CL2015002698A1 - Nuevos compuestos y composiciones para la inhibicion de fasn - Google Patents
Nuevos compuestos y composiciones para la inhibicion de fasnInfo
- Publication number
- CL2015002698A1 CL2015002698A1 CL2015002698A CL2015002698A CL2015002698A1 CL 2015002698 A1 CL2015002698 A1 CL 2015002698A1 CL 2015002698 A CL2015002698 A CL 2015002698A CL 2015002698 A CL2015002698 A CL 2015002698A CL 2015002698 A1 CL2015002698 A1 CL 2015002698A1
- Authority
- CL
- Chile
- Prior art keywords
- fasn
- inhibition
- compositions
- new compounds
- obesity
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 101150003888 FASN gene Proteins 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 abstract 1
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D305/08—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
COMPUESTOS HETEROCICLICOS DERIVADOS DE PIPERAZINA SUSTITUIDA, INHIBIDORES DE FASN; COMPOSICION FARMACEUTICA; COMBINACION FARMACEUTICA; USO EN EL TRATAMIENTO DE UNA ENFERMEDAD O CONDICION TAL COMO CANCER, INFECCION VIRAL, OBESIDAD, DIABETES, ENTRE OTRAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361779962P | 2013-03-13 | 2013-03-13 | |
US201361779908P | 2013-03-13 | 2013-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015002698A1 true CL2015002698A1 (es) | 2016-08-19 |
Family
ID=51658962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015002698A CL2015002698A1 (es) | 2013-03-13 | 2015-09-14 | Nuevos compuestos y composiciones para la inhibicion de fasn |
Country Status (37)
Country | Link |
---|---|
US (8) | US20160002188A1 (es) |
EP (2) | EP2968316B1 (es) |
JP (2) | JP2016517412A (es) |
KR (1) | KR102194745B1 (es) |
CN (2) | CN112521369A (es) |
AU (3) | AU2014249003A1 (es) |
BR (1) | BR112015023279B1 (es) |
CA (1) | CA2905751A1 (es) |
CL (1) | CL2015002698A1 (es) |
CR (1) | CR20150541A (es) |
CU (1) | CU24341B1 (es) |
CY (1) | CY1122244T1 (es) |
DK (1) | DK2968316T3 (es) |
EC (1) | ECSP15043280A (es) |
ES (2) | ES2861180T3 (es) |
HK (1) | HK1220409A1 (es) |
HR (1) | HRP20191860T1 (es) |
HU (1) | HUE045701T2 (es) |
IL (1) | IL241699B (es) |
LT (1) | LT2968316T (es) |
ME (1) | ME03564B (es) |
MX (1) | MX364895B (es) |
MY (1) | MY191366A (es) |
NI (1) | NI201500141A (es) |
NO (1) | NO20151329A1 (es) |
PE (1) | PE20160122A1 (es) |
PH (1) | PH12015502097A1 (es) |
PL (1) | PL2968316T3 (es) |
PT (1) | PT2968316T (es) |
RS (1) | RS59411B1 (es) |
RU (2) | RU2737434C2 (es) |
SA (1) | SA515361086B1 (es) |
SG (2) | SG10201707409PA (es) |
SI (1) | SI2968316T1 (es) |
TN (1) | TN2015000420A1 (es) |
WO (2) | WO2014164749A1 (es) |
ZA (1) | ZA201506922B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2737434C2 (ru) | 2013-03-13 | 2020-11-30 | Форма Терапьютикс, Инк. | Новые соединения и композиции для ингибирования fasn |
CN105008329B (zh) * | 2013-03-21 | 2018-01-05 | 默克专利股份公司 | 作为fasn抑制剂的哌嗪衍生物 |
US10626094B2 (en) * | 2014-10-14 | 2020-04-21 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof |
US11202795B2 (en) | 2014-11-20 | 2021-12-21 | Vib Vzw | Means and methods for treatment of early-onset Parkinson's disease |
ES2821049T3 (es) | 2015-06-18 | 2021-04-23 | 89Bio Ltd | Derivados de piperidina 1,4 sustituidos |
CA3014432A1 (en) | 2015-06-18 | 2016-12-22 | Cephalon, Inc. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
DK3458448T3 (da) | 2016-04-25 | 2021-08-23 | Forma Therapeutics Inc | Fasn-inhibitorer til anvendelse til behandling af non-alkoholisk steatohepatitis |
