CN100428944C - Compound traditional Chinese medicine for improving eyesight and its prepn. method - Google Patents
Compound traditional Chinese medicine for improving eyesight and its prepn. method Download PDFInfo
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- CN100428944C CN100428944C CNB2005100386169A CN200510038616A CN100428944C CN 100428944 C CN100428944 C CN 100428944C CN B2005100386169 A CNB2005100386169 A CN B2005100386169A CN 200510038616 A CN200510038616 A CN 200510038616A CN 100428944 C CN100428944 C CN 100428944C
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Abstract
The present invention discloses a compound traditional Chinese medicine preparation for improving eyesight, which comprises a formula of the traditional Chinese medicine preparation and a preparation method thereof. The traditional Chinese medicine preparation is composed of following raw materials, 180 to 400g of semen cassiae, 142 to 252g of prepared fleeceflower root, 400 to 600g of nacre, 81 to 197g of chrysanthemum, 153 to 293g of self-heal, 138 to 309g of angelica, 129 to 305g of white peony alba, 129 to 317g of wolfberry fruit, 130 to 297g of red peony root, 127 to 313g of safflower, 211 to 527g of motherwort, 135 to 312g of plantain seed, 123 to 323g of tuckahoe, 201 to 519g of waxgourd seed and 42 to 113g of radix glycyrrhiza, wherein alcohol and water extracts of the raw materials or water extracts of raw materials are used as active components. The raw materials of the traditional Chinese medicines are mixed into one or a plurality of compositions which are heated for refluxing and percolating by the water only or the alcohol and the water, so that one or a plurality of extracting solutions used as the active components are obtained. The active component is directly mixed into the required preparation, or the active components are uniformly mixed into the required preparation.
Description
Affiliated technical field
The present invention relates to a kind of compound Chinese medicinal preparation that is used to make eye bright, comprise prescription of this Chinese medicine preparation and preparation method thereof.
Background technology
Centrality slurry retina choroidopathy is one of clinical common internal ophthalmopathy.Pathological changes is positioned at the macula retinae district, has a strong impact on vision, and with metamorphopsia, the eyeball distending pain, symptom such as shadow at the moment, middle prime of life sickness rate is higher, and easily recurrence again after curing, therefore, treat and control its recurrence effectively, have the meaning of particular importance clinically.At present, the medicine of clinical treatment central serous chorioretinopathy is few, only belongs to symptomatic treatment, and curative effect is not satisfied, and Chinese patent medicine yet there are no.
Summary of the invention
The present invention is from the symptom and the pathological changes analysis-by-synthesis of central serous chorioretinopathy, because of its pathogenesis based on the hepatic and renal YIN deficiency, pathological factor has blood stasis and water wet.With void is this, is mark with the reality.The invention provides a kind of new Chinese traditional compound medicine that is used to make eye bright, it has liver and kidney tonifying, nourishing blood for improving eyesight, the energy blood circulation promoting and blood stasis dispelling of holding concurrently, the effect of promoting diuresis to eliminate damp pathogen.
The invention provides a kind of compound Chinese medicinal preparation that makes eye bright, it is made up of as active component the extract of the alcohol and water of following raw materials according, following raw materials according or the extract of following raw materials according water:
Semen Cassiae 180～400g Radix Polygoni Multiflori Preparata 142～252g Concha Margaritifera 400～600g
Flos Chrysanthemi 81～197g Spica Prunellae 153～293g Radix Angelicae Sinensis 138～309g
The Radix Paeoniae Alba 129～305g Fructus Lycii 129～317g Radix Paeoniae Rubra 130～297g
Flos Carthami 127～313g Herba Leonuri 211～527g Semen Plantaginis 135～312g
Poria 123～323g Semen Benincasae 201～519g Radix Glycyrrhizae 42～113g.
