CN103816456A - Pharmaceutical composition for treating post-traumatic brain syndrome - Google Patents
Pharmaceutical composition for treating post-traumatic brain syndrome Download PDFInfo
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- CN103816456A CN103816456A CN201410085199.2A CN201410085199A CN103816456A CN 103816456 A CN103816456 A CN 103816456A CN 201410085199 A CN201410085199 A CN 201410085199A CN 103816456 A CN103816456 A CN 103816456A
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Abstract
The invention discloses a pharmaceutical composition for treating post-traumatic brain syndrome. The pharmaceutical composition is characterized by being prepared from the following materials: szechuan lovage rhizome, bark of oriental variegated coralbean, rhizome of Japanese galangal, radix achyranthis bidentatae, cowherb seed, thickleaf croton root, flos rosae rugosae, root of lemonfragrant ostericum, rhizome et radix notopterygii, radix angelicae pubescentis, photinia serrulata, seed of calyx-shaped carrierea, grassleaf sweelflag rhizome, flos chrysanthemi, uncariae ramulus cum uncis, radix bupleuri, succvinum amber, sargentgloryvine stem, dahurian patrinia herb, plantain seed, sweet wormwood herb, root of straight ladybel, cortex lycii, fructus lycii, semen cuscutae, radix astragali, radix ginseng rubra, radix angelicae sinensis and radix notoginseng. Brain collateral injure, a post-traumatic brain syndrome, causes blood stasis and weakness, and thus endogenous wind and exogenous wind seize the opportunity to get in; pathogenic wind blocks collaterals to cause pathogenic factors to block meridians, and thus causes exuberance of deficiency-heat; qi and blood are unsmooth to cause blood stasis, depression causes heat, and the pathogenesis is blood stasis, qi stagnation, blood stasis on head, qi-blood deficiency, and deficiency of liver and kidney. According to the invention, removing blood stasis and wind, promoting qi circulation, removing obstruction in collaterals, inducing resuscitation, promoting blood circulation, enriching blood and qi, soothing nerves, tonifying deficiency, nourishing liver and kidney, and tonifying brains are taken as rules of treatment so as to achieve the purpose of treating post-traumatic brain syndrome.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of cerebral trauma sequela.
Background technology
Cerebral trauma sequela refers to that patient with brain trauma is after convalescent period, three months one group of above autonomic nervous functions of sustainable existence are lacked of proper care or spirituality symptom, characteristics of incidence comprises brain cortex malfunction, cerebral cortex excitement and process of inhibition imbalance, autonomic nervous system dysfunction etc., clinical symptoms comprises loss of consciousness in various degree, headache, nervousness, irritability, attention disorders, memory disorder, feels sick, dizzy, insomnia, tired etc., the clinical postcerebral injury syndrome that is also called, having a headache, dizziness, hypomnesis etc. be the most common.Cerebral trauma sequela is more common in slight or moderate patients with closed head injury, and sickness rate accounts for 20% of patients with sevious craniocerebral injury, brings great misery and stress to patient, affects patient's work, life.More cerebral trauma sequela patient is simultaneously with anxiety and depressive symptom.The treatment of cerebral trauma sequela, lacks the medicine with definite curative effect at present, and doctor trained in Western medicine is clinical also lacks specific Therapeutic Method.
Motherland's medical science is thought, cerebral trauma sequela belongs to the internal injury category of Chinese traumatology, and pathogenesis is that head or cerebral tissue are subject to external force and cause brain network damage, causes the stasis of blood, void, endogenous wind, exogenous wind are availed oneself of the opportunity to get in, " all YANG-meridians meeting into the head, only wind can arrive ", QI and blood does not freely cause blood stasis delay simultaneously, strongly fragrant and heat-transformation, in ailment said due to cold or exposure resistance network, deficiency-heat, contain, clinical manifestation has stagnation of QI and blood, blood stasis to violate head, QI and blood deficiency, Liver and kidney two void, i.e. " stasis of blood " and " void ".Stasis of blood person, thrombosis forms the stasis of blood for a long time, and blood stasis is violated head retardance brain network, and QI and blood is not smooth; Void person, the brain deficiency of vital energy, Liver and kidney void, QI of the upper portion of the body being insufficient, empty sensation in the brain, ear is bitter ring for it, suffering from the head tilted down feebly, blurring of vision.The stasis of blood is the deficiency of vital energy, the deficiency of vital energy is the stasis of blood, the deficiency of vital energy is transporting incapability, the two association, cause QI and blood deficiency, the clear key of qi depression to blood stasis unfavorable, stagnation of blood stasis brain key, brain is become homeless foster, causes patient's loss of consciousness, headache, nervousness, irritability, attention disorders, memory disorder, feels sick, dizzy, insomnia, the symptom such as tired.The present invention is directed to the cause of disease, take blood stasis dispelling dispel the wind, promoting of the circulation of QI and removing the obstruction in the collaterals, have one's ideas straightened out invigorate blood circulation, blood-enriching qi-invigorating, the tonify deficiency of calming the nerves, nourishing the liver and kidney, beneficial brains be as the rule for the treatment of, reaches the object for the treatment of cerebral trauma sequela.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of cerebral trauma sequela.
