CL2021001722A1 - Inhibidores aza-heterobicíclicos de mat2a y métodos de uso en el tratamiento de cáncer - Google Patents
Inhibidores aza-heterobicíclicos de mat2a y métodos de uso en el tratamiento de cáncerInfo
- Publication number
- CL2021001722A1 CL2021001722A1 CL2021001722A CL2021001722A CL2021001722A1 CL 2021001722 A1 CL2021001722 A1 CL 2021001722A1 CL 2021001722 A CL2021001722 A CL 2021001722A CL 2021001722 A CL2021001722 A CL 2021001722A CL 2021001722 A1 CL2021001722 A1 CL 2021001722A1
- Authority
- CL
- Chile
- Prior art keywords
- methods
- heterobicyclic
- aza
- cancer treatment
- mat2a
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
La presente descripción proporciona compuestos de acuerdo con la Fórmula I, Fórmula II, y sus sales, tautómeros y/o isotopólogos farmacéuticamente aceptables como se describe en la descripción. Los compuestos son inhibidores de la isoforma 2A de la metionina adenosiltransferasa (MAT2A). También se proporcionan composiciones farmacéuticas y métodos para usar los compuestos para tratar cánceres, que incluyen algunos cánceres en los que se elimina el gen que codifica la metiltioadenosina fosforilasa (MTAP).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862785574P | 2018-12-27 | 2018-12-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021001722A1 true CL2021001722A1 (es) | 2022-02-18 |
Family
ID=69400626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021001722A CL2021001722A1 (es) | 2018-12-27 | 2021-06-25 | Inhibidores aza-heterobicíclicos de mat2a y métodos de uso en el tratamiento de cáncer |
Country Status (21)
Country | Link |
---|---|
US (1) | US20220098203A1 (es) |
EP (1) | EP3902804A1 (es) |
JP (1) | JP2022516882A (es) |
KR (1) | KR20220050832A (es) |
CN (1) | CN113474347A (es) |
AR (1) | AR115296A1 (es) |
AU (1) | AU2019414446A1 (es) |
BR (1) | BR112021012599A2 (es) |
CA (1) | CA3124678A1 (es) |
CL (1) | CL2021001722A1 (es) |
CO (1) | CO2021009882A2 (es) |
CR (1) | CR20210409A (es) |
EA (1) | EA202191800A1 (es) |
IL (1) | IL284324A (es) |
JO (1) | JOP20210171A1 (es) |
MA (1) | MA54609A (es) |
MX (1) | MX2021007833A (es) |
PE (1) | PE20212303A1 (es) |
SG (1) | SG11202106627WA (es) |
TW (1) | TW202039489A (es) |
WO (1) | WO2020139992A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020123395A1 (en) | 2018-12-10 | 2020-06-18 | Ideaya Biosciences, Inc. | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors |
WO2021219731A2 (en) * | 2020-04-28 | 2021-11-04 | Iomx Therapeutics Ag | Bicyclic kinase inhibitors and uses thereof |
CN115960098A (zh) * | 2020-09-11 | 2023-04-14 | 上海凌达生物医药有限公司 | 一类含氮稠环类化合物的制备方法和用途 |
CN116670144A (zh) * | 2020-12-31 | 2023-08-29 | 南京再明医药有限公司 | 三环类化合物及用途 |
WO2022206730A1 (zh) * | 2021-03-29 | 2022-10-06 | 武汉人福创新药物研发中心有限公司 | 嘧啶并吡嗪酮化合物及其用途 |
WO2023116696A1 (zh) * | 2021-12-21 | 2023-06-29 | 南京正大天晴制药有限公司 | 蛋氨酸腺苷转移酶2a的杂环抑制剂 |
TW202333696A (zh) * | 2022-01-26 | 2023-09-01 | 大陸商勤浩醫藥(蘇州)有限公司 | 用於治療mtap缺失型癌症的甲硫氨酸腺苷轉移酶2a抑制劑 |
TW202342024A (zh) * | 2022-03-11 | 2023-11-01 | 大陸商賽諾哈勃藥業(成都)有限公司 | 甲硫胺酸腺苷轉移酶抑制劑、其藥物組合物及應用 |
GB202204913D0 (en) | 2022-04-04 | 2022-05-18 | Cambridge Entpr Ltd | antiviral therapy |
WO2024080788A1 (ko) | 2022-10-13 | 2024-04-18 | 한미약품 주식회사 | 신규한 트리사이클 유도체 화합물 및 이의 용도 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6576420B1 (en) | 1998-06-23 | 2003-06-10 | Regents Of The University Of California | Method for early diagnosis of, and determination of prognosis in, cancer |