Raw material weight proportioning preferable in above-mentioned Chinese medicine is:
Semen Cassiae 200～350g Radix Polygoni Multiflori Preparata 171～235g Concha Margaritifera 450～550g
Flos Chrysanthemi 107～169g Spica Prunellae 192～279g Radix Angelicae Sinensis 179～273g
The Radix Paeoniae Alba 170～267g Fructus Lycii 163～259g Radix Paeoniae Rubra 178～271g
Flos Carthami 183～267g Herba Leonuri 269～411g Semen Plantaginis 175～283g
Poria 181～253g Semen Benincasae 277～429g Radix Glycyrrhizae 50～82g.
Raw material weight proportioning better in above-mentioned Chinese medicine is:
Semen Cassiae 264g Radix Polygoni Multiflori Preparata 220g Concha Margaritifera 528g
Flos Chrysanthemi 132g Spica Prunellae 220g Radix Angelicae Sinensis 220g
Radix Paeoniae Alba 220g Fructus Lycii 220g Radix Paeoniae Rubra 220g
Flos Carthami 220g Herba Leonuri 330g Semen Plantaginis 220g
Poria 220g Semen Benincasae 330g Radix Glycyrrhizae 66g.
Above Chinese medicine preparation, it can be the dosage form of recording in any pharmacopeia such as syrup, mixture, oral liquid, granule, tablet, capsule, the preparation of Chinese medicine preparation also can be carried out with reference to the method for conventional Chinese medicine preparation, but in order to improve drug effect, make things convenient for administration, Chinese medicine preparation of the present invention preferably adopts following preparation method.
The preparation technology who above-mentioned Chinese medicine is made Chinese traditional compound medicine of the present invention is:
(1) take by weighing following traditional Chinese medicines and make raw material:
Semen Cassiae 180～400g Radix Polygoni Multiflori Preparata 142～252g Concha Margaritifera 400～600g
Flos Chrysanthemi 81～197g Spica Prunellae 153～293g Radix Angelicae Sinensis 138～309g
The Radix Paeoniae Alba 129～305g Fructus Lycii 129～317g Radix Paeoniae Rubra 130～297g
Flos Carthami 127～313g Herba Leonuri 211～527g Semen Plantaginis 135～312g
Poria 123～323g Semen Benincasae 201～519g Radix Glycyrrhizae 42～113g.
(2) above-mentioned each raw material of Chinese medicine is mixed into one or more assemblys, independent water or water and pure reflux or percolation, corresponding one or more extracting solution that obtain are as active component.
(3) direct or many active component mix homogeneously with above-mentioned active component, and make required preparation.
In above-mentioned steps (2), with above-mentioned Semen Cassiae, Radix Polygoni Multiflori, Fructus Lycii, Poria, Semen Plantaginis five tastes alcohol percolation, collect percolate, standby; In its step (2), all the other raw materials are mixed, through 1-3 extraction, extracting solvent is water, filters, concentrates, and adds alcoholic solution again and carries out precipitate with ethanol, and concentration of alcohol is 40-80% during precipitate with ethanol, places, and gets supernatant, and is standby; After percolate and supernatant mixing, add an amount of sucrose and make syrup, add antiseptic and leave standstill, filter, add water to 1000 volume units again, mixing.All the other raw material extraction times are 2 times, each 1-3 hour.All the other raw materials boiled 1.5 hours for the first time, boiled 1 hour for the second time, and extracting solvent is water, and concentration of alcohol is 70% during precipitate with ethanol.Antiseptic is a potassium sorbate.
