CN101161250A - A novel enteron pharmaceutical preparation and its preparing method - Google Patents
A novel enteron pharmaceutical preparation and its preparing method Download PDFInfo
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Abstract
The present invention relates to a novel digestive canal pharmaceutical preparation and its preparation method, the first contribution of the present invention is to give more choices to people in general oral administration preparations, wherein, oral administration preparations such as honey pill, micropill, concentration pill, water pill, gel preparation, cream, tablet, chewing tablet, powder agent, granule, capsule, slow release capsule etc. is convenient, capable of suitable for different consumption level people; the second contribution of the present invention is to upgrade the general oral administration preparations into stomach retention floating oral administration preparation by inducting corresponding supplementary, greatly prolonging medicine retain time in stomach, greatly increasing the local focal medicine effective concentrate in stomach, in order to short period of treatment, promote clinic effective rate and cure rate to provide necessary condition; the third contribution of the present invention is to upgrade the oral administration preparations and the stomach retention floating oral administration preparation into loading far infrared auxiliary therapeutic function oral administration preparation by inducting corresponding supplementary nanocrystallization, leading product curative effect to promote further.
Description
Technical field
The present invention relates to a kind of enteron pharmaceutical preparation and preparation method thereof.
Background technology
Chronic gastritis generally is meant chronic superficial gastritis and chronic atrophic gastritis, and at same gastric, both can exist simultaneously.Therefore the more significantly relation that has of researching and proposing primary disease and gastric ulcer and gastric cancer in recent years comes into one's own.Peptic ulcer often occurs in position such as the harmonization of the stomach duodenum that contacts with gastric acid, also can betide distal esophagus, reaches the Meckel diverticulum near the stomach intestinal anastomosis mouth.The peptic ulcer of about 95-99% occurs in stomach or duodenum, so be called gastric ulcer or duodenal ulcer again.Its pathogenic factor of generally acknowledging has three kinds: 1. the effect of gastric acid one pepsic invasion and attack effect, especially gastric acid, in ulcer in the highest flight.2. neural Nervous and Mental Factors continues, over-drastic psychentonia, fatigue, neural Nervous and Mental Factors such as excited often be the key factor of the generation and the recurrence of duodenal ulcer.3. helicobacter pylori system causes one of key factor of peptic ulcer.
Western proprietary, owing to only at the 1st, 3 factor symptomatic treatments, ignored the 2nd factor fully, therefore, it is good that western proprietary treatment chronic gastritis, gastroduodenal ulcer have a short term efficacy, the long-term easily characteristics of recurrence.
Chinese medicine patent medicine, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs overcome the deficiency of having fallen western proprietary fully, and treatment chronic gastritis, gastroduodenal ulcer have good effect, instant effect, are difficult for the characteristics of recurrence.
Chinese medicine patent medicine weak point is that the conventional oral Preparation of each Chinese patent medicine is too single, and the selectable leeway of patient is too little; The floating in stomach oral Preparation that is specially adapted to treat chronic gastritis, gastroduodenal ulcer is extremely rare; The means of more not seeing by corresponding adjuvant nanorize make the conventional oral Preparation of Chinese patent medicine, floating in stomach oral Preparation be loaded with the example of far infrared auxiliary treatment function.
Far infrared and human body are closely related: any object of earth surface all has and absorbs ultrared function, also all be simultaneously far infrared contain body and emitter.Human body also has the ability of the micro-far-infrared electromagnetic wave of emission, measures according to science that the far infrared have only the 8-15 micron is the easiest to produce harmonious resonance with human body.60-70% is made of hydrone in the human body, when the far infrared of 8-15 micron acts on human body, after producing " resonance absorption " effect, make and be not easy absorbed big hydrone group's generation resonance in the human body and make the micel depolymerization, be reassembled into less water clusters, (be that hydrone is activated, molecularization), the polluter that is adsorbed on the water clusters surface is removed, the hydrone that is attached to cell activity and surface is increased, cell activity and surface tension have been increased, the metabolism ability of blood is improved, and blood circulation improves, and especially microcirculation is significantly improved.
In addition, because far heat effect has caused a series of physiological effecies then.
1) activated the activity of biomacromolecule.Here should particularly point out, the electron energy level that region of ultra-red photon energy (1.6-0.001 electron-volt) can not activating molecules makes material generation ionization so can not resemble the ultraviolet.Infra-red radiation can only activating molecules vibration level.Energy difference between vibration level is generally below 1 electron-volt.That is to say,, therefore molecular structure is changed because the atomic bond energy of far infrared energy formation molecule is little.However, at the far infrared photon, make especially under the effect of 2-6 micron far infrared photon, the molecular entergy level of organism is excited and is in higher vibration level, this has just activated the activity of biomacromolecules such as nucleic acid protein, thereby brought into play biomacromolecule and regulated active functions such as organism metabolism, immunity, helped the restore peace weighing apparatus of function of human body, the purpose of reach diseases prevention, curing the disease.
2) blood circulation of promotion and improvement part and whole body.After far infrared acted on skin, most of energy was absorbed by skin, and absorbed energy is converted into heat energy, caused the skin temperature rise, and heat sensor in the chafe by the thalamus reflection, makes vascular smooth muscle relaxation, vasodilation, and blood circulation is strengthened.On the other hand, because heat effect causes the release of vaso-active substance, antiotasis reduces, shallow small artery, shallow blood capillary and superficial vein expansion, and blood circulation is accelerated, and blood circulation is improved.
