CN101217870A - 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 - Google Patents
含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 Download PDFInfo
- Publication number
- CN101217870A CN101217870A CNA2004800205345A CN200480020534A CN101217870A CN 101217870 A CN101217870 A CN 101217870A CN A2004800205345 A CNA2004800205345 A CN A2004800205345A CN 200480020534 A CN200480020534 A CN 200480020534A CN 101217870 A CN101217870 A CN 101217870A
- Authority
- CN
- China
- Prior art keywords
- oil
- zinc
- composition
- concentration
- farnesol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 114
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 49
- 239000000341 volatile oil Substances 0.000 title claims abstract description 44
- 150000003856 quaternary ammonium compounds Chemical class 0.000 title claims abstract description 28
- 239000000470 constituent Substances 0.000 title abstract 3
- 239000011885 synergistic combination Substances 0.000 title description 3
- 230000002195 synergetic effect Effects 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 87
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims description 73
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims description 73
- 229940043259 farnesol Drugs 0.000 claims description 73
- 229930002886 farnesol Natural products 0.000 claims description 73
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims description 73
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 53
- 229960001950 benzethonium chloride Drugs 0.000 claims description 49
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 43
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 41
- -1 ZnG Chemical compound 0.000 claims description 40
- 239000003921 oil Substances 0.000 claims description 38
- 235000019198 oils Nutrition 0.000 claims description 38
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 36
- 229960003260 chlorhexidine Drugs 0.000 claims description 36
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 31
- 239000011576 zinc lactate Substances 0.000 claims description 31
- 229940050168 zinc lactate Drugs 0.000 claims description 31
- 235000000193 zinc lactate Nutrition 0.000 claims description 31
- 239000000463 material Substances 0.000 claims description 30
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 29
- 239000004246 zinc acetate Substances 0.000 claims description 29
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims description 25
- 229920002413 Polyhexanide Polymers 0.000 claims description 25
- 150000003751 zinc Chemical class 0.000 claims description 24
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 22
- 239000011701 zinc Substances 0.000 claims description 22
- 229910052725 zinc Inorganic materials 0.000 claims description 21
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 18
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims description 18
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- 229940101267 panthenol Drugs 0.000 claims description 13
- 235000020957 pantothenol Nutrition 0.000 claims description 13
- 239000011619 pantothenol Substances 0.000 claims description 13
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 12
- 239000010671 sandalwood oil Substances 0.000 claims description 12
- 235000019501 Lemon oil Nutrition 0.000 claims description 11
- 239000010501 lemon oil Substances 0.000 claims description 11
- 239000011787 zinc oxide Substances 0.000 claims description 11
- 229940123208 Biguanide Drugs 0.000 claims description 10
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims description 10
- 235000019502 Orange oil Nutrition 0.000 claims description 10
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 10
- 239000010502 orange oil Substances 0.000 claims description 10
- 235000019477 peppermint oil Nutrition 0.000 claims description 10
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims description 9
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims description 9
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 claims description 9
- 229940043350 citral Drugs 0.000 claims description 9
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 claims description 9
- 229930007744 linalool Natural products 0.000 claims description 9
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 8
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 8
- 239000000174 gluconic acid Substances 0.000 claims description 8
- 235000012208 gluconic acid Nutrition 0.000 claims description 8
- 239000003974 emollient agent Substances 0.000 claims description 7
- 239000001738 pogostemon cablin oil Substances 0.000 claims description 7
- 239000002562 thickening agent Substances 0.000 claims description 7
- ORMHZBNNECIKOH-UHFFFAOYSA-N 4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde Chemical compound CC(C)(O)CCCC1=CCC(C=O)CC1 ORMHZBNNECIKOH-UHFFFAOYSA-N 0.000 claims description 6
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 6
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 6
- 239000005770 Eugenol Substances 0.000 claims description 6
- 244000194101 Ginkgo biloba Species 0.000 claims description 6
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 6
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 claims description 6
- 229960005233 cineole Drugs 0.000 claims description 6
- 239000001941 cymbopogon citratus dc and cymbopogon flexuosus oil Substances 0.000 claims description 6
- 239000010642 eucalyptus oil Substances 0.000 claims description 6
- 229940044949 eucalyptus oil Drugs 0.000 claims description 6
- 229960002217 eugenol Drugs 0.000 claims description 6
- 230000000638 stimulation Effects 0.000 claims description 6
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 6
- 239000011746 zinc citrate Substances 0.000 claims description 6
- 235000006076 zinc citrate Nutrition 0.000 claims description 6
- 229940068475 zinc citrate Drugs 0.000 claims description 6
- VGTSYTYRRZZILH-UHFFFAOYSA-N 2,3-dihydroxypropanoic acid;zinc Chemical compound [Zn].OCC(O)C(O)=O VGTSYTYRRZZILH-UHFFFAOYSA-N 0.000 claims description 5
- 241000675108 Citrus tangerina Species 0.000 claims description 5
- 241000350000 Colophospermum mopane Species 0.000 claims description 5
- 239000005792 Geraniol Substances 0.000 claims description 5
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims description 5
- 235000011201 Ginkgo Nutrition 0.000 claims description 5
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 5
- BJIOGJUNALELMI-ONEGZZNKSA-N Isoeugenol Natural products COC1=CC(\C=C\C)=CC=C1O BJIOGJUNALELMI-ONEGZZNKSA-N 0.000 claims description 5
- HMKKIXGYKWDQSV-KAMYIIQDSA-N alpha-Amylcinnamaldehyde Chemical compound CCCCC\C(C=O)=C\C1=CC=CC=C1 HMKKIXGYKWDQSV-KAMYIIQDSA-N 0.000 claims description 5
- 239000010495 camellia oil Substances 0.000 claims description 5
- 239000001772 cananga odorata hook. f. and thomas. oil Substances 0.000 claims description 5
- 239000010627 cedar oil Substances 0.000 claims description 5
- BJIOGJUNALELMI-ARJAWSKDSA-N cis-isoeugenol Chemical compound COC1=CC(\C=C/C)=CC=C1O BJIOGJUNALELMI-ARJAWSKDSA-N 0.000 claims description 5
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 claims description 5
- 239000001524 citrus aurantium oil Substances 0.000 claims description 5
- 239000010633 clary sage oil Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 5
- 239000010639 cypress oil Substances 0.000 claims description 5
- MFGZXPGKKJMZIY-UHFFFAOYSA-N ethyl 5-amino-1-(4-sulfamoylphenyl)pyrazole-4-carboxylate Chemical compound NC1=C(C(=O)OCC)C=NN1C1=CC=C(S(N)(=O)=O)C=C1 MFGZXPGKKJMZIY-UHFFFAOYSA-N 0.000 claims description 5
- 229940113087 geraniol Drugs 0.000 claims description 5
- 239000010649 ginger oil Substances 0.000 claims description 5
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 claims description 5
- 239000010656 jasmine oil Substances 0.000 claims description 5
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims description 5
- 239000001298 pelargonium graveolens oil Substances 0.000 claims description 5
- 239000010668 rosemary oil Substances 0.000 claims description 5
- 229940058206 rosemary oil Drugs 0.000 claims description 5
- 239000010669 rosewood oil Substances 0.000 claims description 5
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 claims description 5
- 239000008371 vanilla flavor Substances 0.000 claims description 5
- SRWMQSFFRFWREA-UHFFFAOYSA-M zinc formate Chemical compound [Zn+2].[O-]C=O SRWMQSFFRFWREA-UHFFFAOYSA-M 0.000 claims description 5
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 5
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 claims description 5
- XDWXRAYGALQIFG-UHFFFAOYSA-L zinc;propanoate Chemical compound [Zn+2].CCC([O-])=O.CCC([O-])=O XDWXRAYGALQIFG-UHFFFAOYSA-L 0.000 claims description 5
- 239000003349 gelling agent Substances 0.000 claims description 4
- 229940032991 zinc picolinate Drugs 0.000 claims 4
- NHVUUBRKFZWXRN-UHFFFAOYSA-L zinc;pyridine-2-carboxylate Chemical compound C=1C=CC=NC=1C(=O)O[Zn]OC(=O)C1=CC=CC=N1 NHVUUBRKFZWXRN-UHFFFAOYSA-L 0.000 claims 4
- 239000000499 gel Substances 0.000 abstract description 27
- 239000006210 lotion Substances 0.000 abstract description 15
- 210000004400 mucous membrane Anatomy 0.000 abstract description 5
- 239000000344 soap Substances 0.000 abstract description 4
- 239000006071 cream Substances 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 25
- 238000005660 chlorination reaction Methods 0.000 description 24
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 20
- 229960003500 triclosan Drugs 0.000 description 20
- 230000000694 effects Effects 0.000 description 19
- 229920001296 polysiloxane Polymers 0.000 description 17
