CN102908425A - Medicine for treating heart diseases and thick blood lipid and preparation method of the medicine - Google Patents

Abstract

The invention belongs to the field of medicines, and provides a medicine for treating heart diseases and thick blood lipid and a preparation method of the medicine. The medicine is produced by taking pure natural traditional Chinese medicines, natural plants and animals as the raw materials, wherein rhizoma corydalis, rhizoma ligustici wallichii, astragalus, kudzu root, red sage root, hawthorn fruit, loranthus parasiticus, radix codonopsitis, pangolin, hirudo and the like are combined and formulated so that the efficacy of the various medicines generates synergistic effect. As a result, the medicine has the functions of promoting blood circulation and removing blood stasis, nourishing blood and tranquilizing mind, expanding the peripheral vessels, reducing blood pressure, increasing blood flow, improving hear activity, exciting central nervous system, reducing blood pressure and cholesterol and softening blood vessels, can promote the tissue repair and regeneration, clears myocardial necrosis, enhances the body resistance and inhibits the pressor action of adrenalin by preventing atherosclerosis and cardiovascular diseases so as to treat hypertension, thick blood lipid and the consequent heart diseases.

Description

A kind of medicine for the treatment of heart disease and thick blood fat and preparation method thereof

Technical field

The invention belongs to medical technical field, a kind of medicine for the treatment of heart disease and thick blood fat and preparation method thereof is provided.

Background technology

Coronary heart disease in the heart disease is because lipid metabolism is undesired, lipid precipitation in the blood be attached to otherwise smooth endarterium on, form the white speckle of some medicated porridge samples, atherosclerotic lesion namely, increasing of these specklees, blood flow is obstructed, the angina pectoris that causes heart ischemia to produce; Myocardial infarction is the blood vessel blockage that has the clot that adheres to of precipitation or other reason to cause owing to blood vessel, makes a part of cardiac muscle lose blood supply and downright bad disease, and it and hypertension have clear and definite relation, and thick blood fat is also to be because the obstruction of blood vessel is caused.These several disease major parts all are the raisings because of people's living standard, plenty of meat and fish and a kind of affluenza that is on the drink and causes, and the state of an illness is general, generally adopt medicine control, but poor effect is to cure the symptoms, not the disease.The shock that severe patient causes, and then cause the case of paralysing also of common occurrence, all rescue measures proved ineffectual dead quite a fewly sees, and somewhat expensive do not say, and the misery that the person is caused and the impact that the household is caused are huge.

Existing medicine is generally Western medicine, although instant effect can't fundamentally be treated above-mentioned disease, its medicine generally all has side effect, for patient's health adverse influence is arranged.

Summary of the invention

For existing many deficiencies for the treatment of the medicine existence of heart disease and thick blood fat, the invention provides a kind of medicine for the treatment of heart disease and thick blood fat and preparation method thereof, this medicine is with the Chinese medicine of pure natural, make raw material by natural plants and animal, mainly with Rhizoma Corydalis, Rhizoma Chuanxiong, the Radix Astragali, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Crataegi, Herba Taxilli, Radix Codonopsis, Squama Manis, the medicines such as Hirudo carry out combination and compatibility, so that efficacy of drugs produces synergism, has blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind, the expansion peripheral vessels increase blood flow that reduces blood pressure, improve the heart vigor, stimulating central nervous system, reduce blood pressure and cholesterol, vessel softening, and can promote reparation and the regeneration organized, myocardial necrosis there is good scavenging action, energy enhancing body resistance, and can suppress adrenergic boosting: prevention of arterial is atherosis, prevention and cure of cardiovascular disease, thus hypertension effectively treated, many diseases such as heart disease of thick blood fat and initiation thereof.

Concrete technical scheme of the invention process is:

A kind of medicine for the treatment of heart disease and thick blood fat is characterized in that: the key component of this medicine is counted by weight:

Rhizoma Corydalis 10-35 part, Rhizoma Chuanxiong 15-45 part, Radix Astragali 40-65 part. Radix Puerariae 15-40 part. Radix Salviae Miltiorrhizae 20-45 part. Fructus Crataegi 15-24 part. Herba Taxilli 20-35 part. Radix Codonopsis 40-65 part, Squama Manis 10-20 part, Hirudo 8-15 part.

