CN100394909C - Antiseptic hand cleaning liquid with out water cleaning and its preparation method - Google Patents
Antiseptic hand cleaning liquid with out water cleaning and its preparation method Download PDFInfo
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- CN100394909C CN100394909C CNB031509592A CN03150959A CN100394909C CN 100394909 C CN100394909 C CN 100394909C CN B031509592 A CNB031509592 A CN B031509592A CN 03150959 A CN03150959 A CN 03150959A CN 100394909 C CN100394909 C CN 100394909C
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Abstract
The present invention relates to antiseptic hand cleaning liquid without water cleaning and a preparation method thereof. The components of the antiseptic hand cleaning liquid contain 57 to 65% of ethanol and tea tree oil is used as a carrier so that the antiseptic hand cleaning liquid has the hard smell of ethanol and has the advantages of no water cleaning, etc. The preparation method of the hand cleaning liquid of the present invention comprises the steps that carbopores are fully dissolved in partial pure water to prepare liquid A; simultaneously, 5-chlorine-2-(2, 4-di-chlorophenoxy) phenol is uniformly stirred with partial ethanol to prepare liquid B; then, the liquid B is poured into the liquid A; the rest of ethanol, skin protecting agents, tea tree oil, humectants and cosolvents are added into the liquid A and are uniformly stirred; pH value regulating agents are added to regulate a pH value to 6.7 to 8.7; then, essence is added and pure water is also added to sufficient quantity; mixing liquid is stirred for 20 minutes.
Description
Technical field
The present invention relates to a kind of handwashing liquid, particularly a kind of disinfection hand cleanser that does not need the water flushing.
The invention still further relates to the preparation method of this water washing avoiding disinfection handwashing liquid.
Background technology
As the wash one's hands renewal product of apparatus fancy soap of tradition, handwashing liquid has sterilization, hand is stimulated little, as to avoid secondary pollution advantage.Because the solids of fancy soap is easy to be infected with to hand dirt and antibacterial, becomes the secondary pollution source, and handwashing liquid and hands contact surface generally are the pump head at bottle, and pump head is easy to clean, can avoid the probability of cross infection preferably.In addition, most of handwashing liquid can reach 90% to kill pathogenic bacteria rates such as Candida albicans, staphylococcus aureus, escherichia coli, and bactericidal effect is good.Compare with fancy soap, alkali content is low, and is little to the stimulation of hand.Therefore the research and development of handwashing liquid just are being called a focus of detergent industry.
Exempt to wash handwashing liquid, do not need the water flushing just can play the effect of washing one's hands, compare, exempt to wash handwashing liquid and not limited by the water source, use more convenient in the open air with general handwashing liquid.The solvent of exempting to wash handwashing liquid mainly adopts volatile organic solvent, and wherein commonly used be alcoholic solvent, considers the safety non-toxic requirement, is many with employing ethanol, isopropyl alcohol etc. especially.Ethanol is the hand sanitizer of using always, and its antibacterial action comes from proteinic Denaturation.External research think alcohol disinfectant have reliable and fast the effect and good tolerability.Alcoholic acid best disinfection concentration is 75% (v/v), but because when containing high concentration ethanol in the handwashing liquid, has intensive sharp aroma, be difficult to be accepted by consumer, therefore at present existingly exempt to wash that consumption of ethanol generally is no more than 50% (w/w) in the handwashing liquid, ethanol only can use as solvent exempting to wash in the handwashing liquid like this, and can't bring into play the effect of its disinfection.Traditional exempt to wash handwashing liquid, must add the disinfectant of sufficient dosage to reach Disinfection Effect, 5-oxygen-2-(2, the two chlorobenzene oxygen of 4-) phenol, be commonly called as triclosan (triclosan) or triclosan (Irgasan), be a kind of nonionic wide-spectrum bactericide, its antibiotic mechanism is the cell wall of destroy microorganisms.It is synthetic that thereby the recent action site that studies show that triclosan suppresses the antibacterial fatty acid at enoyl-carrier protein reductase.Experimentation shows that triclosan has bactericidal activity, is a kind of effective disinfectant, and this chemical compound is widely used in the article of everyday use such as toothpaste, cosmetics, antimicrobial soap as chloride antibacterial commonly used at present, and its typical concentrations is 0.1%-2%.Triclosan has good antibacterial effect, but also can cause skin irritation. the reaction of skin side-effects such as allergy.How to reduce that disinfectant becomes the emphasis of industry research to the side effect of hand skin in the handwashing liquid.
