CN1381512A - 多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用 - Google Patents
多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用 Download PDFInfo
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- CN1381512A CN1381512A CN02101672A CN02101672A CN1381512A CN 1381512 A CN1381512 A CN 1381512A CN 02101672 A CN02101672 A CN 02101672A CN 02101672 A CN02101672 A CN 02101672A CN 1381512 A CN1381512 A CN 1381512A
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- Prior art keywords
- fork type
- polyethylene glycol
- arm
- type functional
- functional polyethylene
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 26
- -1 polyoxyethylene Polymers 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 15
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 13
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 13
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- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
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- 125000004185 ester group Chemical group 0.000 claims description 3
- 229960002949 fluorouracil Drugs 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 125000005647 linker group Chemical group 0.000 claims description 3
- 229960001592 paclitaxel Drugs 0.000 claims description 3
- 229910052697 platinum Inorganic materials 0.000 claims description 3
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 3
- 229940032362 superoxide dismutase Drugs 0.000 claims description 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 3
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 27
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000002244 precipitate Substances 0.000 description 10
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 9
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- LOVPHSMOAVXQIH-UHFFFAOYSA-N (4-nitrophenyl) hydrogen carbonate Chemical group OC(=O)OC1=CC=C([N+]([O-])=O)C=C1 LOVPHSMOAVXQIH-UHFFFAOYSA-N 0.000 description 1
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- BTBWSRPRAGXJJV-UHFFFAOYSA-N 2h-benzotriazole;carbonic acid Chemical group OC(O)=O.C1=CC=C2NN=NC2=C1 BTBWSRPRAGXJJV-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyethers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (11)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021016720A CN1176137C (zh) | 2002-01-15 | 2002-01-15 | 多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用 |
EP03701451A EP1479711A4 (en) | 2002-01-15 | 2003-01-15 | MULTIPLE COTTON FUNCTIONAL POLYETHYLENE GLYCOL, PRODUCTION PROCESS AND USE THEREOF |
PCT/CN2003/000029 WO2003059987A1 (fr) | 2002-01-15 | 2003-01-15 | Polyethylene glycol fonctionnel de type branchement d'arbre multipoint, son procede de preparation et ses applications |
JP2003560083A JP2005514505A (ja) | 2002-01-15 | 2003-01-15 | マルチアーム樹枝状および機能的なpegの調製法および用途 |
AU2003203327A AU2003203327A1 (en) | 2002-01-15 | 2003-01-15 | Multidrop tree branching functional polyethylene glycol, the preparation method and the use of it |
US10/891,945 US7144978B2 (en) | 2002-01-15 | 2004-07-15 | Multidrop tree branching functional polyethylene glycol, methods of preparing and using same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021016720A CN1176137C (zh) | 2002-01-15 | 2002-01-15 | 多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1381512A true CN1381512A (zh) | 2002-11-27 |
CN1176137C CN1176137C (zh) | 2004-11-17 |
Family
ID=4739594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB021016720A Expired - Lifetime CN1176137C (zh) | 2002-01-15 | 2002-01-15 | 多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1479711A4 (zh) |
JP (1) | JP2005514505A (zh) |
CN (1) | CN1176137C (zh) |
AU (1) | AU2003203327A1 (zh) |
WO (1) | WO2003059987A1 (zh) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100475837C (zh) * | 2004-06-11 | 2009-04-08 | 北京键凯科技有限公司 | 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物 |
CN101143916B (zh) * | 2007-08-30 | 2010-11-17 | 复旦大学 | 一种三杂臂星型结构聚合物的制备方法 |