- 238000002360 preparation method Methods 0.000 description 17
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 15
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 15
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 15
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 15
- 244000021150 Orbignya martiana Species 0.000 description 15
- 235000014643 Orbignya martiana Nutrition 0.000 description 15
- 229960005323 phenoxyethanol Drugs 0.000 description 15
- 239000004743 Polypropylene Substances 0.000 description 14
- 229920001155 polypropylene Polymers 0.000 description 14
- 239000012530 fluid Substances 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 12
- 235000011187 glycerol Nutrition 0.000 description 12
- 229920000609 methyl cellulose Polymers 0.000 description 12
- 239000001923 methylcellulose Substances 0.000 description 12
- 241000191967 Staphylococcus aureus Species 0.000 description 11
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 11
- 150000001298 alcohols Chemical class 0.000 description 10
- 239000002253 acid Substances 0.000 description 9
- 239000006072 paste Substances 0.000 description 9
- 239000003755 preservative agent Substances 0.000 description 9
- 230000002335 preservative effect Effects 0.000 description 9
- 235000002639 sodium chloride Nutrition 0.000 description 8
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 150000004283 biguanides Chemical class 0.000 description 6
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 239000011630 iodine Substances 0.000 description 6
- 229910052740 iodine Inorganic materials 0.000 description 6
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 6
- 235000013599 spices Nutrition 0.000 description 6
- 229940099259 vaseline Drugs 0.000 description 6
- 239000002085 irritant Substances 0.000 description 5
- 150000002576 ketones Chemical class 0.000 description 5
- 239000002674 ointment Substances 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 239000003206 sterilizing agent Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000000699 topical effect Effects 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 239000004599 antimicrobial Substances 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000010648 geranium oil Substances 0.000 description 4
- 235000019717 geranium oil Nutrition 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 229930003658 monoterpene Natural products 0.000 description 4
- 150000002773 monoterpene derivatives Chemical class 0.000 description 4
- 235000002577 monoterpenes Nutrition 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
- FQTLCLSUCSAZDY-UHFFFAOYSA-N (+) E(S) nerolidol Natural products CC(C)=CCCC(C)=CCCC(C)(O)C=C FQTLCLSUCSAZDY-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- FQTLCLSUCSAZDY-ATGUSINASA-N Nerolidol Chemical compound CC(C)=CCC\C(C)=C\CC[C@](C)(O)C=C FQTLCLSUCSAZDY-ATGUSINASA-N 0.000 description 3
- 235000010676 Ocimum basilicum Nutrition 0.000 description 3
- 240000007926 Ocimum gratissimum Species 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 235000007303 Thymus vulgaris Nutrition 0.000 description 3
- 240000002657 Thymus vulgaris Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 3
- SNPLKNRPJHDVJA-UHFFFAOYSA-N dl-panthenol Chemical compound OCC(C)(C)C(O)C(=O)NCCCO SNPLKNRPJHDVJA-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- WASNIKZYIWZQIP-AWEZNQCLSA-N nerolidol Natural products CC(=CCCC(=CCC[C@@H](O)C=C)C)C WASNIKZYIWZQIP-AWEZNQCLSA-N 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 3
- 229960003415 propylparaben Drugs 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000001585 thymus vulgaris Substances 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920000289 Polyquaternium Polymers 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 239000004098 Tetracycline Substances 0.000 description 2
- IOUUIFSIQMVYKP-UHFFFAOYSA-N Tetradecyl acetate Chemical compound CCCCCCCCCCCCCCOC(C)=O IOUUIFSIQMVYKP-UHFFFAOYSA-N 0.000 description 2
- 239000005844 Thymol Substances 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 108010059993 Vancomycin Proteins 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- VYOZKLLJJHRFNA-UHFFFAOYSA-N [F].N Chemical compound [F].N VYOZKLLJJHRFNA-UHFFFAOYSA-N 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 230000001857 anti-mycotic effect Effects 0.000 description 2
- 239000002543 antimycotic Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- BWNMWDJZWBEKKJ-UHFFFAOYSA-M benzyl-docosyl-dimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 BWNMWDJZWBEKKJ-UHFFFAOYSA-M 0.000 description 2
- NMJJFJNHVMGPGM-UHFFFAOYSA-N butyl formate Chemical compound CCCCOC=O NMJJFJNHVMGPGM-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- RKLXDNHNLPUQRB-TVJUEJKUSA-N chembl564271 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]2C(C)SC[C@H](N[C@@H](CC(N)=O)C(=O)NC(=O)[C@@H](NC2=O)CSC1C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NC(=C)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H]1NC(=O)C(=C\C)/NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H]3N[C@@H](CC(C)C)C(=O)NC(=O)C(=C)NC(=O)CC[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=4C5=CC=CC=C5NC=4)CSC3)C(O)=O)C(C)SC2)C(C)C)C(C)SC1)C1=CC=CC=C1 RKLXDNHNLPUQRB-TVJUEJKUSA-N 0.000 description 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
- 239000010632 citronella oil Substances 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 229960003276 erythromycin Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 230000000926 neurological effect Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- RXHIKAIVEMAPRU-JRIGQVHBSA-N sequiterpene Natural products C1=C(C)[C@@H](OC(C)=O)[C@H](O)[C@@]2(O)[C@H](C)CC[C@@H](C(C)=C)[C@H]21 RXHIKAIVEMAPRU-JRIGQVHBSA-N 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 108010082567 subtilin Proteins 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 description 2
- 229960002180 tetracycline Drugs 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229960000790 thymol Drugs 0.000 description 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
- 229960003165 vancomycin Drugs 0.000 description 2
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 2
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- WIBCVGUGRCGRSG-UHFFFAOYSA-N zinc oxygen(2-) 1H-pyridine-2-thione Chemical compound [O-2].[Zn+2].SC1=NC=CC=C1 WIBCVGUGRCGRSG-UHFFFAOYSA-N 0.000 description 2
- XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 description 1
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- 239000001306 (7E,9E,11E,13E)-pentadeca-7,9,11,13-tetraen-1-ol Substances 0.000 description 1
- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 description 1
- WUOACPNHFRMFPN-VIFPVBQESA-N (R)-(+)-alpha-terpineol Chemical compound CC1=CC[C@H](C(C)(C)O)CC1 WUOACPNHFRMFPN-VIFPVBQESA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- HANWHVWXFQSQGJ-UHFFFAOYSA-N 1-tetradecoxytetradecane Chemical compound CCCCCCCCCCCCCCOCCCCCCCCCCCCCC HANWHVWXFQSQGJ-UHFFFAOYSA-N 0.000 description 1
- IYOLBFFHPZOQGW-UHFFFAOYSA-N 2,4-dichloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=C(Cl)C(C)=C1Cl IYOLBFFHPZOQGW-UHFFFAOYSA-N 0.000 description 1
- ZNSALEJHPSBXDK-JLHYYAGUSA-N 2-[(2e)-3,7-dimethylocta-2,6-dienyl] cyclopentan-1-one Chemical compound CC(C)=CCC\C(C)=C\CC1CCCC1=O ZNSALEJHPSBXDK-JLHYYAGUSA-N 0.000 description 1
- VDXLAYAQGYCQEO-UHFFFAOYSA-N 2-chloro-1,3-dimethylbenzene Chemical group CC1=CC=CC(C)=C1Cl VDXLAYAQGYCQEO-UHFFFAOYSA-N 0.000 description 1
- HKAGPQUVIAEHSO-UHFFFAOYSA-N 2-iodobutanoic acid Chemical compound CCC(I)C(O)=O HKAGPQUVIAEHSO-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- OJFZXRZZXBFEAP-UHFFFAOYSA-N 5-chloro-1,6-dimethylcyclohexa-2,4-dien-1-ol Chemical compound ClC=1C(C(C=CC1)(C)O)C OJFZXRZZXBFEAP-UHFFFAOYSA-N 0.000 description 1
- QTZBTBLHYPSFMG-UHFFFAOYSA-N 5-chloro-3-methylpyridin-2-amine Chemical compound CC1=CC(Cl)=CN=C1N QTZBTBLHYPSFMG-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 1
- VDXNZEPKIQWMEW-UHFFFAOYSA-N C(CCCCCCCCCCCCC)(=O)O.C1(=CC=CC=C1)OC Chemical compound C(CCCCCCCCCCCCC)(=O)O.C1(=CC=CC=C1)OC VDXNZEPKIQWMEW-UHFFFAOYSA-N 0.000 description 1
- JKHBSEMWNFTGPM-UHFFFAOYSA-N CCCCCCCCCCCCCCOCC(C)OCC(C)OCC(C)O Chemical compound CCCCCCCCCCCCCCOCC(C)OCC(C)OCC(C)O JKHBSEMWNFTGPM-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- GXGJIOMUZAGVEH-UHFFFAOYSA-N Chamazulene Chemical compound CCC1=CC=C(C)C2=CC=C(C)C2=C1 GXGJIOMUZAGVEH-UHFFFAOYSA-N 0.000 description 1
- 241000606153 Chlamydia trachomatis Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 208000007811 Latex Hypersensitivity Diseases 0.000 description 1
- 244000165082 Lavanda vera Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-methylmorpholine Substances CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 1
- UZIQYAYUUNMDMU-UHFFFAOYSA-N N.[Br+] Chemical compound N.[Br+] UZIQYAYUUNMDMU-UHFFFAOYSA-N 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 241000588650 Neisseria meningitidis Species 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- QPONMYCKVFMNMD-UHFFFAOYSA-N OP(O)=O.NC1=CC=CC=C1N Chemical class OP(O)=O.NC1=CC=CC=C1N QPONMYCKVFMNMD-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 229920002023 Pluronic® F 87 Polymers 0.000 description 1
- 108010093965 Polymyxin B Proteins 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- 206010039251 Rubber sensitivity Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 201000005010 Streptococcus pneumonia Diseases 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 241000736892 Thujopsis dolabrata Species 0.000 description 1
