CL2017002514A1 - Anticuerpos anti-c1s humanizados y métodos para usarlos. - Google Patents
Anticuerpos anti-c1s humanizados y métodos para usarlos.Info
- Publication number
- CL2017002514A1 CL2017002514A1 CL2017002514A CL2017002514A CL2017002514A1 CL 2017002514 A1 CL2017002514 A1 CL 2017002514A1 CL 2017002514 A CL2017002514 A CL 2017002514A CL 2017002514 A CL2017002514 A CL 2017002514A CL 2017002514 A1 CL2017002514 A1 CL 2017002514A1
- Authority
- CL
- Chile
- Prior art keywords
- antibodies
- humanized anti
- present description
- description provides
- methods
- Prior art date
Links
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21106—Hepsin (3.4.21.106)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
<p>La presente descripción proporciona anticuerpos anti-C1s humanizados. La presente descripción proporciona ácidos nucleicos que comprenden secuencias de nucleótidos que codifican los anticuerpos anti-C1s humanizados; y las células hospedadoras que comprenden los ácidos nucleicos. La presente descripción proporciona composiciones que comprenden los anticuerpos anti-C1s humanizados. La presente descripción proporciona métodos de uso de los anticuerpos anti-C1s humanizados.</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562143636P | 2015-04-06 | 2015-04-06 | |
US201562200997P | 2015-08-04 | 2015-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017002514A1 true CL2017002514A1 (es) | 2018-04-20 |
Family
ID=57073330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017002514A CL2017002514A1 (es) | 2015-04-06 | 2017-10-05 | Anticuerpos anti-c1s humanizados y métodos para usarlos. |
Country Status (27)
Country | Link |
---|---|
US (3) | US10729767B2 (es) |
EP (2) | EP3280440B1 (es) |
JP (3) | JP7005483B2 (es) |
KR (1) | KR20180006379A (es) |
CN (2) | CN117285634A (es) |
AU (2) | AU2016246452B2 (es) |
BR (1) | BR112017021289A2 (es) |
CA (1) | CA2981321A1 (es) |
CL (1) | CL2017002514A1 (es) |
CO (1) | CO2017011238A2 (es) |
DK (1) | DK3280440T3 (es) |
EA (1) | EA201792080A1 (es) |
ES (1) | ES2938359T3 (es) |
FI (1) | FI3280440T3 (es) |
HK (2) | HK1250930A1 (es) |
HR (1) | HRP20230093T1 (es) |
HU (1) | HUE061076T2 (es) |
IL (2) | IL254670B2 (es) |
LT (1) | LT3280440T (es) |
MX (2) | MX2017012834A (es) |
PH (1) | PH12017501815A1 (es) |
PL (1) | PL3280440T3 (es) |
PT (1) | PT3280440T (es) |
RS (1) | RS63956B1 (es) |
SG (2) | SG10201909180SA (es) |
SI (1) | SI3280440T1 (es) |
WO (1) | WO2016164358A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
AU2013334229B2 (en) | 2012-10-25 | 2018-02-15 | Bioverativ Usa Inc. | Anti-complement C1s antibodies and uses thereof |
EP3906944A1 (en) | 2012-11-02 | 2021-11-10 | Bioverativ USA Inc. | Anti-complement c1s antibodies and uses thereof |
TWI636062B (zh) | 2013-04-02 | 2018-09-21 | 中外製藥股份有限公司 | Fc region variant |
SG10201909180SA (en) | 2015-04-06 | 2019-11-28 | Bioverativ Usa Inc | Humanized anti-c1s antibodies and methods of use thereof |
BR112019007309A2 (pt) * | 2016-10-12 | 2019-07-02 | Bioverativ Usa Inc | anticorpos anti-c1s e métodos de uso dos mesmos |
MA52248A (fr) * | 2018-04-13 | 2021-02-17 | Chugai Pharmaceutical Co Ltd | Anticorps dirigés contre un composant du complément et procédés d'utilisation |
