CN101182562B - 通过金耳液体发酵生产胞外多糖的方法 - Google Patents
通过金耳液体发酵生产胞外多糖的方法 Download PDFInfo
- Publication number
- CN101182562B CN101182562B CN200710190177A CN200710190177A CN101182562B CN 101182562 B CN101182562 B CN 101182562B CN 200710190177 A CN200710190177 A CN 200710190177A CN 200710190177 A CN200710190177 A CN 200710190177A CN 101182562 B CN101182562 B CN 101182562B
- Authority
- CN
- China
- Prior art keywords
- fermentation
- liquid
- golden
- exocellular polysaccharide
- golden fungus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000855 fermentation Methods 0.000 title claims abstract description 60
- 230000004151 fermentation Effects 0.000 title claims abstract description 60
- 239000007788 liquid Substances 0.000 title claims abstract description 59
- 241000233866 Fungi Species 0.000 title claims abstract description 39
- 150000004676 glycans Chemical class 0.000 title claims description 54
- 239000005017 polysaccharide Substances 0.000 title claims description 54
- 229920001282 polysaccharide Polymers 0.000 title claims description 54
- 238000004519 manufacturing process Methods 0.000 title abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000001556 precipitation Methods 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims description 33
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 23
- 239000008103 glucose Substances 0.000 claims description 23
- 244000068988 Glycine max Species 0.000 claims description 18
- 235000010469 Glycine max Nutrition 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 15
- 238000012258 culturing Methods 0.000 claims description 14
- 241001506047 Tremella Species 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 238000009423 ventilation Methods 0.000 claims description 10
- 239000002054 inoculum Substances 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 238000000108 ultra-filtration Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 235000015099 wheat brans Nutrition 0.000 claims description 5
- 238000005516 engineering process Methods 0.000 claims description 4
- 238000011534 incubation Methods 0.000 claims description 4
- 238000001471 micro-filtration Methods 0.000 claims description 3
- 241000117280 Naematelia aurantialba Species 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 21
- 239000008280 blood Substances 0.000 abstract description 20
- 210000004369 blood Anatomy 0.000 abstract description 20
- 235000013305 food Nutrition 0.000 abstract description 4
- 229920002444 Exopolysaccharide Polymers 0.000 abstract 4
- 239000012043 crude product Substances 0.000 abstract 1
- 238000011218 seed culture Methods 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 10
- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 238000010899 nucleation Methods 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 6
- 239000010931 gold Substances 0.000 description 6
- 229910052737 gold Inorganic materials 0.000 description 6
- 238000012807 shake-flask culturing Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000002218 hypoglycaemic effect Effects 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 235000013361 beverage Nutrition 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 201000001421 hyperglycemia Diseases 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- IXZISFNWUWKBOM-ARQDHWQXSA-N fructosamine Chemical compound NC[C@@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O IXZISFNWUWKBOM-ARQDHWQXSA-N 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 210000005090 tracheal smooth muscle Anatomy 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000219428 Fagaceae Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 241000446313 Lamella Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 244000141353 Prunus domestica Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013118 diabetic mouse model Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- -1 polysaccharide compounds Chemical class 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940048102 triphosphoric acid Drugs 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
实施例 | 例1 | 例2 | 例3 | ||
给药后 | 给药前 低剂量 中剂量 高剂量 | 血糖值 降低绝对值 血糖值 降低绝对值 血糖值 降低绝对值 | 19.21±2.13 18.43±1.97 0.78 16.12±2.51 3.09 15.53±2.70 3.68 | 18.73±2.73 18.04±2.64 0.69 16.52±2.03 2.21 15.91±1.99 2.82 | 19.75±2.44 18.49±2.71 1.26 15.92±2.50 3.83 15.17±2.43 4.58 |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200710190177A CN101182562B (zh) | 2007-11-20 | 2007-11-20 | 通过金耳液体发酵生产胞外多糖的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200710190177A CN101182562B (zh) | 2007-11-20 | 2007-11-20 | 通过金耳液体发酵生产胞外多糖的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101182562A CN101182562A (zh) | 2008-05-21 |