In order to realize goal of the invention, raw material composition and weight proportion thereof that the present invention makes this effective ingredient are: 4 parts of Rhizoma Chuanxiongs, 3 parts of Cortex erythrinaes, 3 parts of Alpinia japonica (Thunb.) Miq.s, 3 parts of Radix Achyranthis Bidentataes, 3 parts of Semen Vaccariae, 3 parts of Radix Crotonis Crassifoliis, 3 parts of Flos Rosae Rugosaes, 3 parts of Radix osterici citriodori (Radix Angelicae Citriodorae)s, 4 parts of Rhizoma Et Radix Notopterygiis, 3 parts of Radix Angelicae Pubescentiss, 3 parts of Chinese photinias, 3 parts of Semen Carriereae Calycinaes, 4 parts of Rhizoma Acori Graminei, 3 parts of Flos Chrysanthemis, 2 parts of Ramulus Uncariae Cum Uncis, 2 parts of Radix Bupleuri, 1 part of succinum, 2 parts of Caulis Sargentodoxae, 2 parts of Herba Patriniae, 2 parts of Semen Plantaginiss, 4 parts of Herba Artemisiae Annuaes, 2 parts of Radix Adenophorae (Radix Glehniae), 3 parts of Cortex Lycii, 4 parts of Fructus Lyciis, 3 parts of Semen Cuscutae, 4 parts of the Radixs Astragali, 4 parts of Radix Ginseng Rubra, 4 parts of Radix Angelicae Sinensis, 3 parts of Radix Notoginseng.
Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong.Acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping.
Cortex erythrinae is bark or the root bark of leguminous plant erythrina indica.Bitter in the mouth, property is flat.Return liver, kidney channel.Function channels sootheing and network vessel quickening, promoting the circulation of blood pain relieving.
Alpinia japonica (Thunb.) Miq. is the rhizome of zingiberaceous plant Alpinia japonica (Thunb.) Miq..Acrid in the mouth, warm in nature.Attach to the lung and stomach meridians.Function warming spleen and stomach for dispelling cold, invigorates blood circulation, dispels the wind, and promoting the circulation of blood repercussive.
Semen Vaccariae is the seed of pinkwort Vaccaria segetalis.Bitter in the mouth, property is flat.Enter liver, stomach warp.Function promoting the circulation of blood, invigorate blood circulation, stimulate the menstrual flow, convenient.
Radix Achyranthis Bidentatae is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae.Bitter in the mouth, acid, property is flat.Return liver, kidney channel.Function invigorating the liver and kidney, bone and muscle strengthening, dissipating blood stasis, removing blood stasis, stimulates the menstrual flow.
Radix Crotonis Crassifolii is the root of euphorbia plant Radix Crotonis Crassifolii.Acrid in the mouth hardship, warm in nature.GUIXIN, lung, liver, kidney channel.Function is regulated the flow of vital energy, pain relieving, dispel the wind, dehumidifying, relaxing muscles and tendons, active.
Flos Rosae Rugosae is the dry flower of rosaceous plant Flos Rosae Rugosae.Sweet in the mouth, micro-hardship, warm in nature.Return liver, spleen channel.Function is regulated the flow of vital energy, circulation of qi promoting, resolving depression and blood, dissipating blood stasis, pain relieving.
Radix osterici citriodori (Radix Angelicae Citriodorae) is the root of samphire Radix osterici citriodori (Radix Angelicae Citriodorae).Acrid in the mouth, hardship, slightly warm in nature.Function wind and heat dispersing, promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain.
Rhizoma Et Radix Notopterygii is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii or Radix et Rhizoma Notopterygii.Acrid in the mouth, hardship, warm in nature.Return bladder, kidney channel.Function is dispeled the wind, cold expelling, dehumidifying, pain relieving.
Radix Angelicae Pubescentis is the dry root of samphire Angelica pubescens.Acrid in the mouth, hardship, slightly warm in nature.Return kidney, urinary bladder channel.Function is dispeled the wind, dehumidifying, blood stasis dispelling, pain relieving.