3) strengthen metabolism.If disorder has taken place in the metabolism of human body, caused that the exchange of inside and outside material is not normal, so, various diseases will not made an appointment with and arrived.Such as the disorder of water-electrolyte metabolism, seriously will threat to life; Diabetes due to the carbohydrate metabolism disturbance; Disorders of lipid metabolism causes cardiovascular disease, obesity; The gout that protein metabolism disorder causes etc.By far heat effect, can increase the vigor of cell, regulate neuro-humoral mechanism, add excitometabolic, make intravital mass exchange be in plateau.
4) improve immunologic function.Immunity is a kind of physiology protective reaction of human body, and it comprises two kinds of cellular immunization and humoral immunization, and the human body resist the disease is had important role.Through clinical observation, far infrared really can improve the phagocytic function of macrophage, and mediator's somatic cell immunity and humoral immune function help the health of human body.
5) antiinflammatory, its analgesic mechanism are as follows:
A) far heat effect is reacted by neurohumoral answer, eliminated the pathological process of inflammation, make that to suffer that originally destructive physiological equilibrium's state adds quick-recovery normal, improved the resistance against diseases of local and whole body, simultaneously can activate immune cell function, strengthen the phagocytic function of leukocyte and netted chrotoplast, reached antiinflammatory bacteriostatic purpose.
B) infrared heat effect increases skin temperature, and the sympathetic nerve feeling ability lowers, and the vasodilator active substance discharges, vasodilation, blood flow is accelerated, and blood circulation improves, and has strengthened histotrophic nutrition, enlivened tissue metabolism, improve the cell oxygen-supplying amount, improved the blood supply oxygen supply state of focal zone, strengthened the regeneration capacity of cell, control development of inflammation and made its localization, quickened the reparation of focus.
C) far heat effect has been improved microcirculation, has set up side Zhi Xunhuan, strengthen cell membrane stability, regulated ionic concentration, improved osmotic pressure, accelerate the discharge of the metabolite of noxious substance, quickened the absorption of exudate, caused disappearing of inflammation edema.
6) analgesic activity.Infrared heat effect has reduced the irritability of teleneuron; Sanguimotor improvement, disappearing of edema alleviated the chemistry and the mechanical stimulus of teleneuron; Far heat effect has improved the threshold of pain, more than all, all play lenitive effect.
The unique deficiency of far infrared is too shallow and influence the further performance of above-mentioned effect to the penetration depth of human body, and the penetration depth of far infrared in human body is meant the ultrared intensity decreases degree of depth during to initial intensity 50% that enters human body.Visible light and near infrared penetration depth are about 1 centimetre, and far infrared then only is the 0.05-1 millimeter.The wavelength of far infrared is longer, and then penetrance is poorer.
Summary of the invention:
The purpose of this invention is to provide a kind of good effect, produce effects novel enteron pharmaceutical preparation fast, easy to use and preparation method thereof.
The present invention has the contribution of following three aspects to the quality-improving of novel enteron medicine series of products under the prerequisite of not repelling former digestive tract medicine basic data.
Novel enteron pharmaceutical preparation of the present invention is on the basis of former enteron pharmaceutical preparation prescription, by to the pre-treatment of medical material, add the carrier of different dosage form, preparation program according to a conventional method, make conventional oral Preparation, floating in stomach oral Preparation, be loaded with the oral Preparation of far infrared auxiliary treatment function.
Former digestive tract medicine of the present invention is contained whole digestive tract medication, more preferably acute gastroenteritis medication, chronic gastritis, peptic ulcer, chronic enteritis medication, most preferably chronic gastritis, peptic ulcer medication.Simultaneously, under the prerequisite of not repelling western proprietary, more lay particular emphasis on Chinese medicine patent medicine.
Wherein, former chronic gastritis, digestive ulcer medicament and preparation including, but not limited to:
The peace capsule for treating gastropathy, the peace gastric ulcer capsule, white refreshing ball, Bi tinkling of pieces of jade stomachache electuary, the shenmei stomach nourishing electuary, the ginseng and astragalus stomach strengthening electuary, the hay-scented Weikang capsule for curing gastric disease, the intestines and stomach is fitted capsule, the Lignum Aquilariae Resinatum ball of having a respite, DANGUIXIANG KELI, accent stomach pellet, the stomach regulating liver smoothing ball, fourth osmanthus stomach warming looses, ball in fourth bandit's reason, fly upward the gastroenteritis sheet, the 'Fengliaochangweikang' ' sheet, the compound sheet, compound Gansu julid medicine for gastrosis, compound recipe Radix Notoginseng capsule for treating stomachache, FUFANG WEINING PIAN, the complex stomach powder capsule, ocean stomach medicine, the stomach function regulating sheet, stomach function regulating suppressing the hyperactive liver ball, HOUTOU JIANWEI JIAONANG, the Radix Astragali is built middle ball, the Radix Astragali cream that is good for the stomach, capsule for treating gastropathy alive, Herba Pogostemonis clearing stomach sheet, the strengthening the spleen and nourishing the stomach granule, the chest stuffiness relieving ball is good for the stomach, tabellae stomachicus, JIANWEI XIAOSHI PIAN, antiphlogistic granules is good for the stomach, ulcer curing tablet is good for the stomach, the benefiting stomach and stopping pain sheet, brilliant art Weitai capsule for treating stomach disease, the appetite promoting and the spleen strengthening