CN100475837C - 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物 - Google Patents
多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物 Download PDFInfo
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- CN100475837C CN100475837C CNB2004100480166A CN200410048016A CN100475837C CN 100475837 C CN100475837 C CN 100475837C CN B2004100480166 A CNB2004100480166 A CN B2004100480166A CN 200410048016 A CN200410048016 A CN 200410048016A CN 100475837 C CN100475837 C CN 100475837C
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- polyoxyethylene glycol
- amino acid
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- oligopeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (27)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100480166A CN100475837C (zh) | 2004-06-11 | 2004-06-11 | 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物 |
PCT/CN2005/000834 WO2005121181A1 (fr) | 2004-06-11 | 2005-06-10 | Polyethyleneglycol-oligopeptides de type branchement d'arbre multipoint et leurs derives actifs et composes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100480166A CN100475837C (zh) | 2004-06-11 | 2004-06-11 | 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1706865A CN1706865A (zh) | 2005-12-14 |
CN100475837C true CN100475837C (zh) | 2009-04-08 |
Family
ID=35503014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100480166A Active CN100475837C (zh) | 2004-06-11 | 2004-06-11 | 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物 |
Country Status (2)
Country | Link |
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CN (1) | CN100475837C (zh) |
WO (1) | WO2005121181A1 (zh) |
Families Citing this family (36)
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---|---|---|---|---|
WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
ATE465205T1 (de) | 2005-12-05 | 2010-05-15 | Nitto Denko Corp | Polyglutamat-aminosäure-konjugate und verfahren |
WO2007067622A2 (en) * | 2005-12-06 | 2007-06-14 | Tyco Healthcare Group Lp | Carbodiimide crosslinking of functionalized polethylene glycols |
US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
CN101573141B (zh) | 2006-05-15 | 2016-05-04 | 麻省理工学院 | 用于功能性颗粒的聚合物 |
WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
CN101168594B (zh) * | 2006-10-24 | 2011-07-27 | 北京键凯科技有限公司 | 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物 |
WO2008098165A2 (en) | 2007-02-09 | 2008-08-14 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
EP2144600A4 (en) | 2007-04-04 | 2011-03-16 | Massachusetts Inst Technology | POLY (AMINIC ACID) TARGET MOLECULES |
EP2620157A3 (en) | 2007-10-12 | 2013-10-16 | Massachusetts Institute of Technology | Vaccine nanotechnology |
US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
ITRM20080551A1 (it) * | 2008-10-15 | 2010-04-16 | Univ Catania | Derivati anfifilici del poliossietilenglicole (peg), procedimento di preparazione e loro usi nella preparazione di sistemi farmaceutici. |
CN101724144A (zh) | 2008-11-03 | 2010-06-09 | 北京键凯科技有限公司 | 新型的多臂聚乙二醇及其制备方法和应用 |
CN103755949B (zh) * | 2009-12-25 | 2016-04-13 | 天津键凯科技有限公司 | 多臂聚乙二醇衍生物及其与药物的结合物和凝胶 |
CN102266566B (zh) * | 2010-06-03 | 2013-06-12 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种磁性复合物及其制备方法和用途 |
US20140228279A1 (en) * | 2011-10-03 | 2014-08-14 | Nanyang Technological University | Cationic peptidopolysaccharides with excellent broad- spectrum antimicrobial activities and high selectivity |
CN103083680B (zh) * | 2011-11-07 | 2014-12-24 | 北京键凯科技有限公司 | 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物 |
WO2014114262A1 (zh) * | 2013-01-28 | 2014-07-31 | 天津键凯科技有限公司 | 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途 |
US9700633B2 (en) | 2013-01-28 | 2017-07-11 | Jenkem Technology Co., Ltd., Tianjin Branch | Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof |
CN104448295B (zh) * | 2013-12-02 | 2018-01-23 | 北京键凯科技股份有限公司 | 聚乙二醇‑多爪寡肽键合的雷帕霉素衍生物 |