Summary of the invention
The object of the present invention is to provide a kind of water washing avoiding disinfection handwashing liquid, this handwashing liquid has effectively utilized alcoholic acid sterilization, thereby reduces the use amount of chlorine-containing disinfectant, is aided with skin protectant, reaches the effect that hands is not hindered in skin protection.
Another object of the present invention is to provide the preparation method of this water washing avoiding disinfection handwashing liquid.
Consumption of ethanol is up to 57～65% (w/w) (being equivalent to 69-78.6% (v/v)) in the handwashing liquid of the present invention, not only as volatile solvent, and play certain sterilizing effect, the present invention utilizes the clathration of macromolecular material, in handwashing liquid, used tea tree oil as carrier, alcoholic acid pungent abnormal smells from the patient is carried out enclose, adopt Ka Bobo (carbopol simultaneously; Carboxypolymethylene ultrez10, be a kind of carboxyl polymethylene compound), not only play the effect of thickening agent, and strengthened the enclose effect of tea tree oil, effectively like this overcome handwashing liquid, not the defective of accepting for consumer because of containing the pungent abnormal smells from the patient of high concentration ethanol tool.The pH of handwashing liquid of the present invention is controlled at 6.7-8.7.
The consisting of of water washing avoiding disinfection handwashing liquid of the present invention (percentage by weight):
Ethanol 57～65%
Tea tree oil 0.1～2%
Card ripple pool 3～5%
5-chloro-2-(2, the two chlorobenzene oxygen of 4-) phenol 0.05～0.1%
Cosolvent 0.05～1.0%
PH value regulator 0.1～1.0%
The pure water surplus
In the above-mentioned prescription, ethanol plays the disinfectant effect simultaneously as solvent, and its optimum amount is 62% (by weight).Tea tree oil is a carrier, has the effect of the pungent abnormal smells from the patient of enclose etoh solvent.Ka Bobo can strengthen the clathration of tea tree oil simultaneously not only as thickening agent.5-chloro-2-(2, the two chlorobenzene oxygen of 4-) phenol is disinfection sanitizer.Cosolvent adopts nonionic surfactant, has the hydrophilic and oleophilic function, thereby helps the common molten of inclusions and solvent, for example can adopt tween 20.The pH value regulator should adopt the regulator of skin-friendly, as triethanolamine.
In addition, for increasing skin protection, the moistening effect of handwashing liquid, handwashing liquid of the present invention can also comprise wetting agent, and consumption is 0.1～1.0%, can select hyaluronic acid, aminoacid lactic acid, glycerol etc. for use, is good with glycerol wherein; Skin protectant, consumption are 0.01～1.0%, can select in vitamin E, the Aloe wet goods one or more for use; Essence, consumption are 0.01～1.5%.
The preparation method of handwashing liquid of the present invention is: take by weighing each component by formula proportion, in adding a cover reaction pot, rustless steel adds the pure water that accounts for handwashing liquid gross weight 20% earlier, Ka Bobo divided join in the pure water lentamente 3-5 time, the limit edged stirs, carried out mechanical agitation 150 minutes with 80-100 rev/min speed, fully disperse an even muddy dispersion, standing over night, fully swelling makes first liquid.Add a cover in the reaction pot at another rustless steel and to add the ethanol that accounts for handwashing liquid gross weight 10%, add 5-chloro-2-(2, the two chlorobenzene oxygen of 4-) phenol then, mixed dissolution carried out mechanical agitation 10 minutes with 50-80 rev/min speed, until the liquid clear, make second liquid, airtight preservation, standby.Second liquid is poured in the first liquid, and added surplus and get ethanol, stir 30 minutes mix homogeneously with 50-80 rev/min speed.Add skin protectant, tea tree oil, wetting agent, cosolvent, mixed dissolution then successively.Fully stir 10 minutes to homodisperse with 80-100 rev/min speed, add the pH value regulator and regulate pH value 6.7～8.7, add essence again, replenish pure water restir 20 minutes to the capacity, promptly get handwashing liquid of the present invention.
