CN101011550B - Medicinal composition for relieving stagnation, promoting circulation of qi and relieving pain, and its preparing process - Google Patents
Medicinal composition for relieving stagnation, promoting circulation of qi and relieving pain, and its preparing process Download PDFInfo
- Publication number
- CN101011550B CN101011550B CN2007100483420A CN200710048342A CN101011550B CN 101011550 B CN101011550 B CN 101011550B CN 2007100483420 A CN2007100483420 A CN 2007100483420A CN 200710048342 A CN200710048342 A CN 200710048342A CN 101011550 B CN101011550 B CN 101011550B
- Authority
- CN
- China
- Prior art keywords
- ethanol
- percolation
- preparation
- fructus
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 34
- 239000000203 mixture Substances 0.000 title claims abstract description 16
- 230000001737 promoting effect Effects 0.000 title claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 94
- 238000005325 percolation Methods 0.000 claims abstract description 34
- 239000000284 extract Substances 0.000 claims abstract description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 13
- 239000000706 filtrate Substances 0.000 claims abstract description 11
- 239000012530 fluid Substances 0.000 claims abstract description 9
- 238000005303 weighing Methods 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims description 32
- 238000002360 preparation method Methods 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 239000012567 medical material Substances 0.000 claims description 19
- 241000628997 Flos Species 0.000 claims description 18
- 238000007654 immersion Methods 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 9
- 239000012141 concentrate Substances 0.000 claims description 7
- 239000006187 pill Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 3
- 240000001972 Gardenia jasminoides Species 0.000 claims description 2
- 244000270834 Myristica fragrans Species 0.000 claims description 2
- 235000009421 Myristica fragrans Nutrition 0.000 claims description 2
- 239000001702 nutmeg Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000000890 drug combination Substances 0.000 claims 1
- 244000294611 Punica granatum Species 0.000 abstract description 9
- 235000014360 Punica granatum Nutrition 0.000 abstract description 9
- 238000002156 mixing Methods 0.000 abstract description 6
- 238000001914 filtration Methods 0.000 abstract description 3
- 244000111489 Gardenia augusta Species 0.000 abstract 1
- 235000018958 Gardenia augusta Nutrition 0.000 abstract 1
- 239000000341 volatile oil Substances 0.000 description 27
- 238000000605 extraction Methods 0.000 description 23
- 238000012360 testing method Methods 0.000 description 17
- 239000003814 drug Substances 0.000 description 15
- HRYLQFBHBWLLLL-UHFFFAOYSA-N (+)-costunolide Natural products C1CC(C)=CCCC(C)=CC2OC(=O)C(=C)C21 HRYLQFBHBWLLLL-UHFFFAOYSA-N 0.000 description 14
- CUGKULNFZMNVQI-UHFFFAOYSA-N Costunolid I Natural products CC1=CCC=C(/C)CCC2C(C1)OC(=O)C2=C CUGKULNFZMNVQI-UHFFFAOYSA-N 0.000 description 14
- HRYLQFBHBWLLLL-AHNJNIBGSA-N costunolide Chemical compound C1CC(/C)=C/CC\C(C)=C\[C@H]2OC(=O)C(=C)[C@@H]21 HRYLQFBHBWLLLL-AHNJNIBGSA-N 0.000 description 14
- MMTZAJNKISZWFG-UHFFFAOYSA-N costunolide Natural products CC1CCC2C(CC(=C/C=C1)C)OC(=O)C2=C MMTZAJNKISZWFG-UHFFFAOYSA-N 0.000 description 14
- 239000000243 solution Substances 0.000 description 11
- IBFYXTRXDNAPMM-BVTMAQQCSA-N Geniposide Chemical compound O([C@@H]1OC=C([C@@H]2[C@H]1C(=CC2)CO)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O IBFYXTRXDNAPMM-BVTMAQQCSA-N 0.000 description 10
- 229920001864 tannin Polymers 0.000 description 9
- 239000001648 tannin Substances 0.000 description 9
- 235000018553 tannin Nutrition 0.000 description 9
- 238000001035 drying Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 238000012216 screening Methods 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 238000002481 ethanol extraction Methods 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000006071 cream Substances 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000010298 pulverizing process Methods 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 229920000858 Cyclodextrin Polymers 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 description 4
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 description 4
- 229940075559 piperine Drugs 0.000 description 4
- 235000019100 piperine Nutrition 0.000 description 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 4
- 238000003809 water extraction Methods 0.000 description 4