CN101622295B (zh) * | 2007-02-28 | 2012-07-04 | 日油株式会社 | 多支链聚氧化亚烷基衍生物 |
US8354549B2 (en) | 2006-11-30 | 2013-01-15 | Nektar Therapeutics | Method for preparing a polymer conjugate |
CN103228792A (zh) * | 2011-08-25 | 2013-07-31 | 纳诺亘医药生物科技公司 | PEG-干扰素λ1结合物 |
CN104744685A (zh) * | 2015-04-10 | 2015-07-01 | 吕常海 | 一种三臂聚乙二醇衍生物及其制备方法 |
CN104877127A (zh) * | 2015-06-23 | 2015-09-02 | 厦门赛诺邦格生物科技有限公司 | 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质 |
CN104906594A (zh) * | 2005-11-30 | 2015-09-16 | 遗传工程与生物技术中心 | 用于与蛋白质和肽缀合的四个支链的树枝状大分子peg |
CN109608633A (zh) * | 2018-11-09 | 2019-04-12 | 北京诺康达医药科技股份有限公司 | 一种新型的特异性多臂聚乙二醇衍生物及其制备方法 |
CN110041443A (zh) * | 2019-04-24 | 2019-07-23 | 广东药科大学附属第一医院 | 多分支聚唾液酸衍生物及其制备方法 |
US10543169B2 (en) | 2013-11-07 | 2020-01-28 | Generon (Shanghai) Corporation Ltd. | Use of IL-22 dimer in manufacture of a medicament for intravenous administration |
US10786551B2 (en) | 2007-08-06 | 2020-09-29 | Generon (Shanghai) Corporation Ltd. | Use of interleukin-22 in the treatment of fatty liver disease |
US11510966B2 (en) | 2016-04-15 | 2022-11-29 | Evive Biotechnology (Shanghai) Ltd | Use of IL-22 in treating necrotizing enterocolitis |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101420984B (zh) | 2006-02-21 | 2013-01-02 | 尼克塔治疗公司 | 嵌段可降解聚合物及由其制备的轭合物 |
KR101079993B1 (ko) * | 2006-11-17 | 2011-11-04 | 동아제약주식회사 | 폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체 |
CU20140003A7 (es) * | 2014-01-08 | 2015-08-27 | Ct De Inmunología Molecular Biofarmacuba | Conjugado que comprende eritropoyetina y una estructura polimérica ramificada |
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DE2456813A1 (de) * | 1974-11-30 | 1976-06-10 | Freudenberg Carl Fa | Hydrophiler schaumstoff auf polyurethanbasis |
US5641479A (en) * | 1991-02-12 | 1997-06-24 | Richardson-Vicks Inc. | Cosmetic compositions comprising an imidazolium derivative and branched polyethylene glycol |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
CA2320156A1 (en) * | 1997-09-26 | 1999-04-08 | Uab Research Foundation | Reduced antigenic cells and uses therefor |
EP1037649B1 (en) * | 1997-12-17 | 2009-09-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
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2003
- 2003-01-15 WO PCT/CN2003/000029 patent/WO2003059987A1/zh active Application Filing
- 2003-01-15 AU AU2003203327A patent/AU2003203327A1/en not_active Abandoned
- 2003-01-15 EP EP03701451A patent/EP1479711A4/en not_active Withdrawn
- 2003-01-15 JP JP2003560083A patent/JP2005514505A/ja active Pending
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CN100475837C (zh) * | 2004-06-11 | 2009-04-08 | 北京键凯科技有限公司 | 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物 |
CN104906594A (zh) * | 2005-11-30 | 2015-09-16 | 遗传工程与生物技术中心 | 用于与蛋白质和肽缀合的四个支链的树枝状大分子peg |
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US8541608B2 (en) | 2006-11-30 | 2013-09-24 | Nektar Therapeutics | Method for preparing a polymer conjugate |
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CN101622295B (zh) * | 2007-02-28 | 2012-07-04 | 日油株式会社 | 多支链聚氧化亚烷基衍生物 |
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US10434182B2 (en) | 2015-06-23 | 2019-10-08 | Xiamen Sinopeg Biotech Co., Ltd. | Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof |
US10660969B2 (en) | 2015-06-23 | 2020-05-26 | Xiamen Sinopeg Biotech Co., Ltd. | Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof |
US11510966B2 (en) | 2016-04-15 | 2022-11-29 | Evive Biotechnology (Shanghai) Ltd | Use of IL-22 in treating necrotizing enterocolitis |
CN109608633A (zh) * | 2018-11-09 | 2019-04-12 | 北京诺康达医药科技股份有限公司 | 一种新型的特异性多臂聚乙二醇衍生物及其制备方法 |
CN110041443A (zh) * | 2019-04-24 | 2019-07-23 | 广东药科大学附属第一医院 | 多分支聚唾液酸衍生物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
EP1479711A4 (en) | 2005-01-26 |
AU2003203327A1 (en) | 2003-07-30 |
EP1479711A1 (en) | 2004-11-24 |
JP2005514505A (ja) | 2005-05-19 |
CN1176137C (zh) | 2004-11-17 |
WO2003059987A1 (fr) | 2003-07-24 |
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