in nature, return liver, the heart, stomach warp, the effect such as there is heat clearing away, removing toxic substances, removing heat from blood, hemostasis, blood stasis dispelling, moisturize.
Fructus Mume is about 4%-5.5% containing citric acid, malic acid, oxalic acid, succinic acid and Fumaric acid total acid content, more with first two organic acid content, also containing 5 hydroxymethyl 2 furaldehyde is colorless oil, and contained volatile ingredient mainly contains benzaldehyde, 4-terpinenol, benzyl alcohol.Fructus Mume sour in the mouth, property is put down, and return liver, spleen, lung, large intestine channel, Fructus Mume can stimulate the hormonal secretion of the parotid gland, and this hormone can pre-anti-aging.Fructus Mume can help to clean blood, makes blood flow amount normalization, gets rid of excessive acid element.
Flos Trollii has effect of heat-clearing and toxic substances removing, and human body can be helped to discharge vivotoxin, endocrine regulation imbalance effectively.
Herba Lycopi is containing volatile oil flavonoid glycoside, Saponin, phenols, saccharide and tannin.Bitter in the mouth, slightly warm in nature, returns liver, spleen channel.Have invigorate blood circulation, blood stasis dispelling, Hang Shui, eliminating stagnation, the effect such as detumescence.For the treatment of the symptoms such as menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis stomachache, edema.
Herba Leonuri and Herba Leonuri, bitter in the mouth, cold nature, GUIXIN, liver, urinary bladder channel, Herba Leonuri can remove silt tissue regeneration promoting, promoting blood flow to regulate menstruation, containing the various trace elements such as selenium, manganese, can antioxidation, anti-aging, there is pretty good beneficial face beauty treatment, anti-ageing anti-old effect.Herba Leonuri Herb clear water can be cleaned by tool expert research, drains away the water, chops up, dry, grind as powder.Squeeze the juice with a fresh cucumbers, in Sucus Cucumidis sativi, add Herba Leonuri powder and Mel appropriate, mixes well.Flush coat after washing one's face evening, washes away after drying.This method can remove speckle, skin care.
Radix Salviae Miltiorrhizae is emmenagogue, mildly bitter flavor, cold nature, GUIXIN warp, has blood stasis dispelling, tissue regeneration promoting, invigorates blood circulation, nourishes blood, clears away heart-fire, the effectiveness such as regulating menstruation, is gynecological's key medicine, cures mainly metrorrhagia, menoxenia, blood stasis, stomachache, dysmenorrhoea, amenorrhea, mausoleum pain.
Purple rugose rose (Rosa rugosa var typica) fragrance is sweet, the replenishing vital QI with drugs of warm nature popular feeling, can nurse one's health gloomy emotion, invigorate.In addition, it also has the effect of balancing hormones, contributes to the beauty of women with healthy.For women, except alleviating dysmenorrhoea, it enriches the natural pigment such as the source red pigment of gay colours, flavochrome and carotene, and the material that fatty oil, organic acid etc. are useful, has the effect of quite remarkable skin maintenance.
Spica Prunellae bitter in the mouth, warm in nature, return liver, gallbladder meridian, have dispel the wind, invigorate blood circulation, nourish blood, eliminating stagnation, Run Zao Eng effect.Nutrition is horn of plenty comparatively, containing compositions such as protein, fat, carbohydrate, carotene, vitamin B2, nicotinic acid and vitamin Cs.In addition, also containing Saponin, rutin, Spica Prunellae glycoside, hyperin and volatilization wet goods.
Magnolia denudata Desr. contains volatile oil, is wherein mainly citral, Flos Caryophylli oleic acid etc., also containing compositions such as magnoflorine, alkaloid, Magnolin, capric acid, rutin, oleic acid, vitamin A.Magnolia denudata Desr. acrid in the mouth, warm in nature, have dispel the wind, cold expelling, sensible, eliminating stagnation, recovery skin pigment effect.Modern pharmacology research shows, Magnolia denudata Desr. has inhibitory action to common skin fungus.
Serissa foetida acrid in the mouth, cool in nature, there is invigorating blood circulation, moisturize, nourish blood, eliminating stagnation, the effect such as to dispel the wind.
