CN101085095A - Oral traditional Chinese medicine for treating chronic nasosinusitis - Google Patents
Oral traditional Chinese medicine for treating chronic nasosinusitis Download PDFInfo
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- CN101085095A CN101085095A CN 200710014500 CN200710014500A CN101085095A CN 101085095 A CN101085095 A CN 101085095A CN 200710014500 CN200710014500 CN 200710014500 CN 200710014500 A CN200710014500 A CN 200710014500A CN 101085095 A CN101085095 A CN 101085095A
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Abstract
The invention discloses an oral administration pharmaceutical composition for treating chronic nasal sinusitis, which is prepared from raw astragalus root 30g, Chinese angelica root 12g, Ligusticum wallichii 10g, ledebouriella root 6g, root of ballon flower 15g, flower bud of lily magnolia 10g, dahurian angelica root 12g, cordate houttuynia 15g, honeysuckle flower 15g and licorice root 6g.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of sinusitis, is a kind of Chinese medicine composition of oral medication of chronic sinusitis specifically, belongs to the field of Chinese medicines.
Background technology
Chronic sinusitis motherland medical science is referred to as nasal sinusitis, flows turbid tears when being meant the nose key, and for years more than, as natural flow water, very then tears go out stench a kind of disease.Meaning in the Huangdi's Internal Classics " the gallbladder transferring pathogenic heat to the brain is nasal sinusitis then, the nasal sinusitis person, rhinorrhea with turbid discharge is also ".Liu Wansu's meaning: " the hot person of nose goes out turbid tears.The thick turbid person of all sputum tears salivas, the burning hot utmost point very, sell turbid cause so also." Zhang Jingyue also calls: " nasal sinusitis is always by the fire of sun governor vessel, very is connected in brain on the person and Jin Jin is more than, so have another name called sinusitis with purulent discharge.This card is many because of wine sweet wine delicious food or use hot thing for a long time, or fire is by cold strongly fragrant, so that damp and hot going up steam, and molten the overflowing of body fluid and descending is from through corruption." or attack outward because of six climate exopathogens, violate on the gallbladder-heat, spleen channel is damp and hot, healthy energy is lost empty, resistance descends, cause the nasal obstruction sinus tract obstructed due to.The outbreak repeatedly of chronic sinusitis is even operative treatment also is difficult to control.
The western medical treatment of chronic sinusitis, clinically mainly splash into decongestant drug, puncture of nasal sinus flushing, aerofluxus displacement, nasal sinuses radical operation etc. with the part, though certain curative effect is all arranged, but because the anatomical features of sinunasal and the pathological change due to the inflammation, and the inadequate drainage that cause high as hole stenostomy, Dou Kou position, inflammation causes myxedema or polypoid to become and causes Dou Kou and stops up, and influences the nasal mucosa ciliary movement, cause removing reasons such as dysfunction, and it is not good enough to cause therapeutic effect.And promoted endoscope's operation on nasal sinus of carrying out in recent years, and performing the operation successfully not only needs a twist of the wrist, also needs before the correct art and postoperative medicine and Local treatment, causes the obstruction again of draining hole to prevent the growth of adhesion and granulation, and late result is also undesirable.
Traditional Chinese traditional treatment nasal sinusitis is many based on heat-clearing and toxic substances removing, promoting flow of QI and blood, active pus, the ascending the clear and descending the turbid carried, and short run effect is only arranged, and late result is undesirable, and one meets flu, and Abwehrkraft des Koepers descends and causes and have a relapse.Therefore, need badly filter out effectively, medicine convenient, that accepted by the patient easily and therapeutic scheme to be to improve current treatment.
Summary of the invention
The objective of the invention is to overcome existing Chinese traditional treatment nasal sinusitis only has short run effect, and the undesirable deficiency that waits of late result is carried out the analysis of syndrome at 1000 many cases patients, finds the empty susceptible of Most patients body, and turbid tears are discharged not smooth.Positive QI-insufficiency, the deficiency of both the splenic and pulmonary QI of belonging to, evil poison is detained the nose key more.So adopt therapy of dispersion by invigorating, mend the gas of strengthening spleen and lung, the eliminating the toxic material out by tonification, thus the Chinese medicine composition of having developed this kind oral medication of chronic sinusitis reaches basic therapeutic purposes.
