CN101129971B - 治疗妇女痛经、***的中药组合物及其制备方法 - Google Patents
治疗妇女痛经、***的中药组合物及其制备方法 Download PDFInfo
- Publication number
- CN101129971B CN101129971B CN2007101516065A CN200710151606A CN101129971B CN 101129971 B CN101129971 B CN 101129971B CN 2007101516065 A CN2007101516065 A CN 2007101516065A CN 200710151606 A CN200710151606 A CN 200710151606A CN 101129971 B CN101129971 B CN 101129971B
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- chinese medicine
- medicine composition
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 83
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 238000000034 method Methods 0.000 title claims abstract description 16
- 208000019255 Menstrual disease Diseases 0.000 title claims description 8
- 229940079593 drug Drugs 0.000 claims abstract description 28
- 241000218176 Corydalis Species 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 239000002775 capsule Substances 0.000 claims abstract description 10
- 206010013935 Dysmenorrhoea Diseases 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 241001057584 Myrrha Species 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 12
- 239000000796 flavoring agent Substances 0.000 claims description 10
- 235000019634 flavors Nutrition 0.000 claims description 10
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 9
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 9
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 9
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 9
- 239000000052 vinegar Substances 0.000 claims description 9
- 235000021419 vinegar Nutrition 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 7
- 238000005303 weighing Methods 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 241000545442 Radix Species 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 238000007796 conventional method Methods 0.000 claims 1
- 230000005906 menstruation Effects 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 2
- 241001127714 Amomum Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000202726 Bupleurum Species 0.000 abstract 1
- 235000008671 Calycanthus floridus Nutrition 0.000 abstract 1
- 235000008670 Calycanthus occidentalis Nutrition 0.000 abstract 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- 244000075634 Cyperus rotundus Species 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 244000148992 Lindera benzoin Species 0.000 abstract 1
- 235000004520 Lindera benzoin Nutrition 0.000 abstract 1
- 235000008262 Lindera benzoin var. benzoin Nutrition 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 235000017803 cinnamon Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 description 22
- 230000000694 effects Effects 0.000 description 19
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 description 15
- 101800000989 Oxytocin Proteins 0.000 description 15
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 description 15
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 15
- 229960001723 oxytocin Drugs 0.000 description 15
- 210000004291 uterus Anatomy 0.000 description 14
- 239000000047 product Substances 0.000 description 13
- 238000012360 testing method Methods 0.000 description 12
- 208000005171 Dysmenorrhea Diseases 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 6
- 230000000202 analgesic effect Effects 0.000 description 6
- 230000036407 pain Effects 0.000 description 6
- 230000001105 regulatory effect Effects 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 230000003285 pharmacodynamic effect Effects 0.000 description 4
- 210000002460 smooth muscle Anatomy 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 229960000583 acetic acid Drugs 0.000 description 3
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 3
- 238000011047 acute toxicity test Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- -1 mixing is granulated Substances 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010039897 Sedation Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000036280 sedation Effects 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 101001031591 Mus musculus Heart- and neural crest derivatives-expressed protein 2 Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000002498 deadly effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 1
- 229960000452 diethylstilbestrol Drugs 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000013948 uterine smooth muscle contraction Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
组别 | 剂量g/kg | 动物数(只) | 服用1小时后ip0.6%冰醋酸 | |
20分钟扭体次数 | 抑制率(%) | |||
对照(水) | 30 | 15 | 40.80 | |
月月舒 | 25 | 15 | 17.00 | 58.33 |
供试药物 | 6 | 15 | 16.07 | 60.61 |