Fructus Lycii: the human trial display of fructus lycii extracted solution can obviously suppress Serum LPO to generate, and GSH-PX vigor in blood is increased and therefore has delaying senility function.It is a seed amino acid in collagen fiber and protein that Fructus Lycii is rich in hydroxyproline, is proline hydroxylation.Human body, in aging course, because oxygen is under-supply, affects the dihydroxylation process of proline, thus causes hydroxyproline content in the collagen of old people low.
Fructus Chaenomelis silk sour in the mouth, warm in nature, return liver, spleen channel, have effect of moistening skin beautifying, Fructus Chaenomelis is warm in nature cold not dry, the nutrition of absorption of human body can be made more abundant, allow skin become bright and clean tender, reduce wrinkle more ruddy by complexion.
The composition gamma-Linolenic acids such as Radix Oenotherae erythrosepalae is plain, sad containing lauric acid, myristic acid, Palmic acid, stearic acid, Semen arachidis hypogaeae, oleic acid, linoleic acid, gamma-Linolenic acid are the necessary higher unsaturated fatty acids of human body, contain volatile oil and ter penoids in spending.Be rich in leaf and stem vitamin C, multiple flavonoid glycoside alkaloid and 1% ~ 17% tannin, in anti-ageing waiting for a long time, have medical, medical value widely, directly smear Radix Oenotherae erythrosepalae soak after liquid medicine can allow skin smooth and more have vigor.
Cortex Dictamni bitter in the mouth, cold in nature, return spleen, lung, small intestine meridian, there is heat clearing away, dispel the wind, eliminating stagnation, moisturize, recover the effects such as skin pigment.
Radix Clematidis salty in the mouth, warm in nature, attach to the lung and stomach meridians, have dispel the wind, invigorate blood circulation, nourish blood, moisturize, eliminating stagnation, speckle dispelling, the effect such as recovery skin pigment.Water logging agent has inhibitory action to dermatophytes.
Radix Isatidis bitter in the mouth, cold in nature, return liver, stomach warp, there is eliminating stagnation, dispel the wind, invigorate blood circulation, nourish blood, the effect such as speckle dispelling.
Flos Carthami can promoting blood circulation to restore menstrual flow, scattered silt pain relieving, and the liquid medicine obtained after alcohol-pickled Flos Carthami directly spreads upon skin that skin can moisten, anti-aging, skin-protecting face nursing.
Fructus Forsythiae bitter in the mouth, cool in nature, GUIXIN, liver, gallbladder meridian, have eliminating stagnation, dispel the wind, invigorate blood circulation, nourish blood, detoxify, the effect such as speckle dispelling.
Fructus Cannabis sweet in the mouth, property is put down, and returns spleen, stomach, large intestine channel, have moisturize, invigorate blood circulation, nourish blood, the effect such as eliminating stagnation, speckle dispelling.
Bombyx Batryticatus contains aminoacid and active mercerising element, nutritious skin and beautification function.Protein contained by Bombyx Batryticatus has stimulates epithelium adipose gland, the effect of modulability hormone secretion, thus has certain curative effect to the female sex hormone secretion chloasma caused of lacking of proper care.Bombyx Batryticatus contains vitamin E 9.89%, energy scavenging free radicals, the senile plaque that lipid peroxidation inhibition is formed.Active mercerising element contained by it can impel Skin Cell newborn, regulates sebum, improves skin microcirculation, can brighten sun-proof, eliminates pigmentation, keeps skin elasticity.
Periostracum Cicadae sweet in the mouth, cold in nature, return lung, Liver Channel, have and dispel the wind, eliminating stagnation, invigorate blood circulation, nourish blood, the effect such as to moisturize.
Concha Margaritifera salty in the mouth, cold in nature, return liver, heart channel, have dispel the wind, eliminating stagnation, skin protection, invigorate blood circulation, the effect such as nourish blood.
Containing Saponin 0.68%, fat, carbamide, citrulline etc. in Semen Benincasae.Containing linoleic acid 62.3% in the fatty oil of seed, oleic acid 21.9%, satisfied fatty acid 15.6%, isolates a small amount of adenine, trigonelline etc. in seed, and with can moistening the lung and resolving phlegm in these chemical compositions, external then has the effect of colour killing speckle, moist skin.
Fructus Gleditsia includes flavonoid glycoside, phenols, the compositions such as aminoacid, and external can dispel superabundant fats, unobstructed obstruction hair follicle, makes skin recover gloss and elasticity.