IL300376A (en) | 2020-08-06 | 2023-04-01 | Bioverativ Usa Inc | Inflammatory cytokines and fatigue in subjects with complement-mediated disease |
TW202304508A (zh) | 2021-03-31 | 2023-02-01 | 美商百歐維拉提夫美國公司 | 減少冷凝集素疾病患者之手術相關溶血 |
WO2023287573A2 (en) | 2021-07-13 | 2023-01-19 | Mabwell Therapeutics Inc. | Anti-c1s antibodies and uses thereof |
US20240117021A1 (en) | 2022-06-15 | 2024-04-11 | Bioverativ Usa Inc. | Anti-complement c1s antibody formulation |
WO2023250507A1 (en) | 2022-06-24 | 2023-12-28 | Bioverativ Usa Inc. | Methods for treating complement-mediated diseases |
Family Cites Families (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS60192263A (ja) | 1984-03-13 | 1985-09-30 | Teijin Ltd | 免疫複合体測定用標準物質及びそれを用いた免疫複合体の測定法 |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
ATE243754T1 (de) | 1987-05-21 | 2003-07-15 | Micromet Ag | Multifunktionelle proteine mit vorbestimmter zielsetzung |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
CA2115742A1 (en) | 1991-08-20 | 1993-03-04 | Ronald G. Crystal | Adenovirus mediated transfer of genes to the gastrointestinal tract |
DE69229477T2 (de) | 1991-09-23 | 1999-12-09 | Cambridge Antibody Tech | Methoden zur Herstellung humanisierter Antikörper |
US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
EP1136556B1 (en) | 1991-11-25 | 2005-06-08 | Enzon, Inc. | Method of producing multivalent antigen-binding proteins |
FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
CA2592997A1 (en) | 1992-12-03 | 1994-06-09 | Genzyme Corporation | Pseudo-adenovirus vectors |
CA2115811A1 (en) | 1993-02-17 | 1994-08-18 | Claus Krebber | A method for in vivo selection of ligand-binding proteins |
ES2249761T3 (es) | 1993-06-24 | 2006-04-01 | Advec Inc. | Vectores de adenovirus para terapia genica. |
ES2171465T3 (es) | 1993-09-01 | 2002-09-16 | Sanquin Bloedvoorziening | Inhibidor de la esterasa de c1 para reducir lesiones de miocardio durante un infarto de miocardio agudo. |
EP2113569A1 (en) | 1993-10-25 | 2009-11-04 | CANJI, Inc. | Recombinant adenoviral vector and methods of use |
PT889120E (pt) | 1994-12-09 | 2002-09-30 | Microscience Ltd | Genes de virulencia no grupo vgc2 de salmonella |
US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
US6080849A (en) | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
JP2003529536A (ja) | 1999-02-09 | 2003-10-07 | 3−ディメンショナル ファーマシューティカルズ, インコーポレイテッド | C1s介在疾患および状態の処置法、およびそれのための化合物および組成物 |
WO2000064327A2 (en) | 1999-04-26 | 2000-11-02 | Duke University | Inhibition of complement action |
WO2001013945A1 (en) | 1999-08-23 | 2001-03-01 | Biocrystal Ltd. | Methods and compositions for immunotherapy of b cell involvement in promotion of a disease condition comprising multiple sclerosis |
DK1252184T3 (da) | 2000-01-31 | 2008-02-04 | Pharming Intellectual Pty Bv | Human C1-inhibitor produceret i mælk af transgene dyr |
ATE435873T1 (de) | 2000-03-23 | 2009-07-15 | Genentech Inc | Anti-c2/c2a inhibitoren zur komplement aktivierung |
AU2001282857A1 (en) | 2000-06-21 | 2002-01-02 | Zymogenetics Inc. | Peptide and polypeptide inhibitors of complement c1s |
GB0105924D0 (en) | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
CA2454562A1 (en) | 2001-07-26 | 2003-02-06 | Alexion Pharmaceuticals, Inc. | Method of improving cognitive function |