- 206010013786 Dry skin Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000006356 dehydrogenation reaction Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000011812 mixed powder Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000013558 reference substance Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000001256 steam distillation Methods 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- QGJZLNKBHJESQX-UHFFFAOYSA-N 3-Epi-Betulin-Saeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-UHFFFAOYSA-N 0.000 description 1
- CLOUCVRNYSHRCF-UHFFFAOYSA-N 3beta-Hydroxy-20(29)-Lupen-3,27-oic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C(O)=O)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C CLOUCVRNYSHRCF-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- DIZWSDNSTNAYHK-XGWVBXMLSA-N Betulinic acid Natural products CC(=C)[C@@H]1C[C@H]([C@H]2CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)O DIZWSDNSTNAYHK-XGWVBXMLSA-N 0.000 description 1
- SEBIKDIMAPSUBY-ARYZWOCPSA-N Crocin Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)C(C)=CC=CC(C)=C\C=C\C=C(/C)\C=C\C=C(C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SEBIKDIMAPSUBY-ARYZWOCPSA-N 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 206010051986 Pneumatosis Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000000944 Soxhlet extraction Methods 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- -1 and amount is big Substances 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- ZYZWOSIRFVIBRH-UHFFFAOYSA-N chloroform;cyclohexane Chemical compound ClC(Cl)Cl.C1CCCCC1 ZYZWOSIRFVIBRH-UHFFFAOYSA-N 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- PZXJOHSZQAEJFE-UHFFFAOYSA-N dihydrobetulinic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(C)C)C5C4CCC3C21C PZXJOHSZQAEJFE-UHFFFAOYSA-N 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000003810 ethyl acetate extraction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 239000009627 gardenia yellow Substances 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- 229930013686 lignan Natural products 0.000 description 1
- 235000009408 lignans Nutrition 0.000 description 1
- 150000005692 lignans Chemical class 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- MQYXUWHLBZFQQO-UHFFFAOYSA-N nepehinol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C MQYXUWHLBZFQQO-UHFFFAOYSA-N 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- WRLGYAWRGXKSKG-UHFFFAOYSA-M phenobarbital sodium Chemical compound [Na+].C=1C=CC=CC=1C1(CC)C(=O)NC([O-])=NC1=O WRLGYAWRGXKSKG-UHFFFAOYSA-M 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007100483420A CN101011550B (en) | 2007-01-26 | 2007-01-26 | Medicinal composition for relieving stagnation, promoting circulation of qi and relieving pain, and its preparing process |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007100483420A CN101011550B (en) | 2007-01-26 | 2007-01-26 | Medicinal composition for relieving stagnation, promoting circulation of qi and relieving pain, and its preparing process |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101011550A CN101011550A (en) | 2007-08-08 |
CN101011550B true CN101011550B (en) | 2011-12-28 |
Family
ID=38699390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007100483420A Active CN101011550B (en) | 2007-01-26 | 2007-01-26 | Medicinal composition for relieving stagnation, promoting circulation of qi and relieving pain, and its preparing process |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101011550B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112717093A (en) * | 2021-02-02 | 2021-04-30 | 内蒙古祈蒙药业股份有限公司 | Mongolian medicine, namely six-ingredient costus root granules and preparation method thereof |
CN115814037B (en) * | 2022-11-22 | 2024-01-30 | 海南医学院 | Traditional Chinese medicine composition for treating gastric ulcer and preparation method thereof |
CN116059303B (en) * | 2023-03-03 | 2023-06-13 | 广东青云山药业有限公司 | Composite drynaria extract and preparation process thereof |
-
2007
- 2007-01-26 CN CN2007100483420A patent/CN101011550B/en active Active
Non-Patent Citations (2)
Title |
---|
中华人民共和国***药典委员会.《六味木香胶囊》.《***颁药品标准 新药转正标准 第29册》.2001,16. * |
杨金团.《六味木香胶囊的药理作用及临床应用》.《中国民族医药杂志》.2005,(第6期),22-23. * |
Also Published As
Publication number | Publication date |
---|---|
CN101011550A (en) | 2007-08-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100491318C (en) | Method for preparing paeonol and paeoniflorin from cortex moutan | |
WO2009117953A1 (en) | Pharmaceutical composition having antidepressive, antianxious action and preparation method thereof | |
CN103356801B (en) | Method for preparing bazhen granule by low-temperature continuous extraction combined with membrane separation technology | |
US11160842B2 (en) | Drug or health care product preventing or treating liver and kidney damage-related diseases and use thereof | |
CN101966244A (en) | Preparation method of sugar-free type anti-cold and antidotal granule | |