Ethanol can prevent antibacterial from multiplying, and each component can be kept for a long time effective, can anti-inflammation and sterilization when wiping face, is convenient to the cleaning to dirt in face and pore.
Component described in the present invention, principal agent is many containing speckle dispelling, the Cosmetic Ingredient such as pigment of dispelling, and is the monarch drug in described Chinese medicine; Accessory drugs is many containing improving the composition such as hypodermic blood circulation, refinement pore, is the ministerial drug in described Chinese medicine.No matter be principal agent or accessory drugs, all have and dispel the wind, invigorate blood circulation, nourish blood, moisturize, eliminating stagnation, move back speckle, recover the effects such as skin pigment.After alcohol-pickled, the useful components such as the speckle dispelling himself contained all can whole or large portion be dissolved in ethanol, and each composition keeps original effect, form speckle dispelling liquid medicine.After liquid medicine wiping face, metabolic waste in the dust of face and pore is effectively got rid of by the efficacy of a drug, liquid medicine infiltrates in skin, by destroying each pigment cell, suppress the activity of tyrosine and tryrosinase, suppress the formation of each pigment granule and change its structure, thus get rid of skin endotoxin, the microcirculation of happy skin layer, effectively prevents and improves the pigmentation of skin.Dissolve mottle, speckle desalinated, pore slowly diminishes, attenuate, and blee is bleached, become smooth flexible, the facial speckle of final thoroughly removal.
Liquid medicine of the present invention is free from side effects, and speckle dispelling is obvious, effect stability, without bounce-back.
Manufacture method of the present invention:
All components in principal agent except ethanol and accessory drugs component are on the waiting list by weight, clean, are dried; Get concentration be 50% ethanol 500 milliliters put into container; Principal agent composition after drying put into the container sealing of band ethanol, soak 7 days; Then adjuvant is processed into fine powder, loads in cloth bag, seal cloth bag mouth, put into the container of band ethanol in the lump, continue sealing, soak 75 days, obtain speckle dispelling liquid medicine, liquid medicine is taken out bottling.
Above-mentioned preparation method is in making speckle dispelling liquid medicine process, and make and simply, do not need special equipment and equipment, preparation cost is low, and easy to operate, and it is comparatively easy to prepare.
Using method: before sleep every day, after cleaning face, speckle dispelling liquid medicine is applied to affected part, cleans up after 20 minutes, a month sky is a course for the treatment of.
For investigating clinical efficacy and the safety of speckle dispelling liquid medicine of the present invention further, we have selected the treatment curative effect of 140 routine patients to medicine of the present invention and carry out clinical trial.
Select case:
The routine patient of clinical observation 140, is divided into treatment group and matched group at random, matched group 70 example, and at 18 ~ 55 years old age, 24 years old mean age, the course of disease is the shortest 1 year, the longest 25 years; Treatment group 70 example, at 20 ~ 58 years old age, 26 years old mean age, the course of disease is the shortest 1 year, the longest 30 years.
Therapeutic Method:
Matched group uses spot removal and skin care product on the market; Treatment group uses speckle dispelling liquid medicine of the present invention.
Criterion of therapeutical effect:
Clinical cure: facial speckle disappears, and the colour of skin bleaches, and becomes smooth flexible;
Effective: speckle is obviously thin out, and the colour of skin bleaches, become smooth flexible;
Effective: speckle is thin out, the colour of skin bleaches;
Invalid: speckle is without minimizing, and blee is not any change.
Curative effect comparision result after two groups of case treatments is as table.
Table
By above-mentioned contrast, can find out that Chinese medicine preparation therapeutic effect of the present invention is remarkable, cure rate is high, is free from side effects, and speckle dispelling is obvious, without bounce-back.