Chinese photinia is the root of rosaceous plant Chinese photinia.Acrid in the mouth, hardship, property is flat.Return Liver Channel.Function is dispeled the wind, is invigorated blood circulation, pain relieving.
Semen Carriereae Calycinae is the seed of Flacourtiaceae plant goat hornbeam.Cool in nature, bitter in the mouth.GUIXIN, Liver Channel.That function relieves dizziness, high fever, infantile convulsions, epilepsy, etc. is surely dizzy, except wind supplementing the brain.
Rhizoma Acori Graminei is the rhizome of acorus gramineus araceae plant.Acrid in the mouth, hardship, slightly warm in nature.GUIXIN, liver, spleen channel.Function waking up the patient from unconsciousness by dissipating phlegm, removing dampness circulation of qi promoting, the sharp numbness of dispeling the wind, reducing swelling and alleviating pain.
Radix Bupleuri is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Bitter in the mouth, cold nature.Return liver, gallbladder meridian.Function reconciling superficies and interior, expelling pathogenic factors from the exterior expels the heat-evil, soothing the liver, resolving depression, yang invigorating.
Flos Chrysanthemi is the dry capitulum of feverfew chrysanthemum.Sweet in the mouth, hardship, cold nature.Return lung, Liver Channel.The function wind heat clearing away of faling apart, sharp blood vessels, suppressing the hyperactive liver improving eyesight.
Ramulus Uncariae Cum Uncis is the dry stem and branch with belt hook of Maguireothamnus speciosus Ramulus Uncariae Cum Uncis, Ramulus Uncariae macrophyllae, Ramulus Uncariae Cum Uncis, Uncaria sinensis (Oliv.) Havil., stockless fruit Ramulus Uncariae Cum Uncis.Sweet in the mouth, cool in nature.Return liver, pericardium channel.Function heat clearing away suppressing the hyperactive liver, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.
Succinum is the prolonged Hydrocarbon that condenses and form under the resin burial ground of pinaceae plant in ancient times.Sweet in the mouth, property is flat.GUIXIN, liver, small intestine meridian.Function settling five organs, determines soul, tranquillizing the mind by relieving convulsion, dissipating blood stasis hemostasis, relieving stranguria by diuresis.
Caulis Sargentodoxae is the dry rattan of plants of Lardizabalaceae Caulis Sargentodoxae.Bitter in the mouth, property is flat.Return liver, large intestine channel.Function heat-clearing and toxic substances removing, invigorates blood circulation, and dispels the wind.
Herba Patriniae is root and the herb of Herba Patriniae section plant Hemerocallis citrina Baroni dragon bud, patrima villosa.Acrid in the mouth, hardship, cool in nature.Return stomach, large intestine, Liver Channel.Function heat-clearing and toxic substances removing, blood circulation promoting competent silt.
Semen Plantaginis is the dry mature seed of Plantaginaceae plant Herba Plantaginis or Plantago depressa Willd.Sweet in the mouth, cold nature.Return liver, kidney, lung, small intestine meridian.Function clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, and improving eyesight is eliminated the phlegm.
Herba Artemisiae Annuae is the dry aerial parts of feverfew Herba Artemisiae annuae.Bitter in the mouth, pungent, cold in nature.Return liver, gallbladder meridian.Function clearing away the hectic fever, gram fever due to yin deficiency.
Radix Adenophorae (Radix Glehniae) is the root of Campanulaceae Radix Adenophorae (Radix Glehniae), Folium Pruni Radix Adenophorae (Radix Glehniae), adenophora tetraphylla, Yunnan Radix Adenophorae (Radix Glehniae), bubble Radix Adenophorae (Radix Glehniae).Sweet in the mouth, micro-hardship, cold nature.Attach to the lung and stomach meridians.Function clearing away heat and nourishing YIN.
Cortex Lycii is the dry root bark of matrimony vine of solanaceae plant or lycium barbarum.Sweet in the mouth, cold in nature.Return lung, liver, kidney channel.Function removing heat from blood is except steaming, lung heat clearing pathogenic fire reducing.
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum.Sweet in the mouth, property is flat.Return liver, kidney channel.The main caused by liver and kidney deficiency of function, nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Semen Cuscutae is the dry mature seed of convolvulus cuscuta plant.Sweet in the mouth, warm in nature.Return liver,kidney,spleen warp.Function tonification Liver and kidney, controlling nocturnal emission with astringent drugs, improving eyesight.
The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali.Sweet in the mouth, warm in nature.Return lung, spleen channel.Function invigorating QI to consolidate the body surface resistance.