US20080206242A1 (en) * | 2002-03-01 | 2008-08-28 | Xencor, Inc. | Method of treatment of th2-mediated conditions using optimized anti-cd30 antibodies |
SE0202880D0 (sv) | 2002-07-26 | 2002-09-30 | Wieslab Ab | Complement system deficiency assay |
US7666627B2 (en) | 2002-08-08 | 2010-02-23 | Targetex Kft. | Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof |
US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
ES2614274T3 (es) | 2002-09-06 | 2017-05-30 | Alexion Pharmaceuticals, Inc. | Procedimiento de tratamiento de asma usando anticuerpos frente al componente de complemento C5 |
US7361339B2 (en) | 2003-01-09 | 2008-04-22 | Alexion Pharmaceuticals, Inc. | Methods for reducing morality associated with acute myocardial infarction |
ES2387275T3 (es) | 2003-05-15 | 2012-09-19 | Genentech, Inc. | Métodos y composiciones para la prevención y el tratamiento de la sepsis |
WO2005014849A2 (en) | 2003-07-03 | 2005-02-17 | Euro-Celtique, S.A. | Genes associated with responses to neuropathic pain |
US7482376B2 (en) | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
US8501705B2 (en) | 2003-09-11 | 2013-08-06 | The Board Of Regents Of The University Of Texas System | Methods and materials for treating autoimmune and/or complement mediated diseases and conditions |
WO2005025509A2 (en) | 2003-09-11 | 2005-03-24 | Board Of Regents, The University Of Texas System | Methods and materials for treating autoimmune diseases and conditions |
WO2005035754A1 (ja) | 2003-10-14 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | 機能蛋白質を代替する二重特異性抗体 |
AU2004297616B2 (en) * | 2003-12-04 | 2008-12-18 | Xencor, Inc. | Methods of generating variant proteins with increased host string content and compositions thereof |
US7803931B2 (en) | 2004-02-12 | 2010-09-28 | Archemix Corp. | Aptamer therapeutics useful in the treatment of complement-related disorders |
SG172616A1 (en) | 2004-04-13 | 2011-07-28 | Hoffmann La Roche | Anti-p-selectin antibodies |
LT1753456T (lt) | 2004-06-10 | 2016-11-10 | Omeros Corporation | Ligų, susijusių su nuo masp-2 priklausomu komplemento aktyvinimu, gydymo būdai |
US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
US20060018896A1 (en) | 2004-06-10 | 2006-01-26 | University Of Leicester | Methods for treating conditions associated with lectin-dependent complement activation |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
WO2006063150A2 (en) | 2004-12-08 | 2006-06-15 | Immunomedics, Inc. | Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer |
CA2601523A1 (en) | 2005-03-16 | 2006-09-28 | Janssen Pharmaceutica N.V. | Novel thiophene sulfoximines for treating complement-mediated diseases and conditions |
US7897561B2 (en) | 2005-06-06 | 2011-03-01 | Girish J. Kotwal | Methods for treatment or prophylaxis of atherosclerosis and reperfusion injury |
KR101691692B1 (ko) | 2005-10-21 | 2016-12-30 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 보체 활성화를 억제하는 변형된 프로테아제 |
US9480658B2 (en) | 2005-12-09 | 2016-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of synaptic maintenance |
US8148330B2 (en) | 2005-12-09 | 2012-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of synaptic maintenance |
