CN1231239C - Medicine for curing hydrocephalus, brain abscess and brain tumor and preparation process thereof - Google Patents

Medicine for curing hydrocephalus, brain abscess and brain tumor and preparation process thereof Download PDF

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CN1231239C
CN1231239C CN 02135617 CN02135617A CN1231239C CN 1231239 C CN1231239 C CN 1231239C CN 02135617 CN02135617 CN 02135617 CN 02135617 A CN02135617 A CN 02135617A CN 1231239 C CN1231239 C CN 1231239C
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radix
medicine
rhizoma
brain
radix angelicae
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CN1485071A (en
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殷耀卿
陈建昌
刘卫平
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殷耀卿
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Abstract

The present invention belongs to the technology of Chinese patent medicine, which provides medicine for treating hydrocephalus, brain abscess and brain tumors. The medicine comprises raw materials with the following proportion by weight: 25 to 30g of dahurian angelica, 15 to 20g of snakegourd root, 25 to 30g of water plantain, 10 to 15g of laminaria, 10 to 15g of seaweed, 25 to 30g of white poria, 15 to 18g of baikal skullcap, 10 to 25g of phellodendron bark, 10 to 15g of fineleaf schizonepeta herb, 15 to 20g of largetrifoliolious bugbane rhizome, 10 to 15g of tangkuei tail, 15 to 20g of chuanxiong rhizome, 10 to 35g of prepared common monkshood mother root, 15 to 20g of cassia twig, 10 to 15g of pilose antler, 15 to 20g of sea horse, 1 to 3g of cow-bezoar and 0.1g of musk. The preparation method of the medicine has the following steps: preparing the scutellaria root into Chinese spirit, preparing the common monkshood mother root into vinegar, and parching the phellodendron bark with salt (according to the traditional technology); drying the Chinese spirit, the vinegar and the phellodendron bark after the scutellaria root, the common monkshood mother root and the phellodendron bark are respectively processed; crushing the dried Chinese spirit, the vinegar and the phellodendron bark with the materials together; loading the mixture into No. 0 capsules(the grain weight is 0.5g) after the crushed materials are fully mixed with the musk to prepare the medicine. The medicine has the functions for reducing the intracranial pressure, improving the microcirculation of the brain, and eliminating intracranial edema, hematoma, abscess, cystis and brain tumors.

Description

A kind of medicine for the treatment of hydrocephalus, brain abscess, the cerebral tumor and preparation method thereof
Affiliated technical field
The invention belongs to Chinese patent drug technique field, mainly propose a kind of medicine for the treatment of hydrocephalus, brain abscess, the cerebral tumor, the invention still further relates to the preparation method of this medicine.
Background technology
Encephalopathy is commonly encountered diseases, the frequently-occurring disease of serious threat human health.Especially the harm of hydrocephalus, brain abscess, the cerebral tumor is more serious, disables useless and to cause mortality rate all very high.At present,, mostly be traumatic therapy greatly, had following problem respectively though clinical Therapeutic Method to disease of brain such as hydrocephalus, brain abscess, the cerebral tumors is a lot:
1, operative treatment: wound is bigger, does not descend operating-table promptly dead after many patient's cerebral tumor operations; Defect of skull after the operation that has can't be repaired; Because the complex structure of cerebral tissue, it is clean that operation is difficult for excision, easily recurrence; Many patients have sequela and complication (as secondary epilepsy, cerebral edema, cerebral malacia).After hydrocephalus was done the intraperitoneal drainage operation, pipeline stopped up easily.And cause secondary infection behind the brain abscess operation easily.
2, the side effect of radiotherapy: the influence to hemopoietic system and digestive system is bigger.The radiation injury of radioactivity cerebral edema, skin, skull and normal structure that radiotherapy causes is bigger.Particularly 60 pairs of brain tissue impairments of cobalt are bigger.
3, the problem that exists of cerebroma chemotherapy: 1. blood brain barrier problem.Because the effect of blood brain barrier can not or seldom can enter in the cerebral tissue some antitumor drug, so limited to the curative effect of cerebroma.2. present, still can not affirm its antitumor spectra fully to nervus centralis effective antitumour medicine, so be difficult to select medicine according to the pathology of Brain Tumors principle.And chemotherapy is is easily killed and wounded human leukocytes, reduces the human body immunity.