Detailed description of the invention
Embodiment 1: a kind of speckle dispelling liquid medicine, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, and the component of described principal agent and weight are: Folium Isatidis 10 grams, Fructus Mume 10 grams, Flos Trollii 10 grams, Herba Lycopi 5 grams, Herba Leonuri 5 grams, Radix Salviae Miltiorrhizae 3 grams, purple rugose rose (Rosa rugosa var typica) 5 grams, Flos Chrysanthemi 3 grams, Spica Prunellae 5 grams, Magnolia denudata Desr. 3 grams, Serissa foetida 3 grams, Fructus Lycii 5-gram, Fructus Chaenomelis silk 5 grams, Radix Oenotherae erythrosepalae 5 grams, Cortex Dictamni 3 grams, Radix Clematidis 5 grams, Radix Isatidis 3 grams, 5 grams, Flos Carthami;
The component of described accessory drugs and weight are: Fructus Forsythiae 3 grams, Fructus Cannabis 3 grams, Bombyx Batryticatus 3 grams, Periostracum Cicadae 5 grams, Concha Margaritifera 3 grams, Semen Benincasae 5 grams, Fructus Gleditsia 3 grams, Bulbus Fritillariae Thunbergii 3 grams, Semen Lablab Album 3 grams.
All components in principal agent except ethanol and accessory drugs component are on the waiting list by weight, clean, are dried; Get concentration be 50% ethanol 500 milliliters put into container; Principal agent composition after drying put into the container sealing of band ethanol, soak 7 days; Then adjuvant is processed into fine powder, loads in cloth bag, seal cloth bag mouth, put into the container of band ethanol in the lump, continue sealing, soak 75 days, obtain speckle dispelling liquid medicine, liquid medicine is taken out bottling.Before sleep every day, after cleaning face, speckle dispelling liquid medicine is applied to affected part, cleans up after 20 minutes, a month sky is a course for the treatment of.
Embodiment 2: a kind of speckle dispelling liquid medicine, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, and the component of described principal agent and weight are: Folium Isatidis 20 grams, Fructus Mume 20 grams, Flos Trollii 20 grams, Herba Lycopi 15 grams, Herba Leonuri 10 grams, Radix Salviae Miltiorrhizae 8 grams, purple rugose rose (Rosa rugosa var typica) 10 grams, Flos Chrysanthemi 8 grams, Spica Prunellae 15 grams, Magnolia denudata Desr. 8 grams, Serissa foetida 8 grams, Fructus Lycii 15 grams, Fructus Chaenomelis silk 10 grams, Radix Oenotherae erythrosepalae 10 grams, Cortex Dictamni 8 grams, Radix Clematidis 10 grams, Radix Isatidis 8 grams, 10 grams, Flos Carthami;
The component of described accessory drugs and weight are: Fructus Forsythiae 8 grams, Fructus Cannabis 8 grams, Bombyx Batryticatus 8 grams, Periostracum Cicadae 10 grams, Concha Margaritifera 8 grams, Semen Benincasae 10 grams, Fructus Gleditsia 8 grams, Bulbus Fritillariae Thunbergii 8 grams, Semen Lablab Album 8 grams.
All components in principal agent except ethanol and accessory drugs component are on the waiting list by weight, clean, are dried; Get concentration be 50% ethanol 500 milliliters put into container; Principal agent composition after drying put into the container sealing of band ethanol, soak 7 days; Then adjuvant is processed into fine powder, loads in cloth bag, seal cloth bag mouth, put into the container of band ethanol in the lump, continue sealing, soak 75 days, obtain speckle dispelling liquid medicine, liquid medicine is taken out bottling.Before sleep every day, after cleaning face, speckle dispelling liquid medicine is applied to affected part, cleans up after 20 minutes, a month sky is a course for the treatment of.
Embodiment 3: a kind of speckle dispelling liquid medicine, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, and the component of described principal agent and weight are: Folium Isatidis 15 grams, Fructus Mume 15 grams, Flos Trollii 15 grams, Herba Lycopi 10 grams, Herba Leonuri 8 grams, Radix Salviae Miltiorrhizae 5 grams, purple rugose rose (Rosa rugosa var typica) 8 grams, Flos Chrysanthemi 6 grams, Spica Prunellae 10 grams, Magnolia denudata Desr. 5 grams, Serissa foetida 6 grams, Fructus Lycii 10 grams, Fructus Chaenomelis silk 8 grams, Radix Oenotherae erythrosepalae 7 grams, Cortex Dictamni 5 grams, Radix Clematidis 8 grams, Radix Isatidis 5 grams, 7 grams, Flos Carthami;
The component of described accessory drugs and weight are: Fructus Forsythiae 5 grams, Fructus Cannabis 5 grams, Bombyx Batryticatus 6 grams, Periostracum Cicadae 7 grams, Concha Margaritifera 5 grams, Semen Benincasae 7 grams, Fructus Gleditsia 6 grams, Bulbus Fritillariae Thunbergii 5 grams, Semen Lablab Album 6 grams.