US8071532B2 (en) | 2005-12-21 | 2011-12-06 | Pharming Intellectual Property B.V. | Use of C1 inhibitor for the prevention of ischemia-reperfusion injury |
FR2897868B1 (fr) | 2006-02-24 | 2012-08-31 | Lab Francais Du Fractionnement | Anticorps anti-idiotypiques neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii. |
CN104623692A (zh) | 2006-03-08 | 2015-05-20 | 阿切埃米克斯股份有限公司 | 治疗视觉失调中使用的补体结合适体和抗-c5药物 |
CA2662480C (en) | 2006-09-05 | 2016-11-08 | Alexion Pharmaceuticals, Inc. | Methods and compositions for the treatment of antibody mediated neuropathies |
US8703136B2 (en) | 2006-10-10 | 2014-04-22 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
JP5586961B2 (ja) | 2006-12-19 | 2014-09-10 | バーシテック、リミテッド | 合成イオンチャネル |
EP2148691B1 (en) | 2007-02-05 | 2015-05-20 | Apellis Pharmaceuticals, Inc. | Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system |
US8192742B2 (en) | 2007-03-23 | 2012-06-05 | NovelMed Therapeutics | Method of inhibiting complement activation with human anti-factor C3 antibodies and use thereof |
MY150531A (en) | 2007-07-16 | 2014-01-30 | Genentech Inc | Anti-cd79b antibodies and immunoconjugates and methods of use |
ES2622107T3 (es) | 2007-08-03 | 2017-07-05 | Genentech, Inc. | Antagonistas anti-FGF19 humanizados y métodos de uso de los mismos |
EP2278987A4 (en) | 2008-03-28 | 2012-08-22 | Apellis Ag | MODULATION AND REPLY / IMPROVEMENT OF THE COMPLEMENTARY SYSTEM IN THE TREATMENT OF TRAUMATISM |
WO2009132058A2 (en) | 2008-04-25 | 2009-10-29 | Zymogenetics, Inc. | Levels of bcma protein expression on b cells and use in diagnostic methods |
WO2009151634A1 (en) | 2008-06-12 | 2009-12-17 | The Board Of Trustees Of The Leland Stanford Junior University | Complement inhibitory agents as therapeutics in posttraumatic and degenerative arthritis |
PL2894165T3 (pl) | 2008-11-10 | 2023-04-17 | Alexion Pharmaceuticals, Inc. | Sposoby i kompozycje do leczenia zaburzeń układu dopełniacza |
BRPI0923199B8 (pt) | 2008-12-01 | 2021-07-27 | Univ Leland Stanford Junior | método para determinar a presença de anticorpos de fixação de complemento |
US8401799B2 (en) | 2008-12-05 | 2013-03-19 | Lpath, Inc. | Antibody design using anti-lipid antibody crystal structures |
JP2012531418A (ja) | 2009-06-23 | 2012-12-10 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 補体タンパク質に結合する二重特異性抗体 |
TW201117824A (en) | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
RU2600876C2 (ru) | 2009-10-16 | 2016-10-27 | Омерос Корпорейшен | Способ лечения диссеминированного внутрисосудистого свертывания крови путем ингибирования masp-2 зависимой активации комплемента |
WO2011102342A1 (ja) * | 2010-02-16 | 2011-08-25 | 国立大学法人京都工芸繊維大学 | 抗体固定化担体、抗体固定化担体の製造方法および当該抗体固定化担体の利用 |
SG183541A1 (en) | 2010-03-01 | 2012-10-30 | Alexion Pharma Inc | Methods and compositions for treating degos' disease |
NZ603226A (en) | 2010-04-30 | 2015-02-27 | Alexion Pharma Inc | Anti-c5a antibodies and methods for using the antibodies |
AU2011256290B2 (en) | 2010-05-17 | 2014-06-12 | The Board Of Regents Of The University Of Texas System | Rapid isolation of monoclonal antibodies from animals |
US9421240B2 (en) | 2010-06-22 | 2016-08-23 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of neuropathic pain |
