CN104013849A - Traditional Chinese medicinal composition for treating hypertension and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating hypertension and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of medicines, and particularly relates to a traditional Chinese medicinal composition for treating hypertension. The composition is prepared from the following raw materials in parts by weight: 100-300 parts of gastrodia elata, 500-1500 parts of eucommia ulmoides, 300-900 parts of apocynum venetum, 100-300 parts of earthworm, 100-300 parts of uncaria rhynchophylla, 100-300 parts of achyranthes root, 300-600 parts of salvia miltiorrhiza, 300-900 parts of seaweed, 300-900 parts of astragalus membranaceus, 250-500 parts of radix paeoniae alba, 300-900 parts of cassia occidentalis, 100-300 parts of tabasheer, 250-500 parts of scutellaria baicalensis, 300-900 parts of gynostemma pentaphylla, 200-400 parts of pseudo-ginseng, 200-400 parts of ligusticum wallichii and the like. The composition can be used for treating headache, dizziness, numbness of limbs, insomnia and other symptoms caused by hypertension, is prepared from traditional Chinese medicinal materials, is safe and effective, does not have remarkable side effects, and can be used for assistant treatment of cervical spondylosis, insufficient brain blood supply and other diseases.
Description
Technical field
The present invention relates to field of medicaments, specifically belong to the Chinese medicine formula in field of medicaments, be specially a kind of Chinese medicine composition of Hypertension.
Background technology
Numeral shows according to statistics, the hypertensive sickness rate of China recent years is ascendant trend year by year, even hypertension can cause serious harm to target organs such as patient's the heart, brain, kidneys, and then cause the multiple complications such as apoplexy, myocardial infarction, renal failure, patient's life security in serious threat, affects patient's quality of life.Therefore, hypertension is one of principal disease of harm China people ' s health.Modern medicine thinks that hypertension is to take systolic arterial pressure or diastolic pressure to increase the disease as main clinical manifestation.Hypertension is to take the systemic arterial blood pressure disease that [adult systolic pressure >=140mmHg(18.4kPa) and or diastolic pressure >=90mmHg(12.0kPa)] be main manifestations that continue to raise.Can be divided into two classes, essential hypertension and secondary hypertension.Wherein small part hypertension is a kind of symptom of Other diseases (as chronic glomerulonephritis, renal artery stenosis, adrenal gland and pituitary adenoma etc.), is called symptomatic hypertension or secondary hypertension; Overwhelming majority hypertension is a kind of independence disease that reason understands not yet completely, is called the high blood of constitutional or essential hypertension, is commonly referred to as hypertension.
Hypertension pathogeny is not yet completely clear, at present clearer and more definite paathogenic factor has: inherited genetic factors, dietary factors, occupation and spiritual psychological stressful factors other factors and overweight or fat, sodium too much, smoking, age growth and shortage physical exertion etc., these are all the important risk factor of hypertension.Hypertensive pathogenesis is completely unclear, thinks that at present essential hypertension is by long-term spiritual pessimal stimulation, causes cerebral cortex excited and suppress imbalance, and the many factors of impact jointly causes tiny tremulous pulse contraction, spasm and causes hypertension each other.Sympathetic activation causes renal ischaemia in addition, stimulates the e emiocytosis feritin of the other device of ball.Feritin makes proangiotensin change angiotensinⅠ into; Under the effect of angiotensin activating enzymes (ACE), form angiotensinⅡ.It is generally acknowledged that angiotensinⅡ can cause that tiny tremulous pulse shrinks strongly, causes elevation of the blood pressure.Sodium water stores and can make extracellular fluid increase simultaneously, causes heart output to increase, and causes that petty action astillen water content increases, and Peripheral resistance increases, and gradually causes hypertension; And due to Na+, Ca2+ Enrichment in vascular smooth muscle, arterial wall smooth muscle contraction is strengthened, can make distal vessels spasm, diminish, hardening causes hypertension.
Diagnosing Hypertension standard: with reference to 13 editions standards of the practical internal medicine > > of < <.
SBPmmHg DBPmmHg
Hypertension I level (slightly) 140-159 90-99
Subgroup borderline hypertension 140-149 90-94
Hypertension II level (moderate) 160-179 100-109
Hypertension III level (severe) >180 >110
Hypertension clinical scale standard:
(1) I level hypertension: blood pressure reaches Definite Hypertension level, clinical in heart and brain kidney complication shower.
(2) II level hypertension: high pressure reaches Definite Hypertension level, and there is a following person, x-ray, electrocardiogram or ultrasonic examination are shown in left ventricular hypertrophy, and examination of ocular fundus is shown in has tremulous pulse general or limitation in optical fundus to narrow down, urine protein or creatinine concentration of plasma slightly raise (106-177mmol/L); Ultrasonic or x-ray has atherosclerotic plaque.
(3), there is organ injury clinical manifestation: the heart in III level hypertension: blood pressure reaches Definite Hypertension level: angina pectoris, myocardial infarction, heart failure.Brain: transient ischemic attack, apoplexy, hypertensive encephalopathy.Optical fundus: retinal hemorrhage, ooze out companion or do not accompany papilloedema.Kidney: more than serum creatinine 177mmol/L, renal failure.Vascular dissection aneurysm, arteriosclerosis obliterans.
