CL2017001543A1 - Formulaciones farmacéuticas de inhibidores de la cinasa relacionada con tropomiosina (trk) - Google Patents
Formulaciones farmacéuticas de inhibidores de la cinasa relacionada con tropomiosina (trk)Info
- Publication number
- CL2017001543A1 CL2017001543A1 CL2017001543A CL2017001543A CL2017001543A1 CL 2017001543 A1 CL2017001543 A1 CL 2017001543A1 CL 2017001543 A CL2017001543 A CL 2017001543A CL 2017001543 A CL2017001543 A CL 2017001543A CL 2017001543 A1 CL2017001543 A1 CL 2017001543A1
- Authority
- CL
- Chile
- Prior art keywords
- pharmaceutical formulations
- trk
- related kinase
- tropomyosin
- kinase inhibitors
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
<p>SE DIVULGAN FORMULACIONES FARMACÉUTICAS CON UN INHIBIDOR DE CINASA RELACIONADA CON TROPOMIOSINA ('INHIBIDOR DE TRK"). LAS FORMULACIONES FARMACÉUTICAS COMPRENDEN EN FORMULACIONES DE SUSPENSIÓN MICROCRISTALINA EN SU FORMA DE MONOHIDRATO, QUE MUESTRA CARACTERÍSTICAS MEJORADAS FRENTE A LA FORMA DE ANHIDRATO, Y EN FORMULACIONES DE LIBERACIÓN PROLONGADA. LAS FORMULACIONES FARMACÉUTICAS DE LIBERACIÓN PROLONGADA COMPRENDEN MICROESFERAS CARGADAS CON 3-(3- METOXI-4-((4-METOXTBENCIL)-OXI)BENCIL)-6-(1-METJL-1 H-PIRAZOL-4-II)-3H-IMIDAZO[4,5-B]PIRIDIN-2-AMINA.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462093801P | 2014-12-18 | 2014-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017001543A1 true CL2017001543A1 (es) | 2018-03-16 |
Family
ID=55080206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017001543A CL2017001543A1 (es) | 2014-12-18 | 2017-06-14 | Formulaciones farmacéuticas de inhibidores de la cinasa relacionada con tropomiosina (trk) |
Country Status (22)
Country | Link |
---|---|
US (4) | US10219998B2 (es) |
EP (1) | EP3233057A2 (es) |
JP (1) | JP6606183B2 (es) |
KR (1) | KR102561692B1 (es) |
CN (2) | CN110950862B (es) |
AR (1) | AR103176A1 (es) |
AU (1) | AU2015364557C1 (es) |
BR (1) | BR112017012566B1 (es) |
CA (1) | CA2970938C (es) |
CL (1) | CL2017001543A1 (es) |
CO (1) | CO2017007118A2 (es) |
EA (1) | EA201791336A1 (es) |
IL (1) | IL252901B (es) |
MA (1) | MA40698A3 (es) |
MX (2) | MX2017008058A (es) |
MY (1) | MY195799A (es) |
NZ (1) | NZ733825A (es) |
PH (1) | PH12017501121B1 (es) |
SG (1) | SG11201704872RA (es) |
TN (1) | TN2017000234A1 (es) |
TW (2) | TWI780438B (es) |
WO (1) | WO2016100677A2 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI731317B (zh) | 2013-12-10 | 2021-06-21 | 美商健臻公司 | 原肌球蛋白相關之激酶(trk)抑制劑 |
CN110950862B (zh) | 2014-12-18 | 2024-01-05 | 建新公司 | 原肌球蛋白相关激酶(trk)抑制剂的药物制剂 |
CN110156813B (zh) * | 2018-02-13 | 2023-07-25 | 北京诺诚健华医药科技有限公司 | 作为trk抑制剂的杂环化合物 |
AR114110A1 (es) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | Anticuerpo anti-trka |
EP4180428A1 (en) * | 2021-11-12 | 2023-05-17 | Genzyme Corporation | Crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, and their use in treating medical conditions |
CN114712365B (zh) * | 2022-06-07 | 2022-08-23 | 山东绿叶制药有限公司 | Trk抑制剂在制备治疗迟发性运动障碍药物中的应用 |
Family Cites Families (41)
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JPS60158180A (ja) | 1984-01-30 | 1985-08-19 | Sumitomo Chem Co Ltd | ベンズイミダゾ−ル誘導体、その製造法およびそれを有効成分とする殺虫、殺ダニ剤 |
US4612323A (en) | 1983-06-27 | 1986-09-16 | Sumitomo Chemical Company, Limited | Insecticidal and acaricidal derivatives of 1-benzylbenzimidazole |
JPS6117569A (ja) | 1984-07-03 | 1986-01-25 | Sumitomo Chem Co Ltd | ベンズイミダゾ−ル誘導体およびそれを有効成分とする殺ダニ剤 |
JPS6117569U (ja) | 1984-07-05 | 1986-02-01 | エヌオーケー株式会社 | バルブ装置 |
JPS61151176A (ja) | 1984-12-24 | 1986-07-09 | Sumitomo Chem Co Ltd | ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤 |
DE4219534A1 (de) | 1992-02-19 | 1993-12-16 | Thomae Gmbh Dr K | Substituierte Biphenylylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
DK154092D0 (da) | 1992-12-23 | 1992-12-23 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
US5702637A (en) | 1995-04-19 | 1997-12-30 | Minnesota Mining And Manufacturing Company | Liquid crystal compounds having a chiral fluorinated terminal portion |
US6348474B1 (en) | 1997-06-27 | 2002-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Sulfonamide compounds and medicinal use thereof |
NZ502642A (en) | 1997-07-03 | 2002-06-28 | Du Pont Pharm Co | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders |
EP1217000A1 (en) | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
US7030150B2 (en) | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