All components in principal agent except ethanol and accessory drugs component are on the waiting list by weight, clean, are dried; Get concentration be 50% ethanol 500 milliliters put into container; Principal agent composition after drying put into the container sealing of band ethanol, soak 7 days; Then adjuvant is processed into fine powder, loads in cloth bag, seal cloth bag mouth, put into the container of band ethanol in the lump, continue sealing, soak 75 days, obtain speckle dispelling liquid medicine, liquid medicine is taken out bottling.Before sleep every day, after cleaning face, speckle dispelling liquid medicine is applied to affected part, cleans up after 20 minutes, a month sky is a course for the treatment of.
Embodiment 4: a kind of speckle dispelling liquid medicine, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, and the component of described principal agent and weight are: Folium Isatidis 10 grams, Fructus Mume 10 grams, Flos Trollii 10 grams, Herba Lycopi 5 grams, Herba Leonuri 5 grams, Radix Salviae Miltiorrhizae 3 grams, purple rugose rose (Rosa rugosa var typica) 5 grams, Flos Chrysanthemi 3 grams, Spica Prunellae 5 grams, Magnolia denudata Desr. 3 grams, Serissa foetida 8 grams, Fructus Lycii 15 grams, Fructus Chaenomelis silk 10 grams, Radix Oenotherae erythrosepalae 10 grams, Cortex Dictamni 8 grams, Radix Clematidis 10 grams, Radix Isatidis 8 grams, 10 grams, Flos Carthami;
The component of described accessory drugs and weight are: Fructus Forsythiae 3 grams, Fructus Cannabis 3 grams, Bombyx Batryticatus 3 grams, Periostracum Cicadae 5 grams, Concha Margaritifera 3 grams, Semen Benincasae 10 grams, Fructus Gleditsia 8 grams, Bulbus Fritillariae Thunbergii 8 grams, Semen Lablab Album 8 grams.
All components in principal agent except ethanol and accessory drugs component are on the waiting list by weight, clean, are dried; Get concentration be 50% ethanol 500 milliliters put into container; Principal agent composition after drying put into the container sealing of band ethanol, soak 7 days; Then adjuvant is processed into fine powder, loads in cloth bag, seal cloth bag mouth, put into the container of band ethanol in the lump, continue sealing, soak 75 days, obtain speckle dispelling liquid medicine, liquid medicine is taken out bottling.Before sleep every day, after cleaning face, speckle dispelling liquid medicine is applied to affected part, cleans up after 20 minutes, a month sky is a course for the treatment of.
Embodiment 5: a kind of speckle dispelling liquid medicine, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, and the component of described principal agent and weight are: Folium Isatidis 20 grams, Fructus Mume 20 grams, Flos Trollii 20 grams, Herba Lycopi 15 grams, Herba Leonuri 10 grams, Radix Salviae Miltiorrhizae 8 grams, purple rugose rose (Rosa rugosa var typica) 10 grams, Flos Chrysanthemi 8 grams, Spica Prunellae 15 grams, Magnolia denudata Desr. 8 grams, Serissa foetida 3 grams, Fructus Lycii 5 grams, Fructus Chaenomelis silk 5 grams, Radix Oenotherae erythrosepalae 5 grams, Cortex Dictamni 3 grams, Radix Clematidis 5 grams, Radix Isatidis 3 grams, 5 grams, Flos Carthami;
The component of described accessory drugs and weight are: Fructus Forsythiae 8 grams, Fructus Cannabis 8 grams, Bombyx Batryticatus 8 grams, Periostracum Cicadae 10 grams, Concha Margaritifera 8 grams, Semen Benincasae 5 grams, Fructus Gleditsia 3 grams, Bulbus Fritillariae Thunbergii 3 grams, Semen Lablab Album 3 grams.
All components in principal agent except ethanol and accessory drugs component are on the waiting list by weight, clean, are dried; Get concentration be 50% ethanol 500 milliliters put into container; Principal agent composition after drying put into the container sealing of band ethanol, soak 7 days; Then adjuvant is processed into fine powder, loads in cloth bag, seal cloth bag mouth, put into the container of band ethanol in the lump, continue sealing, soak 75 days, obtain speckle dispelling liquid medicine, liquid medicine is taken out bottling.Before sleep every day, after cleaning face, speckle dispelling liquid medicine is applied to affected part, cleans up after 20 minutes, a month sky is a course for the treatment of.