Hypertension is the common cardiovascular disease of China, and in clinical being more common in, old people, the course of disease is very long, normal because being difficult for adhering to treating to be developed to late period.Hypertension has more existing headache, feeling of fullness in the head, dizzy, numb limbs and tense tendons, agitation, insomnia, cardio palmus, (1) diuretic that adopt: as SHUANGKE more; (2) B-receptor blocking agent: as Pu Nailuoer (propranolol), sotalol; (3) calcium antagonist: as nifedipine (nifedipine), amlodipine; (4) as converting enzyme inhibitor: treatments such as captopril (captopril) benazeprils.These Drug combinations have better effect to the treatment of hypertension, but chemicals side effect is large, (long-term cough after some medicine clothes) and gastrointestinal reaction are serious, and some medicine long-term taking also has impact and infringement in various degree to function and organ simultaneously.In addition indivedual drug prices are expensive, and should not take over a long time, thereby make the extensive life-time service of clinical hyperpietic be subject to larger restriction
Summary of the invention
The object of this invention is to provide a kind of medicine that can be used for the treatment of the symptoms such as headache that hypertension causes, dizzy, numb limbs and tense tendons.This medicine is made by Chinese medicine, safe and effective, and non-evident effect also can be used for the sick auxiliary treatment such as cervical spondylosis, blood supply in brain deficiency.
Capsule formulation providing above-mentioned Chinese medicine composition and preparation method thereof is provided.
Concrete technical scheme of the present invention is:
A kind of Chinese medicine composition of Hypertension, said composition is by the made medicament of the crude drug of following weight portion proportioning: Rhizoma Gastrodiae 100-300 part, Cortex Eucommiae 500-1500 part, Herba Apocyni veneti 300-900 part, Pheretima 100-300 part, Ramulus Uncariae Cum Uncis 100-300 part, Radix Achyranthis Bidentatae 100-300 part, Radix Salviae Miltiorrhizae 300-600 part, Sargassum 300-900 part, Radix Astragali 300-900 part, Radix Paeoniae Alba 250-500 part, Semen Cassiae 300-900 part, Concretio Silicea Bambusae 100-300 part, Radix Scutellariae 250-500 part, Herb Gynostemmae Pentaphylli 300-900 part, Radix Notoginseng 200-400 part, Rhizoma Chuanxiong 200-400 part, Fructus Atriplicis Sibiricae 100-300 part, Radix Cynanchi Paniculati 250-500 part, Spica Prunellae 100-300 part.
As preferably, the weight proportion for the treatment of each crude drug in hypertensive Chinese medicine composition is: Rhizoma Gastrodiae 150-250 part, Cortex Eucommiae 700-1300 part, Herba Apocyni veneti 500-700 part, Pheretima 150-250 part, Ramulus Uncariae Cum Uncis 150-250 part, Radix Achyranthis Bidentatae 150-250 part, Radix Salviae Miltiorrhizae 400-500 part, Sargassum 500-700 part, Radix Astragali 500-700 part, Radix Paeoniae Alba 350-400 part, Semen Cassiae 500-00 part, Concretio Silicea Bambusae 150-250 part, Radix Scutellariae 350-400 part, Herb Gynostemmae Pentaphylli 500-700 part, Radix Notoginseng 250-350 part, Rhizoma Chuanxiong 250-350 part, Fructus Atriplicis Sibiricae 150-250 part, Radix Cynanchi Paniculati 350-400 part, Spica Prunellae 150-250 part.
As further preferred, the weight proportion for the treatment of each crude drug in hypertensive Chinese medicine composition is: 200 parts, Rhizoma Gastrodiae, 1000 parts of the Cortexs Eucommiae, 600 parts of Herba Apocyni venetis, 200 parts of Pheretimas, 200 parts of Ramulus Uncariae Cum Uncis, 200 parts of Radix Achyranthis Bidentataes, 450 parts of Radix Salviae Miltiorrhizaes, 600 parts of Sargassums, 600 parts of the Radixs Astragali, 380 parts of the Radix Paeoniae Albas, 600 parts of Semen Cassiae, 200 parts of Concretio Silicea Bambusaes, 380 parts of Radix Scutellariaes, 600 parts of Herb Gynostemmae Pentaphylli, 300 parts of Radix Notoginseng, 300 parts of Rhizoma Chuanxiongs, 300 parts of Fructus Atriplicis Sibiricaees, 380 parts of Radix Cynanchi Paniculatis, 200 parts of Spica Prunellaes.
Treat hypertensive Chinese medicine composition, described medicament is capsule.