CN106806371A (zh) * | 2017-01-19 | 2017-06-09 | 伊希珍 | 一种化合物在制备治疗发作性睡病药物中的应用 |
CN107056695A (zh) * | 2017-01-26 | 2017-08-18 | 青岛辰达生物科技有限公司 | 一种治疗胃癌药物阿帕替尼的合成方法 |
WO2018204176A1 (en) | 2017-05-01 | 2018-11-08 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitors of low molecular weight protein tyrosine phosphatase (lmptp) and uses thereof |
US20210252011A1 (en) * | 2017-10-25 | 2021-08-19 | Forma Therapeutics, Inc. | Treatment of glioblastoma with fasn inhibitors |
EP3636637A1 (en) * | 2018-10-10 | 2020-04-15 | Forma Therapeutics, Inc. | Inhibiting fatty acid synthase (fasn) |
TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
WO2020092376A1 (en) * | 2018-10-29 | 2020-05-07 | Forma Therapeutics, Inc. | Treating non-alcoholic steatohepatitis (nash) |
EP3892278B1 (en) | 2018-12-06 | 2024-02-28 | Daiichi Sankyo Company, Limited | Cycloalkane-1,3-diamine derivative |
US20220400732A1 (en) * | 2019-03-21 | 2022-12-22 | Cornell University | Anti-fructose therapy for colorectal and small intestine cancers |
JP7430852B2 (ja) * | 2019-12-20 | 2024-02-14 | エヌイミューン バイオファーマ インコーポレイテッド | ランチオニンc様タンパク質2リガンド、それを用いて調製される細胞、およびそれを使用する療法 |
WO2023093700A1 (zh) * | 2021-11-29 | 2023-06-01 | 中国海洋大学 | 咪唑并噻唑衍生物及其制备方法与应用 |
Family Cites Families (206)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5759837A (en) | 1989-01-17 | 1998-06-02 | John Hopkins University | Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway |
EP0385043A1 (en) * | 1989-02-28 | 1990-09-05 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) | New derivatives of 4-substituted piperazines |
HU209678B (en) | 1992-06-09 | 1994-10-28 | Richter Gedeon Vegyeszet | Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them |
US5376664A (en) | 1992-07-27 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
CA2077252C (en) * | 1992-08-31 | 2001-04-10 | Khashayar Karimian | Methods of making ureas and guanidines, and intermediates therefor |
US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US5856326A (en) | 1995-03-29 | 1999-01-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
IL117580A0 (en) | 1995-03-29 | 1996-07-23 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them |
ATE303144T1 (de) | 1995-11-17 | 2005-09-15 | Univ Johns Hopkins | Hemmung der fettsäuresynthase als mittel zur verminderung der adipozytenmenge |
CA2260767A1 (en) | 1996-07-19 | 1998-01-29 | Takeda Chemical Industries, Ltd. | Fas ligand-like protein, its production and use |
DE19743435A1 (de) | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
US6413974B1 (en) | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
AU769917B2 (en) | 1998-04-23 | 2004-02-12 | Duke University | Method of predicting the ability of compounds to modulate the biological activity of receptors |
ATE461210T1 (de) | 1998-06-11 | 2010-04-15 | Ortho Mcneil Pharm Inc | Pyrazine protease inhibitore |
AU772477B2 (en) | 1998-08-28 | 2004-04-29 | Scios Inc. | Inhibitors of p38-alpha kinase |
WO2000022909A2 (en) | 1998-10-19 | 2000-04-27 | Biotech Australia Pty. Limited | Systems for oral delivery |
CO5190665A1 (es) | 1999-06-23 | 2002-08-29 | Smithkline Beecham Corp | Compuestos de indol |
CO5180605A1 (es) | 1999-06-23 | 2002-07-30 | Smithkline Beecham Corp | Compuestos de indol |
JP2003506438A (ja) | 1999-08-10 | 2003-02-18 | ブリティッシュ バイオテック ファーマシューティカルズ リミテッド | 抗菌剤 |