ball, KAIWEI LIPI PIAN, the appetizing Crataegi pill, Kang Hong stomach treasured, Confucian Temple gastritis is peaceful, KUAIWEI PIAN, routed Pingning, the ulcer Yiganning capsule, ball in the reason, LIUJUNZI WAN, Six-element Radix Aucklandiae capsule, Six-element energy capsule for eliminating, Gansu julid tablet for gastrosis, aplotaxis carminative pill, warming the stomach Shu Le sheet, the taste ball that relaxes, the safety ball, Pingwei pill, QIZHIWEITONG CHONGJI, clearing stomach security personnel ball, clearing stomach and middle ball, capsule for treating gastric disease, the SANJIU WEITAI electuary, the Massa Medicata Fermentata capsule for treating stomachache, ten five tastes black powder balls, the SHIXIANG pill for relieving pain, SHUGAN HEWEI WAN, the relaxing liver and strengthening stomach electuary, the Shugan Zhitong ball, four gentleman's balls, it phoenix powder for stomachache, stomach peace capsule, WEIANNING PIAN, the gastropathy ball, the gastrointestinal curing capsule, Weichangning tablets, WEIDE peace capsule, stomach good fortune granule, WEIFUCHUN PIAN, the multiple Yiganning capsule of stomach, stomach clever sheet alive, Weikang capsule for curing gastric disease, stomach-recovering capsule, stomach is sheet rather, the Veytalo capsule, the peaceful sheet of Veytalo, the Veytalo oral liquid for relaxation, the WEILEXIN granule, stomach power recovering particles, stomach power sheet, stomach founds the health sheet, stomach spirit electuary, WEINAI AN JIAONANG, the contrary recovering capsule of stomach, stomach rather looses, the peratodynia sheet, stomach oxazepan electuary, the stomach sheet that relaxes, WEISU CHONGJI, stomach Suning, the peaceful capsule of stomach, peaceful sheet has a stomach-ache, the stomachache stator, the flat capsule of having a stomachache, powder for stomachache, the easypro sheet of stomachache, the gastral cavilty electuary that relaxes, the auspicious peaceful granule of stomach, the gastritis recovering capsule, the gastritis instant granule for curing, stomach infections peace capsule, the Mistura Bismuthi Composta granule, the peaceful ball of stomach infections, stomach medicament capsule, stomach benefit capsule, WENWEISHU JIAONANG, Medicinal powder of cuttlefish and firtillary bulb, crow is sweet to loose, fragrant sand stomach function regulating ball, fragrant sand nine gentleman, the Aucklandiae and Amomi stomach-calming granule, cyperus-amomum stomach, stomachic tablet, heart stomach pellet, the appetizing electuary of being amusing, the cold of insufficiency type and stomachache electuary, stomach nourishing granule, the nourishing the stomach Yiganning capsule, yangweishu capsules, stomach reinforcing cream, the yin deficiency and gastralgia granule, yueju baohe pills, the bent flat stomach mixture of short, bristly hair or beard, precious yellow stomach sheet, Margarita stomach peace ball, positive stomach sheet, Aurantii Immaturi and Atractylodis Pill, control wet Pingwei pill, intelligence hands JIEBAI WAN, Zhong Jing stomach spirit sheet, Zuojin Wan.
First contribution of the present invention is, more selects for aspect the conventional oral Preparation people,
Described a kind of novel enteron pharmaceutical preparation and preparation method thereof:
The medicine of a, safe and effective amount, the medicine that former enteron pharmaceutical preparation provides can suitably be adjusted dosage up and down in conjunction with new dosage form and curative effect and safety;
B, in Chinese patent medicine preparation, but square Chinese crude drug pulverize separately becomes fine powder, sieves, mixing is standby; More preferably extract or extracting section after concentrate, drying, pulverizing, mixing be standby;
C, get above-mentioned standby medicated powder, add the carrier (adjuvant) of different dosage form, make different conventional oral Preparations respectively by the routine operation method of prior art.
Described conventional oral Preparation is including, but not limited to honey pill agent, pellet, concentrated pill, watered pill, gel, ointment, tablet, chewable tablet, powder, granule, capsule, slow releasing capsule.
Second contribution of the present invention is, by the introducing of corresponding adjuvant the floating in stomach oral Preparation is made in above-mentioned conventional oral Preparation upgrading: the honey pill agent, pellet, concentrated pill, watered pill, gel, ointment, tablet, chewable tablet, powder, granule, capsule, the slow releasing capsule that promptly have the floating in stomach function;
More preferably tablet is made routine/floating double-layer tablet; Pellet, concentrated pill, watered pill, gel, granule, capsule content granule are made routine/floating bi-component, or routine/floating/slow release multicomponent pellet, concentrated pill, watered pill, gel, granule, capsule; Conventional, floating two kinds of components respectively account for 1/4～1/2: 1/2～3/4; Conventional, floating, three kinds of components of slow release respectively account for 1/4～1/2: 1/4～1/3: 1/4～1/3;
Wherein, conventional formulation partly plays quick-acting effects, and floating, slow releasing preparation partly plays floating in stomach, slow release, the adherent effect of impaired coat of the stomach.
The corresponding adjuvant of described floating in stomach oral Preparation is included in the adjuvant that can produce the gas generating agent of gas in the gastric juice, can form gel in gastric juice; Wherein,
The described gas generating agent that can produce gas in gastric juice can be selected sodium bicarbonate, calcium carbonate, magnesium carbonate for use.2～45% of its consumption accounting on the accrual basis agent gross weight.
The described adjuvant that can form gel in gastric juice is divided into organic class, mineral-type again, can use separately according to the difference of dosage form, more preferably unites use.Wherein,
A, mineral-type are including, but not limited to one or more in clay, kaolin, Bentonite, Bentonite magnesium, aluminium silicate, aluminium-magnesium silicate, colloidality silicon dioxide, the titanium dioxide.1～50% of its consumption accounting on the accrual basis agent gross weight.