According to above-mentioned formula, prepare the method for the treatment of hypertensive Chinese medicine composition, comprise the following steps:
(1), required medicine selected, clean.First Rhizoma Gastrodiae, the Cortex Eucommiae, Herba Apocyni veneti, Pheretima, Ramulus Uncariae Cum Uncis, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Sargassum, Radix Scutellariae, the Radix Astragali, Herb Gynostemmae Pentaphylli, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, Spica Prunellae removed to silt, lime-ash afterwash, dry, chopping; Semen Cassiae, Concretio Silicea Bambusae are cleaned, dried; Airing after vinegar parch for the Radix Paeoniae Alba; Airing after Radix Notoginseng, Rhizoma Chuanxiong clean with 60 degree Chinese liquor, mashes;
(2) Rhizoma Gastrodiae of, step (1) being processed, the Cortex Eucommiae, Herba Apocyni veneti, Pheretima, Ramulus Uncariae Cum Uncis, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Sargassum, the Radix Paeoniae Alba, Semen Cassiae, Radix Scutellariae, the Radix Astragali, Concretio Silicea Bambusae, Herb Gynostemmae Pentaphylli, Radix Notoginseng, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, Spica Prunellae are in the ratio preparation in formula, mix, again dry, pulverizing is ground into fine powder, cross 80-120 mesh sieve, smalls is standby, under the cryogenic conditions of 60 ℃, is dried, in incapsulating, be prepared into capsule.The method of preparing capsule adopts conventional method.In above-mentioned capsule, in every capsules, containing medicine, be about 0.35-0.38 gram.
In recent years, along with the quickening of living standard of urban and rural population rhythm, the change of the partially different and life style of daily life, hyperpietic is increasing.Especially in mid-aged population, sickness rate sharply increases.Hypertension belongs to the disease categories such as motherland's medical science " headache ", " dizzy ", " apoplexy ", " brain numbness ".Its pathogenic factor is many by having a liking for food greasy and surfeit flavour, overtired or asthenia with age, deficiency of the kidney etc. cause internal organs imbalance between YIN and YANG, or because of angry, excessive drinking, excessively thereby psychentonia causes excessive rising of liver-YANG, wind-fire is fought mutually, disorder of QI and blood, the mutual resistance of the expectorant stasis of blood, the stagnant channels of the stasis of blood is main pathogenesis, and due to main cause wind, fire, expectorant, the stasis of blood.And mainly with headache, dizzy, limb is numb, insomnia, ear toot be main clinical manifestation.Clinical many minutes excessive rising of liver-YANG, liver-fire are flourishing, hyperactivity of YANG due to deficiency of YIN, phlegm-damp are stopped up the pattern of syndrome such as Sheng, obstruction of collaterals by blood stasis, deficiency of both YIN and YANG, with " yang hyperactivity " and " blood stasis " for.Pathological changes internal organs are attached most importance to liver, kidney, take again liver as main, said through > > in < <: " all wind trembling and dizziness, all belong to liver ".The traditional Chinese medical science is determined main with suppressing the hyperactive liver to relieve the wind syndrome, promoting blood circulation to remove obstruction in the collateral, and the relieving convulsion that reduces phlegm is for controlling.Rhizoma Gastrodiae suppressing the hyperactive liver to relieve the wind syndrome, blood pressure lowering in side, Cortex Eucommiae liver and kidney tonifying, blood pressure lowering are monarch; Radix Scutellariae, Ramulus Uncariae Cum Uncis, Folium Apocyni Veneti, Pheretima, the Radix Paeoniae Alba, Radix Achyranthis Bidentatae, Semen Cassiae clearing liver-fire for calming endogenous wind, dredging collateral spasmolytic, easing the affected liver kidney tonifying be take blood pressure lowering as minister; Radix Notoginseng, Rhizoma Chuanxiong, Fructus Tribuli, Radix Cynanchi Paniculati blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain; The loose blood blood pressure lowering of nourishing blood of the blood pressure lowering of Radix Astragali QI invigorating tonify deficiency, Radix Salviae Miltiorrhizae; Concretio Silicea Bambusae, Sargassum, Herb Gynostemmae Pentaphylli, promoting the circulation of QI and reducing phlegm, hypertension and hyperlipemia is assistant; The diuresis of Spica Prunellae removing heat from the liver to lower the high blood pressure is for making.Medicine-feeding is share and is gathered altogether the merit of suppressing the hyperactive liver relieving convulsion, dredging collateral blood pressure lowering, thereby reaches the object of blood pressure lowering and stabilizing blood pressure.