Radix Ginseng Rubra is the dry root of Araliaceae Radix Ginseng after steaming.Sweet in the mouth, micro-hardship, warm in nature.Return spleen, lung, heart channel.Function strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, nourishing qi to stop.
When being classified as the dry root of umbelliferae angelica.Sweet in the mouth, pungent, warm in nature.Return liver, the heart, spleen channel.Function is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Radix Notoginseng is the dry root of panax araliaceae plant.Sweet in the mouth, micro-hardship, warm in nature.Return liver, stomach warp.Functionalization blood stasis, tissue regeneration promoting blood, the clots absorbing of promoting blood circulation.
The present invention treats the pharmaceutical composition of cerebral trauma sequela, for cerebral trauma sequela because of brain network damage, cause the stasis of blood, void, endogenous wind, exogenous wind are availed oneself of the opportunity to get in, " all YANG-meridians meeting into the head, only wind can arrive ", QI and blood does not freely cause blood stasis delay simultaneously, strongly fragrant and heat-transformation, contains in ailment said due to cold or exposure resistance network, deficiency-heat, and clinical manifestation has " stasis of blood " and " void ".Stasis of blood person, thrombosis forms the stasis of blood for a long time, and blood stasis is violated head retardance brain network, and QI and blood is not smooth; Void person, the brain deficiency of vital energy, Liver and kidney void, QI of the upper portion of the body being insufficient, empty sensation in the brain, ear is bitter ring for it, suffering from the head tilted down feebly, blurring of vision.The stasis of blood is the deficiency of vital energy, the deficiency of vital energy is the stasis of blood, the deficiency of vital energy is transporting incapability, the two association, cause QI and blood deficiency, the clear key of qi depression to blood stasis unfavorable, stagnation of blood stasis brain key, brain is become homeless foster, causes cerebral trauma sequela patient loss of consciousness, headache, nervousness, irritability, attention disorders, memory disorder, feels sick, dizzy, insomnia, the symptom such as tired.Pathogenesis is that stagnation of QI and blood, blood stasis are violated head, QI and blood deficiency, Liver and kidney two void.The present invention is directed to the cause of disease, take blood stasis dispelling dispel the wind, promoting of the circulation of QI and removing the obstruction in the collaterals, have one's ideas straightened out invigorate blood circulation, blood-enriching qi-invigorating, the tonify deficiency of calming the nerves, nourishing the liver and kidney, beneficial brains be as the rule for the treatment of, reaches the object for the treatment of cerebral trauma sequela.
In the pharmaceutical composition for the treatment of cerebral trauma sequela provided by the present invention, Rhizoma Chuanxiong, Cortex erythrinae, Alpinia japonica (Thunb.) Miq., Radix Crotonis Crassifolii, Flos Rosae Rugosae, Radix osterici citriodori (Radix Angelicae Citriodorae), Radix Achyranthis Bidentatae, the promoting the circulation of blood of a few taste medicine of Semen Vaccariae, invigorate blood circulation, dispel the wind, stimulate the menstrual flow, circulation of qi promoting, Radix Crotonis Crassifolii, Radix osterici citriodori (Radix Angelicae Citriodorae) fragrance reaches thoroughly, Alpinia japonica (Thunb.) Miq. warming middle-JIAO expelling wind and activating blood circulation, the promoting the circulation of blood of Cortex erythrinae dredging collateral, as " book on Chinese herbal medicine justice " says " Radix Achyranthis Bidentatae, dredge sharp drop-down, all diseases of stagnation of QI-blood of leading ", " property of medicine opinion " says that Semen Vaccariae " controls pathogenic wind toxic, promoting blood circulation ", " Japan hanako materia medica " says that " Rhizoma Chuanxiong is controlled a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjust many arteries and veins, Po Disorder ties stagnated blood, support fresh blood ", " book on Chinese herbal medicine justice " thinks " Flos Rosae Rugosae, fragrance is the denseest, turbid clearly and not, with and not violent, the easing the affected liver stomach of waking up, gas is invigorated blood circulation, a surname is logical stops up stagnant and just dry fraud of absolutely not pungent temperature, disconnected pushing away among edema caused by disorder of QI medicine, there is most prompt effect and the most tractable person ", said medicine compatibility share, the up head, middle relieving stagnation, gram stagnation of QI-blood, play repercussive removing blood stasis, blood stasis dispelling is invigorated blood circulation, invigorating the liver and kidney, dispersing cold for relieving pain effect.
Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Chinese photinia, Semen Carriereae Calycinae, a few taste medicines of Rhizoma Acori Graminei, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis dispel the wind blood stasis dispelling, dispelling cold and removing dampness pain relieving, the pain relieving of Chinese photinia expelling wind and activating blood circulation, Semen Carriereae Calycinae relieves dizziness, high fever, infantile convulsions, epilepsy, etc. surely dizzy except wind supplementing the brain, Rhizoma Acori Graminei dispel the wind sharp numbness, removing dampness circulation of qi promoting, waking up the patient from unconsciousness by dissipating phlegm, say " Radix Angelicae Pubescentis; can declare airway, pushes up certainly to knee joint, with the kidney channel volt wind that falls apart " as " medicine justice ", " Japan hanako materia medica " say Rhizoma Et Radix Notopterygii " control a wind cutting gas ...; five kinds of strain and seven kinds of impairment, deficient cold air, joint ache; tonneau the five internal organs ", medicine-feeding shares and dispels the wind, dehumidifying, pain relieving, comfortable gas, the smooth mind.
Flos Chrysanthemi, Ramulus Uncariae Cum Uncis, Radix Bupleuri, succinum, Caulis Sargentodoxae, Herba Patriniae, Semen Plantaginis, Herba Artemisiae Annuae, Radix Adenophorae (Radix Glehniae), a few taste medicines of Cortex Lycii, tool heat clearing away, invigorate blood circulation, yin nourishing, dispersing the stagnated live-QI to relieve the stagnation of QI, tranquillizing the mind by relieving convulsion effect; Radix Bupleuri reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, succinum settling five organs, determine soul, tranquillizing the mind by relieving convulsion, the heat clearing away of chrysanthemum powder forimproving wind, sharp blood vessels, Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., Caulis Sargentodoxae heat-clearing and toxic substances removing, promoting blood circulation by removing wind, Herba Patriniae heat-clearing and toxic substances removing, blood circulation promoting competent silt, Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, Herba Artemisiae Annuae clearing away the hectic fever, gram fever due to yin deficiency, Radix Adenophorae (Radix Glehniae) clearing away heat and nourishing YIN, Cortex Lycii removing heat from blood is except steaming, lung heat clearing pathogenic fire reducing, Gan Hanping benefit.As " book on Chinese herbal medicine through hundred kinds of records " says that " thing of all fragrance all can be controlled the disease of head's flesh table to Flos Chrysanthemi.But pungent dry person invariably of perfume (or spice), only chrysanthemum is very not dry strong, therefore in the disease of head's wind-fire, You Yiyan ", " Bencao Jingshu " says that " succinum specially enters blood system.The main blood of the heart, blood stored in the liver, enters the heart and enters liver, therefore energy repercussive blood is also ", " property of medicine opinion " says that Semen Plantaginis " can remove pathogenic wind toxic, the liver affected by pathogenic wind heat ", " medicine justice " says that " Cortex Lycii, dispels without determining exogenous pathogen, interior apart from antiperspirant hectic fever due to YIN-deficiency outward, upper reason wind syndrome of head, in remove breast side of body gas, diarrhea intestine and small intestine, logical can proving effective ".Said medicine is share, and pathogenic fire purging clears away heart-fire, YIN nourishing and the production of body fluid promoting, make vital essence fill and pathogenic heat from moving back.
Fructus Lycii, Semen Cuscutae, the Radix Astragali, Radix Ginseng Rubra, Radix Angelicae Sinensis, a few taste medicines of Radix Notoginseng, clear and coherent blood vessels, nourishing the liver and kidney, invigorating the liver and kidney benefit brain, Liver and kidney foot, brain gas is self-sustaining.Fructus Lycii, Semen Cuscutae, nourishing the liver and kidney, beneficial smart controlling nocturnal emission with astringent drugs, Radix Astragali invigorating QI to consolidate the body surface resistance, Radix Ginseng Rubra strongly invigorating primordial QI, nourishing qi to stop Chinese angelica blood supplementing are invigorated blood circulation, Radix Notoginseng blood stasis dispersing and fresh blood promoting, the clots absorbing of promoting blood circulation, the absurd row that stops blooding, as " jade is seized medicine solution " says Radix Notoginseng " with battalion hemostasis, clots absorbing blood and hold back fresh blood ", " book on Chinese herbal medicine is looked for the truth " says Radix Notoginseng " the bitter temperature of abnormal smells from the patient; can be in its blood stasis of blood systemization ", " book on Chinese herbal medicine just " say Fructus Lycii " highly seasoned and pure, therefore can nourishing YIN; have sun in the moon, therefore can QI invigorating.So YIN nourishing and unlikely the moon declines, supporing yang and can make Yang Wang "; " Bencao Jingshu " says " Fructus Lycii, profit and nourish, double can bringing down a fever, and specially in the kidney invigorating, lung moistening, promote the production of body fluid, QI invigorating, for the key medicine of Liver and kidney kidney-YIN being deficient, tired interior-heat tonification "; " book on Chinese herbal medicine converge with speech " says that " medicine that warming the spleen helps stomach is also for Semen Cuscutae, the kidney invigorating nourishing the liver.But mend and not high, warm and not dry, therefore enter kidney channel, void can be mended, in fact can be in order to, trembling with fear can be warm, heat can be cool, wetting can be dry, dry can profit ", " herbal classic " says Radix Ginseng Rubra " main tonifying five ZANG-organs, peace spirit, spasmolytic is throbbed with fear, except pathogen, improving eyesight, happy Fructus Alpiniae Oxyphyllae ", " book on Chinese herbal medicine just " says Radix Angelicae Sinensis " its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, invigorating middle warmer has, in row, there is benefit, the really gas medicine in blood, also the panacea in blood also, mending to mend of assistant, therefore can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, benefit mind, all tangible deficient diseases, unsuitable without institute ".