4, r-cutter, the treatment of x-cutter easily cause complication such as cerebral edema.
5, medical expense costliness.
Summary of the invention
The object of the present invention is to provide a kind of have reduce intracranial pressure, improve big brain microcirculation, eliminate the medicine of intracranial edema, hematoma, abscess, cyst and brain tumor.
Another object of the present invention provides the preparation method of treatment hydrocephalus, brain abscess, cerebral tumor medicine.
Solution of the present invention is based on motherland's medical science to hydrocephalus, brain abscess, the cerebral tumor and complication thereof, pathogenetic understanding and Therapeutic Principle, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out have blood stasis dispersing and deswelling, the natural Chinese medicine of sensible diuretic, heat-clearing and toxic substances removing, strengthening the body resistance, by the theory of Chinese medical science prescription, skim the cream off milk, make it play the therapeutical effect that reduces intracranial pressure, improves big cerebral circulation, dwindles or eliminate intracranial edema, hematoma, abscess, cystic disease.
Medicine of the present invention is made by following component: (consumption is a weight portion)
White 25-30 Radix Trichosanthis 15-20 Rhizoma Alismatis 25-30 Thallus Laminariae (Thallus Eckloniae) 10-15 Sargassum 10-15 Poria 25-30 Radix Scutellariae 15-18 Cortex Phellodendri 10-25 Herba Schizonepetae 10-15 Rhizoma Cimicifugae 15-20 Radix Angelicae Sinensis 10-15 Rhizoma Chuanxiong 15-20 Radix Aconiti Preparata 10-35 Ramulus Cinnamomi 15-20 Cornu Cervi Pantotrichum 10-15 Hippocampus 15-20 Calculus Bovis 1-3 Moschus 0.1.
Formula optimization weight (part) ratio range of preparation medicine of the present invention is
Radix Angelicae Dahuricae 27-28 Radix Trichosanthis 17-18 Rhizoma Alismatis 26-28 Thallus Laminariae (Thallus Eckloniae) 12-14 Sargassum 12-14 Poria 27-28 Radix Scutellariae 16-17 Cortex Phellodendri 15-20 Herba Schizonepetae 10-12 Rhizoma Cimicifugae 16-18 Radix Angelicae Sinensis 10-13 Rhizoma Chuanxiong 17-18 Radix Aconiti Preparata 20-30 Ramulus Cinnamomi 17-18 Cornu Cervi Pantotrichum 12-14 Hippocampus 17-18 Calculus Bovis 1.5-2.5 Moschus 0.1.
The preparation method that above-mentioned each component is made medicine of the present invention is: Radix Scutellariae processed with wine, Radix Aconiti vinegar system, Cortex Phellodendri salt are fried (by traditional handicraft) concoct the back oven dry respectively; with pulverize together after the Radix Angelicae Dahuricae, Rhizoma Alismatis, Poria, Thallus Laminariae (Thallus Eckloniae), Sargassum, Radix Trichosanthis, Calculus Bovis, Herba Schizonepetae, Ramulus Cinnamomi, Rhizoma Cimicifugae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cornu Cervi Pantotrichum, the Hippocampus drying, and promptly make this medicine after Moschus fully mixes.
Prescription of the present invention is that the composition principle by traditional Chinese medical science monarch carries out prescription.Monarch drug in the principal agent side: Rhizoma Alismatis, Poria, Thallus Laminariae (Thallus Eckloniae), Sargassum play the inducing diuresis to remove edema effect, and Calculus Bovis, Moschus have the cephalocathartic effect of having one's ideas straightened out; Ministerial drug: Radix Scutellariae, Cortex Phellodendri, Herba Schizonepetae, Rhizoma Cimicifugae play antipyretic and antidote functions; Adjuvant drug: the Radix Angelicae Dahuricae, Radix Trichosanthis play eliminating stagnation evacuation of pus effect, and Cornu Cervi Pantotrichum, Hippocampus have additional kidney to fill cerebratmon; Messenger drug: Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi play function of promoting blood circulation to disperse blood clots.In sum, the present invention has effects such as inducing diuresis to remove edema, heat-clearing and toxic substances removing, eliminating stagnation evacuation of pus, blood circulation promoting and blood stasis dispelling, strengthening the body resistance, can make cerebral edema, encephalitis granuloma, cerebral cyst, brain abscess, the cerebral tumor progressively dwindles or disappear, and reduces intracranial pressure, reaches the purpose of treatment.