Select Rhizoma Corydalis as monarch drug in the said components, invigorate blood circulation, dissipating blood stasis is regulated the flow of vital energy, and the effect of pain relieving can coronary artery dilator, increases coronary flow, resists myocardial ischemia, anticoagulant, antithrombotic, alleviates neuralgia, headache etc.;

Select Rhizoma Chuanxiong that blood-activating and qi-promoting is arranged, the effect of wind-expelling pain-stopping has the effect of blood vessel dilating;

Select the Radix Astragali that invigorating QI to consolidate the body surface resistance is arranged, the diuresis poison holding, evacuation of pus, expelling pus and promoting granulation, the myocardial ischemia in the treatment coronary heart disease promotes the circulation of blood, and can reduce blood pressure;

Select Radix Puerariae to have the yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is quenched the thirst, cold, warm headache stiffness of the nape cures the wound, dysphoria with smothery sensation is quenched one's thirst, and alleviates hypertension, angina pectoris, deaf symptom, the effect of expansion coronary vasodilator can make the hat blood flow increase, and vascular resistance reduces, reduce the heart total peripheral resistance, reduce myocardial oxygen consumption; Improve myocardium work efficiency; In addition puerarin can also obviously reduce the generation of the myocardial lactate that ischemia causes, improves the metabolism of infarcted myocardium; Treatment thick blood fat, the caused calmness of coronary heart disease increase, and blood flow is liked resistance, alleviate the symptoms such as dizziness, headache, improve the blood supply amount of ischemic tissue, alleviate myocardial ischemia, limit or dwindle the scope of myocardial infarction, anti-quick arrhythmia, cholesterol reducing;

And the selection Radix Salviae Miltiorrhizae mainly is because it has blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind, and the effect of removing heat from blood detumescence shows especially and 1. can strengthen myocardial contraction, improves cardiac function; 2. to the blood vessel function coronary artery dilating, increase myocardial flow; The expansion peripheral blood vessel, blood flow increases; 3. antithrombotic forms and improves plasmin activity; Prolong, clotting time; Anticoagulant, can promote reparation and the regeneration function organized has good scavenging action to myocardial necrosis;

Herba Taxilli has the meridian dredging, beneficial blood, and invigorating the liver and kidney, the effect of bone and muscle strengthening, the treatment blood deficiency is lost and is supported deficiency of the liver and kindey;

Select Radix Codonopsis, it has invigorating middle warmer, QI invigorating, and the effect of promoting the production of body fluid has excitation to nervous system, energy enhancing body resistance, the expansion peripheral vessels reduces blood pressure, and strengthens hemopoietic function;

And select Fructus Crataegi, and be because it has the atherosclerosis of control, strengthen myocardial contraction, increase painstaking effort output, coronary artery dilator blood vessel, increase coronary flow, reduce myocardial oxygen consumption etc., play heart tonifying and the anginal effect of prevention.In addition, the total flavones in the Fructus Crataegi has the effect of blood vessel dilating and lasting blood pressure lowering; Select Squama Manis, it has the treatment amenorrhea due to stagnation of blood, the lump in the abdomen caking, the effects such as rheumatic arthralgia, the contracture of muscle arteries and veins are to the blood vessel in thick blood fat, the coronary heart disease is calm, special efficacy has been obstructed: select Hirudo, it has removing blood stasis, by becoming silted up, stimulate the menstrual flow, prevent blood coagulation, prevent thrombosis, at cardiovascular and cerebrovascular disease specially good effect is arranged.

The Radix Astragali, Hirudo after Squama Manis is used with, can play the effect that increases blood vessel elasticity, and wherein the use of Squama Manis has the effect of gain so that the drug effect of above-mentioned other two flavors Chinese medicines is able to better release.

In order to play better effect, the inventor further defines the key component of this medicine and counts by weight:

Rhizoma Corydalis 15-30 part. Rhizoma Chuanxiong 20-40 part. Radix Astragali 45-60 part. Radix Puerariae 20-35 part. 25-40 parts of Radix Salviae Miltiorrhizaes. Fructus Crataegi 17-22 part. Herba Taxilli 23-32 part. Radix Codonopsis 45-60 part. Squama Manis 12-18 part. Hirudo 9-14 part;

And the key component of this best medicine is counted by weight:

Rhizoma Corydalis 20-25 part. Rhizoma Chuanxiong 25-35 part. Radix Astragali 50-55 part. Radix Puerariae 25-30 part. 30-35 parts of Radix Salviae Miltiorrhizaes. Fructus Crataegi 19-20 part. Herba Taxilli 26-29 part. Radix Codonopsis 50-55 part, Squama Manis 14-16 part, Hirudo 10-13 part.