In the pharmaceutical composition for the treatment of cerebral trauma sequela provided by the present invention, all medicine consonances each other assistant make, and growth encourage curative effect complements each other.For example Rhizoma Chuanxiong is invigorated blood circulation, is dispeled the wind, circulation of qi promoting, and Rhizoma Chuanxiong is joined Rhizoma Et Radix Notopterygii, and the pungent Wen Xiang of Rhizoma Chuanxiong alters, and walks and does not keep, especially can the up head, and promoting blood circulation to remove obstruction in the collateral, is equipped with Rhizoma Et Radix Notopterygii a surname and sends out an ailment said due to cold or exposure, the two mutual-assistance, the up brain network of priming, treats internal injury wind syndrome of head; Rhizoma Chuanxiong is joined the Radix Astragali, the Rhizoma Chuanxiong promoting the circulation of blood of dispeling the wind, and Radix Astragali tonifying Qi and lifting yang, the two matches, can inrigorating qi and promoting blood circulation, draw blood up; Rhizoma Chuanxiong is joined Flos Rosae Rugosae, dispersing the stagnated live-QI to relieve the stagnation of QI, Zhu Danxi says " QI and blood punching and, ten thousand diseases are raw; one strokes strongly fragrantly, and all diease occurrences are here ", Flos Rosae Rugosae fragrant odour, kind can promoting QI circulation for relieving depression, be equipped with Rhizoma Chuanxiong, QI and blood is two to be adjusted, and has the effect of " promoting circulation of QI-blood; make its tune reach, and it is flat to make peace ", and Radix Notoginseng adds Rhizoma Chuanxiong, Radix Notoginseng removes stagnant tissue regeneration promoting, and regulating menstruation is along arteries and veins, and the pungent loose temperature of Rhizoma Chuanxiong is logical, adjust many arteries and veins, warm the five internal organs, amount to regulating menstruation and imitate along feeling pulse;
For example Chinese angelica blood supplementing is invigorated blood circulation, " the arteries and veins person house of blood, all blood all belongs to the heart, all persons of promoting blood circulation must be first reinforcing the heart benefit blood ", Radix Angelicae Sinensis is joined Rhizoma Chuanxiong, and Chinese angelica blood supplementing and battalion are equipped with Rhizoma Chuanxiong blood-activating and qi-promoting, enriches blood and not stagnant, invigorate blood circulation and do not cut down, blood deficiency and blood stasis reciprocal causation, blood stasis does not go, and fresh blood is not raw; The Radix Astragali is QI invigorating panacea, and lid gas is invisible, and blood is tangible, tangible can not fast-growing, gas that must be invisible is with life, the Radix Astragali is used among Radix Angelicae Sinensis, the hemopoietic helping, with its merit speed of gas medicine hemopoietic; Radix Ginseng strongly invigorating primordial QI, Radix Angelicae Sinensis is take Radix Ginseng Rubra as assistant, qi and blood tonifying, the merit that having more enriches blood invigorates blood circulation;
For example Radix Ginseng Rubra strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, nourishing qi to stop." herbal classic " says its " spasmolytic is throbbed with fear; except pathogen, improving eyesight for main tonifying five ZANG-organs, peace spirit, happy Fructus Alpiniae Oxyphyllae ", Sanqi Tongmai clots absorbing, clots absorbing blood and hold back fresh blood, the two compatibility, more increases qi-supplementing, blood-engendering, the effect of the clots absorbing of promoting blood circulation, as the speech of " book on Chinese herbal medicine is newly organized ", Radix Notoginseng " in addition more refreshing in blood-enriching qi-invigorating medicine, cover that this medicine must be mended and without the trouble of boiling, tonic obtain this and the body that has peace and quiet also ";
For example Fructus Lycii nourishing the liver and kidney, " book on Chinese herbal medicine just " says " Fructus Lycii, highly seasoned and pure; therefore can nourishing YIN, have sun, therefore can QI invigorating; so YIN nourishing and unlikely the moon declines is supporing yang and can make Yang Wang in the moon " " Fructus Lycii can make gas fill, and blood can be mended; Yang Kesheng, and the moon can be grown, and fire can fall; rheumatism can be gone; here have perfect magical effect ", with the mutual-assistance of the taste such as the Radix Astragali, Radix Ginseng Rubra, QI invigorating, enrich blood, dispel the wind, the effect of YIN nourishing, liver and kidney tonifying doubles;