- 241000224527 Trichomonas vaginalis Species 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-ADUHFSDSSA-N [2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate Chemical group CC(=O)OC1=C(C)C(C)=C2OC(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-ADUHFSDSSA-N 0.000 description 1
- NSSFQWKWOYIWHL-UHFFFAOYSA-L [Zn+2].N1=C(C=CC=C1)C(=O)[O-].N1=C(C=CC=C1)C(=O)O.N1=C(C=CC=C1)C(=O)[O-] Chemical compound [Zn+2].N1=C(C=CC=C1)C(=O)[O-].N1=C(C=CC=C1)C(=O)O.N1=C(C=CC=C1)C(=O)[O-] NSSFQWKWOYIWHL-UHFFFAOYSA-L 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229920000180 alkyd Polymers 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 229960003942 amphotericin b Drugs 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 238000011203 antimicrobial therapy Methods 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960001716 benzalkonium Drugs 0.000 description 1
- 229960002233 benzalkonium bromide Drugs 0.000 description 1
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 229960003328 benzoyl peroxide Drugs 0.000 description 1
- RWUKNUAHIRIZJG-AFEZEDKISA-M benzyl-dimethyl-[(z)-octadec-9-enyl]azanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC[N+](C)(C)CC1=CC=CC=C1 RWUKNUAHIRIZJG-AFEZEDKISA-M 0.000 description 1
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- 229950011260 betanaphthol Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229960003168 bronopol Drugs 0.000 description 1
- OGPMUTIEFPDJAX-UHFFFAOYSA-M calcium;2-(trimethylazaniumyl)ethyl phosphate Chemical compound [Ca+2].C[N+](C)(C)CCOP([O-])([O-])=O OGPMUTIEFPDJAX-UHFFFAOYSA-M 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 150000001748 carotenols Chemical class 0.000 description 1
- 235000005471 carotenols Nutrition 0.000 description 1
- VRTFVAUMJOGEOH-UHFFFAOYSA-N caryophyllen Natural products CC1C(CCC(=CCCC1=C)C)C(C)(C)C VRTFVAUMJOGEOH-UHFFFAOYSA-N 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 150000001768 cations Chemical group 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229960000800 cetrimonium bromide Drugs 0.000 description 1
- 229960002788 cetrimonium chloride Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- PMRJYBALQVLLSJ-UHFFFAOYSA-N chamazulene Natural products CCC1=CC2=C(C)CCC2=CC=C1 PMRJYBALQVLLSJ-UHFFFAOYSA-N 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229940038705 chlamydia trachomatis Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 229960003405 ciprofloxacin Drugs 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 229960001378 dequalinium chloride Drugs 0.000 description 1
- LTNZEXKYNRNOGT-UHFFFAOYSA-N dequalinium chloride Chemical compound [Cl-].[Cl-].C1=CC=C2[N+](CCCCCCCCCC[N+]3=C4C=CC=CC4=C(N)C=C3C)=C(C)C=C(N)C2=C1 LTNZEXKYNRNOGT-UHFFFAOYSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 125000003963 dichloro group Chemical group Cl* 0.000 description 1
- 229950010569 dichloroxylenol Drugs 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- QIVLQXGSQSFTIF-UHFFFAOYSA-M docosyl(trimethyl)azanium;methyl sulfate Chemical compound COS([O-])(=O)=O.CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)C QIVLQXGSQSFTIF-UHFFFAOYSA-M 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- 229960004884 fluconazole Drugs 0.000 description 1
- 229940124600 folk medicine Drugs 0.000 description 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 1
- WWULHQLTPGKDAM-UHFFFAOYSA-N gamma-eudesmol Natural products CC(C)C1CC(O)C2(C)CCCC(=C2C1)C WWULHQLTPGKDAM-UHFFFAOYSA-N 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000033444 hydroxylation Effects 0.000 description 1
- 238000005805 hydroxylation reaction Methods 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 230000000937 inactivator Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229940075495 isopropyl palmitate Drugs 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 201000005391 latex allergy Diseases 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-N methyl sulfate Chemical compound COS(O)(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-N 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 229960003128 mupirocin Drugs 0.000 description 1
- 229930187697 mupirocin Natural products 0.000 description 1
- DDHVILIIHBIMQU-YJGQQKNPSA-L mupirocin calcium hydrate Chemical compound O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 DDHVILIIHBIMQU-YJGQQKNPSA-L 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- GQEZCXVZFLOKMC-UHFFFAOYSA-N n-alpha-hexadecene Natural products CCCCCCCCCCCCCCC=C GQEZCXVZFLOKMC-UHFFFAOYSA-N 0.000 description 1
- UFWIBTONFRDIAS-UHFFFAOYSA-N naphthalene-acid Natural products C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- NUXCOKIYARRTDC-UHFFFAOYSA-N o-ethylhydroxylamine;hydron;chloride Chemical compound Cl.CCON NUXCOKIYARRTDC-UHFFFAOYSA-N 0.000 description 1
- 229940053549 olealkonium chloride Drugs 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 150000002924 oxiranes Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- LSTDYDRCKUBPDI-UHFFFAOYSA-N palmityl acetate Chemical compound CCCCCCCCCCCCCCCCOC(C)=O LSTDYDRCKUBPDI-UHFFFAOYSA-N 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000024 polymyxin B Polymers 0.000 description 1
- 229960005266 polymyxin b Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229940023565 ppg-10 cetyl ether Drugs 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- WHMDPDGBKYUEMW-UHFFFAOYSA-N pyridine-2-thiol Chemical compound SC1=CC=CC=N1 WHMDPDGBKYUEMW-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 229940057981 stearalkonium chloride Drugs 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- WDHVIZKSFZNHJB-UHFFFAOYSA-L zinc;butanoate Chemical compound [Zn+2].CCCC([O-])=O.CCCC([O-])=O WDHVIZKSFZNHJB-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及含有季铵化合物及精油和/或单个精油成分的组合物,它显示出增强的抗微生物效果。可将这种组合包含在洗剂、凝胶、乳膏、肥皂等中,施用于皮肤或粘膜。本发明基于,或至少部分基于发现了用精油或其单个成分和低浓度的季铵化合物的组合产生协同抗微生物效果。
Description
1.相关申请的交叉参考
本申请要求分别于2003年7月17日和2003年12月18日提交的美国临时申请序列号60/488,349和60/530,864的权益,各自以整体纳入本文作为参考。
2.介绍
本发明涉及含有季铵化合物及精油和/或单个精油成分的组合的组合物,以及使用此种组合物的方法。它基于,或至少部分基于发现了该组合物显示出协同增效的抗微生物效果。
3.发明背景
精油是从植物或动物来源得到的挥发油,由几种成分,例如单萜和倍半萜烃类,单萜和倍半萜醇、酯、醚、醛、酮、氧化物等的复杂混合物组成。这些精油及其分离成分常常用作香料和香精,并广泛用于治愈伤口的民间医药。
科学研究证实了精油的有益效果。人们发现桉树精油“具有中枢和外周止痛效果以及依赖或不依赖于嗜中性粒细胞的消炎活性”(Silva等,2003,J.Ethnopharmacol.89(2-3);277-283),在来自薰衣草的精油中观察到类似活性(Hajhashemi等,2003,J.Ethnopharmacol.89(1):67-71)。有证据证明,精油具有抗菌(Bezic等,2003,Phytother.Res.17(9):1037-1040;Goren等,2003,Z.Naturforsch.58(9-10):687-690;de Abreu Gonzaga等,2003,Planta Med.69(8):773-775;Valero和Salmera,2003,Int.J.Food Microbiol.85(1-2):73-81)和抗真菌(Paranagama等,2003,Lett.Appl.Microbiol.37(1):86-90:Shin,2003,Arch.Pharm.Res.26(5):389-393;Velluti等,2003,Int.J.Food Microbiol.89:145-154)活性。也观察到了精油的抗病毒活性,包括对1型和2型单纯疱疹病毒的直接抗病毒效果(Garcia等,Phytother.Res.17(9):1073-1075;Minami等,2003,Microbial Immunol.47(a):681-684;Schuhmacher等,2003,Phytomedicine10:504-510)。
季铵化合物(″QAC″)是其中有机自由基取代了天然铵阳离子的所有四个氢的一组铵盐。它们含有与四个有机自由基连接的一个中心氮原子和一个酸自由基。QAC趋于分布在两相界面上(液相-液相或固相-液相),在这两个不同相之间引入连续性。已知QAC具有强大的抗微生物活性,能够破坏细菌的细胞活动。QAC已用作杀菌剂、消毒剂、防腐剂、抗微生物剂等。
Johnson等(美国6,319,958和美国20020165130)涉及采用倍半萜化合物促进对外源性抗微生物化合物的摄取。类似地,一篇相关论文揭示了采用倍半萜化合物,如橙花叔醇、法尼醇、没药醇和阿普利酮(apritone)提高细菌穿透性和对外源性抗微生物化合物的易感性,表明倍半萜化合物具有非特异性和普遍的效果(Brehm-Stecher等2003,《抗微生物剂和化疗》(Antimicrobial Agents andChemotherapy),47(10):3357-3360)。具体说,Brehm-Stecher等报道,橙花叔醇、法尼醇、没药醇和阿普利酮提高了金黄色葡萄球菌对抗生素红霉素、庆大霉素、万古霉素、环丙沙星(ciproflaxin)、氯林可霉素和四环素的易感性。此外,Brehm-Stecher等没有公开将QAC用作抗微生物剂。
在各种专业和非专业应用领域中,一直需要一种无刺激性、安全和有效的菌组合物。
4.发明概述
本发明涉及含有季铵化合物及精油和/或单个精油成分的组合的抗微生物组合物。可将这种组合包含于洗剂、凝胶、乳膏、肥皂等中,施用于皮肤或粘膜。本发明基于,或至少部分基于观察到用精油和/或单个精油成分及低浓度的季铵化合物组合获得了协同抗微生物效果。
5.发明详述
本发明涉及组合物及其使用方法,其中通过包括协同量的季铵化合物及精油和/或一种或多种单个精油成分提高了凝胶、乳膏、软膏、洗剂或肥皂的抗微生物活性。本发明制剂包含协同有效量的至少一种季铵化合物及至少一种精油和/或单个精油成分。
本发明所用术语“协同”和“协同有效”指施用两种或多种物质产生的生物学效果大于单独施用这些物质产生的生物学效果之和。
适用于本发明的季铵化合物的例子包括但不限于:苯扎氯铵(″BZK″)、苯索氯铵(″BZT″),其它苯扎卤铵(benzalkonium halides)或苯索卤铵(benzethoniumhalides),包括但不限于:苯扎溴铵、苯扎氟铵、苯索溴铵、苯索氟铵、氯化十六烷基吡啶、氯化烷基酰氨基丙烷鎓(alkylamidopropalkonium chloride)、氯化二十二烷基鎓(behenalkonium chloride),甲基硫酸二十二烷基鎓(behentrimoniummethosulphate),二十二烷基酰氨基丙基乙基二鎓(behenamidopropylethyldimonium ethosulphate),氯化十八烷基鎓(stearalkoniumchloride),氯化十八烯基鎓(olealkonium chloride),氯化十六烷基鎓(cetrimoniumchloride),地喹氯铵,硫酸N-十四烷基-N-甲基-吗啉蓊甲酯,聚二氯[N-[3-(二甲基胺基)丙基]-N’-[3-(乙烯基氧乙烯二甲基胺)丙基]脲],α-4-[1-三(2-羟乙基)氯化铵-2-丁烯基]-ω-三(2-羟乙基)氯化铵,聚[氧乙烯(二甲基亚胺基)乙烯(二甲基亚胺基)-二氯乙烯]。
季铵化合物的浓度可以在约0.01%和0.5%之间;优选的季铵化合物是浓度在0.05%和0.3%之间,更优选在0.1%和0.2%之间的苯索氯铵或苯扎氯铵。除非特别说明,这些百分数和本文中的其它百分数是质量/质量百分数。
本文所述的精油(″EO″)是获自植物或动物来源的挥发油,或其合成等价物,由几种成分,如单萜和倍半萜烃类,单萜和倍半萜醇、酯、醚、醛、酮、氧化物等的复杂混合物组成。EO的例子包括但不限于:佛手柑油、香鼠尾草油、依兰油、橙花油、檀木油、蓝丹油、姜油、薄荷油、薰衣草油、茉莉油、老鹳草油波旁、薄荷油、丁香油、广藿香油、迷迭香油、玫瑰木油、檀木油、茶树油、香草油、柠檬草油、香柏油、香胶树油、红橘油、扁柏油、亥巴油(Hiba oil)、银杏油(ginko oil)、桉叶油、柠檬油、橙油和甜橙油。
精油的单个成分(″IC″)可以是从(天然)油中分离的,或完全或部分合成的,包括但不限于:1-香茅醇、α-戊基肉桂醛、新铃兰醛(lyral)、香叶醇、法尼醇、羟基香茅醛、异丁子香酚、丁子香酚、桉树脑、里哪醇、柠檬醛、麝香草酚、柠檬烯和薄荷醇。
IC的其它例子包括倍半萜化合物,它们可以是精油中的活性化合物。从3个5-碳异戊二烯单元通过生物合成形成含有15个碳的倍半萜化合物。倍半萜化合物包括但不限于:法尼醇、橙花叔醇、没药醇、阿普利酮、母菊兰烯、檀香脑、姜醇、胡萝卜醇和石竹素(caryophyllen)。
本发明包括一种或多种EO的混合物、一种或多种IC的混合物以及一种或多种EO和一种或多种IC的混合物。
EO和IC的浓度可以在0.01%和10%之间;优选在0.05%和1.0%之间或在0.05%和0.5%之间,更优选在0.2%和0.5%之间。在优选实施方式中,EO是柠檬油和/或IC是法尼醇。
在某些具体的非限制性实施方式中,本发明提供了制剂,包括但不限于凝胶、乳膏、洗剂或软膏,它还包含一定量的锌,使其能够抑制该制剂的施用对皮肤或粘膜的刺激。可通过加入锌来抵消精油的刺激效果。在局部用药组合物中使用锌是本领域公知的,公开于以下专利:美国专利号5,708,023、5,965,610、5,985,918和6,037,386。
在本发明优选实施方式中,采用了低浓度的两种或多种水溶性锌盐。术语“低浓度”指以重量比计(w/w),游离锌离子(Zn2+)在凝胶或乳膏中所占百分数小于0.5%。适用于这些组合物的锌盐包括乙酸锌(在水中的摩尔溶解度为1.64摩尔/升)、丁酸锌(在水中的摩尔溶解度为0.4摩尔/升)、柠檬酸锌(在水中的摩尔溶解度为<0.1摩尔/升)、葡糖酸锌(在水中的摩尔溶解度为0.28摩尔/升)、甘油酸锌(水溶性中等)、乙醇酸锌(水溶性中等)、甲酸锌(在水中的摩尔溶解度为0.33摩尔/升)、乳酸锌(在水中的摩尔溶解度为0.17摩尔/升)、吡啶甲酸(picolinate)锌(水溶性中等)、丙酸锌(在水中的摩尔溶解度为1.51摩尔/升)、水杨酸锌(水溶性低)、酒石酸锌(水溶性中等)和十一碳烯酸锌(水溶性中等)。在尤其优选的实施方式中,锌盐包含有效量的两种或多种下述锌盐的组合:乙酸锌(0.05-2.0%)、柠檬酸锌(0.05-2.0%)、葡糖酸锌(0.05-2.0%)和乳酸锌(0.05-2.0%)。在优选实施方式中,锌盐是0.2-0.6%葡糖酸锌、0.1-0.3%乙酸锌和0.1-0.3%乳酸锌。在尤其优选的实施方式中,锌盐是0.3%葡糖酸锌、0.1%乙酸锌和0.1%乳酸锌,或0.2%乳酸锌和0.2%葡糖酸锌。国际专利申请号PCT/US03/03896,2003年8月14日公开为WO 03/066001中描述了可含有本发明的协同组合的其它组合物,以整体纳入本文作为参考。