Embodiment 6: a kind of speckle dispelling liquid medicine, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, and the component of described principal agent and weight are: Folium Isatidis 10 grams, Fructus Mume 10 grams, Flos Trollii 10 grams, Herba Lycopi 5 grams, Herba Leonuri 10 grams, Radix Salviae Miltiorrhizae 8 grams, purple rugose rose (Rosa rugosa var typica) 10 grams, Flos Chrysanthemi 8 grams, Spica Prunellae 5 grams, Magnolia denudata Desr. 3 grams, Serissa foetida 3 grams, Fructus Lycii 5 grams, Fructus Chaenomelis silk 10 grams, Radix Oenotherae erythrosepalae 10 grams, Cortex Dictamni 8 grams, Radix Clematidis 10 grams, Radix Isatidis 3 grams, 5 grams, Flos Carthami;
The component of described accessory drugs and weight are: Fructus Forsythiae 3 grams, Fructus Cannabis 3 grams, Bombyx Batryticatus 8 grams, Periostracum Cicadae 10 grams, Concha Margaritifera 3 grams, Semen Benincasae 5 grams, Fructus Gleditsia 8 grams, Bulbus Fritillariae Thunbergii 8 grams, Semen Lablab Album 3 grams.
All components in principal agent except ethanol and accessory drugs component are on the waiting list by weight, clean, are dried; Get concentration be 50% ethanol 500 milliliters put into container; Principal agent composition after drying put into the container sealing of band ethanol, soak 7 days; Then adjuvant is processed into fine powder, loads in cloth bag, seal cloth bag mouth, put into the container of band ethanol in the lump, continue sealing, soak 75 days, obtain speckle dispelling liquid medicine, liquid medicine is taken out bottling.Before sleep every day, after cleaning face, speckle dispelling liquid medicine is applied to affected part, cleans up after 20 minutes, a month sky is a course for the treatment of.
Some patients healing case is as follows:
Marquis XX, female, 38 years old, face was covered with chloasma, and face jaundice obfuscation, skin is matt, and after diagnosing, its chloasma faciei is that the liver stasis of blood causes, and after the sun shines, color became brown purple, and puerperal is even more serious.After using a course for the treatment of of speckle dispelling liquid medicine of the present invention, chloasma lighter, after four courses for the treatment of, chloasma disappears, and pore attenuates, and skin smooth is moistened, and cures after 1 year and follows up a case by regular visits to without rebounding.
Discipline XX, female, 28 years old, there was cyasma in patient face, and area is comparatively large, be a bit darkish in color, skin jaundice, and after diagnosing, the speckle of patient facial region is because of caused by its miscarriage, blood stasis and menoxenia.Use speckle dispelling liquid medicine of the present invention after 15 days spot colors shoal, after continuously using four courses for the treatment of, facial cyasma all disappears, and does not rebound so far.
Lee XX, female, 46 years old, the discontented heritability freckle of face, with excessively many spot removal and skin care products, without any effect, use speckle dispelling liquid medicine of the present invention after one month, freckle color is thin out, blee is smooth, and after continuing three courses for the treatment of of use, speckle dispelling disappears, skin is moistened smooth flexible, does not rebound after healing.
Claims (7)
1. a speckle dispelling liquid medicine, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, it is characterized in that:
The component of described principal agent and weight are:
Folium Isatidis 10-20 gram, Fructus Mume 10-20 gram, Flos Trollii 10-20 gram, Herba Lycopi 5-15 gram, Herba Leonuri 5-10 gram, Radix Salviae Miltiorrhizae 3-8 gram, purple rugose rose (Rosa rugosa var typica) 5-10 gram, Flos Chrysanthemi 3-8 gram, Spica Prunellae 5-15 gram, Magnolia denudata Desr. 3-8 gram, Serissa foetida 3-8 gram, Fructus Lycii 5-15 gram, Fructus Chaenomelis silk 5-10 gram, Radix Oenotherae erythrosepalae 5-10 gram, Cortex Dictamni 3-8 gram, Radix Clematidis 5-10 gram, Radix Isatidis 3-8 gram, Flos Carthami 5-10 gram;
The component of described accessory drugs and weight are:
Fructus Forsythiae 3-8 gram, Fructus Cannabis 3-8 gram, Bombyx Batryticatus 3-8 gram, Periostracum Cicadae 5-10 gram, Concha Margaritifera 3-8 gram, Semen Benincasae 5-10 gram, Fructus Gleditsia 3-8 gram, Bulbus Fritillariae Thunbergii 3-8 gram, Semen Lablab Album 3-8 gram.