The Cornu Cervi Pantotrichum that the present invention is selected: sweet-salty; Pure sun warm in nature is gone into the kidney channel blood system, and dredging DU Meridian feeling pulse gas reaches the Yang Dao of eight extra-channel.Have spermatogenesis and mend marrow, nourish blood and fill the merit of brain, in fact the key medicine of filling brain for the warming YANG invigorating primordial QI.Can promote the brain cell growth, improve body resistance against diseases.
Hippocampus: sweet in the mouth, warm in nature, go into the Liver and kidney warp.Kidney invigorating and YANG supporting is arranged, the congestion that disappears, the effect of softening cerebral arteriosclerosis.Also have cerebral function improvement, improve immunity, the effect of slow down aging.
The Radix Angelicae Dahuricae: Xin Wen returns lung, and the stomach warp has expelling pathogenic wind from the body surface, reducing swelling and alleviating pain, the merit of dampness evacuation of pus.Be usually used in treatment flu headache, nasal sinusitis headache, superciliary ridge headache, multiple polarization headache such as wind syndrome of head.This product to cold headache effect more so, compatibilities such as many and Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong.This product research now has the pain sensation of inhibition maincenter, regulates the autonomic nervous dysfunction, and the paralysis peripheral nerve suppresses to cause the release of painful material, and the painful effect in stronger town is arranged.This product belongs to the wind medicine, is apt to away extremity, expel wind to dredge collateral, and the excited spinal cord of energy improves muscular tension, cooperates the product of fill blood liver and kidney tonifying medicine and blood circulation promoting and blood stasis dispelling can control myopathy, paralysis.
Radix Scutellariae: cold in nature, bitter in the mouth is returned lung, gallbladder, stomach, large intestine channel, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.Be mainly used in hygropyrexia, heating, carbuncle furuncle, sore, excessive fetal movement due to heat in pregnancy, dysentery etc.Modern medicine research has effects such as blood fat reducing, antithrombotic formation, blood pressure lowering, antiallergic action and antiinflammatory.
Radix Angelicae Sinensis: sweet in the mouth, suffering, tepor is gone into the heart, liver, spleen channel, and having enriches blood invigorates blood circulation, the effect of brain-tonifying and intelligence-raising, heart governing blood and vessels, the brain house mind is bright, deficiency of heart-blood, then refreshing mistake of brain supported, so clinically easily see dizziness, cardiopalmus, disease such as forgetful.But this product is joined the Radix Astragali, Arillus Longan, Semen Ziziphi Spinosae, Radix Polygalae benefiting QI and nourishing blood, cerebral tonic tranquillizing.
Rhizoma Chuanxiong: acrid in the mouth, temperature, go into liver, gallbladder, pericardium channel.Has blood-activating and qi-promoting, the effect of dispeling the wind and relieving the pain.Rhizoma Chuanxiong is the key medicine of treatment encephalopathy, clinically many is equipped with Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, the Radix Rehmanniae with this product.Be treatment apoplexy sequela, the practical medicine of hemiplegia.Treatment such as this product and Herba Schizonepetae, Radix Saposhnikoviae wind and cold headache, with compatibilities such as Flos Chrysanthemi, Bombyx Batryticatus, treatment wind heat headache.The coronary heart disease of this product treatment in recent years, angina pectoris.Rhizoma Chuanxiong energy blood circulation promoting and blood stasis dispelling, dispeling the wind relieves the pain, and is good at wandering away, and has the circulation of qi promoting effect concurrently.It " can the descending sea of blood, the up head ", " being the gas medicine in the blood ".