可将本发明的凝胶、软膏、洗剂或乳膏局部施用于皮肤或身体的各种粘膜,包括但不限于口腔、鼻腔、***或直肠腔粘膜。
在优选实施方式中,凝胶、洗剂、软膏或乳膏可含有水、胶凝剂、增稠剂、亲水或疏水聚合物、乳化剂、润肤剂和/或醇如乙醇的混合物。在优选实施方式中,本文要求保护的组合物含有10-90w/w%的醇、15-70w/w%的水、0.05-3.0w/w%的增稠剂和/或胶凝剂,以及0.1-3.0w/w%的润肤剂。
在优选实施方式中,如果存在增稠剂,它不是聚丙烯酸基增稠剂,例如但不限于:卡波姆、聚羰乙烯或Ultrez,因为发现聚丙烯酸基增稠剂与季铵化合物不相容。虽然不希望受限于任何具体理论,但相信这种增稠剂的阴离子基团可与季铵化合物的阳离子基团可能发生相互作用。优选地,如果采用胶凝剂,它不是阴离子物质,而最好是非离子或阳离子物质。
本发明组合物还可任选地包括一种或多种附加抗微生物剂,例如但不限于:抗病毒药、抗菌药或抗真菌物质。抗微生物剂也包括具有杀病毒或抑病毒,杀菌或抑菌,或者杀真菌或抑真菌性质的任何组合的物质。抗微生物剂是本领域普通技术人员熟知的。抗微生物剂的例子包括但不限于:碘消灵、碘酒、苯甲酸、脱氢乙酸、丙酸、山梨酸、羟苯甲酸甲酯、羟苯甲酸乙酯、羟苯甲酸丙酯、羟苯甲酸丁酯、溴棕三甲铵、氯己定(游离碱和/或盐)、其它双胍如聚亚己基缩二胍(PHMB)和葡糖酸氯己定(CHG)、氯甲酚(chloroeresol)、氯二甲酚(chlorxylenol)、苯甲醇、溴硝丙二醇、氯丁醇、乙醇、苯氧乙醇、苯基乙醇、2,4-二氯苯甲醇、硫柳汞、氯林可霉素、红霉素、过氧化苯甲酰、莫匹罗星、枯草杆菌素、多粘菌素B、新霉素、三氯生、对氯间二甲苯、磷酸胆碱钙、咪康唑、氟康唑、伊康唑(itriconazole)、酮康唑,及其药学上可接受的盐。可在参考文献,如Goodman和Gilman的《治疗学的药理学基础》(The Pharmacological Basis of Therapeutics)(Goodman Gilman A,Rall TW,Nies AS,Taylor P,编(Pergamon Press;Elmsford,N.Y.1990))中找到用于本发明的抗微生物剂的这些和其它例子,将其内容纳入本文作为参考。
在一个实施方式中,本发明组合物含有选自二葡糖酸氯己定(CHG)和聚亚己基缩二胍(PHMB)的双胍化合物。该双胍化合物的优选浓度为0.1-2.0w/w%。
药学上可接受的氯己定盐是本领域普通技术人员熟知的,包括但不限于:棕榈酸氯己定、二氨基苯膦酸氯己定、二葡糖酸氯己定(″CHG″)、二乙酸氯己定、二盐酸氯己定、二氯氯己定、二氢碘氯己定、二高氯酸氯己定、二硝酸氯己定、硫酸氯己定、亚硫酸氯己定、硫代硫酸氯己定、磷酸氯己定二酸、二氟磷酸氯己定、二甲酸氯己定、二丙酸氯己定、二碘代丁酸氯己定、二正戊酸氯己定、二己酸氯己定、丙二酸氯己定、琥珀酸氯己定、苹果酸氯己定、酒石酸氯己定、二单乙醇酸氯己定、单二乙醇酸氯己定、乳酸氯己定、二-α-羟基异丁酸氯己定、二葡糖酸氯己定、二异硫代硫酸氯己定、二苯甲酸氯己定、二肉桂酸氯己定、二扁桃酸氯己定、二间苯二酸氯己定、二-2-羟基萘酸氯己定和双羟萘酸氯己定。
在本发明组合物的配制中,认为制剂还可包含不具有上述成分的活性的成分,它们在制剂中起辅助作用,与所述组合物作为整体使用。这种成分的例子是生物应用制剂的生产领域的普通技术人员熟知的。这些成分的例子包括(例如)以下物质:粘合剂、润肤剂、防腐剂(如羟苯甲酸甲酯)、润滑剂、着色剂、香料等。因此,当所考虑的表面是皮肤时,本发明组合物可含有加入已知洗剂或药剂的成分,它们对皮肤而言是生理可接受的,且不含会逆转或阻碍刺激物灭活剂的作用的成分。
在本发明的某些非限制性实施方式中,可将该组合物加入预先存在的制剂中,只要这些制剂中的成分不防止或阻碍要求保护的组合物的活性。在优选实施方式中,可将要求保护的组合物加入市售的乳膏、软膏、凝胶或洗剂中。市售润滑剂的例子包括但不限于:以商品名″KY JELLY″、″ASTROGLIDE″和″PREVACARE″出售的润滑剂。市售洗剂的例子包括但不限于:以商品名″SOFT-SENSE″、″LOTION SOFT″、″CUREL″和″KERI″出售的洗剂。已知SOFT-SENSE(Johnson & Son,Inc.Racine,Wis.)含有纯化水、甘油USP、氯化二硬酯酰二鎓、凡士林USP、棕榈酸异丙酯、1-十六醇、乙酸生育基(tocopheryl)酯(维生素E USP)、二甲基硅油、二氧化钛USP、羟苯甲酸甲酯、羟苯甲酸丙酯、氯化钠和香料。LOTION SOFT(Calgon Vestal,St.Louise,Mo.)是一种非离子保湿洗剂,已知含有黏多糖。已知CUREL(Bausch & Lomb Incorporated,Rochester,N.Y.)含有去离子水、甘油、季铵-5、凡士林、棕榈酸异丙酯、1-十六烷醇、二甲基硅油、氯化钠、香料、羟苯甲酸甲酯和羟苯甲酸丙酯。
要求保护的组合物可用于防汗剂、须后洗剂、水醇性皮肤消毒剂和治疗性乳膏等。
本发明的某些优选实施方式包含(举例但不作为限制)以下物质的一种或多种:醇(10-90w/w%),可以包括乙醇、正丙醇和异丙醇的一种或多种;一种或多种抗刺激量的锌化合物;一种或多种羟乙基纤维素与三甲基铵取代的环氧化物(聚季铵盐),例如U-care聚合物如Ucare JR125、JR 400、JR 30M、LR 400、LR30M或Ucare聚合物LK发生反应生成的聚季铵盐;羟丙基甲基纤维素如甲基纤维素A、E、K和40系列产品如甲基纤维素K4MS、甲基纤维素K100、甲基纤维素40-202、甲基纤维素K15MS等;一种或多种季铵化合物如BZK或BZT;十六烷基三甲基氯化铵(″CTAC″);十六烷基三甲基溴化铵(″CTAB″);氯化十八烯基鎓;氯化十八烷基鎓;Incroquat BA85(氯化巴西棕榈酰氨基丙基鎓);甲基硫酸二(二十二烷基二鎓);Incroquat BES-35S(乙基硫酸二十二烷基酰氨基丙基乙基二鎓和十八烷醇);Incroquat B-65C(氯化二十二烷基鎓和十六烷醇);Incroquat Behenyl TMS(甲基硫酸二十二烷基三鎓和十六烯醇);以及一种或多种润肤剂,如Procetyl 10聚丙二醇-10十六烷基醚、Procetyl50聚丙二醇-50十六烷基醚、Promyristyl PM-3聚丙二醇-3十四烷基醚、聚丙二醇-3苯甲醚十四烷酸酯(Crodamol STS of Croda)、PEG 20杏树甘油酯、ProbutylDB-10、Glucam P20、Glucam E-10、Glucam P-10、Glucam E-20、Glucam P-20二硬脂酸酯、甘油、丙二醇、乙酸十四烷酯和乙酰化的羊毛脂醇(Acetulan)、羟化牛奶甘油酯(Cremerol HMG);硅酮液如Dow Corning硅酮液245、244、246、344、345、556;精油如柠檬油、香茅油、檀木油、柠檬草油、广藿香油、丁香油、百里香油、老鹳草油、罗勒油;精油的单个成分、如法尼醇、香茅醇、里哪醇、丁子香酚、柠檬醛、麝香草酚、桉树脑、薄荷醇;以及双胍如葡糖酸氯己定或聚亚己基缩二胍。
本发明提供了用上述组合物获得抗微生物效果的方法,该方法包括将有效量的组合物施用于表面。抗微生物效果明显降低了被一种或多种致病性传染物感染或现有感染继续发展的风险。不需将感染风险降低至零,但优选降低至少10%、20%、30%、40%、50%、60%、70%、80%或90%。可提供保护的抗传染物的例子包括但不限于:葡萄球菌属种如金黄色葡萄球菌和表皮葡萄球菌,链球菌属种如肺炎链球菌,肠球菌属种,沙门氏菌属种如伤寒沙门氏菌,埃希氏菌属种如大肠埃希氏菌,弧菌属种,奈瑟氏球菌属如脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌,人类免疫缺陷病毒(HIV),人***瘤病毒(HPV),单纯疱疹病毒(HSV),沙眼衣原体,***滴虫和白念珠菌。
在本发明的一个实施方式中,本发明组合物不含抗生素,包括但不限于:四环素、氨苄青霉素、利福平、万古霉素、两性霉素B、制霉菌素和枯草杆菌素。
以下是含有和不含锌盐的本发明制剂的具体的非限制性例子。
不含锌盐的制剂
一般配方
成分 百分数范围(w/w%)
乙醇 50-90
水 15-35
U-care聚合物 0.1-0.5
Germall+ 0.15-0.3
季铵化合物 0.05-0.2
季盐调节剂 0.2-1.0
润肤剂 0.3-1.0
苯氧乙醇(如果存在) 0.5-1.0
硅酮液 0.2-1.0
精油/单个成分 0.3-1.0
双胍(如果存在) 0.05-2.0
具体配方
(A)醇类手术用手制剂-1
成分 百分数范围(w/w%)
乙醇 68
氯化巴西棕榈酰氨基丙基鎓 0.5
水 28.12
U-care JR 30 0.2
泛酰醇 1.0
BZT 0.18
硅酮液(DC245) 0.5
Procetyl 10(聚丙二醇-10十六烷基醚) 0.5
法尼醇 0.5
苯氧乙醇 0.5
(B)醇类手术用手制剂-2
成分 百分数范围(w/w%)
乙醇 68
氯化巴西棕榈酰氨基丙基鎓 0.5
水 27.97
U-care JR 30 0.2
泛酰醇 1.0
BZT 0.18
硅酮液(DC245) 0.5
Procetyl 10(聚丙二醇-10十六烷基醚) 0.5
法尼醇 0.5
苯氧乙醇 0.5
PHMB 0.15
(C)醇类手术用手制剂-3
成分 百分数范围(w/w%)
乙醇 68
氯化巴西棕榈酰氨基丙基鎓 0.5
水 28.12
U-care JR 30 0.2
泛酰醇 1.0
BZT 0.18
硅酮液(DC245) 0.5
Procetyl 10(聚丙二醇-10十六烷基醚) 0.5
法尼醇 0.25
老鹳草油 0.25
苯氧乙醇 0.5
(D)术前皮肤消毒剂-1
成分 百分数范围(w/w%)
乙醇 60
聚乙烯吡咯烷酮碘 7.5
水 31.07
U-care JR 30 0.2
BZT 0.18
CHG 0.05
法尼醇 0.5
苯氧乙醇 0.5
含有锌盐的制剂
一般配方
成分 百分数范围(w/w%)
乙醇 50-90
水 15-35
U-care聚合物 0.1-0.5
Gernnall+ 0.15-0.3
季铵化合物 0.05-0.2
四调节剂 0.2-1.0
润肤剂 0.3-2.0
苯氧乙醇(如果存在) 0.5-1.0
硅酮液 0.0-1.0
精油/单个成分 0.3-1.0
双胍(如果存在) 0.05-2.0
葡糖酸锌 0.3-0.6
乙酸锌 0.1-0.3
乳酸锌 0.1-0.3
具体配方
(E)醇类手消毒剂-1
成分 百分数范围(w/w%)
乙醇 60
氯化巴西棕榈酰氨基丙基鎓0.3
水 36.23
U-care JR 30 0.2
乙酸锌 0.2
葡糖酸锌 0.3
乳酸锌 0.1
泛酰醇 1.0
葡糖酸氯己定(CHG) 0.05
BZK 0.12
硅酮液(DC245) 0.5
Procetyl 10(聚丙二醇-10十六烷基醚) 0.5
法尼醇 0.5
(F)醇类手消毒剂-2
成分 百分数范围(w/w%)
乙醇 60
氯化巴西棕榈酰氨基丙基鎓 0.3
水 36.08
U-careJR 30 0.2
乙酸锌 0.2
葡糖酸锌 0.3
乳酸锌 0.1
泛酰醇 1.0
葡糖酸氯己定(CHG) 0.05
BZK 0.12
硅酮液(DC245) 0.5
Procetyl 10(聚丙二醇-10十六烷基醚) 0.5
法尼醇 0.5
PHMB 0.15
(G)醇类手术用手制剂-1
成分 百分数范围(w/w%)
水 26.87
乙酸锌 0.2
葡糖酸锌 0.2
甲基纤维素K4MS 0.1
Ucare JR30 0.2
泛酰醇50W 1.0
乙醇 68.0
CrodamolSTS 1.0
氯化巴西棕榈酰氨基丙基鎓 0.3
Procetyl 10 0.5
PHMB 0.15
法尼醇 0.3
BZT 0.18
丙二醇 1.0
(H)醇类手术用手制剂-2
成分 百分数范围(w/w%)
乙醇 68
氯化巴西棕榈酰氨基丙基鎓 0.5
水 27.32
U-care JR 30 0.2
乙酸锌 0.2
葡糖酸锌 0.4
乳酸锌 0.2
泛酰醇 1.0
BZT 0.18
硅酮液(DC245) 0.5
Procetyl 10(聚丙二醇-10十六烷基醚) 0.5
法尼醇 0.5
苯氧乙醇 0.5
(I)醇类手术用手制剂-3
成分 百分数范围(w/w%)
乙醇 68
氯化巴西棕榈酰氨基丙基鎓 0.5
水 27.02
U-care JR 30 0.2
乙酸锌 0.2
葡糖酸锌 0.4
乳酸锌 0.2
泛酰醇 1.0
BZT 0.18
Germall+ 0.15
硅酮液(DC245) 0.5
Procetyl 10(聚丙二醇-10十六烷基醚) 0.5
法尼醇 0.5
苯氧乙醇 0.5
PHMB 0.15
(J)醇类手术用手制剂-3
成分 百分数范围(w/w%)
乙醇 68
氯化巴西棕榈酰氨基丙基鎓 0.5
水 27.27
U-care J R 30 0.2
乙酸锌 0.2
葡糖酸锌 0.4
乳酸锌 0.2
泛酰醇 1.0
BZT 0.18
硅酮液(DC245) 0.5
Procetyl 10(聚丙二醇-10十六烷基醚) 0.5
法尼醇 0.5
苯氧乙醇 0.5
CHG 0.05
(K)抗刺激手术用手制剂-4
成分 百分数范围(w/w%)
水 27.15
乳酸锌 0.2
葡糖酸锌 0.2
甲基纤维素K4MS 0.1
U-care-JR 30M 0.2
D,L-泛酰醇 0.5
苯索氯铵 0.18
乙醇 68.0
CrodamolSTS 1.0
Procetyl 0.5
氯化巴西棕榈酰氨基丙基鎓 0.3
丙二醇 1.0
法尼醇 0.5
聚亚己基缩二胍 0.15
香料 0.02
(L)抗刺激手术用手制剂-5
成分 百分数范围(w/w%)
水 26.45
乳酸锌 0.2
葡糖酸锌 0.2
Klucell MCS 0.8
U-care-JR 30M 0.2
D,L-泛酰醇 0.5
苯索氯铵 0.18
乙醇 68.0
Crodamol STS 1.0
Procetyl 0.5
氯化巴西棕榈酰氨基丙基鎓 0.3
丙二醇 1.0
法尼醇 0.5
聚亚己基缩二胍 0.15
香料 0.02
(M)含锌凝胶的醇类手术用手制剂-5
对于戴乳胶手套而对乳胶过敏的人而言,使用以下制剂是有利的。
成分 百分数范围(w/w%)
乙醇 68
氯化巴西棕榈酰氨基丙基鎓 0.5
水 22.93
U-care JR 30 0.6
乙酸锌 0.2
葡糖酸锌 0.7
乳酸锌 0.2
氧化锌 2.0
泛酰醇 1.0
CHG 0.05
Incroquat TMS Behenyl 0.5
硅酮液(DC245) 0.5
Procetyl 10(聚丙二醇-10十六烷基醚) 0.5
甘油 1.0
法尼醇 0.5
Germall+ 0.2
苯氧乙醇 0.5
苯扎氯铵 0.12
(N)醇基抗刺激手术用制剂
成分 百分数范围(w/w%)
水 26.87
乙酸锌 0.2
葡糖酸锌 0.2
甲基纤维素K4MS 0.1
U-care JR 30 0.2
泛酰醇50W 1.0
醇SDA-40B 68.0
Crodamol STS 1.0
氯化巴西棕榈酰氨基丙基鎓 0.3
Procetyl 10 0.5
PHMB 0.15
法尼醇 0.3
BZT 0.18
丙二醇 1.0
(O)局部乳膏-1
成分 百分数范围(w/w%)
Incroquat TMS Behenyl 0.8
Polawax NF 0.8
矿脂 3.0
Crothix 1.0
Crodomol MM 1.0
Cremerol HMG 1.0
丙二醇 2.0
甘油 8.0
水 78.22
Ucare JR30-M 0.2
Germall+ 0.2
BZT 0.18
老鹳草油 0.5
乙酸锌 0.2
葡糖酸锌 0.7
乳酸锌 0.2
氧化锌 2.0
(P)局部乳膏-2
成分 百分数范围(w/w%)
Incroquat TMS Behenyl 0.8
Polawax NF 0.8
矿脂 3.0
Crothix 1.0
Crodomol MM 1.0
Cremerol HMG 1.0
丙二醇 2.0
甘油 8.0
水 78.22
UcareJR30-M 0.2
Germall+ 0.2
BZT 0.18
罗勒油 0.5
乙酸锌 0.2
葡糖酸锌 0.7
乳酸锌 0.2
氧化锌 2.0
(Q)局部乳膏-3
成分 百分数范围(w/w%)
Incroquat TMS Behenyl 0.8
Polawax NF 0.8
矿脂 3.0
Crothix 1.0
Crodomol MM 1.0
Cremerol HMG 1.0
丙二醇 2.0
甘油 8.0
水 78.22
Ucare JR30-M 0.2
Germall+ 0.2
BZT 0.18
檀木油 0.25
法尼醇 0.25
乙酸锌 0.2
葡糖酸锌 0.7
乳酸锌 0.2
氧化锌 2.0
(R)局部乳膏-4
成分 百分数范围(w/w%)
Incroquat TMS Behenyl 0.8
Polawax NF 0.8
矿脂 3.0
Crothix 1.0
Crodomol MM 1.0
Cremerol HMG 1.0
丙二醇 2.0
甘油 8.0
水 78.22
Ucare JR30-M 0.2
Germall+ 0.2
BZT 0.18
百里香油 0.5
乙酸锌 0.2
葡糖酸锌 0.7
乳酸锌 0.2
氧化锌 2.0
(S)术前皮肤消毒剂-1
成分 百分数范围(w/w%)
乙醇 60
聚乙烯吡咯烷酮碘 7.5
水 30.47
U-care JR 30 0.2
乙酸锌 0.2
葡糖酸锌 0.3
乳酸锌 0.1
BZT 0.18
CHG 0.05
法尼醇 0.5
苯氧乙醇 0.5
(T)术前皮肤消毒剂-2
成分 百分数范围(w/w%)
乙醇 60
聚乙烯吡咯烷酮碘 2.0
水 35.97
U-care JR 30 0.2
乙酸锌 0.2
葡糖酸锌 0.3
乳酸锌 0.1
BZT 0.18
CHG 0.05
法尼醇 0.5
苯氧乙醇 0.5
(U)术前皮肤消毒剂-3
成分 百分数范围(w/w%)
乙醇 60
聚乙烯吡咯烷酮碘 2.0
水 35.52
U-care JR 30 0.2
乙酸锌 0.2
葡糖酸锌 0.3
乳酸锌 0.1
BZT 0.18
CHG 0.5
法尼醇 0.5
苯氧乙醇 0.5
(V)术前皮肤消毒剂-4
成分 百分数范围(w/w%)
乙醇 60
聚乙烯吡咯烷酮碘 2.0
水 34.02
U-care JR 30 0.2
乙酸锌 0.2
葡糖酸锌 0.3
乳酸锌 0.1
BZT 0.18
CHG 2.0
法尼醇 0.5
苯氧乙醇 0.5
(W)锌凝胶洗手液#1
成分 百分数范围(w/w%)
Ucare JR30-M 0.05
甲基纤维素K100 0.1
水 36.08
葡糖酸锌 0.3
乙酸锌 0.1
乳酸锌 0.1
Germall+ 0.2
乙醇 58
异丙醇 2.0
硅酮(二甲基硅酮) 0.2
Incroquat Behenyl TMS 0.7
Polawax A31 0.3
甘油 1.0
十六烷基醚(PPG10) 0.5
CHG 0.05
BZK 0.02
法尼醇 0.3
(X)锌凝胶洗手液#2
成分 百分数范围(w/w%)
水 33.45
乙醇 62.0
法尼醇 0.3
丙二醇 1.0
聚亚己基缩二胍 0.15
氯化巴西棕榈酰氨基丙基鎓 0.3
Procetyl 10(聚丙二醇-10十六烷基醚) 0.5
Crodamol STS 1.0
BZT 0.1
乳酸锌 0.2
葡糖酸锌 0.2
D,L-泛酰醇 0.5
UCare JR 30M 0.2
甲基纤维素K4MS 0.1
(Y)用于下层乳胶手套的锌凝胶乳膏/洗剂
成分 百分数范围(w/w%)
Ucare JR30-M 0.8
甲基纤维素K100 0.3
水 26.63
葡糖酸锌 0.6
乙酸锌 0.2
乳酸锌 0.2
Germall+ 0.2
硬脂酸锌 1.5
氧化锌 1.0
Glucate DO 5.0
乙醇 55.0
异丙醇 3.0
硅酮(二甲基硅酮) 0.5
Incroquat Behenyl TMS 1.0
Polawax A31 0.5
甘油 2.0
十六烷基醚(PPG10) 1.0
CHG 0.05
BZK 0.02
法尼醇 0.3
维生素E 0.2
(Z)抗刺激消毒肥皂
成分 百分数范围(w/w%)
Polyox WSR 205 0.1
Ucare.Jr30-M 0.2
Germall+ 0.2
水 86.93
普朗尼克(pluronic)F87 2.0
椰油酰氨基丙基甜菜碱 1.0
Mirapol A-15 1.0
丙二醇 2.0
聚季铵-47(Merquat 3330) 3.0
甘油 2.0
CHG 0.05
BZK 0.12
三氯生 0.3
法尼醇 0.3
柠檬油 0.3
乙酸锌 0.1
乳酸锌 0.1
葡糖酸锌 0.3
6.有效实施例
6.1.实施例1
在存在或不存在EO和IC,存在或不存在抗微生物化合物,如苯扎氯铵(BZK),葡糖酸氯己定(CHG)、2-巯基吡啶氧化锌(ZP)和三氯生(TC)的情况下制备用作抗刺激药的含锌盐局部制剂。评价了以下EO和IC:代表精油的柠檬油、代表萜烯醇的法尼醇和里哪醇以及代表醛类的柠檬醛。然后评价所得制剂的抗微生物活性。
6.1.1.方法
制备醇基锌凝胶
按以下方法制备醇基凝胶,将抗微生物剂、EO和/或IC加入下述基料中:
基料#1
成分 重量%
Ucare JR30-M 0.1
甲基纤维素K100 0.1
水 36.4
葡糖酸锌 0.3
乙酸锌 0.1
乳酸锌 0.1
Germall+ 0.2
乙醇 58
异丙醇 2.0
硅酮(二甲基硅酮) 0.2
Incroquat Behenyl TMS 0.7
Polawax A31 0.3
甘油 1.0
十六烷基醚(PPG10) 0.5
在血清存在下评价快速抗微生物活性。
为测定可能被含有细菌的血液或其它蛋白质液体污染的抗菌组合物在皮肤上的效力,在血清存在下评价抗微生物活性,如下所述。简要说,将0.5毫升108CFU金黄色葡萄球菌/毫升加入无菌培养管中的成年牛血清中并混合。将0.5毫升测试制剂加入各管并涡旋搅拌。15秒后,用药物灭活培养基(LTSB)将它进一步稀释到1∶100,将0.5毫升铺于TSA平板上。在37℃孵育该板24小时,测定培养物的每毫升菌落数。
6.1.2.结果
据观察,当与BZK组合时,法尼醇、里哪醇、柠檬醛和柠檬油显示出协同的抗微生物效果。当法尼醇与其它抗微生物化合物、CHG、ZP或TC组合时,没有观察到这种协同作用。参见以下表1。
表1.