Technical scheme of the present invention is: a kind of Chinese medicine composition of oral medication of chronic sinusitis, it is characterized in that, make the raw materials of effective components medicine and be: Radix Astragali 30g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 10g, Radix Saposhnikoviae 6g, Radix Platycodonis 15g, Flos Magnoliae 10g, Radix Angelicae Dahuricae 12g, Herba Houttuyniae 15g, Flos Lonicerae 15g and Radix Glycyrrhizae 6g by following weight.
Radix Astragali: be the root of leguminous plant Radix Astagali, main product is returned spleen, lung meridian in the Inner Mongol.Function is the spleen invigorating invigorating middle warmer, ascending up spleen-Qi and Yang, stomach reinforcing consolidating superficial resistance, diuresis, promoting pus discharge and tissue regeneration strengthening.
Radix Angelicae Sinensis: be the root of umbelliferae angelica, main product is returned liver, the heart, spleen channel in Gansu.Function is a tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, loosening bowel to relieve constipation.
Rhizoma Chuanxiong: be samphire Rhizoma Chuanxiong rhizome, main product is returned liver, spleen, pericardium channel in Sichuan.Function is a blood-activating and qi-promoting, wind-expelling pain-stopping.
Radix Saposhnikoviae: be the root of umbelliferae Saposhnikovia divaricata, main product is returned bladder, liver, spleen channel in northeast.Function is an expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.
Radix Platycodonis: be the root of campanulaceae Platycodon grandiflouorum, main product is returned lung meridian in Shandong.Function is a lung qi dispersing, eliminates the phlegm sore-throat relieving, evacuation of pus.
Flos Magnoliae: be the dry flower of Magnoliacea plant Flos Magnoliae, main product attaches to the lung and stomach meridians in Henan.Function is a dispersing wind-cold, clearing the nasal passage.
The Radix Angelicae Dahuricae: be the dry root of the samphire Radix Angelicae Dahuricae, main product is returned lung, stomach, large intestine channel in Zhejiang.Function is the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.
Herba Houttuyniae: be the dry aerial parts of saururaceae plant houttuynia cordata, main product is returned lung meridian in Guangdong.Function is a heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, diuresis relieving constipation.
Flos Lonicerae: be caprifoliaceae plant dry flower or the first flower of opening of band of Radix Ophiopogonis, main product is returned lung, the heart, stomach warp in Shandong.Function is a heat-clearing and toxic substances removing, dispelling wind and heat pathogens.
Radix Glycyrrhizae: be the root and rhizome of glycyrrhizic legume, main product is in the Inner Mongol, GUIXIN, spleen, lung, stomach warp.Function is an invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.
Radix Astragali benefiting vital QI and blood, promoting pus discharge and removing toxic substances among the present invention program, with set upright gas, the eliminating the toxic material out by tonification is a monarch drug; Flos Lonicerae, Herba Houttuyniae heat-clearing and toxic substances removing, toxin expelling are ministerial drug; Radix Angelicae Sinensis, Rhizoma Chuanxiong blood circulation promoting and enriching, wind-expelling pain-stopping, the Radix Angelicae Dahuricae, Radix Platycodonis lung qi dispersing are sensible, wind-expelling pain-stopping; Radix Glycyrrhizae invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription are adjuvant altogether; Medicine-feeding and usefulness are played the QI invigorating poison holding, the sensible curative effect of invigorating blood circulation altogether.
Medicine is selected materials and is concocted in strict accordance with the Pharmacopoeia of the People's Republic of China (1995 editions) and implement, press Radix Astragali 30g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 10g, Radix Saposhnikoviae 6g, Radix Platycodonis 15g, Flos Magnoliae 10g, Radix Angelicae Dahuricae 12g, Herba Houttuyniae 15 g, the ratio of Flos Lonicerae 15g and Radix Glycyrrhizae 6g, 40 times of decoction pieces amounts, above Chinese medicine flush away surface dust, drop into multifunctional efficient Chinese medicine extraction device (by the light machine-processed medicine in Tianjin machinery plant, Tianjin Science and Technology Development Center of Chinese medicine academy Affiliated Hospital provides, model: DGN--3), add clear water 32000ml, soak 30min, decoct under the normal pressure, concentrate, separate, technological process 1.5h, taking liquid 4000ml, add potassium sorbate 12g (2%), every dose of extraction concentrated solution 100ml divides in the plastic bottle of the ethylene oxide sterilizing of packing into, every bottle of 100ml, and every milliliter contains crude drug 3.15g.