The sterilization effect of handwashing liquid of the present invention is described below by test:
One, the Disinfection Effect of handwashing liquid of the present invention and soap is relatively:
1, subjects and grouping:
Subjects comprises 150 of the staff in 5 Medicine and Surgery ICUs of hospital, Blood Dialyzing Center, bacteriological labororatory and 18 Medicine and Surgery wards, with preceding 6 people that run in each lesion is experimental subject, the table of random numbers of taking out in advance by computer enters grouping, 6 people are assigned to 3 groups at random, give respectively handwashing liquid of the present invention wash one's hands and the soap circulating water wash one's hands.Each 50 people of each processed group.
2, test method:
Handwashing liquid test group of the present invention:
Leave and take finger and cultivate directly evenly to rub after the specimen and be applied in hand, treat its natural drying, leave and take finger cultivation specimen behind about 2min again with 2ml handwashing liquid of the present invention.Test that ethanol content is 62% (w/w) in the used handwashing liquid of the present invention, the content of disinfectant 5-chloro-2-(2, the two chlorobenzene oxygen of 4-) phenol is 0.05% (w/w).
The soap matched group of washing one's hands:
Leave and take finger before washing one's hands and cultivate specimen, wash one's hands twice, leave and take finger after blotting with sterile gauze and cultivate specimen with soap running water wash maneuver.Observe the examinee simultaneously and have or not dermoreaction.
Collection of specimens and processing:
With common blood agar plate stamped method sampling, the examinee refers to that with 10 the finger tip facies palmaris contacts dull and stereotyped 2s successively, respectively stays 1 of specimen before and after handling, subsequently censorship.Blood plate is put 35 ℃ of incubators and is cultivated 20h, the counting bacterium colony.
Statistical analysis:
Compare 3 groups degerming rate: degerming rate=(clump count before handling-processing back clump count)/handle preceding clump count * 100%, the measurement data mean of nonnormal distribution is represented with median, relatively adopts nonparametric statistics (Kruskal-Wallis method) between group.P＜0.05 is for there being the statistical significance level.
3, result of the test:
Each group processing front and back finger cultivates clump count and degerming rate (median) comparing data sees Table 1.
2 kinds of processing method effects of table 1 relatively
| Grouping | Clump count (CFU/cm before handling 2) | Handle back clump count (CFU/cm 2) | Degerming rate (%) |
| Handwashing liquid group of the present invention | 28.5 | 1.0 | 96.5 |
| The soap group of washing one's hands | 26.0 | 30.0 | -15.4 |
As seen, the bacteria-eliminating efficacy of handwashing liquid of the present invention is up to 96.5%.Soap running water wash maneuver is the method for washing one's hands commonly used in the hospital.Former studies shows that in most cases this method can make bacterial population on hand reduce 60%～90%.Common soap there is no bactericidal action, it mainly the mechanical kneading action when washing one's hands reduce on hand stay flora temporarily.In this test, the matched group of washing one's hands with the soap circulating water, clump count increases by 15.4% on the contrary on the defensive position of washing one's hands, may be because the method for washing one's hands is incorrect, fail fully to rub flushing, and the soap of washing one's hands in all lesiones all places by the tank of washing one's hands, can be splashed by current, and frequency of utilization is very high, is difficult to keep dry, thereby the back hand of washing one's hands is anti-contaminated.
Observe through skin reaction in addition, each processed group is not all observed skin malaise symptoms such as xerosis cutis, rubescent, pruritus.
Two, the antibiotic prolongation effect of handwashing liquid of the present invention and soap is relatively:
1, test method:
Subjects is Bacteriology Room staff 10 people of hospital, adopt self cross-reference, everyone carries out handwashing liquid of the present invention (test group) respectively and soap circulating water (matched group) is handled each 1 time at same date not, carries out processing of the same race earlier with computer stochastic sampling decision in advance.At least be separated by 4 days between two kinds of processing of each subjects.