EO和IC成分与抗微生物剂的协同效果
受试生物体:金黄色葡萄球菌
组 CFU/毫升 Log10降低
对照(基料) 3.4×107 -
BZK 5.4×105 1.8
CHG 6.6×105 1.7
TC 1.5×106 1.3
ZP 1.4×106 1.4
F 8.4×106 0.6
LI 1.5×106 1.3
CI 1.5×106 1.3
LO 1.6×106 1.3
BZK+F 3.0×102 5.0
BZK+CI 2.0×102 5.2
BZK+LI 6.0×102 4.7
BZK+LO 1.4×103 4.4
CHG+BZK+F 2.3×102 5.2
CHG+BZK+LO 1.4×103 4.4
CHG+BZK+LI 2.0×102 5.2
CHG+BZK+CI 1.0×102 5.5
CHG+BZK+LO+TC 1.4×103 4.4
CHG+BZK+F+TC 1.5×102 5.3
CHG+BZK+F+ZP+LO 2.0×102 5.2
CHG+LO 1.6×105 2.3
TC+LO 1.4×106 1.4
ZP+LO 1.4×106 1.4
CHG+F 6.8×104 2.7
TC+F 1.2×106 1.4
ZP+F 1.3×106 1.4
注:BZK:苯扎氯铵(0.12%);PHMB:盐酸聚亚己基缩二胍(0.15%);CHG:葡糖酸氯己定(0.05%);TC:三氯生(0.3%);ZP:2-巯基吡啶氧化锌(0.5%);F:法尼醇(0.3%);LO:柠檬油(0.3%);LI:里哪醇;(0.3%);CI:柠檬醛(0.3%)。
从表1中可以看出,在所用的这些抗微生物化合物中,只有季铵化合物苯扎氯铵与EO和IC结合后,显示出明显的协同活性。
6.2.实施例2
本实施例显示了含有季铵化合物苯索氯铵(BZT)和法尼醇的组合物在锌盐存在下的抗微生物活性。如实施例1所述评价抗微生物活性。
将法尼醇和BZT以表2所示的比例掺入基料#1(含有锌盐)和下述基料#2(不含锌盐)中。
基料#2(不含锌盐)
成分 重量%
Ucare JR30-M 0.1
甲基纤维素K100 0.1
水 36.9
Germall+ 0.2
乙醇 58
异丙醇 2.0
硅酮(二甲基硅酮) 0.2
Incroquat Behenyl TMS 0.7
Polawax A31 0.3
甘油 1.0
PPG-10十六烷基醚(Procetyl-10) 0.5
表2
测试生物体:金黄色葡萄球菌
结果证明,在存在或不存在锌盐的情况下,BZT和法尼醇都有协同抗微生物效果。
6.3.实施例3
用实施例1所述的相同方法评价了将不同比例的法尼醇和季铵化合物掺入基料#2中的抗微生物效果。结果见表3。
表3
测试生物体:金黄色葡萄球菌
凝胶基中的组(w/w%) | cfu/毫升 | log10降低 |
对照凝胶 | 1.4×107 | 0.0 |
BZT(0.18%)(防腐剂水平) | 3.3×105 | 1.6 |
BZT(0.12%) | 4.7×105 | 1.5 |
BZT(0.06%) | 5.7×105 | 1.4 |
BZK(0.12%)(防腐剂水平) | 5.4×105 | 1.4 |
BZK(0.06%) | 1.8×106 | 0.9 |
法尼醇(0.5%) | 4.5×105 | 1.5 |
法尼醇(0.3%) | 4.6×105 | 1.5 |
BZT(0.18%)+法尼醇(0.5%) | 6.7×101 | 5.3 |
BZT(0.18%)+法尼醇(0.3%) | 6.7×101 | 5.3 |
BZT(0.12%)+法尼醇(0.3%) | 1.0×102 | 5.1 |
BZT(0.06%)+法尼醇(0.3%) | 1.0×102 | 5.1 |
BZK(0.12%)+法尼醇(0.5%) | 2.0×102 | 4.8 |
BZK(0.12%)+法尼醇(0.3%) | 3.7×103 | 3.6 |
BZK(0.06%)+法尼醇(0.3%) | 7.9×103 | 3.2 |
结果证明,当在对金黄色葡萄球菌进行的基于血清的快速测定中与法尼醇组合使用时,季铵化合物BZK和BZT都有协同抗微生物活性。
6.4.实施例4
用实施例1所述的相同测定方法评价了在存在或不存在季铵化合物BZK和BZT的情况下,掺入基料#2中的各种EO和IC的抗微生物效果。所用各种试剂的量见表4。除金黄色葡萄球菌外,也用大肠埃希氏菌进行了快速测定。结果见表4。
表4
注:BZK:苯扎氯铵(0.12w/w%:防腐剂水平);BZT:苯索氯铵(0.18w/w%:防腐剂水平);所有其它EO/IC(0.5w/w%)。
这些结果证明,当各种精油与季铵化合物组合使用时,在基于血清的快速测定中对金黄色葡萄球菌具有快速的协同抗微生物活性。具体说,广藿香油、罗勒油、桉叶油、百里香油、丁香油、老鹳草油和香茅油显示出显著的抗微生物效果。
6.5.实施例5
用实施例1所述的相同测定方法评价了在法尼醇和季铵化合物的组合中加入各种双胍抗微生物化合物,将其掺入基料#2的效果。结果见表5。
表5
PHMB似乎提高了BZT和法尼醇的组合的活性。
6.6.实施例6
该实施例证明了含有法尼醇与各种抗微生物剂组合的凝胶的抗微生物活性。选择抗微生物剂的浓度,使这些成分达到留在皮肤上的护肤制剂中允许的水平。用实施例1所述的方法测定抗微生物活性。数据见表6。
表6
测试生物体:金黄色葡萄球菌
在凝胶中的成分(w/w%) | 作为防腐剂的推荐范围(w/w%) | 对照a,b的菌落数的log10降低 |
法尼醇(0.3%) | - | 0.6 |
CHG(0.05%) | 0.0-0.05 | 1.7 |
PHMB(0.15%) | 0.1-0.3 | 2.9 |
TC(0.3%) | 0.3-0.5 | 1.3 |
BZT(0.18%) | 0.1-0.2 | 1.6 |
BZK(0.12%) | 0.1-0.12 | 1.8 |
法尼醇(0.3%)+CHG(0.05%) | - | 2.7 |
法尼醇(0.3%)+PHMB(0.15%) | - | 3.4 |
法尼醇(0.3%)+TC(0.3%) | - | 1.4 |
法尼醇(0.3%)+BZT(0.18%) | - | 5.3 |
法尼醇(0.3%)+BZK(0.12%) | 5.0 |
(a)对照基料实验的菌落数是3.4×107cfu/毫升。
(b)作为对照,凝胶基料与表6中所示凝胶相同,但不含任何抗微生物剂。
结果显示,法尼醇提高抗微生物剂活性的能力因化合物而不同。法尼醇与季铵化合物苯扎氯铵(BZT)和苯索氯铵(BZK)具有协同作用。在双胍类抗微生物化合物中,它提高了盐酸聚亚己基缩二胍(PHMB)的活性,但未提高葡糖酸氯己定(CHG)的活性。法尼醇与三氯生也没有任何协同作用,也不提高三氯生的作用。因此,法尼醇的协同作用或提高抗微生物剂/防腐剂的活性的能力对所讨论抗微生物剂具有特异性。
用与上述表6相同的法尼醇浓度(0.3w/w%,即1.35mM每100克凝胶)进行了类似研究,将各种抗微生物剂以相同摩尔浓度加入凝胶(0.06mM每100克凝胶)中。数据见下表7。
表7
测试生物体:金黄色葡萄球菌
在凝胶中的成分(每100克凝胶的克毫摩尔数) | 对照a,b的菌落数的log10降低 |
法尼醇(1.35mM) | 1.8 |
CHG(0.06mM) | 1.9 |
PHMB(0.06mM) | 2.1 |
TC(1.04mM)c | 1.3 |
BZT(0.06mM) | 1.9 |
法尼醇(1.35mM)+CHG(0.06mM) | 2.0 |
法尼醇(1.35mM)+PHMB(0.06mM) | 3.2 |
法尼醇(1.35mM)+TC(1.04mM)c | 1.4 |
法尼醇(1.35mM)+BZT(0.06mM) | 5.5 |
(a)对照基料实验的菌落数是6.4×107cfu/毫升。
(b)作为对照,使用凝胶基料与表7中所示凝胶相同,但不含任何防腐剂/抗微生物剂。
(c)由于三氯生即使在1.04mM浓度下也无效,所以没有用0.06mM浓度进行实验。
与表6所示结果类似,法尼醇对各种抗微生物剂的抗微生物活性的提高效果不同。法尼醇似乎与BZT,而非三氯生具有协同的抗微生物活性。PHMB似乎提高了法尼醇的活性。法尼醇发挥协同作用的机制或提高抗微生物剂的活性的机制因化合物而不同,但对于相同化合物是相同的,与浓度无关(无论化合物的浓度是以w/w%计还是以摩尔分数计)。
本说明书引用了各种参考文献、专利、刊物、产品说明书等,将这些公开以整体纳入本文作为参考。
Claims (32)
1.一种局部使用的抗微生物组合物,所述组合物含有季铵化合物和选自精油及单个精油成分的物质,其中所述季铵化合物和所述物质以显示协同抗微生物活性的量存在,其中所述物质的浓度是0.05-1.0%。
2.如权利要求1所述的组合物,其特征在于,所述季铵化合物的浓度是0.01-0.5%。
3.如权利要求1所述的组合物,其特征在于,所述季铵化合物选自苯扎氯铵和苯索氯铵。
4.如权利要求2所述的组合物,其特征在于,所述季铵化合物选自苯扎氯铵和苯索氯铵。
5.如权利要求1所述的组合物,其特征在于,所述物质是选自下组的精油:佛手柑油、香鼠尾草油、依兰油、橙花油、檀木油、蓝丹油、姜油、薄荷油、薰衣草油、茉莉油、老鹳草油波旁、薄荷油、丁香油、广藿香油、迷迭香油、玫瑰木油、檀木油、茶树油、香草油、柠檬草油、香柏油、香胶树油、红橘油、扁柏油、亥巴油、银杏油、桉叶油、柠檬油、橙油和甜橙油。
6.如权利要求2所述的组合物,其特征在于,所述物质是选自下组的精油:佛手柑油、香鼠尾草油、依兰油、橙花油、檀木油、蓝丹油、姜油、薄荷油、薰衣草油、茉莉油、老鹳草油波旁、薄荷油、丁香油、广藿香油、迷迭香油、玫瑰木油、檀木油、茶树油、香草油、柠檬草油、香柏油、香胶树油、红橘油、扁柏油、亥巴油、银杏油、桉叶油、柠檬油、橙油和甜橙油。
7.如权利要求3所述的组合物,其特征在于,所述物质是选自下组的精油:佛手柑油、香鼠尾草油、依兰油、橙花油、檀木油、蓝丹油、姜油、薄荷油、薰衣草油、茉莉油、老鹳草油波旁、薄荷油、丁香油、广藿香油、迷迭香油、玫瑰木油、檀木油、茶树油、香草油、柠檬草油、香柏油、香胶树油、红橘油、扁柏油、亥巴油、银杏油、桉叶油、柠檬油、橙油和甜橙油。
8.如权利要求4所述的组合物,其特征在于,所述物质是选自下组的精油:佛手柑油、香鼠尾草油、依兰油、橙花油、檀木油、蓝丹油、姜油、薄荷油、薰衣草油、茉莉油、老鹳草油波旁、薄荷油、丁香油、广藿香油、迷迭香油、玫瑰木油、檀木油、茶树油、香草油、柠檬草油、香柏油、香胶树油、红橘油、扁柏油、亥巴油、银杏油、桉叶油、柠檬油、橙油和甜橙油。
9.如权利要求1所述的组合物,其特征在于,所述物质是选自下组的单个精油成分:1-香茅醇、α-戊基肉桂醛、新铃兰醛、香叶醇、法尼醇、羟基香茅醛、异丁子香酚、丁子香酚、桉树脑、里哪醇和柠檬醛。
10.如权利要求2所述的组合物,其特征在于,所述物质是选自下组的单个精油成分:1-香茅醇、α-戊基肉桂醛、新铃兰醛、香叶醇、法尼醇、羟基香茅醛、异丁子香酚、丁子香酚、桉树脑、里哪醇和柠檬醛。
11.如权利要求3所述的组合物,其特征在于,所述物质是选自下组的单个精油成分:1-香茅醇、α-戊基肉桂醛、新铃兰醛、香叶醇、法尼醇、羟基香茅醛、异丁子香酚、丁子香酚、桉树脑、里哪醇和柠檬醛。
12.如权利要求4所述的组合物,其特征在于,所述物质是选自下组的单个精油成分:1-香茅醇、α-戊基肉桂醛、新铃兰醛、香叶醇、法尼醇、羟基香茅醛、异丁子香酚、丁子香酚、桉树脑、里哪醇和柠檬醛。
13.如权利要求1所述的组合物,还包含能够降低刺激的量的两种或多种锌盐。
14.如权利要求2所述的组合物,还包含能够降低刺激的量的两种或多种锌盐。
15.如权利要求3所述的组合物,还包含能够降低刺激的量的两种或多种锌盐。
16.如权利要求4所述的组合物,还包含能够降低刺激的量的两种或多种锌盐。
17.如权利要求13所述的组合物,其特征在于,两种或多种锌盐选自乙酸锌、柠檬酸锌、葡糖酸锌、甘油酸锌、乙醇酸锌、甲酸锌、乳酸锌、吡啶甲酸锌、丙酸锌、水杨酸锌、酒石酸锌、十一碳烯酸锌、氧化锌和硬脂酸锌。
18.如权利要求14所述的组合物,其特征在于,两种或多种锌盐选自乙酸锌、柠檬酸锌、葡糖酸锌、甘油酸锌、乙醇酸锌、甲酸锌、乳酸锌、吡啶甲酸锌、丙酸锌、水杨酸锌、酒石酸锌、十一碳烯酸锌、氧化锌和硬脂酸锌。
19.如权利要求15所述的组合物,其特征在于,两种或多种锌盐选自乙酸锌、柠檬酸锌、葡糖酸锌、甘油酸锌、乙醇酸锌、甲酸锌、乳酸锌、吡啶甲酸锌、丙酸锌、水杨酸锌、酒石酸锌、十一碳烯酸锌、氧化锌和硬脂酸锌。
20.如权利要求16所述的组合物,其特征在于,两种或多种锌盐选自乙酸锌、柠檬酸锌、葡糖酸锌、甘油酸锌、乙醇酸锌、甲酸锌、乳酸锌、吡啶甲酸锌、丙酸锌、水杨酸锌、酒石酸锌、十一碳烯酸锌、氧化锌和硬脂酸锌。
21.如权利要求13所述的组合物,其特征在于,所述两种或多种锌盐各自的浓度为0.1-0.5重量%。
22.如权利要求14所述的组合物,其特征在于,所述两种或多种锌盐各自的浓度为0.1-0.5重量%。
23.如权利要求15所述的组合物,其特征在于,所述两种或多种锌盐各自的浓度为0.1-0.5重量%。
24.如权利要求16所述的组合物,其特征在于,所述两种或多种锌盐各自的浓度为0.1-0.5重量%。
25.如权利要求13所述的组合物,还包含泛酰醇,其浓度为0.5%-2%。
26.如权利要求14所述的组合物,还包含泛酰醇,其浓度为0.5%-2%。
27.如权利要求15所述的组合物,还包含泛酰醇,其浓度为0.5%-2%。
28.如权利要求16所述的组合物,还包含泛酰醇,其浓度为0.5%-2%。
29.一种在对象的皮肤区域上产生抗微生物效果的方法,所述方法包括将有效量的权利要求1-28中任一项所述组合物施用于该区域。
30.一种在对象的粘膜区域上产生抗微生物效果的方法,所述方法包括将有效量的权利要求1-28中任一项所述组合物施用于该区域。
31.如权利要求1-28中任一项所述的组合物,还包含选自葡糖酸氯己定(CHG)和聚亚己基缩二胍(PHMB)的双胍化合物,其中所述双胍化合物的浓度为0.1-2.0%w/w。
32.如权利要求31所述的组合物,还包含浓度为10-90%w/w的醇、浓度为15-70%w/w的水、浓度为0.05-3.0%w/w的增稠剂和/或胶凝剂,以及浓度为0.1-3.0%的润肤剂。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48834903P | 2003-07-17 | 2003-07-17 | |
US60/488,349 | 2003-07-17 | ||
US53086403P | 2003-12-18 | 2003-12-18 | |
US60/530,864 | 2003-12-18 | ||
PCT/US2004/022505 WO2005009352A2 (en) | 2003-07-17 | 2004-07-15 | Antimicrobial compositons containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011102381998A Division CN102309473A (zh) | 2003-07-17 | 2004-07-15 | 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 |
CN2011102382242A Division CN102319409A (zh) | 2003-07-17 | 2004-07-15 | 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101217870A true CN101217870A (zh) | 2008-07-09 |
CN101217870B CN101217870B (zh) | 2011-10-12 |
Family
ID=34107767
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011102382242A Pending CN102319409A (zh) | 2003-07-17 | 2004-07-15 | 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 |
CN2004800205345A Expired - Fee Related CN101217870B (zh) | 2003-07-17 | 2004-07-15 | 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 |
CN2011102381998A Pending CN102309473A (zh) | 2003-07-17 | 2004-07-15 | 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011102382242A Pending CN102319409A (zh) | 2003-07-17 | 2004-07-15 | 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011102381998A Pending CN102309473A (zh) | 2003-07-17 | 2004-07-15 | 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 |
Country Status (9)
Country | Link |
---|---|
US (2) | US7871649B2 (zh) |
EP (1) | EP1651176A4 (zh) |
JP (2) | JP2007534620A (zh) |
CN (3) | CN102319409A (zh) |
AU (1) | AU2004258899B2 (zh) |
BR (1) | BRPI0412675A (zh) |
CA (1) | CA2532730C (zh) |
MX (1) | MXPA06000543A (zh) |
WO (1) | WO2005009352A2 (zh) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101843914A (zh) * | 2010-04-30 | 2010-09-29 | 吴杰 | 一种具有空气消毒作用的组合物 |
CN103385977A (zh) * | 2012-05-07 | 2013-11-13 | 毛赢超 | 免疫功能鼻膏 |
CN105754735A (zh) * | 2016-04-19 | 2016-07-13 | 广州市科士威化妆品制造有限公司 | 一种厨房清洁剂及其制备方法 |
CN105828637A (zh) * | 2013-12-30 | 2016-08-03 | 陶氏环球技术有限责任公司 | 杀微生物组合物 |
CN105886160A (zh) * | 2016-05-13 | 2016-08-24 | 无为县荣华鬃刷制品有限公司 | 一种鬃毛杀菌溶液 |
CN106102711A (zh) * | 2014-03-21 | 2016-11-09 | 陶氏环球技术有限责任公司 | 发油调理剂 |
CN108633932A (zh) * | 2011-10-04 | 2018-10-12 | 0903608 B.C.有限公司 | 害虫控制配制物以及制造和使用其的方法 |
CN109287676A (zh) * | 2018-11-13 | 2019-02-01 | 沈阳秉弘环保科技有限公司 | 一种抗菌除螨去异味的水溶液 |
CN109498562A (zh) * | 2018-12-18 | 2019-03-22 | 广州润虹医药科技股份有限公司 | 一种紧急烧伤护理液及其制备方法 |
CN109562182A (zh) * | 2016-06-02 | 2019-04-02 | 先进科学发展公司 | 包含桉树脑和阿莫西林的药物制剂 |
CN111544310A (zh) * | 2020-05-28 | 2020-08-18 | 安徽省天助纺织科技集团股份有限公司 | 一种无刺激抗菌消毒湿巾及其制备方法 |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100055152A1 (en) * | 2008-08-26 | 2010-03-04 | Trutek Corporation | Antihistamine and antihistamine-like nasal application, products, and method |
US6224579B1 (en) * | 1999-03-31 | 2001-05-01 | The Trustees Of Columbia University In The City Of New York | Triclosan and silver compound containing medical devices |
US7329412B2 (en) * | 2000-12-22 | 2008-02-12 | The Trustees Of Columbia University In The City Of New York | Antimicrobial medical devices containing chlorhexidine free base and salt |
GB0104153D0 (en) * | 2001-02-20 | 2001-04-11 | Reckitt Benckiser Inc | Improvements in or relating to organic compositions |
US6846846B2 (en) * | 2001-10-23 | 2005-01-25 | The Trustees Of Columbia University In The City Of New York | Gentle-acting skin disinfectants |
US7745425B2 (en) * | 2002-02-07 | 2010-06-29 | The Trustees Of Columbia University In The City Of New York | Non-irritating compositions containing zinc salts |
US7435429B2 (en) | 2002-02-07 | 2008-10-14 | Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
AU2003216213B2 (en) * | 2002-02-07 | 2008-10-02 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides |
US7563461B2 (en) * | 2002-02-07 | 2009-07-21 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
US7879365B2 (en) * | 2002-02-07 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
WO2005009352A2 (en) | 2003-07-17 | 2005-02-03 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositons containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof |
US9655939B2 (en) | 2004-07-29 | 2017-05-23 | Robert Alan Reeve | Antimicrobial and/or antiviral composition and to methods for preparing and administering same |
GB2417959A (en) * | 2004-09-11 | 2006-03-15 | Reckitt Benckiser Inc | Cleaning and sanitizing compositions |
US20060110416A1 (en) * | 2004-11-23 | 2006-05-25 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Hydroalcoholic cosmetic compositions |
US20060257347A1 (en) * | 2005-05-13 | 2006-11-16 | Kim Joo W | Self-preservation system |
EP1954142B1 (en) * | 2005-11-18 | 2017-04-19 | Wild Child | Pediculicide/ovicide composition |
WO2007070795A2 (en) * | 2005-12-12 | 2007-06-21 | The Trustees Of Columbia University In The City Of New York | Broad spectrum non-traditional preservative system |
US20070134303A1 (en) * | 2005-12-14 | 2007-06-14 | Ali Yahiaoui | Protective and therapeutic article |
WO2007077573A1 (en) * | 2006-01-03 | 2007-07-12 | Cavinkare Private Limited | Antimicrobial composition containing triclosan and at least one functionalized hydrocarbon |