Wherein the Squama Manis consumption is excessive, can cause the cost of whole medicine to improve, and is unfavorable for the popularization of medicine, simultaneously the Squama Manis consumption is crossed when low, can obviously reduce with the fiting effect of other drug, thereby reduce the effect of whole medicine, can't reach the effect for the treatment of, so control above-mentioned consumption.

Simultaneously, the inventor also provides the method for preparing said medicine, and its concrete steps are as follows:

At first the proportioning by raw material weighs up the Chinese medicine of respectively distinguishing the flavor of: the yellow wine that Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Herba Taxilli, Fructus Crataegi is joined the 300-500 weight portion, boil to finish fully to yellow wine and steam, product after steaming is dried, put into the water that marmite adds 600-1000 part, boil and kept fluidized state 35-45 minute, cross and filter to remove medicinal residues, stay medicinal liquid to use;

The Radix Astragali, Radix Codonopsis, Squama Manis, Hirudo grinds, its fineness is the 100-150 order, the temperature of above-mentioned medicinal liquid is heated to puts into above-mentioned medicated powder 20-40 ℃ the time and stir, after being penetrated in the medicinal liquid fully in medicated powder, taking the ventilation dries, after drying this medicine is regrinded once, its fineness is the 150-200 order, can obtain drug target.

Why adopt above-mentioned preparation method, consider that mainly Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Herba Taxilli, Fructus Crataegi are carried out wine with yellow wine steams, effective ingredient wherein better can be retained, general's non-medicinal ingredient wherein steams with yellow wine and discharges simultaneously, thereby reduce the toxicity of said medicine, and also contain various trace elements in the yellow wine itself, these trace element all prevent hypertension and thrombotic effect, these trace element also enter in the medicine after wine steams, and advance into the liquidly with follow-up clear water steaming and decocting, further improve the drug effect of medicine; And the mode that adopts afterwards clear water to boil, with the effective ingredient proposition of said medicine, thereby the concentration of effective ingredient in the raising medicinal liquid improves drug effect; And the stable effective ingredients in the Radix Astragali, Radix Codonopsis, Squama Manis, Hirudo is relatively poor, in case adopting the mode of steaming and decocting can destroy effective ingredient wherein, greatly reduce drug effect, so mode that the inventor has added separately after having selected and having ground, and finally adopt mix with above-mentioned medicinal liquid after powder process, obtain final medicinal mixture, thus the effective ingredient that has guaranteed medicine can not lose, medicine has better mating reaction drug effect better each other.

Adopt the medicine of said method preparation, can adopt the direct administration of oral form, concrete medication is: coronary heart disease, thick blood fat patient sooner or later respectively take a bag half an hour after meal, and 1 day 2 times, severe patient one day three times.

By above-mentioned oral administration, patient with severe symptoms 65-75 days, the lighter 35-50 symptom disappeared substantially.Nervous, dizziness that is brought by coronary heart disease, thick blood fat, asthma etc. are taken medicine and were substantially removed this symptom in 5-10 days, and the patient who abides by after this Therapeutic Method is cured is difficult for recurring, and the total effective rate for the treatment of is greater than 90%.

In sum, the invention provides a kind of medicine for the treatment of heart disease and thick blood fat, effect produces synergism between this pharmaceutical composition, has blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind, the expansion peripheral vessels increase blood flow that reduces blood pressure, improve the heart vigor, stimulating central nervous system, reduce blood pressure and cholesterol, vessel softening, and can promote reparation and the regeneration organized myocardial necrosis is had good scavenging action, energy enhancing body resistance, and can suppress adrenergic boosting: prevention of arterial is atherosis, prevention and cure of cardiovascular disease, thus effectively treat hypertension, many diseases such as heart disease of thick blood fat and initiation thereof.

The specific embodiment

The specific embodiment of form is described in further detail foregoing of the present invention by the following examples, but this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.

Embodiment 1

A kind of medicine for the treatment of heart disease and thick blood fat, the key component of this medicine is counted by weight:

30 parts of Rhizoma Corydalis, 40 parts of Rhizoma Chuanxiongs, 55 parts of the Radixs Astragali, 30 parts of Radix Puerariaes, 35 parts of Radix Salviae Miltiorrhizaes, 22 parts of Fructus Crataegis, 33 parts of Herba Taxillis, 55 parts of Radix Codonopsis, 17 parts of Squama Maniss, 13 parts of Hirudos.