Sweet cold flat benefit of for example Cortex Lycii, removing heat from blood is except steaming, and " detailed outline " says that " root is ground bone, sweet light and cold, and part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels Liver and kidney deficiency-heat person should it, and this is the medicine of three warmers edema caused by disorder of QI all, and so-called heat is excessive in interior, rushes down with sweet and trembles with fear also for Fructus Lycii and Cortex Lycii.Sweet flat and moisten as for son, property is grown and is mended, and can not bring down a fever, only can the kidney invigorating lung moistening, and spermatogenesis QI invigorating, this is the medicine of flat benefit, so-called insufficiency of essence person, tonifying with drugs of thick flavor is also.Point and with it, respectively main to some extent, hold concurrently and with it, kill two birds with one stone ", Fructus Lycii and Cortex Lycii phase 5, has a role to play;
For example Semen Plantaginis clearing away heat and promoting diuresis, Semen Vaccariae promoting the circulation of blood is stimulated the menstrual flow, diuresis.The two medicine mutual-assistances, make blood stasis go from urine, and blood stasis does not go fresh blood difficult raw, collaborative and increase removing blood stasis tissue regeneration promoting effect;
For example Rhizoma Acori Graminei waking up the patient from unconsciousness by dissipating phlegm, removing dampness circulation of qi promoting, the sharp numbness of dispeling the wind, share with Radix Ginseng Rubra, a surname's knot of thought and being proficient in the law of natural movement, as " book on Chinese herbal medicine is newly organized " speech Rhizoma Acori Graminei " happy key must be helped with Radix Ginseng ..., except unhappy; control forgetful, non-take Radix Ginseng as monarch, also can not two odd testing also "; For example Herba Artemisiae Annuae clearing away the hectic fever, with the mutual-assistance of the taste such as Radix Adenophorae (Radix Glehniae), Cortex Lycii, the asthenic fire in Radix Adenophorae (Radix Glehniae), the cool bone of Cortex Lycii energy, Herba Artemisiae Annuae can draw the asthenic fire in bone, and effectiveness is better.
Overall view is side entirely, and all medicine consonances each other assistant make, and jointly bring into play multiple therapeutical effect.
The pharmaceutical composition for the treatment of cerebral trauma sequela provided by the present invention, can be prepared into powder, also can make pill, also can extract the total effective ingredient in medical material, is prepared into other dosage form that is suitable for treating cerebral trauma sequela.
The pharmaceutical composition for the treatment of cerebral trauma sequela provided by the present invention, to make honey pill agent as embodiment, cleans the each medical material in formula to dry, and is ground into the fine powder of No. six medicine sieves, adds proper honey and makes pill, and lucifuge stores for future use.
Usage of the present invention is oral administration.
Invention embodiment
Prepare medicine by following medicament composing prescription consumption: Rhizoma Chuanxiong 4kg, Cortex erythrinae 3kg, Alpinia japonica (Thunb.) Miq. 3kg, Radix Achyranthis Bidentatae 3kg, Semen Vaccariae 3kg, Radix Crotonis Crassifolii 3kg, Flos Rosae Rugosae 3kg, Radix osterici citriodori (Radix Angelicae Citriodorae) 3kg, Rhizoma Et Radix Notopterygii 4kg, Radix Angelicae Pubescentis 3kg, Chinese photinia 3kg, Semen Carriereae Calycinae 3kg, Rhizoma Acori Graminei 4kg, Flos Chrysanthemi 3kg, Ramulus Uncariae Cum Uncis 2kg, Radix Bupleuri 2kg, succinum 1kg, Caulis Sargentodoxae 2kg, Herba Patriniae 2kg, Semen Plantaginis 2kg, Herba Artemisiae Annuae 4kg, Radix Adenophorae (Radix Glehniae) 2kg, Cortex Lycii 3kg, Fructus Lycii 4kg, Semen Cuscutae 3kg, Radix Astragali 4kg, Radix Ginseng Rubra 4kg, Radix Angelicae Sinensis 4kg, Radix Notoginseng 3kg, each medical material in formula is cleaned and dried, be ground into the fine powder of No. six medicine sieves, add proper honey and make pill, lucifuge stores for future use.