Radix Trichosanthis: sweet in the mouth, little bitter cold, return the taste warp.This product has promoting the production of body fluid to quench thirst, heat-clearing and toxic substances removing, the merit of detumescence and apocenosis.The heat of lung heat clearing, stomach again can promoting the production of body fluid to quench thirst.Control consumption of body fluid caused by febrile disease, dry mouth and tougue, excessive thirst, polydipsia, the gastric heat impairment of YIN, easily hungry, diseases such as emaciated physique.Modern this product pharmacological research has antibiotic, anticancer, hypoglycemic effect.
Sargassum: salty-cold, return liver, stomach, kidney channel, eliminating phlegm and softening indurated mass, diuretic, eliminating stagnation.This product has diuretic detumescent and diuretic actions.
Thallus Laminariae (Thallus Eckloniae): salty-cold, return liver, stomach, kidney channel, effect eliminating phlegm and softening indurated mass diuretic.Thallus Laminariae (Thallus Eckloniae) has the merit of the eliminating phlegm and softening indurated mass similar to Sargassum.Must use together with other diuretic a little less than this product energy diuretic detumescent, the power.
Rhizoma Alismatis: cold in nature, slightly sweet flavor, return kidney, spleen, urinary bladder channel, the merit of have promoting diuresis to eliminate damp pathogen, purging heat, for because of disturbing in the phlegm retention, brain god is rather good by the dizzy effect of covering and causing.Rhizoma Alismatis extractum can make delay carbamide and the cholesterol level in the rabbit blood reduce, and progression of atherosclerosis is slowed down, and the effect of its cholesterol reducing also is better than other medicines.
Poria: sweet in the mouth, light flat, GUIXIN, lung, spleen channel.Eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, sharp key dries, and happy beneficial brain is led turbid promoting the production of body fluid, the effect of heart tonifying and tranquilizing.This product can be improved the cardiovascular and cerebrovascular vessel reactivity, increases blood to the internal organs groundwater increment, and the expansion peripheral blood vessel brings high blood pressure down, and adjusts nervous dysfunction, and the central nervous system is had the inhibition effect.
Rhizoma Cimicifugae: acrid-sweet flavor, cold nature is returned lung, spleen, large intestine, stomach warp, effect heat-clearing and toxic substances removing, ascending up spleen-Qi and Yang.The Rhizoma Cimicifugae performance rise to be loose, and can separate pyretic toxicity, is used for the various disease conditions due to the pyretic toxicity.
Calculus Bovis: bitter in the mouth, cool in nature, return liver, heart channel.The effect heat-clearing and toxic substances removing, endogenous wind stopping relieving convulsion, waking up the patient from unconsciousness by dissipating phlegm.Be used for epidemic febrile disease and infantile convulsion, high fever coma, diseases such as spasm tic.Also be used for expectorant thermal resistances such as epidemic febrile disease heat attacking the pericardium or apoplexy, infantile convulsion, epilepsy and close diseases such as coma due to the thinking, locked mouth, also be used for due to the pyretic toxicity pent-up laryngopharynx swelling and pain, fester, disease such as aphtha of the mouth and tongue, carbuncle furunculosis.
Cortex Phellodendri: bitter in the mouth is cold in nature.Return kidney, bladder, large intestine channel.Effect heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever.Be used for sore and toxic, eczema etc.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select medicine for use be raw material with the natural Chinese medicinal herb in the present invention, utilize the reasonable compatibility of the Chinese medicine of respectively distinguishing the flavor of, treatment hydrocephalus, brain abscess, the cerebral tumor have no side effect, having overcome modern times such as operation, radiotherapy, chemotherapy has many drawbacks of traumatic therapy, treats safe and effective.
2, medicine of the present invention need not decoct, no bitterness sense.Use the mixing in water for oral taking capsule, taking convenience.