Usage: each oral 50ml that is grown up, sooner or later 2 times ante cibum decoction being taken warmly, the child is cut down according to the circumstance, 7 days is a course of treatment.
Quality standard:
Character this product is brown clear liquid, and mildly bitter flavor does not have precipitation and float
PH value 5.0-5.4
Relative density 1.02-1.04 (60 ℃)
Sanitary standard:
Antibacterial is less than 100/ml
Mycete is less than 100/ml
Yeast is less than 100/ml
Escherichia coli must not detect
The demodicid mite that lives must not detect
Preliminarily stabilised:
By observing, room temperature keeps in Dark Place medicinal liquid in 3 months below 25 ℃ the time, and its character, pH value, abnormal smells from the patient, relative density, antibacterial culturing etc. are all in prescribed limit.Illustrate that stability is reliable.
Clinical effectiveness:
One, clinical data
1, the diagnostic criteria of chronic sinusitis: according to department of otorhinolaryngology branch of Chinese Medical Association, department of otorhinolaryngology magazine editorial board of Chinese Medical Association (1997 Haikou) about chronic sinusitis nasal polyp clinical stages typing and efficacy assessment standard and decide.All cases are all clarified a diagnosis through nasal sinuses endoscope and X sheet.Cure: no purulent secretion in the transference cure, nasal meatus, nasal sinuses scope, nasal sinuses sheet show that inflammation changes disappearance.Take a turn for the better: subjective symptoms is obviously improved, only a small amount of purulent secretion in the nasal meatus, and nasal sinuses scope, nasal sinuses sheet show that inflammation before alleviates.Invalid: subjective symptoms does not have improvement, and a large amount of purulent secretions in the nasal meatus, nasal sinuses scope, nasal sinuses sheet show that inflammation do not have change.
2, case is selected: be selected from the out-patient of the court 1420 examples in year January in July, 1997 to 2007, be divided into treatment by Chinese herbs group and western medicine group sequentially at random.Treatment by Chinese herbs group 1089 examples, male 592 examples, women 497 examples, age 4-62 year, 37.6 years old mean age, the course of disease 2 months-6 years, average 2.7 years; Western medicine group 331 examples, male 185 examples, women 146 examples, age 5-65 year, 40.1 years old mean age, the course of disease 3 months-5 years, average 2.6 years.Two groups are not had significance in sex, age, the course of disease through t check difference, and (p＞0.05) has comparability.
Two, Therapeutic Method:
Chinese drug-treated group is used bidouyan mixture, bidouyan koufuye (Radix Astragali 30g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 10g, Radix Saposhnikoviae 6g, Radix Platycodonis 15g, Flos Magnoliae 10g, Radix Angelicae Dahuricae 12g, Herba Houttuyniae 15g, Flos Lonicerae 15g and Radix Glycyrrhizae 6g form, and every milliliter contains crude drug 3.15g).Each 50ml, every day 2 times, sooner or later ante cibum decoction being taken warmly, two weeks of the course of treatment.The Western medicine group is used penicillin 8,000,000 (the anti-pharmaceutical manufacturing in Shandong) intravenous drip once a day, 1% chlorine fiber crops drop nose, one week of the course of treatment.
Three, therapeutic outcome:
1, efficacy assessment standard: according to department of otorhinolaryngology branch of Chinese Medical Association, department of otorhinolaryngology magazine editorial board of Chinese Medical Association (1997 Haikou) about chronic sinusitis nasal polyp clinical stages typing and efficacy assessment standard and decide.All cases are all clarified a diagnosis through nasal sinuses endoscope and X sheet.
Cure: no purulent secretion in the transference cure, nasal meatus, nasal sinuses scope, nasal sinuses sheet show that inflammation changes disappearance.
Take a turn for the better: subjective symptoms is obviously improved, only a small amount of purulent secretion in the nasal meatus, and nasal sinuses scope, nasal sinuses sheet show that inflammation before alleviates.