Modern medicine grinds modern pharmacological research and thinks: in this Chinese medicine composition, all medicines all have hypotensive effect in various degree.Wherein not only blood pressure lowering but also control dizzy of Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis; The not only blood pressure lowering but also improve microcirculation of Radix Salviae Miltiorrhizae, Radix Notoginseng; The both blood pressure lowerings and still have stronger effect for reducing fat of Herb Gynostemmae Pentaphylli, Semen Cassiae, Sargassum, all can kill two birds with one stone.The Radix Astragali has blood pressure lowering, and blood sugar lowering, blood fat reducing, improve coronary blood supply, improves renal function, can strengthen immunocompetence again; Not only blood pressure lowering but also control headache of Rhizoma Chuanxiong, also improves microcirculation, is killing three birds with one stone.All medicines have share the merit of blood pressure lowering, blood sugar lowering, blood fat reducing, have expelling wind to relieve convulsion, blood pressure lowering pain relieving.Be used for the treatment of the patients such as headache that hypertension causes, dizzy, numb limbs and tense tendons.Can Long-term taking medicine, and safe and effective, the Chinese medicine of non-evident effect.Also can be used for the sick auxiliary treatment such as cervical spondylosis, blood supply in brain deficiency.Treatment hypertension, except blood pressure lowering, the infringement of the target organs such as the prevention heart, brain, kidney is even more important.This Chinese medicine compositions, with regard to the mechanism of blood pressure lowering, from different angles, having proved its mechanism of action is multipath, multi-faceted.At present research finds, aspect the preventing and treating of the reverse of some damaged organ and complication, also having certain effect.And these effects do not rely on effective controlling of blood pressure that is to say that this medicine has certain preventive and therapeutic effect to hypertension complication.It is regulating metabolism disorder, control target organ damage, the generation of minimizing risk factor, is promoting organ self reparation, improves patient's symptom and improving the aspects such as patients ' life quality have its distinctive curative effect and advantage simultaneously.The hypertensive Chinese medicine composition for the treatment of provided by the invention, is pure Chinese medicine, and treatment hypertension is had to significant curative effect, and safe, nontoxic, pair effect and untoward reaction.Constitutional and secondary hypertension are all had certain effect, can not use separately hypertension III phase (severe) and hypertensive crisis patient, can use Western medicine instead and coordinate Western medicine Comprehensive Treatment.According to observation of curative effect for many years with follow up a case by regular visits to, can not rebound after taking patient's drug withdrawal of pharmaceutical composition of the present invention, and not damage internal organs and do not hinder healthy energy.But the Chinese medicine half-life is short, so need take every day three times.
Good effect of the present invention is embodied in:
(1), this Chinese medicine composition is made by original front ten taste medicines, the hypotensive effect of this medicine is also all well and good, if but meet three-hypers (hypertension, hyperglycemia, hyperlipidemia) patient, just poor effect, and to improve and eliminate headache, dizzy, limb is numb etc., and related symptoms is also ineffective.
(2) by my clinical experiment many times, medicine is added and subtracted to adjustment, and lay particular emphasis on there is blood pressure lowering, the use of selecting the product that reduce phlegm with promoting blood circulation to remove obstruction in the collateral of blood fat reducing, blood sugar lowering triple role medicine, and addition or subtraction of changes repeatedly; On dosage, also carry out repetitious exploration and regulation and control, through the optimization more than 3 years and clinical practice and observation of curative effect, formed present Chinese medicine composition.The clinical result of use of said composition shows this medicine, and not only antihypertensive effect is desirable, and to reducing " three-hypers " index, improving and eliminating related symptoms has good curative effect.
(3), this medicine determined curative effect, without any untoward reaction, have no side effect, and economical and practical, be deeply subject to the favorable comment of extensive patients.
The specific embodiment
Below, by embodiment and clinical observation test example in the specific embodiment, Chinese medicine composition of the present invention and curative effect thereof are described further.
Embodiment 1:
The Chinese medicine composition of the present embodiment is made by the crude drug of following weight, unit (kg):
Rhizoma Gastrodiae 2, the Cortex Eucommiae 10, Herba Apocyni veneti 6, Pheretima 2, Ramulus Uncariae Cum Uncis 2, Radix Achyranthis Bidentatae 2, Radix Salviae Miltiorrhizae 4.5, Sargassum 6, the Radix Astragali 6, the Radix Paeoniae Alba 3.8, Semen Cassiae 6, Concretio Silicea Bambusae 2, Radix Scutellariae 3.8, Herb Gynostemmae Pentaphylli 6, Radix Notoginseng 3, Rhizoma Chuanxiong 3, Fructus Atriplicis Sibiricae 3, Radix Cynanchi Paniculati 3.8, Spica Prunellae 2.
The Chinese medicine composition preparation method of the present embodiment, comprises the following steps:
(1), required medicine selected, clean.First Rhizoma Gastrodiae, the Cortex Eucommiae, Herba Apocyni veneti, Pheretima, Ramulus Uncariae Cum Uncis, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Sargassum, Radix Scutellariae, the Radix Astragali, Herb Gynostemmae Pentaphylli, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, Spica Prunellae removed to silt, lime-ash afterwash, dry, chopping; Semen Cassiae, Concretio Silicea Bambusae are cleaned, dried; The Radix Paeoniae Alba is with carrying out airing after vinegar parch; Airing after Radix Notoginseng, Rhizoma Chuanxiong clean with 60 degree Chinese liquor, mashes.
(2) Rhizoma Gastrodiae of, step (1) being processed, the Cortex Eucommiae, Herba Apocyni veneti, Pheretima, Ramulus Uncariae Cum Uncis, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Sargassum, the Radix Paeoniae Alba, the Radix Astragali, Semen Cassiae, Concretio Silicea Bambusae, Radix Scutellariae, Herb Gynostemmae Pentaphylli, Radix Notoginseng, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, Spica Prunellae are in the ratio preparation in formula, mix, again dry, pulverizing is ground into fine powder, cross 80-120 mesh sieve, smalls is standby, and low temperature (60 ℃) is dry, in incapsulating, be prepared into capsule.In every capsules, contain approximately 0.35 gram of medicine.