AR029001A1 (es) | 1999-08-23 | 2003-06-04 | Smithkline Beecham Corp | Derivados de bencil-3,4-metilendioxicinamico y el uso de los mismos para la manufactura de un medicamento |
WO2001014362A1 (en) | 1999-08-23 | 2001-03-01 | Smithkline Beecham Corporation | Fatty acid synthase inhibitors |
WO2001014363A1 (en) | 1999-08-23 | 2001-03-01 | Smithkline Beecham Corporation | Fatty acid synthase inhibitors |
US6541477B2 (en) * | 1999-08-27 | 2003-04-01 | Scios, Inc. | Inhibitors of p38-a kinase |
JP2003508509A (ja) * | 1999-09-04 | 2003-03-04 | アストラゼネカ アクチボラグ | ピルビン酸デヒドロゲナーゼの阻害剤としてのアミド |
JP2003512452A (ja) | 1999-10-22 | 2003-04-02 | スミスクライン・ビーチャム・コーポレイション | 新規インドール化合物 |
US6486211B1 (en) | 1999-10-22 | 2002-11-26 | Smithkline Beecham Corporation | Indole compounds |
WO2001036003A2 (en) | 1999-11-15 | 2001-05-25 | Drug Innovation & Design, Inc. | Selective cellular targeting: multifunctional delivery vehicles |
EP1255567A1 (en) | 1999-11-15 | 2002-11-13 | Drug Innovation & Design, Inc. | Selective cellular targeting: multifunctional delivery vehicles |
CA2391534A1 (en) | 1999-11-15 | 2001-05-25 | Drug Innovation & Design, Inc. | Selective cellular targeting: multifunctional delivery vehicles |
US20030220392A1 (en) | 2000-05-24 | 2003-11-27 | Leber Jack Dale | Fatty acid synthase inhibitors |
AU2001266070A1 (en) | 2000-06-16 | 2001-12-24 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Method for identifying apoptosis-modified proteins |
EP1164374A1 (en) | 2000-06-16 | 2001-12-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for identifying apoptosis-modified proteins |
AU2001270200A1 (en) | 2000-06-27 | 2002-01-08 | Smith Kline Beecham Corporation | Fatty acid synthase inhibitors |
AU2001271531A1 (en) | 2000-06-27 | 2002-01-08 | Smith Kline Beecham Corporation | Fatty acid synthase inhibitors |
AU2001271718A1 (en) | 2000-06-29 | 2002-01-14 | Smith Kline Beecham Corporation | Fatty acid synthase inhibitors |
AU2001281059A1 (en) | 2000-08-02 | 2002-02-13 | Smith Kline Beecham Corporation | Fatty acid synthase inhibitors |
JP2004505030A (ja) | 2000-08-02 | 2004-02-19 | スミスクライン・ビーチャム・コーポレイション | 脂肪酸シンターゼ阻害剤 |
WO2002024197A1 (en) | 2000-09-22 | 2002-03-28 | Smithkline Beecham Corporation | Fatty acid synthase inhibitors |
AU2001294824A1 (en) * | 2000-09-29 | 2002-04-08 | Millennium Pharmaceuticals, Inc. | Piperazine based inhibitors of factor xa |
KR20030034232A (ko) | 2000-09-29 | 2003-05-01 | 닛뽕소다 가부시키가이샤 | 티에노피리미딘 화합물 및 그 염 및 제조방법 |
US20070208087A1 (en) * | 2001-11-02 | 2007-09-06 | Sanders Virginia J | Compounds, compositions and methods for the treatment of inflammatory diseases |
AU2002243439A1 (en) | 2000-11-17 | 2002-07-24 | Smithkline Beecham Corporation | Fatty acid synthase inhibitors |
AU2002247847A1 (en) | 2001-04-09 | 2002-10-21 | Lorantis Limited | Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways |
CA2447023A1 (en) | 2001-05-23 | 2002-11-28 | Dendreon San Diego Llc | Conjugates activated by cell surface proteases and therapeutic uses thereof |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
FR2829766A1 (fr) | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
AU2001292386B2 (en) | 2001-09-21 | 2006-06-22 | Boryung Pharmaceutical Co., Ltd. | Method for preparing pyrimidinone compound and pharmaceutically acceptable salts thereof |
CN1620294A (zh) | 2001-12-20 | 2005-05-25 | Osi药物公司 | 嘧啶a2b选择性拮抗剂化合物,它们的合成及用途 |
US20030170244A1 (en) | 2001-12-21 | 2003-09-11 | Pluenneke John D. | Inhibition of Fas signaling |