组别 | 子宫数 | 给催产素后频率次/10分(X±SD) | 给洛氏液或药后频率的变化(X±SD) | |
前10分次/10分(±%) | 后10分次/10分(±%) | |||
洛氏液 | 6 | 7.33±2.88 | 6.83±2.48(+3.60±45.88) | 5.33±2.42(-22.46±31.62) |
供试药物(2%×1ml) | 7 | 9.14±0.90 | 4.92±2.21(-54.13±22.33) | 2.29±2.06(-75.83±21.52)※※△△ |
月月舒(30%×1ml) | 7 | 8.71±1.89 | 6.29±1.25(-26.07±17.18) | 5.29±1.38(-37.42±20.83) |
组别 | 子宫数(个) | 给催产素后幅度(X±SDnm)/10分 | 给洛氏液或药后幅度的变化(X±SDnm/10分) | |
前10分nm/10分(±%) | 后10分nm/10分(±%) | |||
洛氏液 | 6 | 36.41±20.30 | 47.51±24.07(36.72±42.66) | 49.42±18.79(46.98±33.86) |
供试药物(2%×1ml) | 7 | 56.51±15.36 | 57.96±16.15(+2.37±7.72) | 23.47±18.29△△△(-59.16±29.09)*** |
月月舒(30%×1ml) | 7 | 56.92±12.69 | 63.55±16.86(+11.36±17.35) | 64.83±14.49(+14.63±14.63)* |
组别 | 子宫数(个) | 给催产素后活动力/10分(X±SD) | 给洛氏液或药后活动力的变化(X±SD) | |
活动力/10分(±%) | 活动力/10分(±%) | |||
洛氏液 | 6 | 256.32±184.34 | 311.35±158.34(+48.10±92.54) | 252.34±119.41(+20.41±75.42) |
供试药物(2%×1ml) | 7 | 516.57±137.66 | 242.71±139.85△(-53.49±21.11) | 68.29±79.97△△△(-87.72±13.58)** |
月月舒(30%×1ml) | 7 | 504.71±181.95 | 404.58±156.66(-16.69±29.26) | 349.85±142.79(-26.98±31.53)* |
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101516065A CN101129971B (zh) | 2007-09-25 | 2007-09-25 | 治疗妇女痛经、***的中药组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101516065A CN101129971B (zh) | 2007-09-25 | 2007-09-25 | 治疗妇女痛经、***的中药组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101129971A CN101129971A (zh) | 2008-02-27 |
CN101129971B true CN101129971B (zh) | 2010-11-24 |
Family
ID=39127483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007101516065A Expired - Fee Related CN101129971B (zh) | 2007-09-25 | 2007-09-25 | 治疗妇女痛经、***的中药组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101129971B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105169076A (zh) * | 2013-07-31 | 2015-12-23 | 朱保生 | 治疗***的中药组合物 |
CN103655940B (zh) * | 2013-12-05 | 2016-08-17 | 陕西东科制药有限责任公司 | 一种治疗月经病的中药复方 |
CN104667249B (zh) * | 2015-03-23 | 2017-11-21 | 张晓辉 | 一种治疗原发性痛经的中药组合物 |
CN105935402A (zh) * | 2016-05-06 | 2016-09-14 | 许美凤 | 一种治疗***的中药组合物 |
CN113332404A (zh) * | 2021-07-13 | 2021-09-03 | 刘中平 | 一种调经止带的中药组合物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1179327A (zh) * | 1997-11-13 | 1998-04-22 | 王汝辉 | 治疗妇女痛经的药物及其制备方法 |
CN1742993A (zh) * | 2005-09-26 | 2006-03-08 | 四川泰华堂制药有限公司 | 治疗妇科疾病的中成药及其制备方法 |
-
2007
- 2007-09-25 CN CN2007101516065A patent/CN101129971B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1179327A (zh) * | 1997-11-13 | 1998-04-22 | 王汝辉 | 治疗妇女痛经的药物及其制备方法 |
CN1742993A (zh) * | 2005-09-26 | 2006-03-08 | 四川泰华堂制药有限公司 | 治疗妇科疾病的中成药及其制备方法 |
Non-Patent Citations (4)
Title |
---|
李莉等.月痛安胶囊治疗原发性痛经的临床观察.湖北中医杂志29 1.2007,29(1),37-38. |
李莉等.月痛安胶囊治疗原发性痛经的临床观察.湖北中医杂志29 1.2007,29(1),37-38. * |
王胜春等.当归 莪术 延胡索及其配伍对小鼠的毒性反应.时珍国医国药15 4.2004,15(4),211-213. |
王胜春等.当归 莪术 延胡索及其配伍对小鼠的毒性反应.时珍国医国药15 4.2004,15(4),211-213. * |
Also Published As
Publication number | Publication date |
---|---|
CN101129971A (zh) | 2008-02-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101239112B (zh) | 调节血脂的中药组合物及其制备方法 | |
CN102670961B (zh) | 一种治疗中老年习惯性便秘的中药 | |
CN104338062A (zh) | 一种治疗腹痛、腹泻的中药制剂 | |
CN104027529A (zh) | 一种调节血脂、血压、血糖的中药组合物及其制备方法 | |
Musthaba et al. | Patented herbal formulations and their therapeutic applications | |
CN101129971B (zh) | 治疗妇女痛经、***的中药组合物及其制备方法 | |
CN102935133B (zh) | 一种用于治疗风湿性关节炎的中药组合物及其制备方法和应用 | |
CN101485870A (zh) | 一种健胃驱虫药 | |
CN102908403B (zh) | 一种治疗痛风的中药制剂及其制备方法 | |
CN102198175B (zh) | 一种中药组合物 | |
CN101664533B (zh) | 一种治疗急慢性乳腺增生的中药及制备方法 | |
CN101664541B (zh) | 一种治疗痛经的药物及其制备方法 | |
CN102895620A (zh) | 一种甘草泻心汤整合型新剂型制备技术及其生产方法 | |
CN104435567A (zh) | 一种含绞股蓝的治疗痛风的中药组合物 | |
CN104056177A (zh) | 一种治疗中耳炎的中药组合物 | |
CN100515462C (zh) | 治疗心、脑血栓性疾病的中药及制备方法 | |
CN101357187A (zh) | 一种治疗***疾病的药物 | |
CN105362630A (zh) | 一种治疗更年期综合症的药物组合物及其制备方法 | |
CN1311849C (zh) | 治疗肿痛的药物组合物 | |
CN103520684A (zh) | 一种降血糖的中药复合物 | |
CN103705868B (zh) | 一种治疗甲状腺功能亢进的药物组合物及其应用 | |
CN102133274A (zh) | 一种中药组合物 | |
CN103751239B (zh) | 一种刺五加总苷和刺五加总苷制剂的制备方法及其应用 | |
CN100411670C (zh) | 一种治疗上消化道肿瘤的药物及其制备方法 | |
CN102824446B (zh) | 一种具有抗疲劳作用的药物组合物及其制备方法与应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: JILIN YIMINGTANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: XU YOUZHANG Effective date: 20110325 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20110325 Address after: 136001 No. 3288, development zone, Siping City, Jilin Patentee after: Yimintang Pharm. Co., Ltd., Jilin Address before: 136001 No. 3288, development zone, Siping City, Jilin Patentee before: Xu Youzhang |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101124 Termination date: 20160925 |
|
CF01 | Termination of patent right due to non-payment of annual fee |