Semen Cassiae is bitter sweet cool in nature in the prescription, goes into the Liver and kidney warp, and merit is arrogated to oneself liver heat removing and eyesight improving, the diuretic relieving constipation; Sweet, the tepor of Radix Polygoni Multiflori hardship is gone into the Liver and kidney warp, and function is a liver and the kidney tonifying, and the treating the liver deficiency of the kidney yin is arrogated to oneself in nourishing blood to expel wind, and the head is dim-sighted, diseases such as soreness of the waist and knees, and the two is when being monarch.Concha Margaritifera, the conscience warp is gone in salty cold, nourish liver and kidney, clearing away liver-fire is to make eye bright; Flos Chrysanthemi sweetness and bitterness is cool in nature, wind and heat dispersing, and detoxifcation makes eye bright; The Fructus Lycii liver heat removing and eyesight improving; When being included into the heart, liver, spleen channel, merit is arrogated to oneself benefiting blood and regulating blood circulation; Radix Paeoniae Alba acid is flat, nourishing blood to suppress the hyperactive liver; Spica Prunellae is arduous cold in nature, goes into liver, gallbladder meridian, can the liver heat removing eliminating stagnation, and the liver-wind of dispelling, the network of passing through, six medicine liver and kidney tonifying and liver heat removing and eyesight improving, nourishing the liver blood and order get flourish, are ministerial drug altogether.Radix Paeoniae Rubra is bitter and cool, goes into liver, spleen channel; The Flos Carthami promoting blood circulation to remove obstruction in the collateral can be transferred blood with blood again; Herba Leonuri is arduous cool in nature, goes into pericardium, Liver Channel; The heat clearing away of the sweet cold energy diuretic of Semen Plantaginis makes eye bright and eliminates the phlegm; Poria is sweet flat, invigorating the spleen to clear away damp pathogen; The Semen Benincasae moistening the lung and resolving phlegm, the eliminating carbuncle diuretic.Above-mentioned all medicines are played the merit that blood circulation promoting and blood stasis dispelling, promoting diuresis to eliminate damp pathogen, tonifying liver make eye bright altogether, are to be adjuvant drug.Radix Glycyrrhizae and middle emergency, coordinating the actions of various ingredients in a prescription is given birth to and is used heat-clearing and toxic substances removing, as messenger drug.
Contain effective ingredient such as multiple anthraquinone derivative, flavone compound, alkaloids among the present invention.This class material has anti-inflammation, blood pressure lowering and physiologically actives such as blood vessel dilating, blood circulation promoting and blood stasis dispelling more.With the low ethanol extractions of five tastes medical material such as Semen Cassiae, Radix Polygoni Multiflori, Poria in the step (2), so both guaranteed the abundant proposition of compositions such as emodin in the monarch drug, the while reduces the phlegmatic temperament in Semen Plantaginis, the Poria again; And medical material proportions such as Herba Leonuri, Spica Prunellae, Flos Carthami are little in the step (3), and volume is big, so adopt water extracting alcohol precipitation method.This method helps the extraction of effective ingredient, gives full play to curative effect, and makes things convenient for administration.
The specific embodiment
Below by embodiment, the present invention is further described:
The preparation of embodiment one Chinese materia medica syrup a of the present invention
(1) following weight proportion takes by weighing each component:
Semen Cassiae 264g Radix Polygoni Multiflori Preparata 220g Concha Margaritifera 528g
Flos Chrysanthemi 132g Spica Prunellae 220g Radix Angelicae Sinensis 220g
Radix Paeoniae Alba 220g Fructus Lycii 220g Radix Paeoniae Rubra 220g
Flos Carthami 220g Herba Leonuri 330g Semen Plantaginis 220g
Poria 220g Semen Benincasae 330g Radix Glycyrrhizae 66g.
(2) above-mentioned weight proportion depends on that pine torch, Radix Polygoni Multiflori, Fructus Lycii, Poria, the Semen Plantaginis five tastes break into coarse powder, with 70% ethanol percolation, collects percolate;
(3) by above-mentioned weight proportion, Concha Margaritifera was added water boil 1 hour, add all the other nine flavors and boil secondary, 1.5 hours for the first time, 1 hour for the second time, filter, merge medicinal liquid, filtrate is concentrated in right amount, adding ethanol makes and contains alcohol amount and reach 70%, left standstill 24 hours, and got supernatant and percolate and merge, reclaim ethanol and be concentrated into an amount of.
(4) get sucrose 100g and add water and make syrup in right amount, add in the above-mentioned concentrated solution, add potassium sorbate 3.0g, add water to 1000ml, stir evenly, filter, embedding, sterilization promptly obtains the made syrup a of the present invention.Every 1ml syrup is equivalent to about 3.6 grams of raw medicinal herbs.