US20050119251A1 (en) | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
BRPI0308208B8 (pt) | 2002-03-05 | 2021-05-25 | Axys Pharm Inc | compostos inibidores de catepsina cisteína protease e composições farmacêuticas compreendendo os mesmos |
AU2003226370A1 (en) | 2002-04-17 | 2003-11-03 | The Burnham Institute | Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation |
US7728153B2 (en) | 2002-04-17 | 2010-06-01 | The Burnham Institute For Medical Research | Method for the asymmetric synthesis of beta-lactone compounds |
CA2483306A1 (en) * | 2002-04-23 | 2003-11-06 | Shionogi & Co., Ltd. | Pyrazolo[1,5-a]pyrimidine derivative and nad(p)h oxidase inhibitor containing the same |
US20040001801A1 (en) | 2002-05-23 | 2004-01-01 | Corvas International, Inc. | Conjugates activated by cell surface proteases and therapeutic uses thereof |
EA013371B1 (ru) | 2002-07-09 | 2010-04-30 | Фасджен, Ллс. | Новые соединения, содержащие их фармацевтические композиции и способы их применения |
US20050288213A1 (en) | 2002-07-18 | 2005-12-29 | Macneil Douglas J | Combination therapy for the treatment of obesity |
EP1536790A2 (en) | 2002-08-09 | 2005-06-08 | AstraZeneca AB | Oxadiazoles as modulators of metabotropic glutamate receptor-5 |
US7414057B2 (en) | 2002-09-11 | 2008-08-19 | Merck & Co., Inc. | Piperazine urea derivatives as melanocortin-4 receptor agonists |
AU2003218462A1 (en) | 2002-10-01 | 2004-04-23 | Merck And Co., Inc. | Treatment of obesity and other disorders associated with excessive food intake |
JP2006512404A (ja) | 2002-10-22 | 2006-04-13 | グラクソ グループ リミテッド | H3受容体リガンドとしてのアリールオキシアルキルアミン誘導体 |
JP2006510630A (ja) | 2002-12-04 | 2006-03-30 | メルク エンド カムパニー インコーポレーテッド | 糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体 |
US20040122033A1 (en) | 2002-12-10 | 2004-06-24 | Nargund Ravi P. | Combination therapy for the treatment of obesity |
US20070099884A1 (en) | 2003-06-06 | 2007-05-03 | Erondu Ngozi E | Combination therapy for the treatment of diabetes |
WO2004110368A2 (en) | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Combination therapy for the treatment of hypertension |
US20060148721A1 (en) | 2003-06-06 | 2006-07-06 | Erondu Ngozi E | Combination therapy for the treatment of dyslipidemia |
US7419990B2 (en) | 2003-07-22 | 2008-09-02 | Merck & Co., Inc. | Piperidine derivatives as melanocortin-4 receptor agonists |
US20050043300A1 (en) | 2003-08-14 | 2005-02-24 | Pfizer Inc. | Piperazine derivatives |
KR20060037442A (ko) * | 2003-08-14 | 2006-05-03 | 화이자 인코포레이티드 | Hiv 감염 치료용 피페라진 유도체 |
WO2005035534A1 (ja) | 2003-10-08 | 2005-04-21 | Ono Pharmaceutical Co., Ltd. | 複素ビシクロ環および複素トリシクロ環化合物およびその医薬 |
GB0326029D0 (en) * | 2003-11-07 | 2003-12-10 | Astrazeneca Ab | Chemical compounds |
WO2005073186A1 (ja) * | 2004-01-29 | 2005-08-11 | Ono Pharmaceutical Co., Ltd. | ピロリジン誘導体 |
TW200528101A (en) * | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
EP1751131B1 (en) | 2004-03-10 | 2008-11-19 | Janssen Pharmaceutica N.V. | Mtp inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles |
PE20060285A1 (es) | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
US7632857B2 (en) | 2004-04-01 | 2009-12-15 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
US8008301B2 (en) | 2004-04-01 | 2011-08-30 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
MXPA06011770A (es) | 2004-04-12 | 2007-04-13 | Torrent Pharmaceuticals Ltd | 2-propen-1-onas como inductores de hsp 70. |