The present invention is as follows at the model case of clinical use:
1, Ma, man, 9 years old, North Street, town, area just outside a city gate, Yichuan County people from village.In February, 1998 excuse pain, faint, limbs twitch, examine at the one attached CT of institute of river medical university to be left parietal lobe inflammatory granuloma.Examined March 9 and be suppurative encephalitis at the CT of the People's Hospital, Yichuan County.In many ways it is invalid to seek medical advice, and receives treatment on May 27th, 1998.The swollen capsule for eliminating of clothes brain cooperates brain disease health electuary after 5 days, and symptom obviously alleviates; Take medicine a course of treatment transference cure, the back after treatment half a year of not recurrence so far.
2, go up certain, woman, 46 years old, the cadre of Sanmenxia City commerce commission.Nineteen ninety-five, the attached CT of institute of the 4th medical university of army was diagnosed as obstructive hydrocephalus in Xi'an because of suffering from headache, dizzy, nauseating, stupor.It is invalid to seek medical advice everywhere, receives treatment on May 16th, 1997.Take the swollen capsule for eliminating of brain and cooperate one course of treatment of brain disease health electuary, transference cure, the clothes disease recovery from illness in three months that continues, recurrence so far.
3, certain is big, the man, 23 years old, Luolong District Xin Dian town, Luoyang City Xu Jiaying people from village, on October 30th, 2000 go into a coma suddenly, faint, tic of the limbs, lisp, syncope.In PLA's 150 hospital's CT examination, be diagnosed as: the right frontal lobe brain abscess, hospitalization, effect does not show.April 27 calendar year 2001, receive treatment in my institute, take one course of treatment of this medicine, stupor, twitch and do not reaccess, patient serve on 8 months, and all are normal.On January 9th, 2002, patient is CT examination once more, finds that the right frontal lobe brain abscess changes disappearance after treating.
4, Wang, man, 40 years old, the Tian Hu south of a town, Songxian County people from village, sudden faintness, stupor, the back headache of waking up.On April 7 calendar year 2001, find left temporal lobe occupying lesion in the People's Hospital, Songxian County CT examination.Be thought of as low classification neuroastrocytoma due to illness the people fear operation, in April 9 calendar year 2001 in my institute's treatment, after taking this medicine, faint, stupor, headache do not have and take place, it is brisk that head is felt, transference cure.
The specific embodiment
Take by weighing raw material (kilogram) by following proportioning:
The Radix Angelicae Dahuricae 26 Radix Trichosanthis 18 Rhizoma Alismatis 28 Thallus Laminariae (Thallus Eckloniae)s 13 Sargassums 13 Porias 28 Radix Scutellariaes 16 Cortex Phellodendris 20 Herba Schizonepetae 13 Rhizoma Cimicifugaes 18 Radix Angelicae Sinensis 13 Rhizoma Chuanxiongs 13 Radix Aconiti Preparatas 25 Ramulus Cinnamomi 13 Cornu Cervi Pantotrichums 13 Hippocampus 18 Calculus Boviss 2 Moschus 0.1
Production method: Radix Scutellariae processed with wine, Radix Aconiti vinegar system, Cortex Phellodendri salt are fried (by traditional handicraft) concoct the back oven dry respectively; with pulverize together after the Radix Angelicae Dahuricae, Rhizoma Alismatis, Poria, Thallus Laminariae (Thallus Eckloniae), Sargassum, Radix Trichosanthis, Calculus Bovis, Herba Schizonepetae, Ramulus Cinnamomi, Rhizoma Cimicifugae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cornu Cervi Pantotrichum, the Hippocampus drying, promptly make this medicine with No. 0 capsule (grain weighs 0.5 gram) of packing into after Moschus fully mixes.