US7759327B2 (en) * | 2006-01-06 | 2010-07-20 | The Trustees Of Columbia University In The City Of New York | Compositions containing zinc salts for coating medical articles |
PL1976532T3 (pl) * | 2006-01-27 | 2016-05-31 | Univ Yale | Szybko działający inhibitor wydzielania kwasu żołądkowego |
ITRM20060163A1 (it) * | 2006-03-24 | 2007-09-25 | Ist Farmacoterapico It Spa | Composizione spray ad uso topico per il tratamento e la prevenzione delle infezioni labiali da herpes simplex |
JP2009538961A (ja) * | 2006-06-02 | 2009-11-12 | ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 医用物品を被覆するための亜鉛塩含有組成物 |
CN101500556A (zh) * | 2006-06-02 | 2009-08-05 | 纽约市哥伦比亚大学托管会 | 用于涂覆医疗制品的含锌盐的组合物 |
US7858126B2 (en) | 2006-08-31 | 2010-12-28 | Trinity Laboratories Inc. | Derivatives of sandalwood oil and santalols for treating cold sores and herpes |
JP5033381B2 (ja) * | 2006-09-14 | 2012-09-26 | 株式会社池田模範堂 | 外用医薬組成物 |
US8517728B2 (en) | 2007-01-24 | 2013-08-27 | Colgate-Palmolive Company | Oral care implement having fluid delivery system |
EP1964576A1 (de) * | 2007-02-27 | 2008-09-03 | Certmedica International GmbH | Wässrige, desinfizierende Gelzubereitung |
GB0710899D0 (en) * | 2007-06-07 | 2007-07-18 | Syntopix Ltd | Formulations |
US9687429B2 (en) * | 2007-06-20 | 2017-06-27 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositions containing low concentrations of botanicals |
US9511040B2 (en) * | 2007-06-20 | 2016-12-06 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
WO2008157092A1 (en) | 2007-06-20 | 2008-12-24 | The Trustees Of Columbia University In The City Of New York | Bio-film resistant surfaces |
WO2008157847A1 (en) * | 2007-06-20 | 2008-12-24 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
US9981069B2 (en) | 2007-06-20 | 2018-05-29 | The Trustees Of Columbia University In The City Of New York | Bio-film resistant surfaces |
US20090035228A1 (en) * | 2007-08-02 | 2009-02-05 | Shanta Modak | Skin and surface disinfectant compositions containing botanicals |
EP2205230B1 (en) * | 2007-10-23 | 2016-03-23 | Wild Child | Anti-microbial composition |
US20090258098A1 (en) * | 2008-04-15 | 2009-10-15 | Lane Rolling | Penetrating carrier, antifungal composition using the same and method for treatment of dermatophyte infections |
NZ589519A (en) * | 2008-04-24 | 2012-11-30 | Sunnywipes Pty Ltd | Disinfecting formulation comprising essential oils, alcohol, gelling agent, emollient and water |
US8173183B2 (en) | 2008-07-02 | 2012-05-08 | Carmell Hergert | Mucosal membrane healant and moisturizer |
US20100172848A1 (en) * | 2008-08-01 | 2010-07-08 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
BRPI0914031B1 (pt) * | 2008-10-20 | 2023-12-12 | Unilever Ip Holdings B.V. | Uso de uma composição para higiene das mãos |
US9149567B2 (en) | 2009-03-11 | 2015-10-06 | Ansell Limited | Powder-free antimicrobial coated glove |
US20100229282A1 (en) * | 2009-03-11 | 2010-09-16 | Ansell Limited | Powder-Free Anti-Blocking Coated Glove |
SG178166A1 (en) | 2009-08-12 | 2012-03-29 | Colgate Palmolive Co | Oral care composition comprising a sesquiterpenoid and an antimicrobial agent |
US8440212B2 (en) * | 2009-08-24 | 2013-05-14 | Arch Chemicals, Inc. | Compositions for treating water systems |
JP5844260B2 (ja) | 2009-09-24 | 2016-01-13 | ユニリーバー・ナームローゼ・ベンノートシヤープ | オイゲノール、テルピネオールおよびチモールを含む殺菌剤 |
US20130252911A1 (en) | 2009-11-02 | 2013-09-26 | Alpha-Biocare Gmbh | Compositions comprising flavonoid-containing extracts from plants of the genus citrus and/or isolated citrus flavonoids and specific cationic surface active agents, and said composition for use as an agent for treating infestations with head lice |
MX2012006032A (es) | 2009-12-18 | 2012-09-07 | Indian Inst Of Integrative Medicine | Calconas como potenciadores de agentes antimicrobianos. |
TWI392513B (zh) | 2010-01-07 | 2013-04-11 | Colgate Palmolive Co | 含查酮的口腔保健調配物之變色 |
EP2555748A2 (en) * | 2010-04-07 | 2013-02-13 | Allergan, Inc. | Combinations of preservatives for ophthalmic compositions |
EP2575744B1 (en) | 2010-05-31 | 2023-02-01 | Unilever Global IP Limited | Skin treatment composition |
WO2012015420A1 (en) * | 2010-07-30 | 2012-02-02 | Colgate-Palmolive Company | Mouthwash formulations for use with toothbrush delivery device |
BR112013013085B1 (pt) | 2010-12-07 | 2018-02-14 | Unilever N.V. | Composição de cuidados orais, enxaguante bucal, creme dental, dentífrico, método para desinfetar a cavidade oral e uso de uma composição |
KR101658361B1 (ko) * | 2010-12-10 | 2016-09-21 | 유영국 | 피부 감염의 예방 및 치료용 조성물 |
AU2011361752B2 (en) | 2011-03-09 | 2015-01-22 | Colgate-Palmolive Company | Interdental cleaning device |
EP2736486B1 (en) * | 2011-07-28 | 2019-03-06 | 3M Innovative Properties Company | Wound-healing compositions and method of use |
US9968101B2 (en) | 2011-11-03 | 2018-05-15 | The Trustees Of Columbia University In The City Of New York | Botanical antimicrobial compositions |
AU2012332495B2 (en) | 2011-11-03 | 2017-06-08 | The Trustees Of Columbia University In The City Of New York | Composition with sustained antimicrobial activity |
CN103998011B (zh) | 2011-11-03 | 2016-11-23 | 荷兰联合利华有限公司 | 个人清洁组合物 |
TW201330856A (zh) | 2011-12-06 | 2013-08-01 | Univ Columbia | 廣效性的天然防腐組成物 |
JP5460766B2 (ja) * | 2012-03-15 | 2014-04-02 | 株式会社池田模範堂 | 外用医薬組成物 |
US20130255061A1 (en) * | 2012-04-03 | 2013-10-03 | Becton, Dickinson And Company | Systems and methods for applying a novel antimicrobial coating material to a medical device |
US9352119B2 (en) | 2012-05-15 | 2016-05-31 | Becton, Dickinson And Company | Blood control IV catheter with antimicrobial properties |
GB201211691D0 (en) | 2012-07-05 | 2012-08-15 | Reckitt Benckiser Llc | Sprayable aqueous alcoholic microbicidal compositions comprising zinc ions |
GB201211688D0 (en) * | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Aqueous alcoholic microbicidal compositions comprising zinc ions |
GB201211701D0 (en) | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Aqueous alcoholic microbicidal compositions comprising zinc ions |
GB201211702D0 (en) * | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Sprayable aqueous alcoholic microbicidal compostions comprising zinc ions |
CA2918491C (en) * | 2012-07-23 | 2021-10-12 | Innovative Biodefense, Inc. | Topical sanitizing formulations and uses thereof |
US9554641B2 (en) | 2012-10-26 | 2017-01-31 | Colgate-Palmolive Company | Oral care implement |
FR2998478B1 (fr) * | 2012-11-23 | 2015-06-05 | Oreal | Utilisation d'un melange d'huiles essentielles comme agent desquamant |
WO2014083330A1 (en) | 2012-11-30 | 2014-06-05 | Reckitt & Colman (Overseas) Limited | Microbicidal personal care compositions comprising metal ions |
CN104822422B (zh) | 2012-12-03 | 2018-03-13 | 高露洁-棕榄公司 | 用于治疗龋齿的组合物和方法 |
EP2931050A4 (en) * | 2012-12-13 | 2016-09-07 | Univ Columbia | ANTIMICROBIAL BOTANICAL COMPOSITIONS |
JP5634492B2 (ja) * | 2012-12-13 | 2014-12-03 | 株式会社トレードワークス | 抗菌・抗カビ組成物および該組成物を使用した肌冷却用ウェット縫製品 |
JP2013099543A (ja) * | 2012-12-27 | 2013-05-23 | Trustees Of Columbia Univ In The City Of New York | 医用物品を被覆するための亜鉛塩含有組成物 |
US9695323B2 (en) | 2013-02-13 | 2017-07-04 | Becton, Dickinson And Company | UV curable solventless antimicrobial compositions |
US9750928B2 (en) | 2013-02-13 | 2017-09-05 | Becton, Dickinson And Company | Blood control IV catheter with stationary septum activator |
US8603550B1 (en) | 2013-05-15 | 2013-12-10 | Normajean Fusco | Compositions for topical treatment |
GB201317005D0 (en) * | 2013-09-25 | 2013-11-06 | Blueberry Therapeutics Ltd | Composition and methods of treatment |
EP3089750A2 (en) * | 2014-01-02 | 2016-11-09 | Cook Medical Technologies LLC | Compositions, devices and methods for treating infections |
US10376686B2 (en) | 2014-04-23 | 2019-08-13 | Becton, Dickinson And Company | Antimicrobial caps for medical connectors |
US9675793B2 (en) | 2014-04-23 | 2017-06-13 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
US9789279B2 (en) | 2014-04-23 | 2017-10-17 | Becton, Dickinson And Company | Antimicrobial obturator for use with vascular access devices |
US10232088B2 (en) | 2014-07-08 | 2019-03-19 | Becton, Dickinson And Company | Antimicrobial coating forming kink resistant feature on a vascular access device |
WO2016041488A1 (en) * | 2014-09-19 | 2016-03-24 | The Hong Kong University Of Science And Technology | Antimicrobial coating for long-term disinfection of surfaces |
JP6103390B2 (ja) * | 2014-12-24 | 2017-03-29 | パナソニックIpマネジメント株式会社 | 有機発光デバイスおよび有機表示装置 |
US9624384B2 (en) | 2015-04-07 | 2017-04-18 | IndusCo, Ltd. | Water stable antimicrobial silanol quaternary ammonium compounds |
AU2016278853A1 (en) * | 2015-06-19 | 2018-02-08 | Global Health Solutions, Llc | Petrolatum-based compositions comprising cationic biocides |
CA2990627A1 (en) | 2015-06-22 | 2016-12-29 | Infection Containment Company, LLC | Topical antiseptic system |
JP6523473B6 (ja) * | 2015-10-23 | 2019-08-21 | 株式会社優しい研究所 | バクテリオシンを含むヘルスケア組成物 |
US10493244B2 (en) | 2015-10-28 | 2019-12-03 | Becton, Dickinson And Company | Extension tubing strain relief |
CN105248461A (zh) * | 2015-11-18 | 2016-01-20 | 李爱冰 | 一种家用消毒液及其制备方法 |
EP3534708A1 (en) | 2016-11-07 | 2019-09-11 | Jubilant Life Sciences Limited | Synergistic antimicrobial compositions |
US10308897B2 (en) * | 2017-04-24 | 2019-06-04 | Gpcp Ip Holdings Llc | Alkaline sanitizing soap preparations containing quaternary ammonium chloride agents |
BR112020001850B1 (pt) * | 2017-08-18 | 2023-03-21 | L'oreal | Mistura antimicrobiana, composição, processo de tratamento cosmético e processo para conservar uma composição |
FR3070109B1 (fr) * | 2017-08-18 | 2019-08-30 | L'oreal | Melange antimicrobien contenant du 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one et d’un sel d’ alkyldimethylbenzylammonium, et composition cosmetique le contenant |
CN108542938B (zh) * | 2018-05-17 | 2021-02-12 | 东莞市卫花生物科技有限公司 | 抗菌剂 |
JP2019131619A (ja) * | 2019-05-16 | 2019-08-08 | 株式会社日健総本社 | 抗菌剤 |
WO2021191297A1 (en) * | 2020-03-25 | 2021-09-30 | Universität Basel | Virucidal hand cream formulation |
JP7073593B1 (ja) * | 2022-01-19 | 2022-05-23 | 大木 彬 | 抗菌、抗カビ、抗ウイルス性消毒剤組成物 |
WO2023213846A1 (en) * | 2022-05-03 | 2023-11-09 | Kamer Patrick | Antimicrobial composition |
Family Cites Families (154)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL31756C (zh) | 1962-04-26 | |||
US3485915A (en) | 1966-04-22 | 1969-12-23 | Revlon | Thickened hydroxypropyl cellulose compositions |
GB1338003A (en) | 1971-06-18 | 1973-11-21 | Ici Ltd | Cleaning compositions |
JPS5247923A (en) | 1975-10-14 | 1977-04-16 | Kao Corp | Hair cosmetics |
US4318907A (en) | 1978-04-04 | 1982-03-09 | Westwood Pharmaceuticals, Inc. | Method for treating acne vulgaris and compositions useful for that purpose |
SU833240A1 (ru) | 1979-03-12 | 1981-05-30 | Московский Ордена Ленина И Орденатрудового Красного Знамени Химико- Технологический Институт Им.Д.И.Менделеева | Защитный крем дл рук |
GB2075837B (en) | 1980-05-14 | 1984-03-14 | Hisamitsu Pharmaceutical Co | Topical pharmaceutical gel containing anti-inflammatory analgesic agents |
FR2483177A1 (fr) | 1980-05-29 | 1981-12-04 | Salkin Nicolas | Nouvelle composition desinfectante comprenant un ammonium quaternaire et un oligomere de chlorhydrate d'hexamethylene biguanide |
US4664909A (en) * | 1980-12-29 | 1987-05-12 | Colgate-Palmolive Company | Stable suspension of powder in alcoholic media |