KR100907354B1 (ko) * | 2004-05-18 | 2009-07-10 | 쉐링 코포레이션 | Pde4 억제제로서 유용한 치환된 2-퀴놀릴-옥사졸 |
EP1750712A2 (en) | 2004-05-19 | 2007-02-14 | Solvay Pharmaceuticals GmbH | Medicaments containing n-sulfamoyl-n'-arylpiperazines for the prophylaxis or treatment of obesity and related conditions |
US20050261292A1 (en) | 2004-05-19 | 2005-11-24 | Solvay Pharmaceuticals Gmbh | Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions |
WO2005116006A1 (ja) | 2004-05-28 | 2005-12-08 | Riken | フラーレン誘導体の製造方法 |
CA2577191A1 (en) | 2004-08-26 | 2006-03-02 | Kudos Pharmaceuticals Limited | 4-heteroarylmethyl substituted phthalazinone derivatives |
CA2580725A1 (en) | 2004-09-20 | 2006-03-30 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
AU2005289710A1 (en) | 2004-09-24 | 2006-04-06 | Merck & Co., Inc. | Combination therapy for the treatment of obesity |
CA2582235A1 (en) | 2004-10-04 | 2006-04-20 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
EP1807102A2 (en) | 2004-10-29 | 2007-07-18 | Merck & Co., Inc. | Compositions and methods for the treatment of obesity and sexual dysfunction |
FR2877667B1 (fr) | 2004-11-05 | 2007-03-23 | Sod Conseils Rech Applic | Derives de 4,7-dioxobenzothiazole-2-carboxamides, leur preparation et leurs applications therapeutiques |
NZ555320A (en) | 2004-12-03 | 2010-11-26 | Schering Corp | Substituted piperazines as CB1 antagonists |
FR2879598B1 (fr) | 2004-12-17 | 2007-03-30 | Sod Conseils Rech Applic | Inhibiteurs de phosphatases cdc25 |
CA2609394A1 (en) | 2005-05-23 | 2006-11-30 | Masaki Takagi | Pyrazole compound and therapeutic agent for diabetes comprising the same |
US20060270650A1 (en) | 2005-05-26 | 2006-11-30 | Macneil Tanya | Combination therapy for the treatment of obesity |
MX2007016523A (es) | 2005-06-20 | 2008-03-06 | Schering Corp | Piperidinas sustituidas ligadas a carbono y derivados de las mismas utiles como antagonistas de hsitamina h3. |
GB0518237D0 (en) | 2005-09-07 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US7473688B2 (en) | 2005-09-13 | 2009-01-06 | Bristol-Myers Squibb Company | Indolobenzazepine HCV NS5B inhibitors |
AU2006297089B2 (en) | 2005-09-27 | 2012-05-03 | Irm Llc | Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors |
ES2537898T3 (es) * | 2005-10-25 | 2015-06-15 | Shionogi & Co., Ltd. | Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1 |
EP1948636A2 (en) | 2005-11-14 | 2008-07-30 | Irm Llc | Compounds and compositions as lxr modulators |
CA2631694A1 (en) | 2005-12-15 | 2007-06-21 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-c]pyridine derivatives |
BRPI0619985A2 (pt) | 2005-12-16 | 2011-10-25 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas, métodos para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, de obesidade e de diabetes do tipo ii em um ser humano ou animal e usos dos compostos |
PE20071136A1 (es) | 2005-12-21 | 2007-12-29 | Schering Corp | Derivados de anilina sustituida como antagonistas de la histamina h3 |
MX2008008337A (es) | 2005-12-21 | 2008-09-03 | Schering Corp | Fenoxipiperidinas y sus analogos utiles como antagonistas de histamina h3. |
US8008354B2 (en) | 2006-01-11 | 2011-08-30 | Burnham Institute For Medical Research | Death receptor sensitizing compounds and methods of use therefor |
US20070203236A1 (en) | 2006-01-11 | 2007-08-30 | Smith Jeffrey W | Novel antagonists of the human fatty acid synthase thioesterase |
