CL2019001694A1 - Compuestos de pirazolopirimidina y métodos de uso de los mismos. - Google Patents

Compuestos de pirazolopirimidina y métodos de uso de los mismos.

Info

Publication number
CL2019001694A1
CL2019001694A1 CL2019001694A CL2019001694A CL2019001694A1 CL 2019001694 A1 CL2019001694 A1 CL 2019001694A1 CL 2019001694 A CL2019001694 A CL 2019001694A CL 2019001694 A CL2019001694 A CL 2019001694A CL 2019001694 A1 CL2019001694 A1 CL 2019001694A1
Authority
CL
Chile
Prior art keywords
methods
pyrazolopyrimidine compounds
compounds
pyrazolopyrimidine
inhibitors
Prior art date
Application number
CL2019001694A
Other languages
English (en)
Inventor
Yun-Xing Cheng
Wei Li
Guiling Zhao
Mark Zak
F Anthony Romero
Limin Cheng
Paul Gibbons
Po-Wai Yuen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2019001694A1 publication Critical patent/CL2019001694A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

EN EL PRESENTE DOCUMENTO SE DESCRIBEN COMPUESTOS DE FÓRMULA (IA) O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DE LOS MISMOS Y MÉTODOS DE USO COMO INHIBIDORES DE JANUS CINASA.
CL2019001694A 2016-12-29 2019-06-19 Compuestos de pirazolopirimidina y métodos de uso de los mismos. CL2019001694A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2016112932 2016-12-29

Publications (1)

Publication Number Publication Date
CL2019001694A1 true CL2019001694A1 (es) 2019-11-22

Family

ID=61094385

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019001694A CL2019001694A1 (es) 2016-12-29 2019-06-19 Compuestos de pirazolopirimidina y métodos de uso de los mismos.

Country Status (18)

Country Link
US (1) US11155557B2 (es)
EP (1) EP3562809B1 (es)
JP (1) JP6900491B2 (es)
KR (1) KR20190100337A (es)
CN (1) CN110114343B (es)
AU (1) AU2017385543A1 (es)
BR (1) BR112019013287A2 (es)
CA (1) CA3046435A1 (es)
CL (1) CL2019001694A1 (es)
CO (1) CO2019006220A2 (es)
CR (1) CR20190310A (es)
IL (1) IL267671A (es)
MA (1) MA47167A (es)
MX (1) MX2019007339A (es)
PE (1) PE20191236A1 (es)
PH (1) PH12019501022A1 (es)
RU (1) RU2019123319A (es)
WO (1) WO2018122212A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019007339A (es) 2016-12-29 2019-09-06 Hoffmann La Roche Compuestos de pirazolopirimidina y metodos de uso de los mismos.
TW201902896A (zh) 2017-05-22 2019-01-16 瑞士商赫孚孟拉羅股份公司 治療化合物及組合物及其使用方法
EP3740488A1 (en) 2018-01-15 2020-11-25 F. Hoffmann-La Roche AG Pyrazolopyrimidine compounds as jak inhibitors
WO2020257142A1 (en) * 2019-06-18 2020-12-24 Genentech, Inc. Tetrazole-substituted pyrazolopyrimidine inhibitors of jak kinases and uses thereof
EP3986901A1 (en) 2019-06-18 2022-04-27 F. Hoffmann-La Roche AG Pyrazolopyrimidine sulfone inhibitors of jak kinases and uses thereof
WO2020257143A1 (en) * 2019-06-18 2020-12-24 Genentech, Inc. Pyrazolopyrimidine aryl ether inhibitors of jak kinases and uses thereof
WO2022175829A1 (en) * 2021-02-17 2022-08-25 Cellix Bio Private Limited Topical formulations and compositions
WO2024052513A1 (en) * 2022-09-09 2024-03-14 Chiesi Farmaceutici S.P.A. Heterocyclic derivatives as janus kinase inhibitors
WO2024052512A1 (en) * 2022-09-09 2024-03-14 Chiesi Farmaceutici S.P.A. Heterocyclic derivatives as janus kinase inhibitors

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AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
US6034057A (en) 1995-07-06 2000-03-07 Zeneca Limited Peptide inhibitors of fibronectine
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
GB0028383D0 (en) 2000-11-21 2001-01-03 Novartis Ag Organic compounds
EP1241176A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Purine derivatives for the treatment of ischemia
WO2003053930A1 (en) 2001-12-20 2003-07-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
GB0502258D0 (en) 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
EP2251341A1 (en) 2005-07-14 2010-11-17 Astellas Pharma Inc. Heterocyclic Janus kinase 3 inhibitors
JP5512665B2 (ja) 2008-06-20 2014-06-04 ジェネンテック， インコーポレイテッド トリアゾロピリジンｊａｋ阻害剤化合物と方法
UA110324C2 (en) * 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
SI3145929T1 (sl) 2014-05-23 2021-10-29 Hoffmann La Roche 5-kloro-2-difluorometoksifenil pirazolopirimidinove spojine, ki so zaviralci janusove kinaze
TW201720828A (zh) 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
CN108473501B (zh) 2016-02-18 2021-07-16 豪夫迈·罗氏有限公司 治疗化合物、其组合物及使用方法
TWI757305B (zh) 2016-06-29 2022-03-11 南韓商韓美藥品股份有限公司 升糖素衍生物、其接合物、及包含其之組成物、及其醫療用途
MX2019007339A (es) 2016-12-29 2019-09-06 Hoffmann La Roche Compuestos de pirazolopirimidina y metodos de uso de los mismos.

Also Published As

Publication number Publication date
CO2019006220A2 (es) 2019-06-28
EP3562809B1 (en) 2021-06-09
IL267671A (en) 2019-08-29
CN110114343B (zh) 2022-09-06
RU2019123319A3 (es) 2021-02-01
MX2019007339A (es) 2019-09-06
EP3562809A1 (en) 2019-11-06
JP2020503339A (ja) 2020-01-30
CR20190310A (es) 2019-08-21
CN110114343A (zh) 2019-08-09
WO2018122212A1 (en) 2018-07-05
MA47167A (fr) 2019-11-06
RU2019123319A (ru) 2021-02-01
CA3046435A1 (en) 2018-07-05
JP6900491B2 (ja) 2021-07-07
BR112019013287A2 (pt) 2019-12-24
US11155557B2 (en) 2021-10-26
PE20191236A1 (es) 2019-09-11
KR20190100337A (ko) 2019-08-28
US20190345165A1 (en) 2019-11-14
PH12019501022A1 (en) 2019-12-16
AU2017385543A1 (en) 2019-05-23

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