The preparation of embodiment two Chinese materia medica syrup b of the present invention
(1) following weight proportion takes by weighing each component:
Semen Cassiae 397g Radix Polygoni Multiflori Preparata 330g Concha Margaritifera 792g
Flos Chrysanthemi 198g Spica Prunellae 330g Radix Angelicae Sinensis 330g
Radix Paeoniae Alba 330g Fructus Lycii 330g Radix Paeoniae Rubra 330g
Flos Carthami 330g Herba Leonuri 495g Semen Plantaginis 330g
Poria 330g Semen Benincasae 496g Radix Glycyrrhizae 99g.
(2) above-mentioned weight proportion depends on that pine torch, Radix Polygoni Multiflori, Fructus Lycii, Poria, the Semen Plantaginis five tastes break into coarse powder, with 60% ethanol percolation, collects percolate.
(3) by above-mentioned weight proportion, all the other ten flavors are boiled three times, each each 1 hour, filter, merge medicinal liquid, filtrate is concentrated in right amount, adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, gets supernatant and percolate and merges, and recovery ethanol also is concentrated in right amount.
Other gets sucrose 180g and adds water and make syrup in right amount, adds in the above-mentioned concentrated solution, adds potassium sorbate 4.6g, adds water to 1000ml, stirs evenly, filter, and embedding, sterilization promptly obtains the made syrup b of the present invention.Every 1ml syrup is equivalent to about 5.3 grams of raw medicinal herbs.
The animal long term toxicity test of embodiment three syrup a of the present invention
Syrup a of the present invention shows oral three months chronic test results of rat: big or middle dosage group body weight gain percentage rate is lower than matched group and small dose group, and heavy dose of group BUN has the trend of increasing, and the statistics inspection does not have remarkable change.The leukocyte of heavy dose of group has reduction trend, but its value is still in normal range.Case control, 2 routine slight hepatic cell steatosis appear in heavy dose of group, the prompting heavy dose might cause the slight fat metabolic disturbance of liver when using, illustrate that heavy dose shows certain toxic action to animal, so should control clinical consumption, but just test generally speaking, syrup a of the present invention is still simply the relatively Chinese patent medicine of safety.
The animal acute toxicity experiment of embodiment four syrup a of the present invention
Syrup a of the present invention is to the mouse stomach acute toxicity testing.The result shows: two kinds of extractum of syrup a of the present invention all fail to make LD50, the observation of maximum tolerance experiment, and the extractum of two kinds of syrup a of the present invention there is no animal dead behind mouse stomach.Respectively there are 2 animals after administration, to see in two groups to receive food and activity all to reduce, promptly recover normally after second day, do not see other poisoning symptom.So two kinds of extractum every day maximum tolerated dose all greater than 1099.8g/kg, by people's consumption kg body weight conversion about 500 times greater than people's consumption per day.
Clinical practice
II phase clinical experiment group is verified 338 of 321 examples altogether, and matched group adopts QIJU DIHUANG KOUFUYE to verify 104 of 100 examples altogether.The result:
(1) syrup a of the present invention has significant curative effect through II phase clinical verification to central serous chorioretinopathy.In 338 of 321 examples, through a treatment in month, its 139 (42.12%) of fully recovering, total effective rate is 86.09%, than QIJU DIHUANG KOUFUYE 5 examples (4.80%) of fully recovering, total effective rate 45.19%, compare that there were significant differences for two groups, syrup a curative effect of the present invention is reliable and imitate high.
(2) syrup a of the present invention has enriching yin and nourishing kidney, blood circulation promoting and blood stasis dispelling, and liver heat removing and eyesight improving, the effect of promoting diuresis to eliminate damp pathogen, on tcm syndrome the hepatic and renal YIN deficiency, stagnation of dampness due to deficiency of the spleen amphitypy being had equal curative effect is the active drug that therapeutic community's property serous chorioretinopathy becomes.