KR20080085031A (ko) | 2006-01-13 | 2008-09-22 | 에프. 호프만-라 로슈 아게 | 사이클로헥실 피페라지닐 메탄온 유도체 및 히스타민 h3수용체 조절제로서의 이의 용도 |
CA2637717A1 (en) | 2006-01-20 | 2007-08-02 | Schering Corporation | Heterocycles as nicotinic acid receptor agonists for the treatment of dyyslipidemia |
AU2007206997B2 (en) | 2006-01-23 | 2011-11-24 | F. Hoffmann-La Roche Ag | Cyclohexyl sulfonamide derivatives having H3 receptor activity |
EP1981341A4 (en) | 2006-01-30 | 2011-01-05 | Merck Sharp & Dohme | FATTY ACID SYNTHESIS HEMMER (FAS) |
US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
US7601716B2 (en) | 2006-05-01 | 2009-10-13 | Cephalon, Inc. | Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors |
WO2007137955A1 (en) | 2006-05-30 | 2007-12-06 | F. Hoffmann-La Roche Ag | Piperidinyl pyrimidine derivatives |
WO2007138355A1 (en) | 2006-05-31 | 2007-12-06 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Pyrrolo[1,2-a]pyrazin-1(2h)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2h)-one derivatives as inhibitors of poly(adp-ribose)polymerase(parp) |
GB0610680D0 (en) | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
US8088923B2 (en) | 2006-07-07 | 2012-01-03 | The Texas A&M University System | Cyclic-fused beta-lactones and their synthesis |
AU2007275301A1 (en) * | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1 |
CA2665804A1 (en) * | 2006-08-23 | 2008-02-28 | Astellas Pharma Inc. | Urea compound or salt thereof |
US7994222B2 (en) | 2006-09-05 | 2011-08-09 | Bipar Sciences, Inc. | Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds |
EP2698157B1 (en) | 2006-09-22 | 2015-05-20 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
JO2653B1 (en) | 2006-10-24 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Tetrahydroflavin 1-carboxylic acid substituted with pyridine or pyrazine inhibit MTB |
BRPI0718052A2 (pt) | 2006-11-02 | 2015-06-16 | Sanofi Aventis Deutschland | Difenilazotidinona substituída por ácido piperazino-1 sulfônico e possuindo propriedades farmacológicas melhoradas |
WO2008059214A1 (en) | 2006-11-13 | 2008-05-22 | Astrazeneca Ab | Bisamlde derivatives and use thereof as fatty acid synthase inhibitors |
CN101190894A (zh) | 2006-11-23 | 2008-06-04 | 中国人民解放军军事医学科学院毒物药物研究所 | 脂肪酸合成酶抑制剂及其制药用途 |
JP2010510987A (ja) | 2006-11-27 | 2010-04-08 | ハー・ルンドベック・アクチエゼルスカベット | ヘテロアリールアミド誘導体 |
CN101679297B (zh) | 2006-12-08 | 2012-01-11 | 埃克塞利希斯股份有限公司 | Lxr和fxr调节剂 |
TW200831092A (en) | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
TW200833663A (en) | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Therapeutic agents |
WO2008075077A1 (en) | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Piperidine derivatives for the treatment of obesity |
US8466150B2 (en) | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
DE102007007751A1 (de) | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
CN101668520A (zh) | 2007-02-28 | 2010-03-10 | 科内图斯医药公司 | 使用特定基质金属蛋白酶(mmp)抑制剂治疗肝脏疾病的方法 |
EP2144604B1 (en) | 2007-02-28 | 2011-09-21 | Conatus Pharmaceuticals, Inc. | Methods for the treatment of chronic viral hepatitis C using RO 113-0830 |
WO2008106167A1 (en) | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases |
JP2010520291A (ja) | 2007-03-07 | 2010-06-10 | コンサート ファーマシューティカルズ インコーポレイテッド | 抗狭心症化合物としての重水素化ピペラジン誘導体 |
KR101171433B1 (ko) | 2007-03-30 | 2012-08-06 | 에프. 호프만-라 로슈 아게 | 이미다졸리딘온 유도체 |
US7682857B2 (en) | 2007-04-16 | 2010-03-23 | Mitsubishi Electric Corporation | Method for manufacturing semiconductor optical device |
JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
JP2010525062A (ja) | 2007-04-25 | 2010-07-22 | エグゼリクシス, インコーポレイテッド | Pimモジュレーターとしてのピリミジノン類 |
JP2010529994A (ja) | 2007-06-13 | 2010-09-02 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | 置換ピペラジン |
CN101686989B (zh) | 2007-06-21 | 2016-10-19 | 卡拉治疗学股份有限公司 | 取代的咪唑并杂环 |
EP2019091A1 (en) | 2007-06-25 | 2009-01-28 | Fundació Privada Institut d'Investigació Biomédica de Girona - Dr. Josep Trueta | Novel polyhydroxylated compounds as Fatty Acid Synthase (FASN) inhibitors |
US20090023727A1 (en) | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
US8314091B2 (en) | 2007-08-20 | 2012-11-20 | Msd Oss B.V. | N-benzyl,N'-arylcarbonylpiperazine derivatives |
CN104710408A (zh) * | 2007-10-09 | 2015-06-17 | 霍夫曼-拉罗奇有限公司 | 手性顺式-咪唑啉类 |
WO2009064927A2 (en) | 2007-11-13 | 2009-05-22 | Fasgen, Inc. | Phosphorylated fatty acid synthase and cancer |
EP2219646A4 (en) | 2007-12-21 | 2010-12-22 | Univ Rochester | METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS |
WO2009098282A1 (en) * | 2008-02-06 | 2009-08-13 | Novasaid Ab | Low molecular weight 2,5-disubstituted thiophene derivatives and use thereof in therapy |
CN101998959B (zh) * | 2008-02-06 | 2013-08-28 | 生物马林药物股份有限公司 | 聚(adp-核糖)聚合酶(parp)的苯并噁唑甲酰胺抑制剂 |
US8129398B2 (en) | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
JP2011518836A (ja) | 2008-04-24 | 2011-06-30 | インサイト・コーポレイション | 大環状化合物およびそれらのキナーゼ阻害剤としての使用 |
TW201006816A (en) | 2008-05-15 | 2010-02-16 | Organon Nv | Hexafluoroisopropanol derivatives |
WO2009143404A1 (en) | 2008-05-23 | 2009-11-26 | Wyeth | Piperazine metabotropic glutamate receptor 5 (mglur5) negative allosteric modulators for anxiety/depression |
WO2009151910A2 (en) | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
ES2625817T3 (es) | 2008-08-06 | 2017-07-20 | Medivation Technologies, Inc. | Inhibidores de tipo Dihidropiridoftalazinona de poli(ADP-ribosa)polimerasa (PARP) |
TW201022230A (en) | 2008-08-28 | 2010-06-16 | Organon Nv | 1-(4-ureidobenzoyl)piperazine derivatives |
US8772318B2 (en) | 2008-11-14 | 2014-07-08 | The Scripps Research Institute | Methods and compositions related to targeting monoacylglycerol lipase |
EP2414348B1 (en) | 2009-04-03 | 2013-11-20 | Merck Sharp & Dohme Corp. | Bicyclic piperidine and piperazine derivatives as gpcr modulators for the treatment of obesity, diabetes and other metabolic disorders |
CA2759098A1 (en) | 2009-04-14 | 2010-10-21 | Smith Holdings, Llc | Methods and compositions for the treatment of medical conditions involving cellular programming |
CA2761445A1 (en) * | 2009-05-27 | 2010-12-02 | Genentech, Inc. | Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
WO2010150100A1 (en) | 2009-06-24 | 2010-12-29 | Entarco Sa | The use of spinosyns and spinosyn compositions against diseases caused by protozoans, viral infections and cancer |
WO2011035018A2 (en) | 2009-09-18 | 2011-03-24 | Fate Therapeutics, Inc. | Suicide ready cells |
WO2011037793A1 (en) | 2009-09-25 | 2011-03-31 | Merck Sharp & Dohme Corp. | Substituted aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
JP5546636B2 (ja) | 2009-09-28 | 2014-07-09 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンゾキセピンpi3k阻害剤化合物及び使用方法 |
US8865704B2 (en) | 2009-10-07 | 2014-10-21 | Siena Biotech S.P.A. | Wnt pathway antagonists |
JP2013508461A (ja) | 2009-10-27 | 2013-03-07 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 脂肪酸シンターゼ阻害剤としてのベンズイミダゾール |