US4478853A (en) | 1982-05-17 | 1984-10-23 | S. C. Johnson & Son, Inc. | Skin conditioning composition |
DE3376957D1 (en) | 1982-06-24 | 1988-07-14 | Robert Alan Smith | Pharmaceutical gel composition |
US4670185A (en) * | 1982-07-19 | 1987-06-02 | Lion Corporation | Aqueous vesicle dispersion having surface charge |
US4587266A (en) | 1982-09-24 | 1986-05-06 | Johnson & Johnson Baby Products Company | Antimicrobial compositions |
FR2552305B1 (fr) * | 1983-09-22 | 1985-12-20 | Salkin Andre | Composition a pouvoir bactericide eleve contenant un biguanide et une pyrimidine |
ATE97440T1 (de) | 1984-09-26 | 1993-12-15 | Gluck Bruno A | Antiseptische waschmittelzusammensetzungen. |
US4889844A (en) | 1985-10-22 | 1989-12-26 | Silvetti Sr Anthony N | Fructose containing wound healing preparation |
US4963591A (en) * | 1985-12-16 | 1990-10-16 | Carter-Wallace Inc. | Cosmetic compositions |
GB8630823D0 (en) | 1986-01-16 | 1987-02-04 | Ici Plc | Antiseptic compositions |
DE3601132A1 (de) | 1986-01-16 | 1987-07-23 | Christian Bannert | Verfahren zur behandlung der schleimhaut |
FR2601850B1 (fr) * | 1986-07-25 | 1990-05-04 | Garcin Francoise | Composition antiseptique incorporant des huiles essentielles. |
WO1988003799A1 (en) | 1986-11-19 | 1988-06-02 | Chemex Pharmaceuticals, Inc. | Pharmaceutical vehicles for reducing transdermal flux |
JP2662006B2 (ja) * | 1987-04-13 | 1997-10-08 | ストレイ,クレイグ,フランシス | 手押し車 |
US4853978A (en) | 1987-07-24 | 1989-08-08 | Surgikos, Inc. | Antimicrobial medical glove |
DE3879811T2 (de) * | 1987-08-25 | 1993-10-07 | Kuebler Gmbh Dr | Pharmazeutische Zusammensetzung und ihre Verwendung. |
CA1273576A (en) * | 1987-09-16 | 1990-09-04 | Patrick A. Beauchamp | Topical treatment for diseased skin disorders |
US4869897A (en) | 1987-10-22 | 1989-09-26 | The Procter & Gamble Company | Photoprotection compositions comprising sorbohydroxamic acid |
US4868169A (en) | 1987-11-13 | 1989-09-19 | E. R. Squibb & Sons, Inc. | Steroid cream formulation |
DK505488D0 (da) | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
US5133090A (en) | 1988-02-11 | 1992-07-28 | The Trustees Of Columbia University In The City Of New York | Antiviral glove |
US5110809A (en) | 1988-03-21 | 1992-05-05 | Bristol-Myers Squibb Company | Antifungal gel formulations |
US5031245B1 (en) | 1989-04-20 | 1996-09-10 | Smith & Nephew | Gloves their manufacture and use |
US4910205A (en) | 1988-05-02 | 1990-03-20 | Schering Corporation | Transdermal delivery of loratadine |
US4966754A (en) | 1988-08-08 | 1990-10-30 | Aveda Corporation | Preservation of cosmetic compositions |
US4870108A (en) | 1988-09-20 | 1989-09-26 | Page Leslie A | Liquid antiseptic composition |
EP0402078A3 (en) | 1989-06-06 | 1991-07-31 | Patrick Daniel Kelly | Sexual lubricants containing zinc as an anti-viral agent |
US5624675A (en) | 1989-06-06 | 1997-04-29 | Kelly; Patrick D. | Genital lubricants containing zinc salts to reduce risk of HIV infection |
US5208031A (en) | 1989-06-06 | 1993-05-04 | Kelly Patrick D | Sexual lubricants containing zinc as an anti-viral agent |
US5059416A (en) | 1989-06-26 | 1991-10-22 | Warner-Lambert Company | Zinc compound delivery system with improved taste and texture |
US4956170A (en) | 1989-06-28 | 1990-09-11 | S. C. Johnson & Son, Inc. | Skin moisturizing/conditioning antimicrobial alcoholic gels |
US5089205A (en) | 1989-09-25 | 1992-02-18 | Becton, Dickinson And Company | Process for producing medical devices having antimicrobial properties |
US5116602A (en) * | 1989-09-27 | 1992-05-26 | Colgate-Palmolive Company | Antiplaque oral compositions |
US5073372A (en) | 1990-11-30 | 1991-12-17 | Richardson-Vicks, Inc. | Leave-on facial emulsion compositions |
JP3115625B2 (ja) | 1991-03-30 | 2000-12-11 | 帝國製薬株式会社 | リドカイン含有外用貼付剤 |
US5164107A (en) | 1991-04-25 | 1992-11-17 | Becton, Dickinson And Company | Chlorhexidine composition useful in a surgical scrub |
TW247878B (zh) | 1991-07-02 | 1995-05-21 | Takeda Pharm Industry Co Ltd | |
US5980477A (en) | 1991-07-29 | 1999-11-09 | Patrick Kelly | Genital lubricants with zinc salts as anti-viral additives |
EG20380A (en) | 1991-10-16 | 1999-02-28 | Richardson Vicks Inc | Enhanced skin penetration system for improved topical delivery of drugs |
EP0613369A1 (en) | 1991-11-22 | 1994-09-07 | Richardson-Vicks, Inc. | Combined personal cleansing and moisturizing compositions |
DE4140474C2 (de) | 1991-12-09 | 1995-07-13 | Schuelke & Mayr Gmbh | Hautpflegeadditiv |
DE4140473C2 (de) | 1991-12-09 | 1995-12-21 | Schuelke & Mayr Gmbh | Hautantiseptikum und Händedesinfektionsmittel |
IL101241A (en) | 1992-03-16 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier |
WO1993018745A1 (en) | 1992-03-23 | 1993-09-30 | Geda International S.A. | Use of antiviral coating for latex items such as condoms |
JPH07506367A (ja) * | 1992-05-05 | 1995-07-13 | ザ、プロクター、エンド、ギャンブル、カンパニー | アクネ治療組成物 |
US5357636A (en) | 1992-06-30 | 1994-10-25 | Dresdner Jr Karl P | Flexible protective medical gloves and methods for their use |
DE4240674C2 (de) | 1992-11-26 | 1999-06-24 | Schuelke & Mayr Gmbh | Desodorierende Wirkstoffe |
JP2533723B2 (ja) | 1992-12-28 | 1996-09-11 | 東興薬品工業株式会社 | 速乾性ゲルタイプ手指消毒剤 |
US5370876A (en) | 1993-01-08 | 1994-12-06 | Microbarriers | Antimicrobial protective skin composition and method for protecting skin from body fluids |
ZA94438B (en) * | 1993-02-19 | 1994-08-29 | Warner Lambert Co | Pre-brushing rinse composition |
US5403864A (en) | 1993-04-01 | 1995-04-04 | John A. Manfuso, Jr. | Rapidly-acting topical antimicrobial composition |
DK0694310T3 (da) | 1993-04-16 | 2000-06-05 | Wakamoto Pharma Co Ltd | Reversibelt, termisk gelatinerende, vandbaseret, medicinsk præparat |
US6321750B1 (en) | 1993-05-03 | 2001-11-27 | Patrick D. Kelly | Condom lubricants with zinc salts as anti-viral additives |
US5447930A (en) | 1993-05-06 | 1995-09-05 | Warner-Lambert Company | Topical anesthetic compositions |
FR2709666B1 (fr) | 1993-09-07 | 1995-10-13 | Oreal | Composition cosmétique ou dermatologique constituée d'une émulsion huile dans eau à base de globules huileux pourvus d'un enrobage cristal liquide lamellaire. |
KR100344568B1 (ko) | 1993-09-21 | 2002-12-28 | 가부시키가이샤 시세이도 | 소독용조성물 |
WO1995012395A1 (en) | 1993-11-05 | 1995-05-11 | E.R. Squibb And Sons, Inc. | Topical antimicrobial cleanser containing chlorhexidine gluconate and alcohol |
IT1272191B (it) * | 1994-03-28 | 1997-06-16 | Bandini Srl | Composizione di materiale dentario a base di resine sintetiche con proprieta' antisettiche. |
US5708023A (en) | 1994-03-28 | 1998-01-13 | The Trustees Of Columbia University In The City Of New York | Zinc gluconate gel compositions |
US5776430A (en) | 1994-11-01 | 1998-07-07 | Calgon Vestal, Inc. | Topical antimicrobial cleanser containing chlorhexidine gluconate and alcohol |
US5804203A (en) | 1994-12-21 | 1998-09-08 | Cosmederm Technologies | Topical product formulations containing strontium for reducing skin irritation |
FR2729050A1 (fr) | 1995-02-23 | 1996-07-12 | Oreal | Compositions resistant a la degradation microbienne |
ZA962455B (en) | 1995-03-31 | 1996-10-02 | B Eugene Guthery | Fast acting and persistent topical antiseptic |
GB9506841D0 (en) | 1995-04-03 | 1995-05-24 | Unilever Plc | Deodorant compositions |
FR2734158B1 (fr) | 1995-05-17 | 1997-06-27 | Roche Posay Lab Pharma | Association d'un compose a activite anti-microbienne et d'un monoalkylether de glycerol |
EP0749694A1 (fr) | 1995-06-20 | 1996-12-27 | Societe Des Produits Nestle S.A. | Traitement enzymatique du cacao |
EP2322137A1 (en) | 1995-06-22 | 2011-05-18 | Minnesota Mining And Manufacturing Company | Stable hydroalcoholic compositions |
DE19523320A1 (de) | 1995-06-27 | 1997-01-02 | Henkel Ecolab Gmbh & Co Ohg | Terpenhaltige Desinfektionsmittel-Konzentrate und ihre Verwendung |
FR2740341B1 (fr) * | 1995-10-26 | 1997-12-19 | Oreal | Utilisation de sel de lanthanide, d'etain, de zinc, de manganese, d'yttrium, de cobalt, de baryum, de strontium dans une composition pour la peau |
US5648389A (en) | 1995-10-27 | 1997-07-15 | Medicis Pharmaceutical, Inc. | Compositions for the treatment of dermatological disorders and methods for their use |
US5705532A (en) | 1995-11-13 | 1998-01-06 | The Trustees Of Columbia University Of The City Of New York | Triple antimicrobial composition |
US5750122A (en) * | 1996-01-16 | 1998-05-12 | The Procter & Gamble Company | Compositions for treating hair or skin |
US5869071A (en) * | 1996-11-07 | 1999-02-09 | B & G Labs, Inc. | One-step skin cleaning composition and skin treatment method for incontinent dermatitis |
FR2755852B1 (fr) | 1996-11-15 | 1998-12-24 | Oreal | Utilisation d'un alkylether de glycerol dans une composition cosmetique et/ou dermatologique comme actif pour le traitement de la seborrhee et de l'acne |
US5985918A (en) * | 1996-12-04 | 1999-11-16 | The Trustees Of Columbia University In The City Of New York | Zinc-based antiirritant creams |
US6582711B1 (en) | 1997-01-09 | 2003-06-24 | 3M Innovative Properties Company | Hydroalcoholic compositions thickened using polymers |
US5747021A (en) * | 1997-01-10 | 1998-05-05 | Mckenzie; Therman | After shave treatment composition |
US5763412A (en) * | 1997-04-08 | 1998-06-09 | Becton Dickinson And Company | Film-forming composition containing chlorhexidine gluconate |
DE19719856A1 (de) * | 1997-05-12 | 1998-11-19 | Henkel Kgaa | Hautpflegemittel |
JPH10328284A (ja) * | 1997-05-29 | 1998-12-15 | Lion Corp | 抗菌・消臭剤組成物 |
KR20010013377A (ko) | 1997-06-04 | 2001-02-26 | 데이비드 엠 모이어 | 마일드한 잔류성 항균 조성물 |
US6287577B1 (en) | 1997-11-12 | 2001-09-11 | The Procter & Gamble Company | Leave-on antimicrobial compositions which provide improved residual benefit versus gram positive bacteria |
US5902572A (en) | 1997-06-23 | 1999-05-11 | Procter & Gamble Company | Anhydrous gel deodorant compositions |
AU8412098A (en) | 1997-07-18 | 1999-02-10 | Marc A. Golden | Genital lubricants with zinc to reduce irritation and allergic reactions |
US6045817A (en) | 1997-09-26 | 2000-04-04 | Diversey Lever, Inc. | Ultramild antibacterial cleaning composition for frequent use |
US6287583B1 (en) | 1997-11-12 | 2001-09-11 | The Procter & Gamble Company | Low-pH, acid-containing personal care compositions which exhibit reduced sting |
FR2771927B1 (fr) * | 1997-12-05 | 2001-12-07 | Oreal | Composition cosmetique ou dermatologique comprenant un polymere filmogene et une emulsion aqueuse de silicone |
CO5040174A1 (es) | 1997-12-12 | 2001-05-29 | Colgate Palmolive Co | Composiciones antimicrobianas para multiples propositos en microemulsion que contienen un tensioactivo cationico |
US5980925A (en) | 1997-12-30 | 1999-11-09 | Ethicon, Inc. | High glycerin containing anti-microbial cleansers |
US6248343B1 (en) * | 1998-01-20 | 2001-06-19 | Ethicon, Inc. | Therapeutic antimicrobial compositions |
US6022551A (en) | 1998-01-20 | 2000-02-08 | Ethicon, Inc. | Antimicrobial composition |
US20020022660A1 (en) | 1998-01-20 | 2002-02-21 | Hanuman B. Jampani | Deep penetrating antimicrobial compositions |
AU2466399A (en) * | 1998-01-30 | 1999-08-16 | Procter & Gamble Company, The | Compositions for prevention and treatment of cold and influenza-like symptoms associated with respiratory tract infections |
US6682749B1 (en) | 1998-04-03 | 2004-01-27 | Colgate-Palmolive Company | Low Residue cosmetic composition |
BR9909351A (pt) | 1998-04-03 | 2000-12-12 | Colgate Palmolive Co | Composição cosmética |