(3) confirm that through clinical fluorescence fundus angiography (FFA) syrup a of the present invention also has comparatively significant curative effect for the pigment epithelium disengaging of macula lutea portion.
(4) clinical research process finds no the impairer through liver function test, does not also have clinical other toxic and side effects.
Claims (8)
1, a kind of compound Chinese medicinal preparation that is used to make eye bright is characterized in that it is by following raw materials according, be made up of as active component alcohol and the extract of water or the extract of following raw materials according water of following raw materials according:
Semen Cassiae 180～400g Radix Polygoni Multiflori Preparata 142～252g Concha Margaritifera 400～600g
Flos Chrysanthemi 81～197g Spica Prunellae 153～293g Radix Angelicae Sinensis 138～309g
The Radix Paeoniae Alba 129～305g Fructus Lycii 129～317g Radix Paeoniae Rubra 130～297g
Flos Carthami 127～313g Herba Leonuri 211～527g Semen Plantaginis 135～312g
Poria 123～323g Semen Benincasae 201～519g Radix Glycyrrhizae 42～113g.
2, compound Chinese medicinal preparation according to claim 1 is characterized in that its raw material is consisted of as active component by the alcohol of following raw materials according and the extract of water or the extract of following raw materials according water:
Semen Cassiae 200～350g Radix Polygoni Multiflori Preparata 171～235g Concha Margaritifera 450～550g
Flos Chrysanthemi 107～169g Spica Prunellae 192～279g Radix Angelicae Sinensis 179～273g
The Radix Paeoniae Alba 170～267g Fructus Lycii 163～259g Radix Paeoniae Rubra 178～271g
Flos Carthami 183～267g Herba Leonuri 269～411g Semen Plantaginis 175～283g
Poria 181～253g Semen Benincasae 277～429g Radix Glycyrrhizae 50～82g.
3, compound Chinese medicinal preparation according to claim 1 is characterized in that its raw material is consisted of as active component by the alcohol of following raw materials according and the extract of water or the extract of following raw materials according water:
Semen Cassiae 264g Radix Polygoni Multiflori Preparata 220g Concha Margaritifera 528g
Flos Chrysanthemi 132g Spica Prunellae 220g Radix Angelicae Sinensis 220g
Radix Paeoniae Alba 220g Fructus Lycii 220g Radix Paeoniae Rubra 220g
Flos Carthami 220g Herba Leonuri 330g Semen Plantaginis 220g
Poria 220g Semen Benincasae 330g Radix Glycyrrhizae 66g.
4, a kind of preparation method of the compound Chinese medicinal preparation that is used to make eye bright:
(1) take by weighing following traditional Chinese medicines and make raw material:
Semen Cassiae 180～400g Radix Polygoni Multiflori Preparata 142～252g Concha Margaritifera 400～600g
Flos Chrysanthemi 81～197g Spica Prunellae 153～293g Radix Angelicae Sinensis 138～309g
The Radix Paeoniae Alba 129～305g Fructus Lycii 129～317g Radix Paeoniae Rubra 130～297g
Flos Carthami 127～313g Herba Leonuri 211～527g Semen Plantaginis 135～312g
Poria 123～323g Semen Benincasae 201～519g Radix Glycyrrhizae 42～113g
(2) above-mentioned each raw material of Chinese medicine is mixed into one or more assemblys, independent water or water and pure reflux or percolation, corresponding one or more extracting solution that obtain are as active component;
(3) direct or many active component mix homogeneously with above-mentioned active component, and make required preparation.
5, method according to claim 4 is characterized in that in above-mentioned steps (2), with above-mentioned Semen Cassiae, Radix Polygoni Multiflori, Fructus Lycii, Poria, Semen Plantaginis five tastes alcohol percolation, collects percolate, and is standby; In its step (2), all the other raw materials are mixed, through 1-3 extraction, extracting solvent is water, filters, concentrates, and adds alcoholic solution again and carries out precipitate with ethanol, and concentration of alcohol is 40-80% during precipitate with ethanol, places, and gets supernatant, and is standby; After percolate and supernatant mixing, add an amount of sucrose and make syrup, add antiseptic and leave standstill, filter, add water to 1000 volume units again, mixing.