Clinical observation on the therapeutic effect: medicine of the present invention, through clinical trial for many years, is accepted out-patient's 120 examples for medical treatment, age 35-86 year, medical history June-30 year, men and women does not limit.Through measuring blood pressure, be all systolic pressure >=140mmHg(18.4kPa) and or diastolic pressure >=90mmHg(12.0kPa)] for main manifestations, hypertension I level (slightly) 80 examples wherein, hypertension II level (moderate) 30 examples; Hypertension III level (severe) 10 examples.Excessive rising of liver-YANG 50 examples wherein, flourishing 20 examples of liver-fire, phlegm-damp is stopped up and is contained 25 examples, obstruction of collaterals by blood stasis 15 examples, deficiency of both YIN and YANG 10 examples.High blood hypertension 110 examples of constitutional, secondary hypertension 10 examples.This group case major part is through western medical treatment poor effect person or the person that is reluctant to take Western medicine.
Above-mentioned patient takes the capsule 3 times of the present embodiment every day, and each serving with 2-3, every day, took half an hour after meal, within 30 days, is a course for the treatment of, and be a treatment cycle March; Be an observation cycle half a year.According to the state of an illness, take for 1-June continuously.During taking this medicine, inactive other medicines, emphasize low salt diet.
Curative effect judging standard: cure: symptom is eliminated.Blood pressure is normal or critical; Take a turn for the better: symptom, sign obviously alleviate, or alleviate to some extent, indivedual transference cures.Blood pressure drops, or the one-level that declines forward, (falling one-level, as II level is down to I level); Invalid: symptom, sign are not improved.Blood pressure is without obvious decline.
After treatment March (cycle), symptom is obviously improved, and especially headache, dizzy, insomnia, limb fiber crops are clearly better.Treat half a year, transference cure, blood pressure is normal.If half a year is demonstrate,proved shape without improvement in treatment, blood pressure is without this medicine of stopping using that declines.Use instead or add and use Western medicine.In 120 examples, cure 25 examples, 87 examples that take a turn for the better, invalid 8 examples.Total effective rate 93%.Mostly carried out following up a case by regular visits to of half a year to two year.
Embodiment 2:
Chinese medicine composition in the present embodiment is made by the crude drug of following weight, unit (g):
Rhizoma Gastrodiae 200g, Cortex Eucommiae 1000g, Herba Apocyni veneti 600g, Pheretima 200g, Ramulus Uncariae Cum Uncis 200g, Radix Achyranthis Bidentatae 200g, Radix Salviae Miltiorrhizae 450g, Sargassum 600g, Radix Astragali 600g, Radix Paeoniae Alba 380g, Semen Cassiae 600g, Concretio Silicea Bambusae 200g, Radix Scutellariae 380g, Herb Gynostemmae Pentaphylli 600g, Radix Notoginseng 300g, Rhizoma Chuanxiong 300g, Fructus Atriplicis Sibiricae 300g, Radix Cynanchi Paniculati 380g, Spica Prunellae 200g.
Chinese medicine composition in the present embodiment is prepared as to capsule, and preparation method, with implementing 1, contains approximately 0.35 gram of medicine in every capsules.
Model case: shut out certain, female, 47 years old, because of headache repeatedly, dizzy 1 year, accompany agitation, have a sleepless night March, October 2 in 2003, Lai institute was medical.Patient is the year before because being subject to occur headache, dizzy, insomnia after direct stimulation, through taking a turn for the better with Chinese medicine and western medicine medical treatment first quarter moon, afterwards every because of headache after anxious state of mind or flu, dizzy increasing the weight of, half a year, cause and household quarrelled rear severe headache, dizzy vomiting then, and measuring blood pressure 146/105mmHg. is through treating January with captopril and Chinese medicine (decoction medicine is not quite clear), card shape slightly take a favorable turn, blood pressure is in a slight decrease, increases the weight of companion's dry cough but have a sleepless night, vexed, continue with medicine-feeding without being clearly better.Examine quarter: headache paroxysm is more acute, and take both sides as Millefolium, dizzy, being irritable and getting angry easily, vomiting sputum, inappetence, insomnia and dreamful sleep, oliguria with reddish urine, red tongue, tongue is white thick greasy, in micro-Huang, stringy,thready and rapid pulse.Measuring blood pressure 140/102mmHg. Syndrome Differentiation of Chinese Medicine belongs to headache.Be that liver-fire is hot and suffocating, due to stasis of blood stagnation of phlegm is stagnant.Control with purging liver-heat clearing away phlegm and removing blood stasis, removing obstruction in the collateral to relieve pain.Take the capsule 3 times of the Chinese medicine composition of the present embodiment every day, each serving with 3,30 minutes after meal boiled water takes at every turn.Within 30 days, be a course for the treatment of, alcohol prohibition and maror, low salt diet, and advise its maintenance to be emotionally stable, phychology is genial.Take after 1 course for the treatment of (January) further consultation on November 1 in 2003: it is aobvious that patient tells headache, dizzy alleviating, in time, coughs up phlegm, and still can eat, and sleep is steady, light red tongue, tongue is white, stringy and thready pulse.Measuring blood pressure 130/95mmHg. following the service March.On February 1st, 2004 examines again: appetite is good, and all diseases are eliminated.Measuring blood pressure 130/90mmHg. is continuous takes half a year, follows up a case by regular visits to blood pressure normal.