Concrete preparation method is:

At first the proportioning by raw material weighs up the Chinese medicine of respectively distinguishing the flavor of: the yellow wine that Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Herba Taxilli, Fructus Crataegi is joined the 300-400 weight portion, boil to finish fully to yellow wine and steam, product after steaming is dried, put into the water that marmite adds 600-800 part, boil and kept fluidized state 35-45 minute, cross and filter to remove medicinal residues, stay medicinal liquid to use;

The Radix Astragali, Radix Codonopsis, Squama Manis, Hirudo grinds, its fineness is the 100-150 order, the temperature of above-mentioned medicinal liquid is heated to puts into above-mentioned medicated powder 20-40 ℃ the time and stir, when being penetrated in the medicinal liquid fully in medicated powder, taking the ventilation dries, after drying this medicine is regrinded once, its fineness is the 150-200 order, can obtain drug target.

Embodiment 2

A kind of medicine for the treatment of heart disease and thick blood fat, the key component of this medicine is counted by weight:

25 parts of Rhizoma Corydalis, 35 parts of Rhizoma Chuanxiongs, 50 parts of the Radixs Astragali, 25 parts of Radix Puerariaes, 30 parts of Radix Salviae Miltiorrhizaes, 20 parts of Fructus Crataegis, 30 parts of Herba Taxillis, 50 parts of Radix Codonopsis, 15 parts of Squama Maniss, 12 parts of Hirudos.

Concrete preparation method is:

At first the proportioning by raw material weighs up the Chinese medicine of respectively distinguishing the flavor of: the yellow wine that Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Herba Taxilli, Fructus Crataegi is joined the 400-500 weight portion, boil to finish fully to yellow wine and steam, product after steaming is dried, put into the water that marmite adds 800-1000 part, boil and kept fluidized state 35-45 minute, cross and filter to remove medicinal residues, stay medicinal liquid to use;

The Radix Astragali, Radix Codonopsis, Squama Manis, Hirudo grinds, its fineness is the 100-150 order, the temperature of above-mentioned medicinal liquid is heated to puts into above-mentioned medicated powder 20-40 ℃ the time and stir, when being penetrated in the medicinal liquid fully in medicated powder, taking the ventilation dries, after drying this medicine is regrinded once, its fineness is the 150-200 order, can obtain drug target.

Embodiment 3

A kind of medicine for the treatment of heart disease and thick blood fat, the key component of this medicine is counted by weight:

20 parts of Rhizoma Corydalis, 30 parts of Rhizoma Chuanxiongs, 45 parts of the Radixs Astragali, 20 parts of Radix Puerariaes, 25 parts of Radix Salviae Miltiorrhizaes, 18 parts of Fructus Crataegis, 27 parts of Herba Taxillis, 45 parts of Radix Codonopsis, 13 parts of Squama Maniss, 11 parts of Hirudos.

Concrete preparation method is:

At first the proportioning by raw material weighs up the Chinese medicine of respectively distinguishing the flavor of: the yellow wine that Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Herba Taxilli, Fructus Crataegi is joined the 350-450 weight portion, boil to finish fully to yellow wine and steam, product after steaming is dried, put into the water that marmite adds 600-1000 part, boil and kept fluidized state 35-45 minute, cross and filter to remove medicinal residues, stay medicinal liquid to use;

The Radix Astragali, Radix Codonopsis, Squama Manis, Hirudo grinds, its fineness is the 100-150 order, the temperature of above-mentioned medicinal liquid is heated to puts into above-mentioned medicated powder 20-40 ℃ the time and stir, when being penetrated in the medicinal liquid fully in medicated powder, taking the ventilation dries, after drying this medicine is regrinded once, its fineness is the 150-200 order, can obtain drug target.

Test example

Sternly so-and-so, the man, 64 years old, Cui Jia village village, Cu Lai town, Tai’an, Shandong Province, fall in a swoon in April, 2008, be diagnosed as the blood supply insufficiency that thick blood fat causes in The Central Hospital of Taian afterwards, because of family's difficulty, can not stay for a long time institute, rear this medicine (medicine that obtains among the embodiment 1) that takes, blood fat recovered normal in 45 days, took again consolidation in 10 days, did not violate so far.

2. Yang, the woman, 55 years old, Shandong Province's Xintai City in palace pressed down Xia Jia village village, because of nervous Long-term taking medicine uncomfortable in chest, did not have clear improvement always, began to take this medicine (medicine that obtains among the embodiment 1) in June, 2008, recovered normal, and violated so far in 30 days.