6, preparation method according to claim 5 is characterized in that all the other raw material extraction times are 2 times, each 1-3 hour.
7, preparation method according to claim 5 is characterized in that all the other raw materials boiled 1.5 hours for the first time, boils 1 hour for the second time, and extracting solvent is water, and concentration of alcohol is 70% during precipitate with ethanol.
8, preparation method according to claim 5 is characterized in that antiseptic is a potassium sorbate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100386169A CN100428944C (en) | 2005-03-31 | 2005-03-31 | Compound traditional Chinese medicine for improving eyesight and its prepn. method |
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| CNB2005100386169A CN100428944C (en) | 2005-03-31 | 2005-03-31 | Compound traditional Chinese medicine for improving eyesight and its prepn. method |
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| CN1692938A CN1692938A (en) | 2005-11-09 |
| CN100428944C true CN100428944C (en) | 2008-10-29 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700317B (en) * | 2009-11-16 | 2012-02-01 | 武汉代代木生物科技有限公司 | Preparation capable of improving fundus and retina microcirculation lesion and restoring ocular and retina microcirculation lesion and damage, and method for preparing same |
| CN104043011A (en) * | 2014-06-19 | 2014-09-17 | 王春水 | Traditional Chinese medicine composition for treating central retinitis |
| CN108245584A (en) * | 2018-04-13 | 2018-07-06 | 江苏艾兰得营养品有限公司 | A kind of traditional Chinese medicine composition for relieving asthenopia and preparation method |
| CN113144101A (en) * | 2021-01-25 | 2021-07-23 | 中科智盟(北京)科技有限公司 | Medicine for correcting vision and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159938A (en) * | 1997-01-15 | 1997-09-24 | 郭银峰 | Eyesight-improving preparation for treatment of myopia and preparing process thereof |
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2005
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159938A (en) * | 1997-01-15 | 1997-09-24 | 郭银峰 | Eyesight-improving preparation for treatment of myopia and preparing process thereof |
Non-Patent Citations (2)
| Title |
|---|
| 明珠口服液治疗脉络膜视网膜疾病的临床研究. 缪也夫.中药新药与临床药理，第9卷第1期. 1998 |
| 明珠口服液治疗脉络膜视网膜疾病的临床研究. 缪也夫.中药新药与临床药理，第9卷第1期. 1998 * |
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Inventor after: Sun Tianjiang Inventor after: Lu Hongguo Inventor after: Zhang Yubin Inventor after: Zhou Bin Inventor after: Chen Jianqiu Inventor after: Shi Weilian Inventor after: Ren Dong Inventor before: Lu Hongguo Inventor before: Zhang Yubin Inventor before: Zhou Bin Inventor before: Chen Jianqiu Inventor before: Shi Weilian Inventor before: Ren Dong |
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Free format text: CORRECT: INVENTOR; FROM: LU HONGGUO ZHANG YUBIN ZHOU BIN CHEN JIANQIU SHI WEILIAN REN DONG TO: SUN TIANJIANG LU HONGGUO ZHANG YUBIN ZHOU BIN CHEN JIANQIU SHI WEILIAN REN DONG |
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Effective date of registration: 20211221 Address after: 225300 No. 9, Longfeng Tang Road, Yongan Town, Taizhou, Jiangsu. Patentee after: YANGZIJIANG PHARMACEUTICAL GROUP JIANGSU LONGFENGTANG TRADITIONAL CHINESE MEDICINE Co.,Ltd. Patentee after: Yangzi River Pharmaceutical Group Co., Ltd. Address before: 225321 No. 1 Jiangnan Road, Taizhou, Jiangsu Patentee before: YANGTZE RIVER PHARMACEUTICAL GROUP Co.,Ltd. |
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