Invalid: subjective symptoms does not have improvement, and a large amount of purulent secretions in the nasal meatus, nasal sinuses scope, nasal sinuses sheet show that inflammation do not have change.
2, two groups of curative effects relatively
| n | Cure | Take a turn for the better | Invalid | Total effective rate |
| Treatment group matched group | 384 74 | 661 162 | 44 95 | 96% 71.4% |
| Annotate: there were significant differences in p＜0.05. | ||||
Result of study shows, the Chinese medicine composition of this kind oral medication of chronic sinusitis is to the treatment of chronic sinusitis, two groups of contrasts, and treatment by Chinese herbs group curative effect obviously is better than the western medicine group, property that there were significant differences (t=3.556, p＜0.01).Obtain satisfactory therapeutic effects, be worth clinical expansion.For further specifying, it is as follows that the spy enumerates model case:
Case one: Niu Xiaoyu, the woman, 17 years old, middle school, Zhangqiu student, because of nasal obstruction rhinorrhea 1 year, one week of companioned with headache, institute went to a doctor.Have a medical check-up: see the hyperemia of bilateral nasal mucosa under the scope, middle first and unciform process edema, the yellow purulent secretion of middle nasal meatus, nasal sinuses X sheet shows: maxillary sinus and the increase in density of sieve hole, sclerotin is not seen obvious destruction, diagnosis: chronic sinusitis.Outpatient service gives medicine of the present invention, every day sooner or later 2 times ante cibum decoction being taken warmly, each oral 50ml, 7 days is a course of treatment.The back further consultation of one week, the readme watery nasal discharge obviously reduces, and headache alleviates, and continues with two weeks of bidouyan mixture, bidouyan koufuye, and the hyperemia of check intranasal mirror nasal mucosa obviously alleviates, and middle first and unciform process do not have obvious edema, and the yellow purulent secretion of middle nasal meatus disappears, and headache disappears.Follow up a case by regular visits to and do not have recurrence in three months.
Case two: Liu Yuhao, the man, 7 years old, the student of experimental primary school because of nasal obstruction watery nasal discharge first quarter moon, came institute to go to a doctor.Have a medical check-up: see bilateral nasal mucosa congestion and edema under the scope, middle first and unciform process edema, the meatus nasi communis purulent secretion, nasal sinuses X sheet shows: the maxillary sinus increase in density; Diagnosis: chronic sinusitis, maxillary sinusitis.Outpatient service gives medicine of the present invention, every day sooner or later 2 times ante cibum decoction being taken warmly, each oral 30ml, 7 days is a course of treatment.The back further consultation of one week, the infant watery nasal discharge obviously reduces, and continues with one week of bidouyan mixture, bidouyan koufuye, and check intranasal mirror nasal mucosa edema alleviates, and middle first and unciform process do not have obvious edema, and the nasal meatus purulent secretion disappears.Follow up a case by regular visits to and do not have recurrence in two months.
Case three: Dong Qichang, man, 35 years old, the middle collection worker of group.Because of nasal obstruction watery nasal discharge half a year, surplus companion's ophthalmic bloated ten day over institute go to a doctor.Have a medical check-up: see the hyperemia of bilateral nasal mucosa under the scope, middle first and unciform process edema, sieve bubble protuberance, middle nasal meatus and nasopharynx part viscous secretion, nasal sinuses CT sheet shows: full nasal sinuses increase in density, with sieve Dou Mingxian, sclerotin is not seen obvious destruction; Diagnosis: chronic sinusitis, ethmoiditis.Outpatient service gives Drug therapy of the present invention, every day sooner or later 2 times ante cibum decoction being taken warmly, each oral 50ml, 7 days is a course of treatment, cooperates 1% chlorine fiber crops drop nose.The back further consultation of one week, the readme watery nasal discharge reduces, and ophthalmic bloated obviously alleviates, and continues with three weeks of bidouyan mixture, bidouyan koufuye, and the hyperemia of check intranasal mirror nasal mucosa obviously alleviates, and middle first and unciform process do not have obvious edema, and the yellow purulent secretion of middle nasal meatus disappears.Follow up a case by regular visits to and do not have recurrence in three months.