B, organic class is including, but not limited to methylcellulose, ethyl cellulose, ethylhydroxyethylcellulose, hydroxy methocel, hydroxyethyl-cellulose, hydroxyethylmethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, cross-linking sodium carboxymethyl cellulose, carboxymethylcellulose calcium, carboxy-propyl cellulose, carbomer, modified starch, amylopectin, carboxymethyl starch sodium, sodium starch phosphate, the starch glycolic acid is received, dextrin, alginic acid, sodium alginate, potassium alginate, ammonium alginate, the propylene glycol sodium alginate, propylene glycol alginate, microbial alginate, mattress nuclear glucosan, glucosan, tragacanth, arabic gum, locust bean gum, guar gum, pectin, Sesbania cannabina (Retz.) Pers. glue, tara gum, Ficus elastica, Furcellaran, carrageenin, glue is drawn in red match, tamarind gum, POLY-karaya, xanthan gum, carrageenan, locust bean gum, gelatin, hyaluronate sodium, chitin, chitosan, chitosan (chitosan), Polyethylene Glycol, polyvinylpyrrolidone, polyvinyl alcohol, sodium acrylate, polyacrylic acid, sodium polyacrylate, cross linked sodium polyacrylate, polyacrylamide, hyaluronic acid sodium, casein, in the casein sodium one or more.1～50% of its consumption accounting on the accrual basis agent gross weight.
The adjuvant that can form gel in the described gastric juice can play gas and be detained effect aspect agent, medicinal slow release agent, the gastrointestinal mucosal binder three in preparation.Wherein,
Gas is detained the agent effect, and the gas that gas generating agent is produced is stranded in the formed gel of the medicine group equably, thereby and its density is progressively eased down to less than the 1g/ cubic centimetre form floating in stomach;
Medicinal slow release agent effect, the action time of prolong drug greatly;
Gastrointestinal mucosal binder effect, the ulcer surface and the inflammatory zone that hide gastrointestinal mucosal make it avoid stimulating, and prolong drug is to its action time.
Another contribution of the present invention is, with the author at the number of patent application of first to file is: the core technology of the people who additionally has the far infrared health care function of CN200510125227.X and animal foodstuff medicine preparation and preparation method thereof is introduced the preparation of this patent.More particularly, (about 36 ℃ of human temperature) under the normal temperature condition absorbed heat energy from environment, simultaneously send wavelength 4～20 mu m range far infrareies, the material that people and animal can tolerate to environment.More preferably have adjuvant commonly used on the pharmaceutics of above-mentioned functions by the micronized mode of nanoscale, under the prerequisite that does not increase any new adjuvant, make the said goods be loaded with far infrared auxiliary treatment function.In other words, introducing by corresponding adjuvant nanorize is with above-mentioned conventional oral Preparation, the oral Preparation that is loaded with far infrared auxiliary treatment function is made in the upgrading of gastric extended release oral dosage preparation: the honey pill agent commonly used that promptly is loaded with far infrared auxiliary treatment function, pellet, concentrated pill, watered pill, gel, ointment, tablet, chewable tablet, powder, granule, capsule, slow releasing capsule, and the honey pill agent that has the floating in stomach function when being loaded with far infrared auxiliary treatment function, pellet, concentrated pill, watered pill, gel, ointment, tablet, chewable tablet, powder, granule, capsule, slow releasing capsule.
The described respective secondary material that is loaded with far infrared auxiliary treatment function is including, but not limited to the natural crystal class, as: " multicolored stone " in rare ice stone, Sibin floating stone, the deep-sea, Muscovitum, Kaolin, cordierite, zircon, Pumex, Haematitum; Artificial sintering stone class, as: mullite, cordierite, Pumex; Great soil group, as: Kaolin, Suzhou soil; Ceramic-like, as: the sinter of the oxide that the Mg-Al-Si-Zr-rare earth is, Mn-Fe-Co-Ni-Cu-Cr is metal, carbide, nitride, boride, aluminium oxide, zirconium oxide, titanium dioxide, magnesium oxide and their composite oxides-mullite, zircon and cordierite, transition-metal oxide and cordierite (2MgO2Al such as ferrum, cobalt, manganese
2O
35SiO
2) wait the mixed sintering thing of composite oxides, Si
3N
4The complex sintered thing of-SiC, TiC (or TiN)-Si
3N
4Complex sintered thing, TiC-Al
2O
3-TiO
2Complex sintered thing, HfB (or TaN)-Fe
2O
3, MnO
2Be complex sintered thing, aluminium oxide-silicate is sinter, Al
2O
3-SiO
2The base sinter; The biological carbon class, as: Sargassum carbon, bamboo charcoal; Plant fiber's class, as: the petal fiber; The animal class, as: Margarita, Concha Margaritifera, Concha Haliotidis, Endoconcha Sepiae; Organic class, as: casein, fibrin; Mineral-type, metal as shown in Table 1, nonmetallic oxide, carbide, nitride, boride.1～30% of its consumption accounting on the accrual basis agent gross weight.
Table one: common inorganic far-infrared material
More preferably: breed the adjuvant commonly used on above-mentioned pharmaceutics among all kinds of: as: Pulvis Talci, Kaolin, active hargil, Pumex, silicon dioxide (micropowder silica gel), titanium dioxide (titanium dioxide), magnesium oxide, ferrum oxide, zinc oxide, calcium oxide, activated alumina, aluminium hydroxide, magnesium carbonate, magnesium stearate, calcium carbonate, silicic acid, calcium silicates, aluminium silicate, magnesium silicate, aluminium-magnesium silicate, Aluminum calcium silicate. etc.1～30% of its consumption accounting on the accrual basis agent gross weight.