Routine was washed one's hands twice after test group was left and taken finger cultivation specimen, blot with sterile gauze, evenly rub by operation instruction with 2ml handwashing liquid of the present invention and to smear hand, leave and take finger after about 2 minutes and cultivate specimen, wore sterile gloves 6 hours, the sterile gloves of slipping out of the hand the cover specimen taken at 2,4,6 hours and renewing.Observe user simultaneously and have or not dermoreaction.Conventional soap circulating water washed one's hands twice after matched group was left and taken finger cultivation specimen, left and took finger after blotting with gauze and cultivated specimen, wore sterile gloves 6 hours, slipped out of the hand at 2,4,6 hours and overlapped specimen taken and renew glove.The acquiring and processing method of specimen and data statistical approach are with test one.
2, result of the test
The clump count and the degerming rate (median) of the cultivation of two different time point fingers of processed group see Table 2.
Each time point clump count (CFU/cm of table 2 liang processed group
2) and degerming rate (%)
As seen use handwashing liquid of the present invention 6 hours, and still had excellent antibiotic prolongation of effect effect.
Beneficial effect:
1, handwashing liquid of the present invention does not need water flushing, can be to the hand cleaning and sterilizing, and easy to use, be particularly useful for field usage.
2, ethanol content plays the effect of sterilization up to 57～65% (w/w) in the handwashing liquid of the present invention, thereby makes the use amount of chlorine-containing disinfectant reduce to 0.05～0.1% (w/w), lacks than the traditional product consumption, and is little to the side effect of hand.
3, handwashing liquid of the present invention adopts the macromolecule inclusion technique, has eliminated the pungent abnormal smells from the patient of high concentration ethanol.
4, the inventive method technology is simple, and use equipment is few.
The specific embodiment:
The present invention is further elaborated below in conjunction with specific embodiment, but do not limit the present invention.
Batching used in the following example is the commercially available prod, and wherein tea tree oil is produced by oasis, Luxi, Yunnan Oleum Camelliae tree Development Co., Ltd; 5-oxygen-2-(2, the two chlorobenzene oxygen of 4-) phenol (triclosan, CP level) is produced by Nanjing fine chemistry industry company; Ethanol is the medical ethanol of 95% (v/v, density 0.82); Ka Bobo (Dow Chemical company limited), glycerol are pharmaceutical level.
Embodiment 1:
Ethanol 6713 grams, card ripple pool 300 grams, triclosan 5 grams, glycerol 100 grams, aloe 50 grams, vitamin E 5 grams, tea tree oil 100 grams, triethanolamine 100 grams, tween 20 5 grams, pure water 2622 grams.
Its preparation method is: take by weighing each component by formula proportion, add a cover to add in the drum at 40 liters of rustless steels earlier and account for 2000 gram pure water, Ka Bobo divided join in the pure water lentamente 3 times, the limit edged stirs, carried out mechanical agitation 150 minutes with 100 rev/mins speed, fully disperse an even muddy dispersion, standing over night, fully swelling makes first liquid.Add a cover adding 1083 gram ethanol in the drum at another 10 liters of rustless steels, add triclosan then, mixed dissolution carried out mechanical agitation 10 minutes with 50 rev/mins speed, and until the liquid clear, airtight placement makes second liquid.Second liquid is poured in the first liquid, and added remaining 5630 gram ethanol, stir 30 minutes mix homogeneously.Add vitamin E, aloe, tea tree oil, glycerol, tween 20, mixed dissolution then successively.Be stirred well to homodisperse, add triethanolamine and regulate pH value 6.7～8.7, replenish pure water restir 20 minutes to the capacity.
Embodiment 2:
Ethanol 6608 grams, card ripple pool 300 grams, triclosan 5 grams, glycerol 100 grams, menthol 50 grams, vitamin E 5 grams, tea tree oil 100 grams, triethanolamine 100 grams, tween 20 5 grams, pure water 2727 grams.