US6361787B1 (en) * | 1998-05-27 | 2002-03-26 | The Clorox Company | Enhanced antimicrobial composition |
EP1085804B1 (en) | 1998-06-09 | 2009-03-04 | Unger, Martin | Method and composition for the treatment of epidermal irritations and infections |
US6319958B1 (en) | 1998-06-22 | 2001-11-20 | Wisconsin Alumni Research Foundation | Method of sensitizing microbial cells to antimicrobial compound |
DE19834355A1 (de) | 1998-07-30 | 2000-02-03 | Henkel Kgaa | Entzündungshemmende Zahnpflegemittel |
EP1001012A1 (en) * | 1998-11-10 | 2000-05-17 | The Procter & Gamble Company | Disinfecting and cleaning compositions |
US5989531A (en) | 1998-11-13 | 1999-11-23 | Colgate-Palmolive Company | Antiperspirant formulation for porous applicator |
US5965137A (en) | 1998-11-16 | 1999-10-12 | Advanced Medical Instruments | Insect repellent composition and method for inhibiting the transmission and treatment of symptoms of vector-borne diseases |
US6344218B1 (en) | 1998-11-23 | 2002-02-05 | The Procter & Gamble Company | Skin deodorizing and santizing compositions |
DE19859427A1 (de) | 1998-12-22 | 2000-06-29 | Beiersdorf Ag | Kosmetische oder pharmazeutische lecithinhaltige Gele oder niedrigviskose, lecithinhaltige O/W-Mikroemulsionen |
US6183766B1 (en) | 1999-02-12 | 2001-02-06 | The Procter & Gamble Company | Skin sanitizing compositions |
MXPA01008160A (es) | 1999-02-12 | 2002-04-24 | Procter & Gamble | Composiciones desinfectantes de la piel. |
US6187327B1 (en) | 1999-05-19 | 2001-02-13 | Kevin Stack | Antimicrobial sanitizing lotion with skin protection properties |
DE60001471T2 (de) * | 1999-05-20 | 2003-12-18 | Ciba Speciality Chemicals Holding Inc., Basel | 4-Hydroxyisothiazolverbindungen |
US6107261A (en) | 1999-06-23 | 2000-08-22 | The Dial Corporation | Compositions containing a high percent saturation concentration of antibacterial agent |
US6211243B1 (en) | 1999-09-22 | 2001-04-03 | B. Ron Johnson | Methods for treating cold sores with anti-infective compositions |
US6281350B1 (en) | 1999-12-17 | 2001-08-28 | Paper Technology Foundation Inc. | Methods for the reduction of bleeding of lignosulfonates from lignosulfonate-treated substrates |
US6967023B1 (en) | 2000-01-10 | 2005-11-22 | Foamix, Ltd. | Pharmaceutical and cosmetic carrier or composition for topical application |
BR0107748A (pt) | 2000-01-20 | 2002-10-22 | Procter & Gamble | Composições antimicrobianas |
US6403067B1 (en) | 2000-05-19 | 2002-06-11 | Colgate-Palmolive Company | Stable emulsions for cosmetic products |
RU2166309C1 (ru) | 2000-06-26 | 2001-05-10 | Разумова Татьяна Николаевна | Лечебно-профилактическая и косметическая композиция |
US6387357B1 (en) | 2000-10-20 | 2002-05-14 | Colgate-Palmolive Company | High oil clear emulsion with diene elastomer |
EP1201226A3 (en) | 2000-10-25 | 2003-05-07 | Unilever Plc | Antiperspirant products made from wet-milled anhydrous antiperspirant salts |
US6403071B1 (en) | 2001-03-05 | 2002-06-11 | The Procter & Gamble Company | Anhydrous antiperspirant and deodorant compositions containing solid d-pantothenate salts |
US7122211B2 (en) | 2001-03-28 | 2006-10-17 | Morinda, Inc. | Methods for manufacturing an enhanced cosmetic skin care toner |
US6511657B2 (en) | 2001-04-20 | 2003-01-28 | Colgate-Palmolive Company | Two-phase roll-on cosmetic product |
FR2826851B1 (fr) | 2001-07-03 | 2004-08-06 | Nielsen Innovation | Aspirateur autonome a efficacite elevee |
JP2003120210A (ja) | 2001-10-05 | 2003-04-23 | Kawasaki Heavy Ind Ltd | ガスタービン装置 |
US20030134780A1 (en) | 2001-10-05 | 2003-07-17 | Procyte Corporation | Skin care compositions containing peptide copper complexes and retinol, retinol derivatives, or a mixture thereof |
US6426062B1 (en) | 2001-10-05 | 2002-07-30 | Colgate-Palmolive Company | Underarm gel products with water lock component |
US6485716B1 (en) | 2001-10-05 | 2002-11-26 | Colgate-Palmolive Company | High efficacy liquid gel product |
US6846846B2 (en) | 2001-10-23 | 2005-01-25 | The Trustees Of Columbia University In The City Of New York | Gentle-acting skin disinfectants |
CA2472206C (en) | 2001-12-31 | 2013-04-09 | Genencor International, Inc. | Proteases producing an altered immunogenic response and methods of making and using the same |
US7745425B2 (en) * | 2002-02-07 | 2010-06-29 | The Trustees Of Columbia University In The City Of New York | Non-irritating compositions containing zinc salts |
US7879365B2 (en) | 2002-02-07 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
AU2003216213B2 (en) | 2002-02-07 | 2008-10-02 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides |
US7435429B2 (en) | 2002-02-07 | 2008-10-14 | Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
US7563461B2 (en) | 2002-02-07 | 2009-07-21 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
JP2003246726A (ja) | 2002-02-22 | 2003-09-02 | Shiseido Co Ltd | 抗菌組成物 |
EP1487949A2 (en) * | 2002-03-28 | 2004-12-22 | Council of Scientific and Industrial Research | Composition and process for preparing herbal disinfectants and their use |
NZ575241A (en) | 2002-08-12 | 2010-10-29 | Lonza Ag | Antimicrobial compositions |
US8835014B2 (en) * | 2002-10-22 | 2014-09-16 | Allegiance Corporation | Coating composition for skin-contacting surface of elastomeric articles and articles containing the same |
US6723689B1 (en) | 2003-01-08 | 2004-04-20 | Becton Dickinson And Company | Emollient alcohol skin disinfecting formulation |
MXPA05008702A (es) * | 2003-02-21 | 2005-10-05 | Gentex Corp | Montajes de sistema automatico de control de luces exteriores del vehiculo. |
US20040208908A1 (en) | 2003-04-16 | 2004-10-21 | The Trustees Of Columbia University In The City Of New York | Antimicrobial medical articles containing a synergistic combination of anti-infective compounds and octoxyglycerin |
WO2005009352A2 (en) | 2003-07-17 | 2005-02-03 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositons containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof |
US20060141017A1 (en) | 2004-12-23 | 2006-06-29 | Kling William O | Zinc-based compositions and methods of use |
WO2006099359A2 (en) | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of reducing microbial contamination |
WO2007069214A2 (en) | 2005-12-15 | 2007-06-21 | The Procter & Gamble Company | Wet wipes with natural antimicrobial agents |
US7759327B2 (en) * | 2006-01-06 | 2010-07-20 | The Trustees Of Columbia University In The City Of New York | Compositions containing zinc salts for coating medical articles |
JP2009538961A (ja) | 2006-06-02 | 2009-11-12 | ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 医用物品を被覆するための亜鉛塩含有組成物 |
TW201113091A (en) * | 2009-06-15 | 2011-04-16 | Gojo Ind Inc | Methods and compositions for use with gel dispensers |
-
2004
- 2004-07-15 WO PCT/US2004/022505 patent/WO2005009352A2/en active Application Filing
- 2004-07-15 EP EP04778149A patent/EP1651176A4/en not_active Withdrawn
- 2004-07-15 US US10/891,624 patent/US7871649B2/en not_active Expired - Fee Related
- 2004-07-15 CN CN2011102382242A patent/CN102319409A/zh active Pending
- 2004-07-15 CA CA2532730A patent/CA2532730C/en not_active Expired - Fee Related
- 2004-07-15 AU AU2004258899A patent/AU2004258899B2/en not_active Ceased
- 2004-07-15 CN CN2004800205345A patent/CN101217870B/zh not_active Expired - Fee Related
- 2004-07-15 BR BRPI0412675-0A patent/BRPI0412675A/pt not_active IP Right Cessation
- 2004-07-15 CN CN2011102381998A patent/CN102309473A/zh active Pending
- 2004-07-15 MX MXPA06000543A patent/MXPA06000543A/es active IP Right Grant
- 2004-07-15 JP JP2006520288A patent/JP2007534620A/ja active Pending
-
2010
- 2010-11-29 US US12/955,432 patent/US9421263B2/en not_active Expired - Fee Related
-
2012
- 2012-01-19 JP JP2012008901A patent/JP2012107027A/ja active Pending
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101843914B (zh) * | 2010-04-30 | 2013-04-03 | 吴杰 | 一种具有空气消毒作用的组合物 |
CN101843914A (zh) * | 2010-04-30 | 2010-09-29 | 吴杰 | 一种具有空气消毒作用的组合物 |
CN108633932A (zh) * | 2011-10-04 | 2018-10-12 | 0903608 B.C.有限公司 | 害虫控制配制物以及制造和使用其的方法 |
CN103385977A (zh) * | 2012-05-07 | 2013-11-13 | 毛赢超 | 免疫功能鼻膏 |
CN105828637A (zh) * | 2013-12-30 | 2016-08-03 | 陶氏环球技术有限责任公司 | 杀微生物组合物 |
CN105828637B (zh) * | 2013-12-30 | 2020-03-24 | 陶氏环球技术有限责任公司 | 杀微生物组合物 |
CN106102711A (zh) * | 2014-03-21 | 2016-11-09 | 陶氏环球技术有限责任公司 | 发油调理剂 |
CN105754735A (zh) * | 2016-04-19 | 2016-07-13 | 广州市科士威化妆品制造有限公司 | 一种厨房清洁剂及其制备方法 |
CN105754735B (zh) * | 2016-04-19 | 2019-08-16 | 广州市科士威化妆品制造有限公司 | 一种厨房清洁剂及其制备方法 |
CN105886160A (zh) * | 2016-05-13 | 2016-08-24 | 无为县荣华鬃刷制品有限公司 | 一种鬃毛杀菌溶液 |
CN109562182A (zh) * | 2016-06-02 | 2019-04-02 | 先进科学发展公司 | 包含桉树脑和阿莫西林的药物制剂 |
CN109287676A (zh) * | 2018-11-13 | 2019-02-01 | 沈阳秉弘环保科技有限公司 | 一种抗菌除螨去异味的水溶液 |
CN109498562A (zh) * | 2018-12-18 | 2019-03-22 | 广州润虹医药科技股份有限公司 | 一种紧急烧伤护理液及其制备方法 |
CN111544310A (zh) * | 2020-05-28 | 2020-08-18 | 安徽省天助纺织科技集团股份有限公司 | 一种无刺激抗菌消毒湿巾及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
EP1651176A2 (en) | 2006-05-03 |
CA2532730A1 (en) | 2005-02-03 |
CN102319409A (zh) | 2012-01-18 |
JP2012107027A (ja) | 2012-06-07 |
WO2005009352A2 (en) | 2005-02-03 |
MXPA06000543A (es) | 2006-03-30 |
BRPI0412675A (pt) | 2006-10-03 |
AU2004258899B2 (en) | 2009-09-03 |
AU2004258899A1 (en) | 2005-02-03 |
US20110070316A1 (en) | 2011-03-24 |
CN102309473A (zh) | 2012-01-11 |
CN101217870B (zh) | 2011-10-12 |
US9421263B2 (en) | 2016-08-23 |
JP2007534620A (ja) | 2007-11-29 |
EP1651176A4 (en) | 2008-05-07 |
CA2532730C (en) | 2013-02-26 |
US20050019431A1 (en) | 2005-01-27 |
US7871649B2 (en) | 2011-01-18 |
WO2005009352A3 (en) | 2007-11-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101217870B (zh) | 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 | |
US20180153177A1 (en) | Botanical antimicrobial compositions | |
US20150265666A1 (en) | Botanical antimicrobial compositions | |
US20170079282A1 (en) | Skin and Surface Disinfectant Compositions Containing Botanicals | |
US20080311231A1 (en) | Broad Spectrum Non-Traditional Preservative System | |
JPH11322591A (ja) | 防腐殺菌剤及び人体施用組成物 | |
CN104039338A (zh) | 植物性抗微生物组合物 | |
JP2012532141A (ja) | 植物性成分を含有する抗微生物/防腐組成物 | |
CN111135160B (zh) | 一种泡沫私护免洗抗菌液及其制备方法 | |
AU2019200786B2 (en) | Antimicrobial/preservative compositions comprising botanicals | |
AU2004287281A1 (en) | Disinfecting composition and methods of making and using same | |
JP2693859B2 (ja) | 尋常性▲ざ▼瘡用皮膚外用剤 | |
CA2578665A1 (en) | Synergistic preservative systems and their use in cosmectic compositions | |
US20180092942A1 (en) | Hypochlorous acid-based hand sanitizer | |
CN108653121A (zh) | 一种含中草药成分的抑菌洗手消毒液 | |
JP5990344B2 (ja) | 相乗作用を有する防腐剤ブレンド | |
US20150157583A1 (en) | Pharmaceutical Composition | |
Kusumawatia et al. | Expansion of hand hygiene compliance and decreasing counterfeiting of sanitation products in the era of the COVID-19 through diversification and standardization of alcohol-based gel and wipes hand sanitizer | |
JP4587673B2 (ja) | 洗浄剤組成物 | |
RU2691410C1 (ru) | Средство для ухода за полостью рта и горла | |
EP1487440B1 (en) | A use of a synergistic formulation of antifungal agents for the treatment of fungal infections | |
WO2024028179A1 (en) | Biocidal composition | |
KR20040098400A (ko) | 손 피부 세정용조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111012 Termination date: 20160715 |
|
CF01 | Termination of patent right due to non-payment of annual fee |