Describedly make product be loaded with far infrared auxiliary treatment function to be meant, when above-mentioned nanoscale adjuvant commonly used enters the extraneous heat energy of human gastrointestinal tract absorption by preparation after, can discharge wavelength and be 4～14 microns far infrared, this infrared ray easily is absorbed by the body, and it is consistent with the atom and the vibrational frequency of molecule of human body cell, thereby can activate histiocyte, increase blood flow, promote microcirculation, the metabolic obstacle full scale clearances of impairment such as congestion is clean, tissue is brought back to life, improve the metabolism and the immunologic function of human body, the general curative effect of product is improved.
The invention has the beneficial effects as follows:
First contribution of the present invention is, more select for aspect the conventional oral Preparation people: wherein, oral formulations taking conveniences such as honey pill agent, pellet, concentrated pill, watered pill, gel, ointment, tablet, chewable tablet, powder, granule, capsule, slow releasing capsule, applicable crowd without level of consumption; Second contribution of the present invention is, introducing by corresponding adjuvant is made the floating in stomach oral Preparation with above-mentioned conventional oral Preparation upgrading, prolonged the holdup time of medicine widely at gastric, improved the drug level of gastric local lesion greatly, for shorten the course of treatment, improve clinical effective rate, cure rate provides essential condition; The 3rd contribution of the present invention is, introducing by corresponding adjuvant nanorize is made the oral Preparation that is loaded with far infrared auxiliary treatment function with above-mentioned conventional oral Preparation, the upgrading of gastric extended release oral dosage preparation, makes the general curative effect of product be able to further raising.
The specific embodiment:
For further specifying the present invention, but not limited provide following embodiment,
1, the pre-treatment of medical material, Chinese patent medicine can be selected a kind of in following two kinds of modes according to the characteristics of dosage form:
(1), the pre-treatment 1 of medical material:
The raw material pulverize separately becomes fine powder in the prescription, sieves, and mixing is standby.
(2), the pre-treatment 2 of medical material:
In the prescription raw material extract or extracting section after concentrate, drying, pulverizing, mix homogeneously be standby; If can be standby during extracting section with the fine powder mix homogeneously that does not extract raw material pulverizing.
2, the preparation of described preparation:
(1) slow releasing capsule preparation: get above-mentioned standby medicated powder, the spermaceti or other blocker coating that add 0.5-5%, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, pack into behind the mix homogeneously in the capsulae vacuus, be packaged into box or be hot pressed into aluminium-plastic panel and obtain the finished product slow releasing capsule.
(2) capsule preparation: get above-mentioned standby medicated powder and add right amount of auxiliary materials (calcium carbonate, sodium carboxymethyl cellulose) granulation, drying, granulate adds Nano titanium dioxide, mix homogeneously, encapsulated, In Aluminium Foil Packing gets the finished capsule product agent.
(3) preparation tablets: get above-mentioned standby medicated powder and add the right amount of auxiliary materials granulation, drying, granulate adds Nano titanium dioxide, calcium silicates and/or Aluminum calcium silicate., mixing, tabletting, coating, promptly.
(4) granule preparation: get above-mentioned standby medicated powder, add corresponding adjuvant (an amount of hydroxypropyl emthylcellulose, calcium carbonate), mixing, granulation, granulate add nanoscale silicic acid aluminum, mixing, and packing promptly gets granule.
The instructions of taking of this granule is: granule is swallowed after with the low amounts of water moistening.
(5) pellet preparation: get above-mentioned standby medicated powder, an amount of Aluminum calcium silicate., with 65% ethanol and 1.2% soybean oil system soft material, the soft material that makes micropill mechanism ball, wet feed pushed the 0.8mm sieve aperture, the wet grain of strip cuts off round as a ball, and 50～60 ℃ of drying and mouldings are crossed 16～20 mesh sieves and selected ball, packing, promptly.
Or get above-mentioned 1/3 standby medicated powder, and with 65% ethanol and 1.2% soybean oil system soft material, the soft material that makes is with micropill mechanism ball, and wet feed pushed the 0.8mm sieve aperture, and the wet grain of strip cuts off round as a ball, and 50～60 ℃ of drying and mouldings are crossed 16～20 mesh sieves and are selected ball standby; Get above-mentioned 2/3 standby medicated powder, an amount of Aluminum calcium silicate., calcium carbonate, methylcellulose, with 65% ethanol and 1.2% soybean oil system soft material, the soft material that makes micropill mechanism ball, wet feed pushed the 0.8mm sieve aperture, the wet grain of strip cuts off round as a ball, 50～60 ℃ of drying and mouldings are crossed 16～20 mesh sieves and are selected ball standby; With above-mentioned two kinds of standby micropill mix homogeneously, packing promptly gets the pellet that can rapid delivery of pharmaceuticals combines with the intragastric floating sustained-release medicine.
Claims (10)
1. novel enteron pharmaceutical preparation and preparation method thereof, it is characterized in that, on the basis of former enteron pharmaceutical preparation prescription, by to the pre-treatment of medical material, add the carrier (adjuvant) of different dosage form, preparation program according to a conventional method, make conventional oral Preparation, floating in stomach oral Preparation, be loaded with the oral Preparation of far infrared auxiliary treatment function;
Described former digestive tract medicine is contained whole digestive tract medication, more preferably acute gastroenteritis medication, chronic gastritis, peptic ulcer, chronic enteritis medication, most preferably chronic gastritis, peptic ulcer medication.