The specific embodiment
Example one: a kind of Chinese medicine composition of oral medication of chronic sinusitis, make the raw materials of effective components medicine and be: Radix Astragali 30g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 10g, Radix Saposhnikoviae 6g, Radix Platycodonis 15g, Flos Magnoliae 10g, Radix Angelicae Dahuricae 12g, Herba Houttuyniae 15g, Flos Lonicerae 15g and Radix Glycyrrhizae 6g by following weight.
Medicine is selected materials and is concocted in strict accordance with the Pharmacopoeia of the People's Republic of China (1995 editions) and implement, in the prescription ratio, 40 times of decoction pieces amounts, above Chinese medicine flush away surface dust, drop into multifunctional efficient Chinese medicine extraction device (by the light machine-processed medicine in Tianjin machinery plant, Tianjin Science and Technology Development Center of Chinese medicine academy Affiliated Hospital provides, model: DGN--3), add clear water 32000ml, soak 30min, decoct under the normal pressure, concentrate, separate, technological process 1.5h, taking liquid 4000ml, add potassium sorbate 12g (2%), every dose of extraction concentrated solution 100ml divides in the plastic bottle of the ethylene oxide sterilizing of packing into, every bottle of 100ml, and every milliliter contains crude drug 3.15g.
Usage: each oral 50ml that is grown up, sooner or later 2 times ante cibum decoction being taken warmly, the child is cut down according to the circumstance, 7 days is a course of treatment.
Claims (1)
1, a kind of Chinese medicine composition of oral medication of chronic sinusitis, it is characterized in that, make the raw materials of effective components medicine and be: Radix Astragali 30g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 10g, Radix Saposhnikoviae 6g, Radix Platycodonis 15g, Flos Magnoliae 10g, Radix Angelicae Dahuricae 12g, Herba Houttuyniae 15g, Flos Lonicerae 15g and Radix Glycyrrhizae 6g by following weight.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205026A (en) * | 2011-05-27 | 2011-10-05 | 李佃场 | Chinese medicinal composition for treating children chronic sinusitis and preparation method thereof |
| CN102727644A (en) * | 2011-03-29 | 2012-10-17 | 胡维民 | Rhinitis treatment Chinese patent drug for direct nasal lavage and oral administration |
| CN104000953A (en) * | 2014-04-25 | 2014-08-27 | 万强胜 | Traditional Chinese medicinal composition for treating rhinitis |
| CN105267669A (en) * | 2014-07-02 | 2016-01-27 | 李一圣 | Traditional Chinese medicine compound for treating chronic sinusitis and preparation method of traditional Chinese medicine compound |
| CN106442828A (en) * | 2016-11-28 | 2017-02-22 | 重庆大易科技投资有限公司 | Sinusitis oral liquid fingerprinting measuring method and sinusitis oral liquid fingerprinting |
-
2007
- 2007-06-20 CN CN 200710014500 patent/CN101085095A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727644A (en) * | 2011-03-29 | 2012-10-17 | 胡维民 | Rhinitis treatment Chinese patent drug for direct nasal lavage and oral administration |
| CN102205026A (en) * | 2011-05-27 | 2011-10-05 | 李佃场 | Chinese medicinal composition for treating children chronic sinusitis and preparation method thereof |
| CN102205026B (en) * | 2011-05-27 | 2013-03-27 | 李佃场 | Chinese medicinal composition for treating children chronic sinusitis and preparation method thereof |
| CN104000953A (en) * | 2014-04-25 | 2014-08-27 | 万强胜 | Traditional Chinese medicinal composition for treating rhinitis |
| CN105267669A (en) * | 2014-07-02 | 2016-01-27 | 李一圣 | Traditional Chinese medicine compound for treating chronic sinusitis and preparation method of traditional Chinese medicine compound |
| CN106442828A (en) * | 2016-11-28 | 2017-02-22 | 重庆大易科技投资有限公司 | Sinusitis oral liquid fingerprinting measuring method and sinusitis oral liquid fingerprinting |
| CN106442828B (en) * | 2016-11-28 | 2018-01-26 | 重庆大易科技投资有限公司 | The assay method and its finger-print of bidouyan mixture, bidouyan koufuye finger-print |
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Open date: 20071212 |