Claims (4)

1, a kind of medicine for the treatment of hydrocephalus, brain abscess, the cerebral tumor, it is characterized in that: it is the medicament of being made by the following weight proportion raw material: Radix Angelicae Dahuricae 25-30 Radix Trichosanthis 15-20 Rhizoma Alismatis 25-30 Thallus Laminariae (Thallus Eckloniae) 10-15 Sargassum 10-15 Poria 25-30 Radix Scutellariae 15-18 Cortex Phellodendri 10-25 Herba Schizonepetae 10-15 Rhizoma Cimicifugae 15-20 Radix Angelicae Sinensis 10-15 Rhizoma Chuanxiong 15-20 Radix Aconiti Preparata 10-35 Ramulus Cinnamomi 15-20 Cornu Cervi Pantotrichum 10-15 Hippocampus 15-20 Calculus Bovis 1-3 Moschus 0.1, and wherein: Rhizoma Alismatis, Poria, Thallus Laminariae (Thallus Eckloniae), Sargassum, Calculus Bovis, Moschus are monarch drug; Radix Scutellariae, Cortex Phellodendri, Herba Schizonepetae, Rhizoma Cimicifugae are ministerial drug; The Radix Angelicae Dahuricae, Radix Trichosanthis, Cornu Cervi Pantotrichum, Hippocampus are adjuvant drug; Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi are messenger drug.
2, the medicine of treatment hydrocephalus according to claim 1, brain abscess, the cerebral tumor, it is characterized in that: wherein the weight proportion of each raw material is: Radix Angelicae Dahuricae 27-28 Radix Trichosanthis 17-18 Rhizoma Alismatis 26-28 Thallus Laminariae (Thallus Eckloniae) 12-14 Sargassum 12-14 Poria 27-28 Radix Scutellariae 16-17 Cortex Phellodendri 15-20 Herba Schizonepetae 10-12 Rhizoma Cimicifugae 16-18 Radix Angelicae Sinensis 10-13 Rhizoma Chuanxiong 17-18 Radix Aconiti Preparata 20-30 Ramulus Cinnamomi 17-18 Cornu Cervi Pantotrichum 12-14 Hippocampus 17-18 Calculus Bovis 1.5-2.5 Moschus 0.1, and wherein: Rhizoma Alismatis, Poria, Thallus Laminariae (Thallus Eckloniae), Sargassum, Calculus Bovis, Moschus are monarch drug; Radix Scutellariae, Cortex Phellodendri, Herba Schizonepetae, Rhizoma Cimicifugae are ministerial drug; The Radix Angelicae Dahuricae, Radix Trichosanthis, Cornu Cervi Pantotrichum, Hippocampus are adjuvant drug; Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi are messenger drug.
3, the medicine of treatment hydrocephalus according to claim 1 and 2, brain abscess, the cerebral tumor, it is characterized in that: said medicament is a capsule.
4, the method for preparing the described medicine of claim 3; it is characterized in that: Radix Scutellariae processed with wine, Radix Aconiti vinegar system, Cortex Phellodendri salt are fried by traditional handicraft concocted the back oven dry respectively; with pulverize together after the Radix Angelicae Dahuricae, Rhizoma Alismatis, Poria, Thallus Laminariae (Thallus Eckloniae), Sargassum, Radix Trichosanthis, Calculus Bovis, Herba Schizonepetae, Ramulus Cinnamomi, Rhizoma Cimicifugae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cornu Cervi Pantotrichum, the Hippocampus drying, weigh 0.5 gram with No. 0 capsule grain of packing into after Moschus fully mixes and promptly make this medicine.
CN 02135617 2002-09-29 2002-09-29 Medicine for curing hydrocephalus, brain abscess and brain tumor and preparation process thereof Expired - Fee Related CN1231239C (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101099781B (en) * 2006-10-11 2010-06-23 张财 External-applied traditional Chinese medicine for treating middle and late brain tumor
CN101559152B (en) * 2009-05-19 2011-09-07 李桂华 Chinese materia medica preparation for treating hydrocephalus and preparation method thereof
CN103705639B (en) * 2013-12-31 2016-03-09 徐海燕 One treats hydrocephalic Chinese medicine preparation
CN104740362A (en) * 2015-03-13 2015-07-01 韦邦力 Traditional Chinese medicine composition for treating perencephaly
CN105169055A (en) * 2015-09-28 2015-12-23 张光荣 Pharmaceutical preparation for treating cerebral cancer and preparation method thereof
CN106361916A (en) * 2016-10-26 2017-02-01 华北理工大学 The application of traditional Chinese medicine composition in preparation of nasogenic brain abscess medicine
CN108042748A (en) * 2018-01-29 2018-05-18 青岛大学附属医院 A kind of drug and preparation method for treating brain tumor

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