2. a kind of speckle dispelling liquid medicine according to claim 1, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, it is characterized in that:
The component of described principal agent and weight are:
Folium Isatidis 10 grams, Fructus Mume 10 grams, Flos Trollii 10 grams, Herba Lycopi 5 grams, Herba Leonuri 5 grams, Radix Salviae Miltiorrhizae 3 grams, purple rugose rose (Rosa rugosa var typica) 5 grams, Flos Chrysanthemi 3 grams, Spica Prunellae 5 grams, Magnolia denudata Desr. 3 grams, Serissa foetida 3 grams, Fructus Lycii 5-gram, Fructus Chaenomelis silk 5 grams, Radix Oenotherae erythrosepalae 5 grams, Cortex Dictamni 3 grams, Radix Clematidis 5 grams, Radix Isatidis 3 grams, 5 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 3 grams, Fructus Cannabis 3 grams, Bombyx Batryticatus 3 grams, Periostracum Cicadae 5 grams, Concha Margaritifera 3 grams, Semen Benincasae 5 grams, Fructus Gleditsia 3 grams, Bulbus Fritillariae Thunbergii 3 grams, Semen Lablab Album 3 grams.
3. a kind of speckle dispelling liquid medicine according to claim 1, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, it is characterized in that:
The component of described principal agent and weight are:
Folium Isatidis 20 grams, Fructus Mume 20 grams, Flos Trollii 20 grams, Herba Lycopi 15 grams, Herba Leonuri 10 grams, Radix Salviae Miltiorrhizae 8 grams, purple rugose rose (Rosa rugosa var typica) 10 grams, Flos Chrysanthemi 8 grams, Spica Prunellae 15 grams, Magnolia denudata Desr. 8 grams, Serissa foetida 8 grams, Fructus Lycii 15 grams, Fructus Chaenomelis silk 10 grams, Radix Oenotherae erythrosepalae 10 grams, Cortex Dictamni 8 grams, Radix Clematidis 10 grams, Radix Isatidis 8 grams, 10 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 8 grams, Fructus Cannabis 8 grams, Bombyx Batryticatus 8 grams, Periostracum Cicadae 10 grams, Concha Margaritifera 8 grams, Semen Benincasae 10 grams, Fructus Gleditsia 8 grams, Bulbus Fritillariae Thunbergii 8 grams, Semen Lablab Album 8 grams.
4. a kind of speckle dispelling liquid medicine according to claim 1, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, it is characterized in that:
The component of described principal agent and weight are:
Folium Isatidis 15 grams, Fructus Mume 15 grams, Flos Trollii 15 grams, Herba Lycopi 10 grams, Herba Leonuri 8 grams, Radix Salviae Miltiorrhizae 5 grams, purple rugose rose (Rosa rugosa var typica) 8 grams, Flos Chrysanthemi 6 grams, Spica Prunellae 10 grams, Magnolia denudata Desr. 5 grams, Serissa foetida 6 grams, Fructus Lycii 10 grams, Fructus Chaenomelis silk 8 grams, Radix Oenotherae erythrosepalae 7 grams, Cortex Dictamni 5 grams, Radix Clematidis 8 grams, Radix Isatidis 5 grams, 7 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 5 grams, Fructus Cannabis 5 grams, Bombyx Batryticatus 6 grams, Periostracum Cicadae 7 grams, Concha Margaritifera 5 grams, Semen Benincasae 7 grams, Fructus Gleditsia 6 grams, Bulbus Fritillariae Thunbergii 5 grams, Semen Lablab Album 6 grams.