CN105017522A (zh) * | 2015-07-20 | 2015-11-04 | 湖南华腾制药有限公司 | 聚乙二醇修饰的非天然氨基酸的制备方法 |
CN106924753B (zh) * | 2015-12-30 | 2021-11-09 | 北京大学 | 制备蛋白质-聚氨基酸环状偶联物的方法 |
CN107469089B (zh) * | 2016-06-07 | 2022-01-07 | 北京键凯科技股份有限公司 | 一种peg连接子及配基药物偶联物 |
CN108264538B (zh) * | 2017-01-04 | 2023-08-29 | 辽宁药联制药有限公司 | 门冬氨酸缩合物的固相合成方法 |
WO2018177055A1 (zh) * | 2017-03-30 | 2018-10-04 | 北京键凯科技股份有限公司 | 一种y型分支的亲水性聚合物羧酸衍生物的制备方法 |
CN108659227B (zh) * | 2017-03-30 | 2020-11-06 | 北京键凯科技股份有限公司 | 一种y型分支的亲水性聚合物羧酸衍生物的制备方法 |
CN108003342A (zh) * | 2018-02-02 | 2018-05-08 | 中国科学院长春应用化学研究所 | 聚氨基酸、其制备方法和载药凝胶 |
EP3778705A4 (en) * | 2018-03-29 | 2022-01-05 | NOF Corporation | DEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE |
CN109897179B (zh) * | 2019-04-02 | 2021-08-17 | 中国科学院长春应用化学研究所 | 一种多臂聚乙二醇-聚(l-谷氨酸酯)嵌段共聚物及其制备方法和应用 |
EP4036149A4 (en) * | 2019-09-26 | 2023-10-25 | NOF Corporation | HETEROBIFUNCTIONAL MONODISPERSPERED POLYETHYLENE GLYCOL WITH PEPTIDE LINKER |
CN112251484B (zh) * | 2020-10-26 | 2022-05-24 | 江南大学 | 一种脂肪酶催化制备甘氨酸寡肽-聚乙二醇共聚物的方法 |
CN115975182A (zh) * | 2023-01-10 | 2023-04-18 | 深圳市乐土生物医药有限公司 | 一种氨基酸共聚物及其应用 |
CN116178733B (zh) * | 2023-03-03 | 2023-08-01 | 浙江博美生物技术有限公司 | 一种基于三官能团氨基酸的支化单分散peg衍生物、制备方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1381512A (zh) * | 2002-01-15 | 2002-11-27 | 泛亚生物技术有限公司 | 多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1251530A3 (en) * | 2001-04-16 | 2004-12-29 | Shipley Company LLC | Dielectric laminate for a capacitor |
CN100475269C (zh) * | 2002-03-05 | 2009-04-08 | 北京键凯科技有限公司 | 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途 |
CN1254496C (zh) * | 2002-05-30 | 2006-05-03 | 中国科学院过程工程研究所 | 制备分枝型聚乙二醇的方法 |
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2004
- 2004-06-11 CN CNB2004100480166A patent/CN100475837C/zh active Active
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2005
- 2005-06-10 WO PCT/CN2005/000834 patent/WO2005121181A1/zh active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1381512A (zh) * | 2002-01-15 | 2002-11-27 | 泛亚生物技术有限公司 | 多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用 |
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Publication number | Publication date |
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CN1706865A (zh) | 2005-12-14 |
WO2005121181A1 (fr) | 2005-12-22 |
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Effective date of registration: 20091202 Pledge (preservation): Pledge |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20110401 Granted publication date: 20090408 Pledgee: Bank of China, Limited by Share Ltd, Beijing subbranch Pledgor: Beijing Kai Kai Technology Co., Ltd.|Tianjin key Kay Technology Co., Ltd. Registration number: 2009110000662 |
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Denomination of invention: Branched polyglycol-amino acid oligopeptide and its active derivative and medicinal composition Effective date of registration: 20110629 Granted publication date: 20090408 Pledgee: Zhongguancun Beijing science and technology Company limited by guarantee Pledgor: Beijing Kai Kai Technology Co., Ltd.|Tianjin key Kay Technology Co., Ltd. Registration number: 2011990000250 |
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Date of cancellation: 20120607 Granted publication date: 20090408 Pledgee: Zhongguancun Beijing science and technology Company limited by guarantee Pledgor: Beijing Kai Kai Technology Co., Ltd.|Tianjin key Kay Technology Co., Ltd. Registration number: 2011990000250 |
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Effective date of registration: 20161223 Address after: 124000 Liaoning Province, Panjin city Shuangtaizi District Park Street, South and West No. 2111020090140248 Patentee after: Liaoning Kai Kai Technology Co., Ltd. Address before: 100085 Haidian District, Beijing on the road to information on the international science and Technology Park, building C, floor four, layer Patentee before: Beijing Jiankai Sci-Tech Co.,Ltd. |