Further illustrate below the effect of the pharmaceutical composition for the treatment of cerebral trauma sequela of the present invention by clinical treatment observation case.
1, physical data
MethodsThe cases enrolled: meet patient's 71 examples of cerebral trauma sequela diagnostic criteria, medical history 5 months～26 months, patient age 37 ± 15.4 years old (19～62 years old), wherein male 41 examples, female's 30 examples;
Therapeutic scheme: it is oral that MethodsThe cases enrolled gives pill prepared by pharmaceutical composition embodiment that the present invention treats cerebral trauma sequela, each 20g, a twice-daily, warm water delivery service.28 days was 1 course for the treatment of, was used in conjunction observe the curative effect after 2 courses for the treatment of.
Criterion of therapeutical effect: press grade III Standard and judge curative effect.Obvious effective rate and effective percentage sum are total effective rate.
Effective: cerebral trauma sequela symptom all disappears.Effective: cerebral trauma sequela symptom obviously alleviates.Invalid: cerebral trauma sequela symptom is without improvement, or symptom is improved not obvious.
2, therapeutic outcome
After treatment finishes, effective 34 examples of cerebral trauma sequela patient, effective 30 examples, total effective rate 82.9%.Do not observe patient adverse effect occurs, clinical drug safety.
The present invention treats the pharmaceutical composition of cerebral trauma sequela, for cerebral trauma sequela because of brain network damage, stagnation of QI and blood, blood stasis are violated the pathogenesis cause of disease of head, QI and blood deficiency, Liver and kidney two void, comprehensive measure, make to note in head on the gas of the clear sun of blood, six internal organs of the five internal organs elite, reach the object for the treatment of cerebral trauma sequela, drug use is convenient, and treatment cerebral trauma sequela curative effect is obvious.
Claims (2)
1. treat the pharmaceutical composition of cerebral trauma sequela for one kind, it is characterized in that ingredients and the weight proportion thereof of making this pharmaceutical composition are: 4 parts of Rhizoma Chuanxiongs, 3 parts of Cortex erythrinaes, 3 parts of Alpinia japonica (Thunb.) Miq.s, 3 parts of Radix Achyranthis Bidentataes, 3 parts of Semen Vaccariae, 3 parts of Radix Crotonis Crassifoliis, 3 parts of Flos Rosae Rugosaes, 3 parts of Radix osterici citriodori (Radix Angelicae Citriodorae)s, 4 parts of Rhizoma Et Radix Notopterygiis, 3 parts of Radix Angelicae Pubescentiss, 3 parts of Chinese photinias, 3 parts of Semen Carriereae Calycinaes, 4 parts of Rhizoma Acori Graminei, 3 parts of Flos Chrysanthemis, 2 parts of Ramulus Uncariae Cum Uncis, 2 parts of Radix Bupleuri, 1 part of succinum, 2 parts of Caulis Sargentodoxae, 2 parts of Herba Patriniae, 2 parts of Semen Plantaginiss, 4 parts of Herba Artemisiae Annuaes, 2 parts of Radix Adenophorae (Radix Glehniae), 3 parts of Cortex Lycii, 4 parts of Fructus Lyciis, 3 parts of Semen Cuscutae, 4 parts of the Radixs Astragali, 4 parts of Radix Ginseng Rubra, 4 parts of Radix Angelicae Sinensis, 3 parts of Radix Notoginseng.
2. a kind of pharmaceutical composition for the treatment of cerebral trauma sequela claimed in claim 1, the application in the medicine for the preparation for the treatment of cerebral trauma sequela.
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| CN105770501A (en) * | 2016-05-18 | 2016-07-20 | 高福源 | Traditional Chinese medicine capsule for treating post-traumatic brain syndrome and preparation method of traditional Chinese medicine capsule |
| CN106860709A (en) * | 2017-03-28 | 2017-06-20 | 华北理工大学 | A kind of Chinese medicine preparation for treating post cerebral traumatic syndrome |
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| CN103816456B (en) | 2016-04-13 |
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