Its preparation method is: take by weighing each component by formula proportion, add a cover to add in the drum at 40 liters of rustless steels earlier and account for 2000 gram pure water, Ka Bobo divided join in the pure water lentamente 3 times, after leaving standstill 1 hour, carried out mechanical agitation 150 minutes with 100 rev/mins speed, fully disperse an even muddy dispersion, standing over night, fully swelling makes first liquid.Add a cover adding 1083 gram ethanol in the drum at another 10 liters of rustless steels, add triclosan then, mixed dissolution carried out mechanical agitation 10 minutes with 80 rev/mins speed, until the liquid clear, made second liquid, and airtight preservation is standby.Second liquid is poured in the first liquid, and added remaining 5525 gram ethanol, mix.Add vitamin E, tea tree oil, glycerol, tween 20, mixed dissolution then successively.Be stirred well to homodisperse, add triethanolamine and regulate pH value 6.7～8.7, add menthol again, replenish pure water restir 20 minutes to the capacity.
Claims (5)
1. water washing avoiding disinfection handwashing liquid, it consists of (percentage by weight):
Ethanol 57～65%;
Tea tree oil 0.1～2%;
Card ripple pool 3～5%;
5-chloro-2-(2, the two chlorobenzene oxygen of 4-) phenol 0.05～0.1%;
Cosolvent 0.05～1.0%;
PH value regulator 0.1～1.0%;
The pure water surplus.
2. water washing avoiding disinfection handwashing liquid according to claim 1 is characterized in that consumption of ethanol is 62%.
3. water washing avoiding disinfection handwashing liquid according to claim 1 is characterized in that comprising wetting agent, and consumption is 0.1～1.0%, selects hyaluronic acid, aminoacid lactic acid, glycerol for use; Skin protectant, consumption is 0.01～1.0%, selects in vitamin E, the aloe one or more for use; Essence, consumption are 0.01～1.5%.
4. water washing avoiding disinfection handwashing liquid according to claim 3 is characterized in that, wetting agent is a glycerol.
5. the preparation method of water washing avoiding disinfection handwashing liquid as claimed in claim 3 may further comprise the steps:
(1) takes by weighing each component by formula proportion, in adding a cover reaction pot, rustless steel adds the pure water that accounts for handwashing liquid gross weight 20% earlier, Ka Bobo divided join in the pure water lentamente 3-5 time, the limit edged stirs, carried out mechanical agitation 150 minutes with 80-100 rev/min speed, fully disperse an even muddy dispersion, standing over night, fully swelling makes first liquid;
(2) add a cover in the reaction pot at another rustless steel and add the ethanol that accounts for handwashing liquid gross weight 10%, add 5-chloro-2-(2, the two chlorobenzene oxygen of 4-) phenol then, mixed dissolution carried out mechanical agitation 10 minutes with 50-80 rev/min speed, until the liquid clear, make second liquid, airtight preservation is standby;
(3) second liquid is poured in the first liquid, and the adding surplus gets ethanol, speed with 50-80 rev/min mixes, add skin protectant, tea tree oil, wetting agent, cosolvent then successively, mixed dissolution is stirred well to homodisperse with 80-100 rev/min speed, add the pH value regulator and regulate pH value 6.7～8.7, add essence again, it is fully mixed to replenish pure water restir to the capacity, promptly gets the water washing avoiding disinfection handwashing liquid.
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| CNB031509592A CN100394909C (en) | 2003-09-16 | 2003-09-16 | Antiseptic hand cleaning liquid with out water cleaning and its preparation method |
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| CNB031509592A CN100394909C (en) | 2003-09-16 | 2003-09-16 | Antiseptic hand cleaning liquid with out water cleaning and its preparation method |
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| CN1596877A CN1596877A (en) | 2005-03-23 |
| CN100394909C true CN100394909C (en) | 2008-06-18 |
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| CN113521042A (en) * | 2021-06-28 | 2021-10-22 | 青岛童医生海洋生物科技股份有限公司 | Alcohol-free wash-free virus inactivation disinfectant special for children and preparation method thereof |
| CN113521261A (en) * | 2021-07-16 | 2021-10-22 | 四川美嘉龙生物科技有限公司 | Anti-coronavirus and anti-bacterium dual nano washing-free disinfection gel and preparation method and application thereof |
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