5. a kind of speckle dispelling liquid medicine according to claim 1, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, it is characterized in that:
The component of described principal agent and weight are:
Folium Isatidis 10 grams, Fructus Mume 10 grams, Flos Trollii 10 grams, Herba Lycopi 5 grams, Herba Leonuri 5 grams, Radix Salviae Miltiorrhizae 3 grams, purple rugose rose (Rosa rugosa var typica) 5 grams, Flos Chrysanthemi 3 grams, Spica Prunellae 5 grams, Magnolia denudata Desr. 3 grams, Serissa foetida 8 grams, Fructus Lycii 15 grams, Fructus Chaenomelis silk 10 grams, Radix Oenotherae erythrosepalae 10 grams, Cortex Dictamni 8 grams, Radix Clematidis 10 grams, Radix Isatidis 8 grams, 10 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 3 grams, Fructus Cannabis 3 grams, Bombyx Batryticatus 3 grams, Periostracum Cicadae 5 grams, Concha Margaritifera 3 grams, Semen Benincasae 10 grams, Fructus Gleditsia 8 grams, Bulbus Fritillariae Thunbergii 8 grams, Semen Lablab Album 8 grams.
6. a kind of speckle dispelling liquid medicine according to claim 1, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, it is characterized in that:
The component of described principal agent and weight are:
Folium Isatidis 20 grams, Fructus Mume 20 grams, Flos Trollii 20 grams, Herba Lycopi 15 grams, Herba Leonuri 10 grams, Radix Salviae Miltiorrhizae 8 grams, purple rugose rose (Rosa rugosa var typica) 10 grams, Flos Chrysanthemi 8 grams, Spica Prunellae 15 grams, Magnolia denudata Desr. 8 grams, Serissa foetida 3 grams, Fructus Lycii 5 grams, Fructus Chaenomelis silk 5 grams, Radix Oenotherae erythrosepalae 5 grams, Cortex Dictamni 3 grams, Radix Clematidis 5 grams, Radix Isatidis 3 grams, 5 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 8 grams, Fructus Cannabis 8 grams, Bombyx Batryticatus 8 grams, Periostracum Cicadae 10 grams, Concha Margaritifera 8 grams, Semen Benincasae 5 grams, Fructus Gleditsia 3 grams, Bulbus Fritillariae Thunbergii 3 grams, Semen Lablab Album 3 grams.
7. a kind of speckle dispelling liquid medicine according to claim 1, this liquid medicine comprises the ethanol 500 milliliters that principal agent, accessory drugs and concentration are 50%, it is characterized in that:
The component of described principal agent and weight are:
Folium Isatidis 10 grams, Fructus Mume 10 grams, Flos Trollii 10 grams, Herba Lycopi 5 grams, Herba Leonuri 10 grams, Radix Salviae Miltiorrhizae 8 grams, purple rugose rose (Rosa rugosa var typica) 10 grams, Flos Chrysanthemi 8 grams, Spica Prunellae 5 grams, Magnolia denudata Desr. 3 grams, Serissa foetida 3 grams, Fructus Lycii 5 grams, Fructus Chaenomelis silk 10 grams, Radix Oenotherae erythrosepalae 10 grams, Cortex Dictamni 8 grams, Radix Clematidis 10 grams, Radix Isatidis 3 grams, 5 grams, Flos Carthami;
The component of described accessory drugs and weight are:
Fructus Forsythiae 3 grams, Fructus Cannabis 3 grams, Bombyx Batryticatus 8 grams, Periostracum Cicadae 10 grams, Concha Margaritifera 3 grams, Semen Benincasae 5 grams, Fructus Gleditsia 8 grams, Bulbus Fritillariae Thunbergii 8 grams, Semen Lablab Album 3 grams.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210736A (en) * | 2018-01-26 | 2018-06-29 | 孙显林 | A kind of preparation method of Chinese medicine glue of smoothing wrinkle dispelling speckles and whitening face and combinations thereof |
| CN109106776A (en) * | 2018-09-28 | 2019-01-01 | 福建农林大学 | A kind of compound spot-eliminating ointment and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940807A (en) * | 2012-11-23 | 2013-02-27 | 李会美 | Freckle-removing liquid medicine and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940807A (en) * | 2012-11-23 | 2013-02-27 | 李会美 | Freckle-removing liquid medicine and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210736A (en) * | 2018-01-26 | 2018-06-29 | 孙显林 | A kind of preparation method of Chinese medicine glue of smoothing wrinkle dispelling speckles and whitening face and combinations thereof |
| CN109106776A (en) * | 2018-09-28 | 2019-01-01 | 福建农林大学 | A kind of compound spot-eliminating ointment and preparation method thereof |
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Application publication date: 20151111 |