2. a kind of novel enteron pharmaceutical preparation as claimed in claim 1 and preparation method thereof is characterized in that, described former digestive tract medicine and preparation under the prerequisite of not repelling western proprietary, more lay particular emphasis on Chinese medicine patent medicine; Wherein, chronic gastritis, digestive ulcer medicament and preparation including, but not limited to: the peace capsule for treating gastropathy, the peace gastric ulcer capsule, white refreshing ball, Bi tinkling of pieces of jade stomachache electuary, the shenmei stomach nourishing electuary, the ginseng and astragalus stomach strengthening electuary, the hay-scented Weikang capsule for curing gastric disease, the intestines and stomach is fitted capsule, the Lignum Aquilariae Resinatum ball of having a respite, DANGUIXIANG KELI, accent stomach pellet, the stomach regulating liver smoothing ball, fourth osmanthus stomach warming looses, ball in fourth bandit's reason, fly upward the gastroenteritis sheet, the 'Fengliaochangweikang' ' sheet, the compound sheet, compound Gansu julid medicine for gastrosis, compound recipe Radix Notoginseng capsule for treating stomachache, FUFANG WEINING PIAN, the complex stomach powder capsule, ocean stomach medicine, the stomach function regulating sheet, stomach function regulating suppressing the hyperactive liver ball, HOUTOU JIANWEI JIAONANG, the Radix Astragali is built middle ball, the Radix Astragali cream that is good for the stomach, capsule for treating gastropathy alive, Herba Pogostemonis clearing stomach sheet, the strengthening the spleen and nourishing the stomach granule, the chest stuffiness relieving ball is good for the stomach, tabellae stomachicus, JIANWEI XIAOSHI PIAN, antiphlogistic granules is good for the stomach, ulcer curing tablet is good for the stomach, the benefiting stomach and stopping pain sheet, brilliant art Weitai capsule for treating stomach disease, the appetite promoting and the spleen strengthening ball, KAIWEI LIPI PIAN, the appetizing Crataegi pill, Kang Hong stomach treasured, Confucian Temple gastritis is peaceful, KUAIWEI PIAN, routed Pingning, the ulcer Yiganning capsule, ball in the reason, LIUJUNZI WAN, Six-element Radix Aucklandiae capsule, Six-element energy capsule for eliminating, Gansu julid tablet for gastrosis, aplotaxis carminative pill, warming the stomach Shu Le sheet, the taste ball that relaxes, the safety ball, Pingwei pill, QIZHIWEITONG CHONGJI, clearing stomach security personnel ball, clearing stomach and middle ball, capsule for treating gastric disease, the SANJIU WEITAI electuary, the Massa Medicata Fermentata capsule for treating stomachache, ten five tastes black powder balls, the SHIXIANG pill for relieving pain, SHUGAN HEWEI WAN, the relaxing liver and strengthening stomach electuary, the Shugan Zhitong ball, four gentleman's balls, it phoenix powder for stomachache, stomach peace capsule, WEIANNING PIAN, the gastropathy ball, the gastrointestinal curing capsule, Weichangning tablets, WEIDE peace capsule, stomach good fortune granule, WEIFUCHUN PIAN, the multiple Yiganning capsule of stomach, stomach clever sheet alive, Weikang capsule for curing gastric disease, stomach-recovering capsule, stomach is sheet rather, the Veytalo capsule, the peaceful sheet of Veytalo, the Veytalo oral liquid for relaxation, the WEILEXIN granule, stomach power recovering particles, stomach power sheet, stomach founds the health sheet, stomach spirit electuary, WEINAI AN JIAONANG, the contrary recovering capsule of stomach, stomach rather looses, the peratodynia sheet, stomach oxazepan electuary, the stomach sheet that relaxes, WEISU CHONGJI, stomach Suning, the peaceful capsule of stomach, peaceful sheet has a stomach-ache, the stomachache stator, the flat capsule of having a stomachache, powder for stomachache, the easypro sheet of stomachache, the gastral cavilty electuary that relaxes, the auspicious peaceful granule of stomach, the gastritis recovering capsule, the gastritis instant granule for curing, stomach infections peace capsule, the Mistura Bismuthi Composta granule, the peaceful ball of stomach infections, stomach medicament capsule, stomach benefit capsule, WENWEISHU JIAONANG, Medicinal powder of cuttlefish and firtillary bulb, crow is sweet to loose, fragrant sand stomach function regulating ball, fragrant sand nine gentleman, the Aucklandiae and Amomi stomach-calming granule, cyperus-amomum stomach, stomachic tablet, heart stomach pellet, the appetizing electuary of being amusing, the cold of insufficiency type and stomachache electuary, stomach nourishing granule, the nourishing the stomach Yiganning capsule, yangweishu capsules, stomach reinforcing cream, the yin deficiency and gastralgia granule, yueju baohe pills, the bent flat stomach mixture of short, bristly hair or beard, precious yellow stomach sheet, Margarita stomach peace ball, positive stomach sheet, Aurantii Immaturi and Atractylodis Pill, control wet Pingwei pill, intelligence hands JIEBAI WAN, Zhong Jing stomach spirit sheet, Zuojin Wan.