CN1551866A (zh) | 2001-08-09 | 2004-12-01 | СҰҩƷ��ҵ��ʽ���� | 羧酸衍生物化合物及包含这些化合物为活性成分的药物 |
GB0122190D0 (en) | 2001-09-14 | 2001-10-31 | Qinetiq Ltd | Novel compounds |
US20040002145A1 (en) | 2002-03-18 | 2004-01-01 | Shewchuk Lisa Marie | Crystal structure of liganded cFMS kinase domain |
EP1505966A4 (en) | 2002-05-10 | 2006-08-30 | Bristol Myers Squibb Co | 1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA HEMMER |
FR2852957B1 (fr) | 2003-03-31 | 2005-06-10 | Sod Conseils Rech Applic | Nouveaux derives d'imidazo-pyridine et leur utilisation en tant que medicament |
TWI332003B (en) | 2004-01-30 | 2010-10-21 | Lilly Co Eli | Kinase inhibitors |
EP1731524A4 (en) | 2004-03-31 | 2009-05-20 | Kissei Pharmaceutical | PHENOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE DERIVATIVE, AND ITS MEDICINAL USE |
NZ550769A (en) | 2004-05-07 | 2010-06-25 | Warner Lambert Co | 3- or 4-Monosubstituted phenol and thiophenol derivatives useful as H3 ligands |
CA2587566A1 (en) | 2004-11-18 | 2006-05-26 | The Institutes For Pharmaceutical Discovery, Llc | Heterocyclylbiphenyl derivates as protein tyrosine phosphatase inhibitors |
DK1853588T3 (da) | 2005-02-16 | 2008-09-15 | Astrazeneca Ab | Kemiske forbindelser |
JP2006273879A (ja) | 2005-03-25 | 2006-10-12 | Fuji Photo Film Co Ltd | カラー表示素子及びカラー表示方法 |
EP1935890B1 (en) | 2005-09-30 | 2016-03-16 | Msd K.K. | 2-heteroaryl-substituted indole derivative |
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US20130165426A1 (en) | 2010-07-06 | 2013-06-27 | Université de Montréal | Imidazopyridine, imidazopyrimidine and imidazopyrazine derivatives as melanocortin-4 receptor modulators |
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CN104114553B (zh) | 2011-12-12 | 2017-03-01 | 雷迪博士实验室有限公司 | 作为原肌球蛋白受体激酶(Trk)抑制剂的取代的吡唑并[1,5‑a]吡啶 |
WO2013176970A1 (en) * | 2012-05-22 | 2013-11-28 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
JP6117569B2 (ja) | 2013-02-28 | 2017-04-19 | 三甲株式会社 | ボックスパレット |
GB201321741D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
TWI731317B (zh) | 2013-12-10 | 2021-06-21 | 美商健臻公司 | 原肌球蛋白相關之激酶(trk)抑制劑 |
CN110950862B (zh) | 2014-12-18 | 2024-01-05 | 建新公司 | 原肌球蛋白相关激酶(trk)抑制剂的药物制剂 |
CN107197528B (zh) | 2016-03-14 | 2020-12-25 | 华为技术有限公司 | 一种资源调度和分配的方法和装置 |
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2015
- 2015-12-17 CN CN201911088940.XA patent/CN110950862B/zh active Active
- 2015-12-17 SG SG11201704872RA patent/SG11201704872RA/en unknown
- 2015-12-17 JP JP2017532722A patent/JP6606183B2/ja active Active
- 2015-12-17 BR BR112017012566-8A patent/BR112017012566B1/pt active IP Right Grant
- 2015-12-17 NZ NZ733825A patent/NZ733825A/en unknown
- 2015-12-17 EP EP15823088.8A patent/EP3233057A2/en active Pending
- 2015-12-17 US US15/536,544 patent/US10219998B2/en active Active
- 2015-12-17 TW TW109118415A patent/TWI780438B/zh active
- 2015-12-17 CA CA2970938A patent/CA2970938C/en active Active
- 2015-12-17 TN TN2017000234A patent/TN2017000234A1/en unknown
- 2015-12-17 WO PCT/US2015/066396 patent/WO2016100677A2/en active Application Filing
- 2015-12-17 EA EA201791336A patent/EA201791336A1/ru unknown
- 2015-12-17 KR KR1020177019802A patent/KR102561692B1/ko active IP Right Grant
- 2015-12-17 MY MYPI2017702037A patent/MY195799A/en unknown
- 2015-12-17 MX MX2017008058A patent/MX2017008058A/es unknown
- 2015-12-17 AU AU2015364557A patent/AU2015364557C1/en active Active
- 2015-12-17 TW TW104142525A patent/TWI696621B/zh active
- 2015-12-17 MA MA40698A patent/MA40698A3/fr unknown
- 2015-12-17 CN CN201580076248.9A patent/CN107231803B/zh active Active
- 2015-12-18 AR ARP150104196A patent/AR103176A1/es unknown
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2017
- 2017-06-14 CL CL2017001543A patent/CL2017001543A1/es unknown
- 2017-06-14 IL IL252901A patent/IL252901B/en active IP Right Grant
- 2017-06-15 PH PH12017501121A patent/PH12017501121B1/en unknown
- 2017-06-16 MX MX2020013015A patent/MX2020013015A/es unknown
- 2017-07-17 CO CONC2017/0007118A patent/CO2017007118A2/es unknown
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2019
- 2019-01-04 US US16/239,904 patent/US11110055B2/en active Active
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2021
- 2021-08-20 US US17/407,419 patent/US11793749B2/en active Active
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2023
- 2023-10-20 US US18/491,503 patent/US20240189223A1/en active Pending
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