3. Hu, the man, 53 years old, Shandong Province's Xintai City mining machinery plant, in May, 2009, the People's Hospital is diagnosed as hypertension through Xintai City, thick blood fat, coronary heart disease.Take this medicine (medicine that obtains among the embodiment 2) and returned examination in hospital in 80 days, hypertension, the complete obiteration of thick blood fat symptom, coronary heart disease symptom disappears substantially, takes again 10 days medicines and consolidates, and is not eating medicine so far.

4. Zhang, the woman, Jinan City, Shandong Province air hospital surgeon because of the cardiac muscle stalk match that coronary heart disease causes, rescues in time, there is not life danger, though often take medicine, DeGrain begins to take this medicine (medicine that obtains among the embodiment 2) in March, 2010, take and return institute's inspection after 65 days, coronary heart disease symptom disappears.

Lee so-and-so, the woman, Liang Zhuan town, Tai’an, Shandong Province was diagnosed as coronary heart disease through The Central Hospital of Taian and Beijing Railway hospital in 2009, took this medicine (medicine that obtains the embodiment 3) 70 days from June, 2009, violated so far.

Xu certain, the man, Shandong Province's Xintai City mining machinery plant, find coronary heart disease the end of the year 2009 after, begin to take this medicine (medicine that obtains among the embodiment 3), went back to institutes less than 3 months and check thorough rehabilitation, violate so far.

Except above-mentioned model case, the present inventor intercepts the clinical case 58 people first half of the year in 2010, male 38 people wherein, women 20 people, age 40-70,55 years old mean age;

Give the medicine of embodiment 1-3 according to method of administration of the present invention, treatment January to 4 month.

Therapeutic effect: cure 40 examples, account for 69%; The state of an illness 15 examples that are clearly better account for 26%; Total effective rate is 95%.

Claims (4)

1. medicine for the treatment of heart disease and thick blood fat, it is characterized in that: the key component of this medicine is counted by weight:

Rhizoma Corydalis 10-35 part, Rhizoma Chuanxiong 15-45 part, Radix Astragali 40-65 part, Radix Puerariae 15-40 part, Radix Salviae Miltiorrhizae 20-45 part, Fructus Crataegi 15-24 part, Herba Taxilli 20-35 part, Radix Codonopsis 40-65 part, Squama Manis 10-20 part, Hirudo 8-15 part.

2. medicine according to claim 1, it is characterized in that: the key component of this medicine is counted by weight:

Rhizoma Corydalis 15-30 part, Rhizoma Chuanxiong 20-40 part, Radix Astragali 45-60 part, Radix Puerariae 20-35 part, 25-40 parts of Radix Salviae Miltiorrhizaes, Fructus Crataegi 17-22 part, Herba Taxilli 23-32 part, Radix Codonopsis 45-60 part, Squama Manis 12-18 part, Hirudo 9-14 part.

3. medicine according to claim 1, it is characterized in that: the key component of this medicine is counted by weight:

Rhizoma Corydalis 20-25 part, Rhizoma Chuanxiong 25-35 part, Radix Astragali 50-55 part, Radix Puerariae 25-30 part, 30-35 parts of Radix Salviae Miltiorrhizaes, Fructus Crataegi 19-20 part, Herba Taxilli 26-29 part, Radix Codonopsis 50-55 part, Squama Manis 14-16 part, Hirudo 10-13 part.

4. preparation is such as the method for medicine as described in the claim 1-3, and its concrete steps are as follows:

At first the proportioning by raw material weighs up the Chinese medicine of respectively distinguishing the flavor of: the yellow wine that Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Puerariae, Radix Salviae Miltiorrhizae, Herba Taxilli, Fructus Crataegi is joined the 300-500 weight portion, boil to finish fully to yellow wine and steam, product after steaming is dried, put into the water that marmite adds 600-1000 part, boil and kept fluidized state 35-45 minute, cross and filter to remove medicinal residues, stay medicinal liquid to use;

The Radix Astragali, Radix Codonopsis, Squama Manis, Hirudo grinds, its fineness is the 100-150 order, the temperature of above-mentioned medicinal liquid is heated to puts into above-mentioned medicated powder 20-40 ℃ the time and stir, after being penetrated in the medicinal liquid fully in medicated powder, taking the ventilation dries, after drying this medicine is regrinded once, its fineness is the 150-200 order, can obtain drug target.