CN100560063C (en) | Renal aid pill and preparation method thereof method of quality control | |
CN101011550B (en) | Medicinal composition for relieving stagnation, promoting circulation of qi and relieving pain, and its preparing process | |
CN101919979A (en) | Traditional Chinese medicine composite for soothing liver-qi stagnation and tonifying spleen and removing dampness and preparation method thereof | |
CN1814170B (en) | Medicinal drop pills for treating cardiovascular disease and preparing method | |
CN101912594A (en) | Traditional Chinese medicine preparation for treating gastrointestinal diseases | |
CN102058637B (en) | Preparation method of patrimia scabiosaefolia extract | |
CN100571760C (en) | The prescription of mouth ulcer bilayer film and preparation technology | |
WO2006122454A1 (en) | A pharmaceutical composition for treating diabetes and preparation method thereof | |
CN109620906A (en) | It is a kind of for preventing and treating the composition of alcoholic liver injury and antialcoholism action | |
CN101485779B (en) | Medicinal composition for treating psoriasis as well as preparation method and quality detection method | |
CN101606973B (en) | Shizandra berry soft capsule for improving sleep and preparation method thereof | |
CN101869644B (en) | Dark-skinned chicken dispersible tablet and preparation process thereof | |
CN109419833A (en) | A kind of antihypelipidemic active substance and its preparation and application | |
CN108704049B (en) | Traditional Chinese medicine composition with antioxidant function and preparation method of health food thereof | |
CN102940724A (en) | Preparation method of traditional Chinese medicine compound capsule for diminishing inflammation | |
CN101444571A (en) | Jiuweiqianghuo soft capsule and preparation method thereof | |
CN102085233A (en) | Compound fortune euonymus capsule | |
CN102178891B (en) | Chinese medicinal dispersible tablets for treating gastritis and preparation method thereof | |
CN1325104C (en) | Method for preparing Chinese medicine concentrated pill for treating women's cimacteric metancholia | |
CN101919919A (en) | Fukean dispersible tablet and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: CHENGDU SHENHE PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: CHENGDU XINXICHEN PHARMACEUTICAL CO., LTD. Effective date: 20120917 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20120917 Address after: Yu Hong Lu, Heshan Pujiang County town of Chengdu city in Sichuan province 611633 Chengdu Shenhe pharmaceutical limited liability company Patentee after: CHENGDU SHENHE PHARMACEUTICAL Co.,Ltd. Address before: Pujiang County of Chengdu City, Sichuan province 611633 Yuan Zhen Shi Yutuo Chengdu Xichen Pharmaceutical Co Ltd Patentee before: Chengdu Xichen Pharmaceutical Co.,Ltd. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Medicinal composition for relieving stagnation, promoting circulation of qi and relieving pain, and its preparing process Effective date of registration: 20130503 Granted publication date: 20111228 Pledgee: Bank of East Asia (China) Co.,Ltd. Chengdu branch Pledgor: CHENGDU SHENHE PHARMACEUTICAL Co.,Ltd. Registration number: 2013990000256 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20181022 Granted publication date: 20111228 Pledgee: Bank of East Asia (China) Co.,Ltd. Chengdu branch Pledgor: CHENGDU SHENHE PHARMACEUTICAL Co.,Ltd. Registration number: 2013990000256 |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20190724 Address after: 610000 No. 4 Chunjiang Lane, Heshan Town, Pujiang County, Chengdu City, Sichuan Province Patentee after: Li Mingjin Address before: Yu Hong Lu, Heshan Pujiang County town of Chengdu city in Sichuan province 611633 Chengdu Shenhe pharmaceutical limited liability company Patentee before: CHENGDU SHENHE PHARMACEUTICAL Co.,Ltd. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: The invention relates to a pharmaceutical composition for opening depression, promoting qi and relieving pain and a preparation method thereof Effective date of registration: 20220513 Granted publication date: 20111228 Pledgee: Industrial Bank Limited by Share Ltd. Chengdu branch Pledgor: Li Mingjin Registration number: Y2022510000123 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20111228 Pledgee: Industrial Bank Limited by Share Ltd. Chengdu branch Pledgor: Li Mingjin Registration number: Y2022510000123 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A drug combination for promoting depression, promoting qi circulation, and relieving pain and its preparation method Granted publication date: 20111228 Pledgee: Shanghai Pudong Development Bank Co.,Ltd. Chengdu Branch Pledgor: Li Mingjin Registration number: Y2024980016816 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |