CN100528180C - Medication for treating diseases of cranial nerve and cerebrovascular, and preparation method - Google Patents

Abstract

A Chinese medicine for treating cerebral nervous diseases and cerebrovascular diseases is proportionally prepared from 7 Chinese-medicinal materials including dandelion herb, Chuan-xiong rhizome, snow lotus flower, tremella, etc through immersing, decocting, filtering and concentrating.

Description

A kind of medicine for the treatment of cranial nerve and cerebrovascular disease and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, relate to limited medicine of a kind of reparation that is mainly used in brain neuroblastoma, hemiplegia, brainpan damage and limb activity and preparation method thereof.

Background technology

Encephalopathy is a kind of commonly encountered diseases, and the power of charging is the strongest, and sickness rate is the highest, and the rate of dieing is the highest.More than 40 national all kinds of diseases cause and come front three in the rate of dying in the world through investigation, and the number of dieing because of hemiplegia accounts for 22.6% of annual total death toll.The annual minimum life that will seize 1,000 ten thousand above people in the whole world is so this disease is acknowledged as one of " four big killers ".The Chinese and western drugs of treatment encephalopathy is a lot of at present, the treatment face of these medicines is generally narrower, particularly reparation, hemiplegia, the brainpan to cranial nerve damages or the limited disease of limb activity, merely can only relief of symptoms with doctor trained in Western medicine or tcm therapy, and therapy of combining Chinese and Western medicine, rescued life and do not controlled disease, so poor effect.Also there is not ideal medicament at present at above-mentioned symptom.

Summary of the invention

The objective of the invention is to propose limited medicine of a kind of reparation, hemiplegia, brainpan damage and limb activity that is mainly used in brain neuroblastoma and preparation method thereof, it has solved the existing traditional Chinese medical science can only activating blood circulation to dissipate blood stasis, the technical problem of the treatment that doctor trained in Western medicine can only blood vessel dilating.

Implementation of the present invention is:

A kind of medicine for the treatment of cranial nerve and cerebrovascular disease is mainly made by the crude drug of following parts by weight: Herba Taraxaci 10-35 part, Herba Taxilli 8-35 part, Rhizoma Chuanxiong 5-16 part, Lentinus Edodes 10-25 part, agrocyb eaegerita 10-30 part, Herba Saussureae Involueratae 12-24 part.Also can include the Tremella of 5～30 parts by weight in its crude drug.

The preferable consumption of above-mentioned each crude drug is: 10～20 parts of Herba Taraxacis, 10～20 parts of Herba Taxillis, 8～15 parts of Rhizoma Chuanxiongs, 15～17 parts on Lentinus Edodes, 16～20 parts of agrocyb eaegerita, 15～18 parts of Herba Saussureae Involuerataes.Also can include the Tremella of 10～15 parts by weight in its crude drug.

The optimum amount of above-mentioned each crude drug is: 15 parts of Herba Taraxacis, 12 parts in Tremella, 15 parts of Herba Taxillis, 10 parts of Rhizoma Chuanxiongs, 16 parts on Lentinus Edodes, 18 parts of agrocyb eaegerita, 16 parts of Herba Saussureae Involuerataes.

The preparation method of the medicine of above-mentioned treatment cranial nerve and cerebrovascular disease comprises the following steps:

1) standby by following parts by weight proportioning weighting raw materials: 5～30 parts in Tremella, Herba Taraxaci 10-35 part, Herba Taxilli 8-35 part, Rhizoma Chuanxiong 5-16 part, Lentinus Edodes 10-25 part, agrocyb eaegerita 10-30 part, Herba Saussureae Involueratae 12-24 part;

2) get Tremella, Lentinus Edodes, agrocyb eaegerita, Herba Saussureae Involueratae in proportion 1: 5 water mix, room temperature soak down 3～6 hours standby;

3) be incubated 40～120 minutes down at 50～80 ℃;

4) add Rhizoma Chuanxiong, Herba Taxilli, Herba Taraxaci, temperature is raised to 80～100 ℃, and slow fire boiled 1～3 hour;

5) filter, medicinal liquid is concentrated to 1/10 of total amount promptly can be made into oral liquid.

The best performing step of above-mentioned preparation method is as follows:

1) standby by following parts by weight proportioning weighting raw materials: 10～15 parts in Tremella, 10～20 parts of Herba Taraxacis, 10～20 parts of Herba Taxillis, 8～15 parts of Rhizoma Chuanxiongs, 15～17 parts on Lentinus Edodes, 16～20 parts of agrocyb eaegerita, 15～18 parts of Herba Saussureae Involuerataes;

2) get Tremella, Lentinus Edodes, agrocyb eaegerita, Herba Saussureae Involueratae in proportion 1: 5 water mix, room temperature soak down 4 hours standby;

3) be incubated 45 minutes down at 55～60 ℃;

4) add Rhizoma Chuanxiong, Herba Taxilli, Herba Taraxaci, temperature is raised to 90～100 ℃, and slow fire boiled 1～2 hour;

5) filter, medicinal liquid is concentrated to 1/10 of total amount promptly can be made into oral liquid.

Viewpoint with " international 4G therapy " and " modernization of Chinese medicine ", the research of applicant surplus ten year is clinical, work out a kind of reparation cranial nerves rehabilitation medicine---cranial nerve sheath enzyme (Enigmols) and preparation method, having overcome the traditional Chinese medical science can only activating blood circulation to dissipate blood stasis, doctor trained in Western medicine can only blood vessel dilating the treatment limitation, embodied the innovative idea of " repair cerebral nerve and be this, auxiliary blood, brain, the heart, kidney are ruled together, and stop sequela ".

This product belongs to the weak base type, arrive former focus after, remove rapidly " acid poison ", alleviate the calcium ion overload, stop neuron further downright bad, increase neurotrophic factor ribonucleic acid (RNA) quantity, DNA skin base cell and gene, promote that neurocyte grows new first bud, feeler, increase the cerebral gray matter element, these yuan bud and feeler and Toplink are connected with each other, and form many new nerve net, quick active residue brain cell is fully repaired impaired nerve and regenerates.Impel a large amount of compensatory vessel open simultaneously, blood enters from the compensatory blood vessel of brain cell periphery, has increased the supply and the oxygen uptake of blood, and it is external that especially hemorrhage and embolus is got rid of rapidly, the effect of activating blood circulation to dissipate blood stasis, removing heat from blood, hemostasis, clean blood are arranged, enriching blood.Make original focus more and more littler, a large amount of cranial nerve cells have been lived again.After calculating 21 days, the injured nerve reparation will reach about 17%.

The present invention mixes Lentinus Edodes, agrocyb eaegerita, Herba Taxilli, Herba Saussureae Involueratae according to above-mentioned treatment mechanism in 55～60 ℃ of temperature, chemical combination is aphingolipid.Tremella contains abundant colloid, phospholipid, sterin, to brain cell and the nutritious effect of neurocyte, thereby supplementing the brain.Herba Taraxaci is rich in lecithin, and Rhizoma Chuanxiong is rich in the gallbladder element, is the synthetic necessary composition of cerebral gray matter, and Herba Taxilli is rich in inositol.Soak by mixing once more, synthetic Toplink, peptide is the principal element by the brain barrier, the nerve sheath enzyme of having derived simultaneously.

Herba Taraxaci Herba Taraxaci: another name Herba crotalariae albidae, grandmother's fourth, milk grass, for feverfew Herba Taraxaci Taraxacum mongolicum Hand.-Mazz. and belong to the whole herb with root of various plants together.Select for use Herba Taraxaci because of its hardship, sweet, cold, the effect of tool detoxification and promoting urination, removing pathogenic heat from blood and inducing diuresis.Modern Chinese medicine thinks that the Herba Taraxaci herb contains taraxasterol taraxasterol, choline, inulin and pectin etc., can participate in containing the compound recipe of ketone, ketone, the drug matching of active alkali class, has the microcirculation improvement effect.

Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Selecting Rhizoma Chuanxiong for use is because of its suffering, temperature, the effect of tool blood-activating and qi-promoting, wind-expelling pain-stopping.Modern Chinese medicine thinks that the Rhizoma Chuanxiong alkaloid in the Rhizoma Chuanxiong can be benumbed nervus centralis, antalgic and sedative, excited respiratory center, vasomotor center are directly expanded peripheral vessels, the blood flow of coronary blood flow increasing and lower limb body, cholesterol reducing, blood fat reducing, blood pressure lowering; Can also reduce the platelet aggregation degree, promote the dissolving of blood inner fibrin, anti-tampon has spasmolysis.In this prescription, Rhizoma Chuanxiong is rich in active alkaloid, and it is more obvious to make Herba Taraxaci improve sanguimotor effect, promotes each prescription medicine complementary action to strengthen, and improves curative effect, the collaborative effect that reaches the radical cure cardiovascular and cerebrovascular disease.

Herba Saussureae Involueratae Herba Saussureae Involucratae: the another name Saussurea involucrata is the wounded in the battle Herb of feverfew Saussurea medusa Maxim. Saussurea medusaMaxim..Its main component is globulariacitrin, xuelianlactone, alkaloid, volatile oil, polysaccharide.Herba Saussureae Involueratae has the effect of warming the kidney to invigorate YANG, dispelling cold by warming the meridian, warming the lung to resolve fluid-retention, expelling wind and removing dampness.

Herba Taxilli: this product is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Selecting Herba Taxilli for use is because of its hardship, sweet, flat, tool dredge the meridian passage, the smart effect of the benefit that nourishes blood.Herba Taxilli can expansion artery, increase blood supply flow coronarius, has the effect of blood fat reducing, blood sugar lowering, cholesterol reducing, is the good medicine of thromboembolism.

Tremella: the another name Tremella is the sporophore of Tremellaceae plant Tremella Tremella fuciformis Berk..Tremella has heat clearing away, white more activating YANG and eliminating stagnation, heart tonifying and brain strengthening, refresh oneself enrich blood, effect such as QI invigorating.Cure mainly chest pain radiating to the back, the thoracic obstruction of breathing hard, coronary atherosclerosis, diseases such as heart stricture of vagina pain.It contains abundant colloid, multivitamin, inorganic salt, aminoacid, acid different polysaccharide and several mineral materials.Clinical proof, Tremella can improve body immunity, enriching yin and nourishing kidney, lung moistening brain-strengthening, nourishing the stomach QI invigorating, bring high blood pressure down, blood fat and certain anti-cancer and kill cancer action is arranged.

Agrocyb eaegerita: belong to excrement umbrella section, have another name called Agroeybe cylindracea mycelia, tea mushroom, oil tea mushroom, refreshing mushroom, the new mushroom of tea, the traditional Chinese medical science thinks that this mushroom property is sweet, warm, nontoxic, and the effect of invigorating the spleen to arrest diarrhea is arranged, and defying age, cholesterol reducing, anti-cancer and anticancer special role are arranged.Agrocyb eaegerita contains 17 seed amino acids of needed by human body, and wherein human body is can not synthetic amino acid content high especially, contains 10 several mineral materials trace element and polysaccharide in addition.

Lentinus Edodes belongs to Pleurotaceae, has another name called Lentinus Edodes, fragrant letter, fragrant wild rice, vertebra young pilose antler, and contained lentinan has antitumor action; Adenine and choline can prevent liver cirrhosis and sclerosis of blood vessels; The tyrosine oxidase has the effect that brings high blood pressure down, but the generation of double stranded RNA inducing interferon has antivirus action.Among the people Lentinus Edodes is used for detoxifcation, stomach reinforcing gas and control the wind removing blood stasis.

Selected Tremella, agrocyb eaegerita, the Lentinus Edodes of the present invention can also strengthen the immunity of human body.

More than each medicine share, can nourshing blood and promoting blood circulation, repair damagedly, eliminate the dirty pathogenic factor, QI and blood regulating makes the rapid rehabilitation of all kinds of cardiovascular and cerebrovascular diseases, radical cure.

The present invention is pure traditional Chinese biological preparation, absorb fast, drug effect is rapid, active constituent content is high, dose is few, features good taste, safely, have no side effect and taking convenience.The present invention is not limited only to oral liquid, and the peroral dosage form of other form (decoction, tablet, powder etc.) also belongs to category of the present invention.

Each related in above-mentioned preparation method technological parameter all obtains through after a large amount of contrast tests, according to said method can extract the effective ingredient in the medicine to greatest extent, and the steady quality of gained medicine.

In view of above-mentioned pharmacology, this medicine is effective in cure to diseases such as cerebrovascular, cardiovascular, high blood viscosity, cerebral hemorrhage, cerebral infarction, cerebral embolism, hemiplegia, facial hemiparalysis, numb limbs and tense tendons, insomnia forgetfulness, myocardial infarction, alzheimer disease, extremity tremble.

The specific embodiment

Embodiment 1:

15 parts of Herba Taraxacis, 12 parts in Tremella, 15 parts of Herba Taxillis, 10 parts of Rhizoma Chuanxiongs, 16 parts on Lentinus Edodes, 18 parts of agrocyb eaegerita, 16 parts of Herba Saussureae Involuerataes.

Its preparation method is:

1) by weight proportioning to take by weighing Herba Taraxaci, Tremella, Herba Taxilli, Rhizoma Chuanxiong, Lentinus Edodes, agrocyb eaegerita, Herba Saussureae Involueratae standby;

2) get Tremella, Lentinus Edodes, agrocyb eaegerita, Herba Saussureae Involueratae in proportion 1: 5 water mix, room temperature soak down 4 hours standby;

3) be incubated 45 minutes down at 55～60 ℃;

4) add Rhizoma Chuanxiong, Herba Taxilli, Herba Taraxaci, temperature is raised to 90～100 ℃, and slow fire boiled 1～2 hour;

5) filter, medicinal liquid is concentrated to 1/10 of total amount promptly can be made into oral liquid.

Embodiment 2:

Get 10 parts of Herba Taraxacis, 5 parts in Tremella, 8 parts of Herba Taxillis, 5 parts of Rhizoma Chuanxiongs, 10 parts on Lentinus Edodes, 10 parts of agrocyb eaegerita, 12 parts of Herba Saussureae Involuerataes.

1) by weight proportioning to take by weighing Herba Taraxaci, Tremella, Herba Taxilli, Rhizoma Chuanxiong, Lentinus Edodes, agrocyb eaegerita, Herba Saussureae Involueratae standby;

2) get Tremella, Lentinus Edodes, agrocyb eaegerita, Herba Saussureae Involueratae in proportion 1: 5 water mix, room temperature soak down 3 hours standby;

3) be incubated 40 minutes down at 50 ℃;

4) add Rhizoma Chuanxiong, Herba Taxilli, Herba Taraxaci, temperature is raised to 80 ℃, and slow fire boiled 1 hour;

5) filter, medicinal liquid is concentrated to 1/10 of total amount promptly can be made into oral liquid.

Embodiment 3:

Get 35 parts of Herba Taraxacis, 30 parts in Tremella, 35 parts of Herba Taxillis, 16 parts of Rhizoma Chuanxiongs, 25 parts on Lentinus Edodes, 30 parts of agrocyb eaegerita, 24 parts of Herba Saussureae Involuerataes.

1) proportioning takes by weighing Herba Taraxaci by weight, Tremella, and Herba Taxilli, Rhizoma Chuanxiong, Lentinus Edodes, agrocyb eaegerita, Herba Saussureae Involueratae is standby;

2) get Tremella, Lentinus Edodes, agrocyb eaegerita, Herba Saussureae Involueratae in proportion 1: 5 water mix, room temperature soak down 4 hours standby;

3) be incubated 45 minutes down at 60 ℃;

4) add Rhizoma Chuanxiong, Herba Taxilli, Herba Taraxaci, temperature is raised to 100 ℃, and slow fire boiled 2 hours;

5) filter, medicinal liquid is concentrated to 1/10 of total amount promptly can be made into oral liquid.

Embodiment 4:

Get 10 parts of Herba Taraxacis, 10 parts in Tremella, 10 parts of Herba Taxillis, 8 parts of Rhizoma Chuanxiongs, 15 parts on Lentinus Edodes, 16 parts of agrocyb eaegerita, 15 parts of Herba Saussureae Involuerataes.

Preparation method is with embodiment 1.

Clinical trial:

Subjects is totally 103 examples, male's 72 examples wherein, women's 31 examples; Age 32 was to 68 years old; The course of disease 3 to 18 years; Cardiovascular diseases's 17 examples, encephalopathy 86 examples (severe disease 55 examples); " apoplexy diagnosis efficacy assessment standard " (the trying) that diagnostic criteria is drafted formulation with reference to " all kinds of cerebrovascular disease diagnosis main points " and State Administration of Traditional Chinese Medicine's encephalopathy emergency case scientific research cooperative groups of the 4th national cerebrovascular academic conference revision of nineteen ninety-five Chinese Medical Association; Test group is taken oral liquid of the present invention, and specification is that 10ml/ props up.Each 1,3 times on the 1st, 8 weeks were 1 course of treatment.

Clinical test results sees Table 1.

Table 1

The example number	Recovery from illness	Produce effects	Effectively	Invalid	Total effective rate
						103	99(96％)	3(3％)	1(1％)	0(0％)	100％

Its curative effect of evidence is significant.

Toxicity test:

Test drug is a preparation of the present invention, and every 1ml oral liquid contains crude drug 2g.Experimental animal is an ICR kind white mice, body weight 20g ± 2g, male and female half and half, totally 20.Test method is: fasting was pressed 20g/Kg and is given mice lavage 3 months after 12 hours, and the long term toxicity test result shows, the white mice body weight, and liver, renal function, hemogram etc. and matched group no significant difference show that the safety of this medicine is big, belong to nontoxic rank.

Claims (7)

1, a kind of medicine for the treatment of cranial nerve and cerebrovascular disease is characterized in that mainly being made by the crude drug of following parts by weight: Herba Taraxaci 10-35 part, Herba Taxilli 8-35 part, Rhizoma Chuanxiong 5-16 part, Lentinus Edodes 10-25 part, agrocyb eaegerita 10-30 part, Herba Saussureae Involueratae 12-24 part.

2, the medicine of treatment cranial nerve according to claim 1 and cerebrovascular disease is characterized in that also including in the crude drug Tremella of 5～30 parts by weight.

3, the medicine of treatment cranial nerve according to claim 1 and cerebrovascular disease is characterized in that the consumption of each crude drug is: 10～20 parts of Herba Taraxacis, 10～20 parts of Herba Taxillis, 8～15 parts of Rhizoma Chuanxiongs, 15～17 parts on Lentinus Edodes, 16～20 parts of agrocyb eaegerita, 15～18 parts of Herba Saussureae Involuerataes.

4, the medicine of treatment cranial nerve according to claim 3 and cerebrovascular disease is characterized in that also including in the crude drug Tremella of 10～15 parts by weight.

5, the medicine of treatment cranial nerve according to claim 4 and cerebrovascular disease is characterized in that the consumption of each crude drug is: 15 parts of Herba Taraxacis, 12 parts in Tremella, 15 parts of Herba Taxillis, 10 parts of Rhizoma Chuanxiongs, 16 parts on Lentinus Edodes, 18 parts of agrocyb eaegerita, 16 parts of Herba Saussureae Involuerataes.

6, a kind of preparation method for the treatment of the medicine of cranial nerve and cerebrovascular disease is characterized in that comprising the following steps:

1) standby by following parts by weight proportioning weighting raw materials: 5～30 parts in Tremella, Herba Taraxaci 10-35 part, Herba Taxilli 8-35 part, Rhizoma Chuanxiong 5-16 part, Lentinus Edodes 10-25 part, agrocyb eaegerita 10-30 part, Herba Saussureae Involueratae 12-24 part;

2) get Tremella, Lentinus Edodes, agrocyb eaegerita, Herba Saussureae Involueratae in proportion 1: 5 water mix, room temperature soak down 3～6 hours standby;

3) be incubated 40～120 minutes down at 50～80 ℃;

4) add Rhizoma Chuanxiong, Herba Taxilli, Herba Taraxaci, temperature is raised to 80～100 ℃, and slow fire boiled 1～3 hour;

5) filter, medicinal liquid is concentrated to 1/10 of total amount promptly can be made into oral liquid.

7, according to the preparation method of the medicine of described treatment cranial nerve of claim 6 and cerebrovascular disease, it is characterized in that comprising the following steps:

1) standby by following parts by weight proportioning weighting raw materials: 10～15 parts in Tremella, 10～20 parts of Herba Taraxacis, 10～20 parts of Herba Taxillis, 8～15 parts of Rhizoma Chuanxiongs, 15～17 parts on Lentinus Edodes, 16～20 parts of agrocyb eaegerita, 15～18 parts of Herba Saussureae Involuerataes;

2) get Tremella, Lentinus Edodes, agrocyb eaegerita, Herba Saussureae Involueratae in proportion 1: 5 water mix, room temperature soak down 4 hours standby;

3) be incubated 45 minutes down at 55～60 ℃;

4) add Rhizoma Chuanxiong, Herba Taxilli, Herba Taraxaci, temperature is raised to 90～100 ℃, and slow fire boiled 1～2 hour;

5) filter, medicinal liquid is concentrated to 1/10 of total amount promptly can be made into oral liquid.