CN103249432A (zh) | 2010-06-22 | 2013-08-14 | 科罗拉多大学董事会,法人团体 | 补体成分3的C3d片段的抗体 |
TWI560199B (en) | 2010-08-31 | 2016-12-01 | Sanofi Sa | Peptide or peptide complex binding to α2 integrin and methods and uses involving the same |
TW201241008A (en) | 2010-10-01 | 2012-10-16 | Alexion Pharma Inc | Polypeptides that bind to human complement component C5 |
US8865164B2 (en) | 2010-11-02 | 2014-10-21 | Kypha, Inc. | Detecting complement activation |
LT2648752T (lt) | 2010-12-06 | 2017-04-10 | Seattle Genetics, Inc. | Humanizuoti antikūnai prieš liv-1 ir jų panaudojimas vėžio gydymui |
NZ731596A (en) | 2011-04-08 | 2022-07-01 | Omeros Corp | Methods for treating conditions associated with masp-2 dependent complement activation |
WO2012151481A1 (en) | 2011-05-04 | 2012-11-08 | Omeros Corporation | Compositions for inhibiting masp-2 dependent complement acitivation |
US9289467B2 (en) | 2011-08-10 | 2016-03-22 | Case Western Reserve University | Compositions and methods for treating bone conditions |
KR102022231B1 (ko) | 2011-12-22 | 2019-09-19 | 체에스엘 베링 게엠베하 | 중추 신경계의 2차 부종을 치료하기 위한 c1-억제제의 용도 |
JP6081699B2 (ja) * | 2011-12-28 | 2017-02-15 | 雅史 溝上 | Il−28bの分析方法 |
AU2013334229B2 (en) | 2012-10-25 | 2018-02-15 | Bioverativ Usa Inc. | Anti-complement C1s antibodies and uses thereof |
EP3906944A1 (en) | 2012-11-02 | 2021-11-10 | Bioverativ USA Inc. | Anti-complement c1s antibodies and uses thereof |
US10280215B2 (en) | 2013-01-31 | 2019-05-07 | Seoul National University R&Db Foundation | Anti-C5 antibodies and methods of treating complement-related diseases |
EA037325B1 (ru) | 2013-07-09 | 2021-03-12 | Аннексон, Инк. | Антитела против фактора комплемента c1q и их применения |
WO2015084999A1 (en) | 2013-12-06 | 2015-06-11 | True North Therapeutics, Inc. | Complement component biomarker assays |
SG10201909180SA (en) | 2015-04-06 | 2019-11-28 | Bioverativ Usa Inc | Humanized anti-c1s antibodies and methods of use thereof |
EP3313417A4 (en) | 2015-06-26 | 2019-06-12 | Bioverativ USA Inc. | METHODS OF TREATING AUTOIMMUNE AND ALLO-IMMUNE DISORDERS |
BR112019007309A2 (pt) | 2016-10-12 | 2019-07-02 | Bioverativ Usa Inc | anticorpos anti-c1s e métodos de uso dos mesmos |
KR20190128676A (ko) | 2017-03-14 | 2019-11-18 | 바이오버라티브 유에스에이 인코포레이티드 | 보체-매개된 질환 및 장애의 치료 방법 |
-
2016
- 2016-04-05 SG SG10201909180S patent/SG10201909180SA/en unknown
- 2016-04-05 EP EP16777134.4A patent/EP3280440B1/en active Active
- 2016-04-05 EP EP22207626.7A patent/EP4212175A1/en active Pending
- 2016-04-05 ES ES16777134T patent/ES2938359T3/es active Active
- 2016-04-05 WO PCT/US2016/026038 patent/WO2016164358A1/en active Application Filing
- 2016-04-05 PL PL16777134.4T patent/PL3280440T3/pl unknown
- 2016-04-05 CN CN202311019350.8A patent/CN117285634A/zh active Pending
- 2016-04-05 AU AU2016246452A patent/AU2016246452B2/en active Active
- 2016-04-05 LT LTEPPCT/US2016/026038T patent/LT3280440T/lt unknown
- 2016-04-05 DK DK16777134.4T patent/DK3280440T3/da active
- 2016-04-05 CN CN201680032952.9A patent/CN108348598B/zh active Active
- 2016-04-05 EA EA201792080A patent/EA201792080A1/ru unknown
- 2016-04-05 MX MX2017012834A patent/MX2017012834A/es unknown
- 2016-04-05 HR HRP20230093TT patent/HRP20230093T1/hr unknown