3. as the medical material pre-treatment and the preparation of claim 1,2 described a kind of novel enteron pharmaceutical preparations and preparation method thereof, it is characterized in that,
The medicine of a, safe and effective amount, the medicine that former enteron pharmaceutical preparation provides can suitably be adjusted dosage up and down in conjunction with new dosage form and curative effect and safety;
B, in Chinese patent medicine preparation, but square Chinese crude drug pulverize separately becomes fine powder, sieves, mixing is standby; More preferably extract or extracting section after concentrate, drying, pulverizing, mixing be standby;
C, get above-mentioned standby medicated powder, add the carrier (adjuvant) of different dosage form, make different conventional oral Preparations respectively by the routine operation method of prior art.
Described conventional oral Preparation is including, but not limited to honey pill agent, pellet, concentrated pill, watered pill, gel, ointment, tablet, chewable tablet, powder, granule, capsule, slow releasing capsule.
4. as the floating in stomach oral Preparation of claim 1,2,3 described a kind of novel enteron pharmaceutical preparations and preparation method thereof, it is characterized in that, by the introducing of corresponding adjuvant the floating in stomach oral Preparation is made in above-mentioned conventional oral Preparation upgrading: the honey pill agent, pellet, concentrated pill, watered pill, gel, ointment, tablet, chewable tablet, powder, granule, capsule, the slow releasing capsule that promptly have the floating in stomach function;
More preferably tablet is made routine/floating double-layer tablet; Pellet, concentrated pill, watered pill, gel, granule, capsule content granule are made routine/floating bi-component, or routine/floating/slow release multicomponent pellet, concentrated pill, watered pill, gel, granule, capsule;
Wherein, conventional, floating two kinds of components respectively account for 1/4～1/2: 1/2～3/4; Conventional, floating, three kinds of components of slow release respectively account for 1/4～1/2: 1/4～1/3: 1/4～1/3.
5. as the floating in stomach oral Preparation of claim 1,4 described a kind of novel enteron pharmaceutical preparations and preparation method thereof, it is characterized in that, the corresponding adjuvant of described floating in stomach oral Preparation is included in the adjuvant that can produce the gas generating agent of gas in the gastric juice, can form gel in gastric juice.
6. as the corresponding adjuvant of the floating in stomach oral Preparation of claim 1,5 described a kind of novel enteron pharmaceutical preparations and preparation method thereof, it is characterized in that, in gastric juice, can produce the gas generating agent of gas, can select sodium bicarbonate, calcium carbonate, magnesium carbonate for use; 2～45% of its consumption accounting on the accrual basis agent gross weight.
7. as the corresponding adjuvant of the floating in stomach oral Preparation of claim 1,5 described a kind of novel enteron pharmaceutical preparations and preparation method thereof, it is characterized in that, the adjuvant that can form gel in gastric juice is divided into organic class, mineral-type again, difference according to dosage form can be used separately, more preferably unites use.Wherein,
A, mineral-type are including, but not limited to one or more in clay, kaolin, Bentonite, Bentonite magnesium, aluminium silicate, aluminium-magnesium silicate, colloidality silicon dioxide, the titanium dioxide.1～50% of its consumption accounting on the accrual basis agent gross weight.
B, organic class is including, but not limited to methylcellulose, ethyl cellulose, ethylhydroxyethylcellulose, hydroxy methocel, hydroxyethyl-cellulose, hydroxyethylmethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, cross-linking sodium carboxymethyl cellulose, carboxymethylcellulose calcium, carboxy-propyl cellulose, carbomer, modified starch, amylopectin, carboxymethyl starch sodium, sodium starch phosphate, the starch glycolic acid is received, dextrin, alginic acid, sodium alginate, potassium alginate, ammonium alginate, the propylene glycol sodium alginate, propylene glycol alginate, microbial alginate, mattress nuclear glucosan, glucosan, tragacanth, arabic gum, locust bean gum, guar gum, pectin, Sesbania cannabina (Retz.) Pers. glue, tara gum, Ficus elastica, Furcellaran, carrageenin, glue is drawn in red match, tamarind gum, POLY-karaya, xanthan gum, carrageenan, locust bean gum, gelatin, hyaluronate sodium, chitin, chitosan, chitosan (chitosan), Polyethylene Glycol, polyvinylpyrrolidone, polyvinyl alcohol, sodium acrylate, polyacrylic acid, sodium polyacrylate, cross linked sodium polyacrylate, polyacrylamide, hyaluronic acid sodium, casein, in the casein sodium one or more.1～50% of its consumption accounting on the accrual basis agent gross weight.
8. as claim 1,2,3, the oral Preparation that is loaded with far infrared auxiliary treatment function of 4 described a kind of novel enteron pharmaceutical preparations and preparation method thereof, it is characterized in that, introducing by corresponding adjuvant nanorize is with above-mentioned conventional oral Preparation, the oral Preparation that is loaded with far infrared auxiliary treatment function is made in the upgrading of gastric extended release oral dosage preparation: the honey pill agent commonly used that promptly is loaded with far infrared auxiliary treatment function, pellet, concentrated pill, watered pill, gel, ointment, tablet, chewable tablet, powder, granule, capsule, slow releasing capsule, and the honey pill agent that has the floating in stomach function when being loaded with far infrared auxiliary treatment function, pellet, concentrated pill, watered pill, gel, ointment, tablet, chewable tablet, powder, granule, capsule, slow releasing capsule.