CN101182562B true CN101182562B (zh) | 2012-08-29 |
Family
ID=39447986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200710190177A Expired - Fee Related CN101182562B (zh) | 2007-11-20 | 2007-11-20 | 通过金耳液体发酵生产胞外多糖的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101182562B (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102250722B (zh) * | 2011-07-04 | 2013-01-09 | 江苏同源堂生物工程有限公司 | 一种以白果为基质发酵制备银杏金耳果酒的方法 |
CN102899368A (zh) * | 2012-11-19 | 2013-01-30 | 江南大学 | 一种深层液体发酵法制备富硒金耳粗多糖粉的方法 |
CN102908303B (zh) * | 2012-11-19 | 2014-10-08 | 江南大学 | 一种金耳发酵美白液的制备方法 |
CN103145865B (zh) * | 2013-02-21 | 2015-12-02 | 北京绿科天成生物科技有限公司 | 粗毛韧革菌菌丝体多糖的制备方法及其应用 |
CN103396198B (zh) * | 2013-08-22 | 2014-10-22 | 昆明云蕈科技开发有限责任公司 | 一种金耳菌种培养基及菌种制备的方法 |
CN103555787A (zh) * | 2013-10-16 | 2014-02-05 | 江南大学 | 一种具有抗氧化活性的金耳发酵液多糖的制备方法 |
CN104382000A (zh) * | 2014-12-04 | 2015-03-04 | 李振铭 | 一种云金苓多糖及其制备工艺 |
CN107158231A (zh) * | 2017-06-07 | 2017-09-15 | 马凯 | 一种预防和控制糖尿病的益生菌发酵中草药的组合物 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6383799B1 (en) * | 1999-10-15 | 2002-05-07 | Medmyco Ltd. | Process for producing, methods and compositions of glucuronoxylomannan as nutriceutical agent from higher basidiomycetes mushroom |
-
2007
- 2007-11-20 CN CN200710190177A patent/CN101182562B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6383799B1 (en) * | 1999-10-15 | 2002-05-07 | Medmyco Ltd. | Process for producing, methods and compositions of glucuronoxylomannan as nutriceutical agent from higher basidiomycetes mushroom |
Non-Patent Citations (4)
Title |
---|
李艳琴.金耳高级营养保健饮料的研究——I金耳的深层发酵条件.《山西农业大学学报》.1996,第16卷(第3期),298-301. * |
荣福雄等.金耳深层发酵生产工艺的研究.《山西农业科学》.1987,(第12期),6-8. * |
邓云霞.金耳胞外多糖的结构分析及其生物学活性的探讨.《中国优秀博硕士学位论文全文数据库(硕士)基础科学辑》.2004,(第4期),全文. * |
高观世等.金耳多糖化学与生物活性研究进展及对研究的思考.《中国食用菌》.2007,第26卷(第4期),8-10. * |
Also Published As
Publication number | Publication date |
---|---|
CN101182562A (zh) | 2008-05-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101182562B (zh) | 通过金耳液体发酵生产胞外多糖的方法 | |
CN101143002B (zh) | 一种深层液体发酵法制备富硒金针菇粗多糖原粉的方法 | |
CN107151632B (zh) | 蝙蝠蛾被毛孢菌丝体及其发酵技术 | |
CN102845221B (zh) | 一种冬虫夏草发酵生产方法 | |
CN101328487B (zh) | 鸡腿菇液体转化桑叶的发酵液制备方法及其用途 | |
CN103820299B (zh) | 一种虫草菌丝体发酵醋及其制备方法 | |
CN107475130B (zh) | 细柄棒束孢新菌种及其栽培方法和用途 | |
CN102318864A (zh) | 一种含大豆肽和食用真菌多糖饮料及其制备方法 | |
CN102668880A (zh) | 冬虫夏草菌种培养方法 | |
CN101225361B (zh) | 通过金耳液体发酵生产的金耳发酵液或倍半萜 | |
CN111996129B (zh) | 蝉花新菌株及其在抗肿瘤及抑菌方面的用途 | |
CN103667082B (zh) | 一种蜜环菌浓缩液的制备方法 | |
CN104694356A (zh) | 人参护肝保健酒及其制备方法 | |
CN102293122B (zh) | 一种刺五加北虫草的培养方法 | |
CN102771765A (zh) | 一种含有中药提取物的灰树花保健品及其制备方法 | |
CN106165811A (zh) | 一种金银花菌深层发酵液加工制成饮料制备工艺 | |
CN105441333A (zh) | 桑黄菌的培养基、培养方法及其作为桑黄菊花菌茶应用 | |
CN102250722A (zh) | 一种以白果为基质发酵制备银杏金耳果酒的方法 | |
CN109566272B (zh) | 一种羊肚菌菌丝体的培养方法及其培养基 | |
CN109055242A (zh) | 一种紫红曲霉菌株及其发酵工艺与应用 | |
CN105726607A (zh) | 党参酵母发酵提取物的制备方法 | |
CN101407767A (zh) | 一种通过发酵生产冬虫夏草的方法 | |
CN103392513A (zh) | 冬虫夏草菌丝体发酵物及其应用 | |
CN102771773A (zh) | 一种含有中药提取物的松露保健品及其制备方法 | |
CN103230003B (zh) | 一种具有增强免疫力功能的保健食品及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: BEIJING LVKE TIANCHENG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: JIANGSU UNIVERSITY Effective date: 20131015 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 212013 ZHENJIANG, JIANGSU PROVINCE TO: 100041 SHIJINGSHAN, BEIJING |
|
TR01 | Transfer of patent right |
Effective date of registration: 20131015 Address after: West Wells Road 100041 Beijing city Shijingshan District high tech park at the Bada No. 3 Building No. 3 room 652 Patentee after: BEIJING LYUKE TIANCHENG BIO-TECHNOLOGY Co.,Ltd. Address before: 212013, Jiangsu University, 301, Xuefu Road, Jiangsu, Zhenjiang Patentee before: Jiangsu University |
|
DD01 | Delivery of document by public notice |
Addressee: BEIJING LYUKE TIANCHENG BIO-TECHNOLOGY Co.,Ltd. Document name: Notification of Passing Examination on Formalities |
|
DD01 | Delivery of document by public notice |
Addressee: Wang Yongsheng Document name: Notification of Passing Examination on Formalities |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120829 |
|
CF01 | Termination of patent right due to non-payment of annual fee |