- 2016-04-05 JP JP2018503727A patent/JP7005483B2/ja active Active
- 2016-04-05 RS RS20230104A patent/RS63956B1/sr unknown
- 2016-04-05 KR KR1020177032117A patent/KR20180006379A/ko not_active Application Discontinuation
- 2016-04-05 BR BR112017021289A patent/BR112017021289A2/pt active Search and Examination
- 2016-04-05 PT PT167771344T patent/PT3280440T/pt unknown
- 2016-04-05 IL IL254670A patent/IL254670B2/en unknown
- 2016-04-05 US US15/564,904 patent/US10729767B2/en active Active
- 2016-04-05 HU HUE16777134A patent/HUE061076T2/hu unknown
- 2016-04-05 SI SI201631662T patent/SI3280440T1/sl unknown
- 2016-04-05 SG SG11201707886WA patent/SG11201707886WA/en unknown
- 2016-04-05 CA CA2981321A patent/CA2981321A1/en active Pending
- 2016-04-05 IL IL298180A patent/IL298180A/en unknown
- 2016-04-05 FI FIEP16777134.4T patent/FI3280440T3/fi active
-
2017
- 2017-10-03 PH PH12017501815A patent/PH12017501815A1/en unknown
- 2017-10-05 CL CL2017002514A patent/CL2017002514A1/es unknown
- 2017-10-05 MX MX2022001085A patent/MX2022001085A/es unknown
- 2017-10-31 CO CONC2017/0011238A patent/CO2017011238A2/es unknown
-
2018
- 2018-08-14 HK HK18110393.2A patent/HK1250930A1/zh unknown
-
2019
- 2019-01-30 HK HK19101609.0A patent/HK1259251A1/zh unknown
-
2020
- 2020-06-11 US US16/898,908 patent/US11246926B2/en active Active
- 2020-09-28 JP JP2020161908A patent/JP7153696B2/ja active Active
-
2022
- 2022-03-07 JP JP2022034295A patent/JP2022078221A/ja active Pending
- 2022-05-30 AU AU2022203679A patent/AU2022203679A1/en active Pending
- 2022-08-10 US US17/818,885 patent/US20230218753A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2017002514A1 (es) | Anticuerpos anti-c1s humanizados y métodos para usarlos. | |
ECSP19026178A (es) | Anticuerpos anti-pd-1 y sus usos | |
CO2017005842A2 (es) | Anticuerpos heterodiméricos que se unen a cd3 y cd38 | |
ECSP19050049A (es) | Anticuerpos anti-ox40 y sus usos | |
CL2017002820A1 (es) | Variantes de alfa-amilasa y polinucleótidos que codifican las mismas | |
ECSP18094829A (es) | Anticuerpos anti-cd40 y sus usos | |
PE20210107A1 (es) | Anticuerpos anti-cd3 y metodos de uso | |
CL2018000829A1 (es) | Anticuerpos anti-cd19 humano con alta afinidad | |
BR112017025564A2 (pt) | anticorpos anti-ctla-4 e métodos de uso dos mesmos | |
CR20150462A (es) | Inhibidores de erk y sus usos | |
BR112018074463A2 (pt) | anticorpos anti-tim-3 e métodos de uso dos mesmos. | |
AR111288A1 (es) | Anticuerpos anti-phf-tau y sus usos | |
AR103225A1 (es) | Composiciones detergentes, variantes de lipasa y polinucleótidos que las codifican | |
AR093446A1 (es) | Anticuerpos de antihemaglutinina y metodos de uso | |
CL2017000576A1 (es) | Inhibidores de mk2 y sus usos | |
AR095774A1 (es) | Anticuerpos anti-il-4 y anticuerpos biespecíficos y sus usos | |
DOP2015000219A (es) | Compuestos de heteroarilo y sus usos | |
PE20151613A1 (es) | Construcciones de anticuerpos para cdh19 y cd3 | |
AR110677A1 (es) | Anticuerpos anti-c1s y métodos para usarlos | |
CL2020001137A1 (es) | Anticuerpos anti-apoc3 y métodos de uso de estos. | |
EA201791437A1 (ru) | Композиции микросфер c инкапсулированным в липиде газом и соответствующие способы | |
AR103294A1 (es) | Composiciones y procedimientos para la glicosilación de proteínas |