9. as the corresponding adjuvant that is loaded with far infrared auxiliary treatment function of claim 1,8 described a kind of novel enteron pharmaceutical preparations and preparation method thereof, it is characterized in that, the respective secondary material that is loaded with far infrared auxiliary treatment function is including, but not limited to the natural crystal class, as: " multicolored stone " in rare ice stone, Sibin floating stone, the deep-sea, Muscovitum, Kaolin, cordierite, zircon, Pumex, Haematitum; Artificial sintering stone class, as: mullite, cordierite, Pumex; Great soil group, as: Kaolin, Suzhou soil; Ceramic-like, as: the sinter of the oxide that the Mg-Al-Si-Zr-rare earth is, Mn-Fe-Co-Ni-Cu-Cr is metal, carbide, nitride, boride, aluminium oxide, zirconium oxide, titanium dioxide, magnesium oxide and their composite oxides one mullite, zircon and cordierite, transition-metal oxide and cordierite (2MgO2Al such as ferrum, cobalt, manganese
2O
35SiO
2) wait the mixed sintering thing of composite oxides, Si
3N
4The complex sintered thing of-SiC, TiC (or TiN)-Si
3N
4Complex sintered thing, TiC-Al
2O
3-TiO
2Complex sintered thing, HfB (or TaN)-Fe
2O
3, MnO
2Be complex sintered thing, aluminium oxide-silicate is sinter, Al
2O
3-SiO2 base sinter; The biological carbon class, as: Sargassum carbon, bamboo charcoal; Plant fiber's class, as: the petal fiber; The animal class, as: Margarita, Concha Margaritifera, Concha Haliotidis, Endoconcha Sepiae; Organic class, as: casein, fibrin; Mineral-type, metal, nonmetallic oxide, carbide, nitride, boride; 1～30% of its consumption accounting on the accrual basis agent gross weight.
10. as claim 1,8, the corresponding adjuvant that is loaded with far infrared auxiliary treatment function of 9 described a kind of novel enteron pharmaceutical preparations and preparation method thereof, it is characterized in that, more preferably: breed the adjuvant commonly used on above-mentioned pharmaceutics among all kinds of: as: Pulvis Talci, Kaolin, active hargil, Pumex, silicon dioxide (micropowder silica gel), titanium dioxide (titanium dioxide), magnesium oxide, ferrum oxide, zinc oxide, calcium oxide, activated alumina, aluminium hydroxide, magnesium carbonate, magnesium stearate, calcium carbonate, silicic acid, calcium silicates, aluminium silicate, magnesium silicate, aluminium-magnesium silicate, Aluminum calcium silicate. etc.; 1～30% of its consumption accounting on the accrual basis agent gross weight.
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Cited By (8)
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| CN101396542B (en) * | 2008-11-13 | 2012-01-11 | 陕西东泰制药有限公司 | Traditional Chinese medicine formulation for treating gastrosis and preparation method thereof |
| CN102579693A (en) * | 2012-03-29 | 2012-07-18 | 黄荣 | Chinese medicine for treating ulcer disease and preparation method thereof |
| CN105878199A (en) * | 2016-06-07 | 2016-08-24 | 山东中医药大学 | Flavored-liver-fire-stomach-invading-treating gastric floating adhesive tablet and preparing method thereof |
| CN106758221A (en) * | 2016-12-02 | 2017-05-31 | 江苏新瑞贝科技股份有限公司 | A kind of spinning post-finishing microcapsules and its production and use |
| CN106728634A (en) * | 2015-11-19 | 2017-05-31 | 哈尔滨圣吉药业股份有限公司 | One kind more brings up guarantor and dispersible tablet and preparation method thereof |
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| CN101396542B (en) * | 2008-11-13 | 2012-01-11 | 陕西东泰制药有限公司 | Traditional Chinese medicine formulation for treating gastrosis and preparation method thereof |
| CN102579693A (en) * | 2012-03-29 | 2012-07-18 | 黄荣 | Chinese medicine for treating ulcer disease and preparation method thereof |
| CN102579693B (en) * | 2012-03-29 | 2013-08-07 | 黄荣 | Chinese medicine for treating ulcer disease and preparation method thereof |
| CN106728634A (en) * | 2015-11-19 | 2017-05-31 | 哈尔滨圣吉药业股份有限公司 | One kind more brings up guarantor and dispersible tablet and preparation method thereof |
| CN105878199A (en) * | 2016-06-07 | 2016-08-24 | 山东中医药大学 | Flavored-liver-fire-stomach-invading-treating gastric floating adhesive tablet and preparing method thereof |
| CN105878199B (en) * | 2016-06-07 | 2019-02-19 | 山东中医药大学 | Piece and preparation method thereof is sticked in one kind plus the left golden stomach floating of taste |
| CN106758221A (en) * | 2016-12-02 | 2017-05-31 | 江苏新瑞贝科技股份有限公司 | A kind of spinning post-finishing microcapsules and its production and use |
| CN113149022A (en) * | 2021-04-30 | 2021-07-23 | 南昌大学 | Silica @ calcium silicate hollow nanosphere and preparation method and application thereof |
| CN113149022B (en) * | 2021-04-30 | 2022-07-22 | 南昌大学 | Silica @ calcium silicate hollow nanosphere and preparation method and application thereof |
| CN115554375A (en) * | 2022-11-23 | 2023-01-03 | 昆明中药厂有限公司 | Stomach calming Xiangsha granules with high molding rate, low hygroscopicity and good dissolubility and fluidity |
| CN116439150A (en) * | 2023-06-14 | 2023-07-18 | 四川省畜牧科学研究院 | Dry-wet piglet feeding system and feeding method |
| CN116439150B (en) * | 2023-06-14 | 2023-09-19 | 四川省畜牧科学研究院 | Dry-wet piglet feeding system and feeding method |
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Application publication date: 20080416 |