CA2347474C (en) * | 1998-10-23 | 2008-08-26 | F. Hoffmann-La Roche Ag | Bicyclic nitrogen heterocycles |
BR0015243A (pt) * | 1999-10-21 | 2002-07-16 | Hoffmann La Roche | Heterociclos de nitrogênio bicìclico substituìdos por heteroalquilamino como inibidores da proteìna cinase p38 |
PA8577501A1 (es) * | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
US7084270B2 (en) * | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
US7129351B2 (en) * | 2002-11-04 | 2006-10-31 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
CN100497339C (zh) * | 2003-04-10 | 2009-06-10 | 霍夫曼-拉罗奇有限公司 | 嘧啶并化合物 |
US7897762B2 (en) * | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
JP5478488B2 (ja) | 2007-06-20 | 2014-04-23 | メルク・シャープ・アンド・ドーム・コーポレーション | Janusキナーゼの阻害剤 |
CN104418860B (zh) * | 2013-08-20 | 2016-09-07 | 中国科学院广州生物医药与健康研究院 | 嘧啶并杂环类化合物及其药用组合物和应用 |
SG11201901747VA (en) * | 2016-08-31 | 2019-03-28 | Agios Pharmaceuticals Inc | Inhibitors of cellular metabolic processes |
WO2019029541A1 (zh) * | 2017-08-08 | 2019-02-14 | 南京药捷安康生物科技有限公司 | 成纤维细胞生长因子受体抑制剂及其用途 |
US11524960B2 (en) * | 2018-03-30 | 2022-12-13 | Servier Pharmaceuticals Llc | Heterobicyclic inhibitors of MAT2A and methods of use for treating cancer |
-
2019
- 2019-12-27 EP EP19845797.0A patent/EP3902804A1/en not_active Withdrawn
- 2019-12-27 KR KR1020217023830A patent/KR20220050832A/ko unknown
- 2019-12-27 AU AU2019414446A patent/AU2019414446A1/en not_active Abandoned
- 2019-12-27 CN CN201980092839.3A patent/CN113474347A/zh active Pending
- 2019-12-27 WO PCT/US2019/068653 patent/WO2020139992A1/en unknown
- 2019-12-27 CA CA3124678A patent/CA3124678A1/en active Pending
- 2019-12-27 BR BR112021012599-0A patent/BR112021012599A2/pt not_active Application Discontinuation
- 2019-12-27 JO JOP/2021/0171A patent/JOP20210171A1/ar unknown
- 2019-12-27 MA MA054609A patent/MA54609A/fr unknown
- 2019-12-27 MX MX2021007833A patent/MX2021007833A/es unknown
- 2019-12-27 PE PE2021001090A patent/PE20212303A1/es unknown
- 2019-12-27 AR ARP190103901A patent/AR115296A1/es unknown
- 2019-12-27 CR CR20210409A patent/CR20210409A/es unknown
- 2019-12-27 US US17/418,406 patent/US20220098203A1/en active Pending
- 2019-12-27 SG SG11202106627WA patent/SG11202106627WA/en unknown
- 2019-12-27 EA EA202191800A patent/EA202191800A1/ru unknown
- 2019-12-27 JP JP2021538125A patent/JP2022516882A/ja active Pending
- 2019-12-27 TW TW108148080A patent/TW202039489A/zh unknown
-
2021
- 2021-06-23 IL IL284324A patent/IL284324A/en unknown
- 2021-06-25 CL CL2021001722A patent/CL2021001722A1/es unknown
- 2021-07-27 CO CONC2021/0009882A patent/CO2021009882A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20220098203A1 (en) | 2022-03-31 |
CR20210409A (es) | 2022-01-24 |
MA54609A (fr) | 2022-04-06 |
TW202039489A (zh) | 2020-11-01 |
KR20220050832A (ko) | 2022-04-25 |
IL284324A (en) | 2021-08-31 |
PE20212303A1 (es) | 2021-12-10 |
SG11202106627WA (en) | 2021-07-29 |
EP3902804A1 (en) | 2021-11-03 |
JP2022516882A (ja) | 2022-03-03 |
AU2019414446A1 (en) | 2021-07-15 |
CO2021009882A2 (es) | 2021-10-29 |
CN113474347A (zh) | 2021-10-01 |
JOP20210171A1 (ar) | 2023-01-30 |
WO2020139992A1 (en) | 2020-07-02 |
BR112021012599A2 (pt) | 2021-09-08 |
EA202191800A1 (ru) | 2021-09-13 |
CA3124678A1 (en) | 2020-07-02 |
MX2021007833A (es) | 2021-10-26 |
AR115296A1 (es) | 2020-12-16 |
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