Embodiment 3:
Chinese medicine composition in the present embodiment is made by the crude drug of following weight, unit (g):
Rhizoma Gastrodiae 300g, Cortex Eucommiae 1500g, Herba Apocyni veneti 900g, Pheretima 300g, Ramulus Uncariae Cum Uncis 300g, Radix Achyranthis Bidentatae 300g, Radix Salviae Miltiorrhizae 600g, Sargassum 900g, Radix Astragali 900g, Radix Paeoniae Alba 500g, Semen Cassiae 900g, Concretio Silicea Bambusae 300g, Radix Scutellariae 500g, Herb Gynostemmae Pentaphylli 900g, Radix Notoginseng 400g, Rhizoma Chuanxiong 400g, Fructus Atriplicis Sibiricae 300g, Radix Cynanchi Paniculati 500g, Spica Prunellae 300g.
Chinese medicine composition in the present embodiment is prepared as to capsule, and preparation method, with implementing 1, contains approximately 0.35 gram of medicine in every capsules.
Model case: Wang, man 62 years old, first visit on March 6 in 2008.Readme headache, insomnia half a year, companion's numb limbs and tense tendons March.At county hospital, examine as hypertension.Examine quarter: headache, dizzy, and companion's numb limbs and tense tendons, take left hand as Millefolium, bends and stretches the limbs freely, light red tongue, tongue is greasy in vain, and there is petechia on limit, thready pulse.Measuring blood pressure 160/110mmHg. shows through the how general duty of cranium: the blood supply insufficiency that circulates after brain, cerebral blood vessel elasticity reduces.Syndrome Differentiation of Chinese Medicine belong to stasis of blood stagnation of phlegm stagnant due to.Control with clearing away phlegm and removing blood stasis removing obstruction in the collateral to relieve pain.Take the capsule 3 times of the Chinese medicine composition of the present embodiment every day, each serving with 3,30 minutes after meal boiled water takes at every turn.Within 30 days, be a course for the treatment of, fasting wine and maror, low salt diet.Take after 1 course for the treatment of (January) further consultation on April 6 in 2008: patient only tells headache, dizzy alleviating, numb limbs and tense tendons takes a turn for the better, light red tongue, tongue is white, and limit has petechia light, thready pulse.Measuring blood pressure 152/105mmHg. following the service March.2008 7 month in and month out 6 Lai institutes examine again: appetite is good, and all diseases are aobvious.Measuring blood pressure 130/95mmHg. is continuous takes half a year, advises it to strengthen upper limb neck functional exercise.Examine the elimination of all diseases on January 5th, 2009, measuring blood pressure 130/88mmHg.Follow up a case by regular visits to 2 years, this medicine is taken always, and blood pressure is normal.
Embodiment 4:
Chinese medicine composition in the present embodiment is made by the crude drug of following weight, unit (g):
Rhizoma Gastrodiae 100g, Cortex Eucommiae 500g, Herba Apocyni veneti 300g, Pheretima 100g, Ramulus Uncariae Cum Uncis 100g, Radix Achyranthis Bidentatae 100g, Radix Salviae Miltiorrhizae 300g, Sargassum 300g, Radix Astragali 300g, Radix Paeoniae Alba 250g, Semen Cassiae 300g, Concretio Silicea Bambusae 100g, Radix Scutellariae 250g, Herb Gynostemmae Pentaphylli 300g, Radix Notoginseng 200g, Rhizoma Chuanxiong 200g, Fructus Atriplicis Sibiricae 100g, Radix Cynanchi Paniculati 250g, Spica Prunellae 100g.
