CL2016002017A1 - Inhibición dirigida del factor de crecimiento transformador b (tgfb). - Google Patents

Inhibición dirigida del factor de crecimiento transformador b (tgfb).

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Publication number
CL2016002017A1
CL2016002017A1 CL2016002017A CL2016002017A CL2016002017A1 CL 2016002017 A1 CL2016002017 A1 CL 2016002017A1 CL 2016002017 A CL2016002017 A CL 2016002017A CL 2016002017 A CL2016002017 A CL 2016002017A CL 2016002017 A1 CL2016002017 A1 CL 2016002017A1
Authority
CL
Chile
Prior art keywords
tgfb
growth factor
transforming growth
directed inhibition
inhibition
Prior art date
Application number
CL2016002017A
Other languages
English (en)
Inventor
Kin-Ming Lo
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CL2016002017A1 publication Critical patent/CL2016002017A1/es

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    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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Abstract

<p>PROTEÍNA QUE COMPRENDE TGFbetaRII HUMANO O FRAGMENTO DEL MISMO DE UNIÓN A TGFbeta Y UN ANTICUERPO QUE SE UNE AL LIGANDO 1A DE LA PROTEÍNA HUMANA DE MUERTE PROGRAMADA (PD-L1); Y USO PARA TRATAR CANCER.</p>
CL2016002017A 2014-02-10 2016-08-10 Inhibición dirigida del factor de crecimiento transformador b (tgfb). CL2016002017A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461938048P 2014-02-10 2014-02-10

Publications (1)

Publication Number Publication Date
CL2016002017A1 true CL2016002017A1 (es) 2017-06-09

Family

ID=52988007

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002017A CL2016002017A1 (es) 2014-02-10 2016-08-10 Inhibición dirigida del factor de crecimiento transformador b (tgfb).

Country Status (27)

Country Link
US (4) US9676863B2 (es)
EP (2) EP3889172B1 (es)
JP (2) JP6731346B2 (es)
KR (1) KR102363008B1 (es)
CN (2) CN106103488B (es)
AU (3) AU2015213988B2 (es)
BR (1) BR112016014952A2 (es)
CA (1) CA2934979A1 (es)
CL (1) CL2016002017A1 (es)
CY (1) CY1124408T1 (es)
DK (1) DK3105246T3 (es)
ES (1) ES2876430T3 (es)
HR (1) HRP20210977T1 (es)
HU (1) HUE054873T2 (es)
IL (2) IL246968B (es)
LT (1) LT3105246T (es)
MX (2) MX2016010067A (es)
NZ (1) NZ721364A (es)
PE (2) PE20210168A1 (es)
PH (1) PH12016501549A1 (es)
PL (1) PL3105246T3 (es)
PT (1) PT3105246T (es)
RS (1) RS62038B1 (es)
RU (2) RU2021114500A (es)
SG (2) SG10202108879SA (es)
SI (1) SI3105246T1 (es)
WO (1) WO2015118175A2 (es)

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