CN100434093C - 注射用肾康葡萄糖注射液及其制备工艺 - Google Patents
注射用肾康葡萄糖注射液及其制备工艺 Download PDFInfo
- Publication number
- CN100434093C CN100434093C CNB2004100394207A CN200410039420A CN100434093C CN 100434093 C CN100434093 C CN 100434093C CN B2004100394207 A CNB2004100394207 A CN B2004100394207A CN 200410039420 A CN200410039420 A CN 200410039420A CN 100434093 C CN100434093 C CN 100434093C
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- Prior art keywords
- alcohol
- crude drug
- filtrate
- contain
- distilled water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 27
- 229940093181 glucose injection Drugs 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 563
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 221
- 239000012153 distilled water Substances 0.000 claims abstract description 148
- 239000003814 drug Substances 0.000 claims abstract description 142
- 229940079593 drug Drugs 0.000 claims abstract description 139
- 238000007865 diluting Methods 0.000 claims abstract description 83
- 229940090044 injection Drugs 0.000 claims abstract description 74
- 238000002347 injection Methods 0.000 claims abstract description 74
- 239000007924 injection Substances 0.000 claims abstract description 74
- 239000007788 liquid Substances 0.000 claims abstract description 73
- 238000002360 preparation method Methods 0.000 claims abstract description 18
- 239000008103 glucose Substances 0.000 claims abstract description 16
- 230000001954 sterilising effect Effects 0.000 claims abstract description 16
- 238000001914 filtration Methods 0.000 claims abstract description 9
- 210000003734 kidney Anatomy 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims description 188
- 238000004321 preservation Methods 0.000 claims description 96
- 239000000796 flavoring agent Substances 0.000 claims description 81
- 235000019634 flavors Nutrition 0.000 claims description 81
- 238000004064 recycling Methods 0.000 claims description 81
- 239000000243 solution Substances 0.000 claims description 69
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 45
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 45
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 36
- 238000000605 extraction Methods 0.000 claims description 33
- 241000628997 Flos Species 0.000 claims description 28
- 108010010803 Gelatin Proteins 0.000 claims description 22
- 229920000159 gelatin Polymers 0.000 claims description 22
- 239000008273 gelatin Substances 0.000 claims description 22
- 235000019322 gelatine Nutrition 0.000 claims description 22
- 235000011852 gelatine desserts Nutrition 0.000 claims description 22
- 238000003756 stirring Methods 0.000 claims description 22
- 235000018553 tannin Nutrition 0.000 claims description 22
- 229920001864 tannin Polymers 0.000 claims description 22
- 239000001648 tannin Substances 0.000 claims description 22
- 241000545442 Radix Species 0.000 claims description 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 15
- 229910052799 carbon Inorganic materials 0.000 claims description 15
- 238000003810 ethyl acetate extraction Methods 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 15
- 238000001802 infusion Methods 0.000 claims description 15
- 239000012528 membrane Substances 0.000 claims description 15
- 239000009636 Huang Qi Substances 0.000 claims description 11
- 208000020832 chronic kidney disease Diseases 0.000 claims description 5
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 5
- 230000002879 macerating effect Effects 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 2
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- 239000009457 shenkang Substances 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100394207A CN100434093C (zh) | 2004-02-11 | 2004-02-11 | 注射用肾康葡萄糖注射液及其制备工艺 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100394207A CN100434093C (zh) | 2004-02-11 | 2004-02-11 | 注射用肾康葡萄糖注射液及其制备工艺 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1654060A CN1654060A (zh) | 2005-08-17 |
CN100434093C true CN100434093C (zh) | 2008-11-19 |
Family
ID=34892338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100394207A Expired - Lifetime CN100434093C (zh) | 2004-02-11 | 2004-02-11 | 注射用肾康葡萄糖注射液及其制备工艺 |
Country Status (1)
Country | Link |
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CN (1) | CN100434093C (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102475753B (zh) * | 2010-11-30 | 2014-04-02 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾衰的肾康贴剂及其制备方法 |
CN102475755B (zh) * | 2010-11-30 | 2013-12-04 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾衰的肾康气雾剂及其制备方法 |
CN102475761B (zh) * | 2010-11-30 | 2013-12-18 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾衰的肾康口服固体复方制剂及其制备方法 |
CN102475757B (zh) * | 2010-11-30 | 2013-10-16 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾衰的肾康外用复方制剂及其制备方法 |
CN102475759B (zh) * | 2010-11-30 | 2013-10-16 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾衰的肾康氯化钠注射液及制备方法 |
CN102475754B (zh) * | 2010-11-30 | 2013-12-18 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾衰的肾康软胶囊及其制备方法 |
CN102475762B (zh) * | 2010-11-30 | 2013-12-18 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾衰的肾康口服液体复方制剂及其制备方法 |
CN102475756B (zh) * | 2010-11-30 | 2014-03-19 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾功能衰竭的肾康注射复方制剂及其制备方法 |
CN102475763B (zh) * | 2010-11-30 | 2013-12-04 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾衰的肾康滴丸及其制备方法 |
CN102475758B (zh) * | 2010-11-30 | 2013-12-18 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾衰的肾康片剂及其制备方法 |
CN102475760B (zh) * | 2010-11-30 | 2014-04-02 | 西安世纪盛康药业有限公司 | 一种治疗慢性肾功能衰竭的肾康复方制剂及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1146358A (zh) * | 1996-07-16 | 1997-04-02 | 成都中医药大学附属医院 | 肾康注射液及其制备工艺 |
CN1430992A (zh) * | 2003-01-10 | 2003-07-23 | 安徽天洋药业有限公司 | 一种治疗心血管病症的香丹滴注液 |
CN1444949A (zh) * | 2003-04-29 | 2003-10-01 | 中国药科大学 | 一种防治心血管病的中药黄芪有效部位 |
-
2004
- 2004-02-11 CN CNB2004100394207A patent/CN100434093C/zh not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1146358A (zh) * | 1996-07-16 | 1997-04-02 | 成都中医药大学附属医院 | 肾康注射液及其制备工艺 |
CN1430992A (zh) * | 2003-01-10 | 2003-07-23 | 安徽天洋药业有限公司 | 一种治疗心血管病症的香丹滴注液 |
CN1444949A (zh) * | 2003-04-29 | 2003-10-01 | 中国药科大学 | 一种防治心血管病的中药黄芪有效部位 |
Non-Patent Citations (2)
Title |
---|
输液型丹参葡萄糖注射液研制及质量标准研究. 黄敏.时珍国医国药,第10卷第1期. 1999 |
输液型丹参葡萄糖注射液研制及质量标准研究. 黄敏.时珍国医国药,第10卷第1期. 1999 * |
Also Published As
Publication number | Publication date |
---|---|
CN1654060A (zh) | 2005-08-17 |
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Owner name: XI'AN CENTURY SHENGKANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: WU FANG Effective date: 20091002 |
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Effective date of registration: 20091002 Address after: Shaanxi province Xi'an Fengjing Industrial Park Fengjing Road No. 6 Patentee after: XI'AN SHIJISHENGKANG PHARMACEUTICAL INDUSTRY Co.,Ltd. Address before: Shaanxi city of Xi'an province high tech Zone Tang Yan Road No. 35 room B2003 Mong modern city Patentee before: Wu Fang |
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