Chinese medicine composition in the present embodiment is prepared as to capsule, and preparation method, with implementing 1, contains approximately 0.35 gram of medicine in every capsules
Model case: to certain, female.63 years old, first visit on October 11 in 2009.Readme has hypertension history 5 years, normal existing headache, dizziness, dizzy, upper limb body is numb, lumbago and skelalgia, soreness of the waist and knees, ear toot, insomnia and dreamful sleep.Before 2 years, suffered from diabetes.Now above demonstrate,prove as before, and dizzy, bitterly gradually heavy.Look into hands and bend and stretch the limbs freely, cervical vertebra moving is slightly limited, and waist is kowtowed pain, and leg extensions is normal, light red tongue, and tongue is white, thready and rapid pulse.Measuring blood pressure 165/112mmHg. shows through the how general duty of cranium: bilateral vertebra sound basilar artery blood flow slows down, and left side brain machine vertebral artery blood vessel moves exponent increase.The heart is super to be shown: left diastolic function obviously reduces.X-ray shows: cervical vertebra, many vertebral bodys of lumbar vertebra hyperosteogeny.Fasting glucose 7.8mmoI/L.Triglyceride 1.83mmoI/L.Syndrome Differentiation of Chinese Medicine belongs to Liver and kidney the moon, due to stagnation of blood stasis.Control with liver and kidney tonifying disperse blood stasis and dredge collateral.Take the capsule 3 times of the Chinese medicine composition of the present embodiment every day, each serving with 3,30 minutes after meal boiled water takes at every turn.Within 30 days, be a course for the treatment of, alcohol prohibition and maror, low salt diet.Take after 1 course for the treatment of further consultation on November 9 in 2009: patient tells headache only, ear toot, dizzy alleviating, limb fiber crops are aobvious, sleep, but lumbago and skelalgia is without subtracting, light red tongue, tongue is white, thready pulse.Measuring blood pressure 155/110mmHg. check blood fat is normal.Following the service March.Advise it suitably to carry out neck, waist, lower limb functional exercise.2010 2 month in and month out 8 Lai institutes examine again: dizzy only, ear toot, limb fiber crops more, sleep is steady, neck, waist, the pain that has a pain in the leg take a turn for the better obviously.Fasting glucose 6.2mmoI/L.Measuring blood pressure 135/96mmHg. is continuous takes half a year, and on August 5th, 2010 examines, and all diseases are eliminated, blood pressure 130/88mmHg.Follow up a case by regular visits to 1 year, blood pressure is normal.
Embodiment 5:
Chinese medicine composition in the present embodiment is made by the crude drug of following weight, unit (g):
Rhizoma Gastrodiae 50g, Cortex Eucommiae 250g, Herba Apocyni veneti 150g, Pheretima 50g, Ramulus Uncariae Cum Uncis 50g, Radix Achyranthis Bidentatae 50g, Radix Salviae Miltiorrhizae 150g, Sargassum 150g, Radix Astragali 150g, Radix Paeoniae Alba 225g, Semen Cassiae 150g, Concretio Silicea Bambusae 50g, Radix Scutellariae 175, Herb Gynostemmae Pentaphylli 150g, Radix Notoginseng 100g, Rhizoma Chuanxiong 100g, Fructus Atriplicis Sibiricae 50g, Radix Cynanchi Paniculati 170g, Spica Prunellae 50g.
Chinese medicine composition in the present embodiment is prepared as to capsule, and preparation method, with implementing 1, contains approximately 0.35 gram of medicine in every capsules.
Model case: Zhang, man, 38 years old.First visit on March 20 in 20012; Readme is normal existing headache, vexed near month, insomnia.It is higher that blood pressure is measured in health check-up last week, and blood pressure is 130/95mmHg.Take the capsule 3 times of the Chinese medicine composition of the present embodiment every day, each serving with 2,30 minutes after meal boiled water takes at every turn.30 days is a course for the treatment of, advises its careful food maror, requires low salt diet.Take after 1 course for the treatment of further consultation on April 19 in 2012: patient only tells headache, and ataraxia, sleeps.Measuring blood pressure 120/85mmHg. following the service March.Within 2012 7, within 16th, examine check month in and month out, blood pressure is normal.Follow up a case by regular visits to half a year without extremely.
Embodiment 6:
Chinese medicine composition in the present embodiment is made by the crude drug of following weight, unit (g):
Rhizoma Gastrodiae 20g, Cortex Eucommiae 100g, Herba Apocyni veneti 60g, Pheretima 20g, Ramulus Uncariae Cum Uncis 20g, Radix Achyranthis Bidentatae 20g, Radix Salviae Miltiorrhizae 45g, Sargassum 60g, Radix Astragali 60g, Radix Paeoniae Alba 38g, Semen Cassiae 60g, Concretio Silicea Bambusae 20g, Radix Scutellariae 38g, Herb Gynostemmae Pentaphylli 60g, Radix Notoginseng 30g, Rhizoma Chuanxiong 30g, Fructus Atriplicis Sibiricae 30g, Radix Cynanchi Paniculati 38g, Spica Prunellae 20g.
Chinese medicine composition in the present embodiment is prepared as to capsule, and preparation method, with implementing 1, contains approximately 0.35 gram of medicine in every capsules.
Model case: permitted certain, 78 years old, first visit on January 5 in 2013.Patient's readme, the flat body of stating is good for, seldom ill.A few days ago meet grandson daughter-in-law, conscious dizziness after drinking continuously several days, insomnia.Yesterday is higher at school infirmary's measuring blood pressure, blood pressure 160/98mmHg.Take the capsule 3 times of the Chinese medicine composition of the present embodiment every day, each serving with 2,30 minutes after meal boiled water takes at every turn.Within 30 days, be a course for the treatment of, alcohol prohibition and maror, advise its low salt diet.Take after 1 course for the treatment of further consultation on February 5 in 2013: patient only tells headache, sleeps.Measuring blood pressure 150/86mmHg. following the service March.On August 5th, 2013 checks, and blood pressure is normal, and health is healthy.
Important component in the present invention is indispensable, lacks medical material wherein, and its medicinal efficacy bringing is just corresponding disappearance also, and the composition in this medicine also exists co-operating effect, indispensable.
Claims (5)
1. the Chinese medicine composition of a Hypertension, it is characterized in that: said composition is by the made medicament of the crude drug of following weight portion proportioning: Rhizoma Gastrodiae 100-300 part, Cortex Eucommiae 500-1500 part, Herba Apocyni veneti 300-900 part, Pheretima 100-300 part, Ramulus Uncariae Cum Uncis 100-300 part, Radix Achyranthis Bidentatae 100-300 part, Radix Salviae Miltiorrhizae 300-600 part, Sargassum 300-900 part, Radix Astragali 300-900 part, Radix Paeoniae Alba 250-500 part, Semen Cassiae 300-900 part, Concretio Silicea Bambusae 100-300 part, Radix Scutellariae 250-500 part, Herb Gynostemmae Pentaphylli 300-900 part, Radix Notoginseng 200-400 part, Rhizoma Chuanxiong 200-400 part, Fructus Atriplicis Sibiricae 100-300 part, Radix Cynanchi Paniculati 250-500 part, Spica Prunellae 100-300 part.
2. according to the hypertensive Chinese medicine composition for the treatment of described in right 1, it is characterized in that: the weight proportion of crude drug is: Rhizoma Gastrodiae 150-250 part, Cortex Eucommiae 700-1300 part, Herba Apocyni veneti 500-700 part, Pheretima 150-250 part, Ramulus Uncariae Cum Uncis 150-250 part, Radix Achyranthis Bidentatae 150-250 part, Radix Salviae Miltiorrhizae 400-500 part, Sargassum 500-700 part, Radix Astragali 500-700 part, Radix Paeoniae Alba 350-400 part, Semen Cassiae 500-00 part, Concretio Silicea Bambusae 150-250 part, Radix Scutellariae 350-400 part, Herb Gynostemmae Pentaphylli 500-700 part, Radix Notoginseng 250-350 part, Rhizoma Chuanxiong 250-350 part, Fructus Atriplicis Sibiricae 150-250 part, Radix Cynanchi Paniculati 350-400 part, Spica Prunellae 150-250 part.
3. according to the hypertensive Chinese medicine composition for the treatment of described in right 1, it is characterized in that the weight proportion of crude drug is: 200 parts, Rhizoma Gastrodiae, 1000 parts of the Cortexs Eucommiae, 600 parts of Herba Apocyni venetis, 200 parts of Pheretimas, 200 parts of Ramulus Uncariae Cum Uncis, 200 parts of Radix Achyranthis Bidentataes, 450 parts of Radix Salviae Miltiorrhizaes, 600 parts of Sargassums, 600 parts of the Radixs Astragali, 380 parts of the Radix Paeoniae Albas, 600 parts of Semen Cassiae, 200 parts of Concretio Silicea Bambusaes, 380 parts of Radix Scutellariaes, 600 parts of Herb Gynostemmae Pentaphylli, 300 parts of Radix Notoginseng, 300 parts of Rhizoma Chuanxiongs, 300 parts of Fructus Atriplicis Sibiricaees, 380 parts of Radix Cynanchi Paniculatis, 200 parts of Spica Prunellaes.
4. according to the hypertensive Chinese medicine composition of the treatment described in any one in right 1-3, it is characterized in that: described medicament is capsule.
5. the preparation method of the hypertensive Chinese medicine composition for the treatment of claimed in claim 4, is characterized in that comprising the following steps:
(1), required medicine is selected, clean, first Rhizoma Gastrodiae, the Cortex Eucommiae, Herba Apocyni veneti, Pheretima, Ramulus Uncariae Cum Uncis, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Sargassum, Radix Scutellariae, the Radix Astragali, Herb Gynostemmae Pentaphylli, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, Spica Prunellae removed to silt, lime-ash afterwash, dry, chopping; Semen Cassiae, Concretio Silicea Bambusae are cleaned, dried; Airing after vinegar parch for the Radix Paeoniae Alba; Airing after Radix Notoginseng, Rhizoma Chuanxiong clean with 60 degree Chinese liquor, mashes;
(2) Rhizoma Gastrodiae of, step (1) being processed, the Cortex Eucommiae, Herba Apocyni veneti, Pheretima, Ramulus Uncariae Cum Uncis, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Sargassum, the Radix Paeoniae Alba, Semen Cassiae, Radix Scutellariae, the Radix Astragali, Concretio Silicea Bambusae, Herb Gynostemmae Pentaphylli, Radix Notoginseng, Rhizoma Chuanxiong, Fructus Atriplicis Sibiricae, Radix Cynanchi Paniculati, Spica Prunellae are in the ratio preparation in formula, mix, again dry, pulverizing is ground into fine powder, cross 80-120 mesh sieve, smalls is standby, under the cryogenic conditions of 60 ℃, is dried, pack in Capsules, be prepared into capsule.
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| CN111821354A (en) * | 2019-04-17 | 2020-10-27 | 闫家旭 | Medicine for treating hypertension |
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