CN102812037A (zh) | 2009-10-30 | 2012-12-05 | 特兰齐姆制药公司 | 大环生长素释放肽受体拮抗剂和反向激动剂及其使用方法 |
JP2013512245A (ja) | 2009-11-24 | 2013-04-11 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 脂肪酸合成酵素阻害剤としてのアザベンズイミダゾール |
EP2538787B1 (en) | 2010-02-22 | 2014-07-16 | GlaxoSmithKline LLC | Triazolones as fatty acid synthase inhibitors |
WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
EP2566853B1 (en) | 2010-05-05 | 2017-01-25 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
WO2011163612A1 (en) | 2010-06-24 | 2011-12-29 | Trustees Of Tufts College | Niacin mimetics, and methods of use thereof |
AU2011270726C1 (en) | 2010-06-24 | 2016-02-18 | Arisaph Pharmaceuticals, Inc. | Niacin mimetics, and methods of use thereof |
AU2011283684B2 (en) | 2010-07-29 | 2015-08-27 | Rigel Pharmaceuticals, Inc. | AMPK-activating heterocyclic compounds and methods for using the same |
CN102372698A (zh) | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
EP2615918A4 (en) | 2010-09-17 | 2014-01-29 | Glaxosmithkline Ip Dev Ltd | INHIBITORS OF ACID GRAS SYNTHASE |
WO2012037299A2 (en) | 2010-09-17 | 2012-03-22 | Glaxosmithkline Llc | Fatty acid synthase inhibitors |
JP2013542960A (ja) | 2010-11-08 | 2013-11-28 | グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッド | 脂肪酸シンターゼ阻害剤 |
WO2012064632A1 (en) * | 2010-11-12 | 2012-05-18 | Wake Forest University Health Sciences | Methods of treating cancer and other disorders |
UY33726A (es) | 2010-11-15 | 2012-06-29 | Abbott Lab | Inhibidores de nampt y rock |
CA2849207A1 (en) | 2010-11-24 | 2012-05-31 | Craig Townsend | Methods of screening compounds that are cytotoxic to tumor cells and methods of treating tumor cells using such compounds |
TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
WO2012096928A2 (en) | 2011-01-10 | 2012-07-19 | Glaxosmithkline Llc | Pyrimidinone derivatives as fatty acid synthase inhibitors |
EP2668177B1 (en) | 2011-01-28 | 2014-10-22 | Boehringer Ingelheim International GmbH | Substituted pyridinyl-pyrimidines and their use as medicaments |
AR086837A1 (es) | 2011-03-08 | 2014-01-29 | 3 V Biosciences Inc | Moduladores heterociclicos de sintesis lipidica |
ES2624131T3 (es) | 2011-03-08 | 2017-07-13 | 3-V Biosciences, Inc. | Moduladores heterocíclicos de la síntesis de lípidos |
EP2686305B1 (en) | 2011-03-14 | 2020-09-16 | Impact Therapeutics, Inc. | Quinazolinediones and their use |
TWI527800B (zh) | 2011-04-01 | 2016-04-01 | 南京英派藥業有限公司 | 作為聚(二磷酸腺苷酸-核醣)聚合酶(parp)之抑制劑之1-(芳基甲基)喹唑啉-2,4(1h,3h)-二酮及其應用 |
CN103608016A (zh) | 2011-05-03 | 2014-02-26 | 安吉奥斯医药品有限公司 | 丙酮酸激酶激活剂在治疗中的用途 |
SG194697A1 (en) | 2011-05-03 | 2013-12-30 | Agios Pharmaceuticals Inc | Pyruvate kinase activators for use in therapy |
WO2013028495A1 (en) * | 2011-08-19 | 2013-02-28 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) for the treatment of multiple myeloma |
WO2013028445A1 (en) * | 2011-08-19 | 2013-02-28 | Glaxosmithkline Llc | Fatty acid synthase inhibitors |
BR112014004845A2 (pt) * | 2011-08-30 | 2017-04-04 | Chdi Foundation Inc | pelo menos uma entidade química; pelo menos um composto; composição farmacêutica; uso de uma quantidade terapeuticamente eficaz de pelo menos uma entidade química; composição farmacêutica embalada |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013060636A1 (en) | 2011-10-25 | 2013-05-02 | Sanofi | 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013064083A1 (en) | 2011-11-01 | 2013-05-10 | Impact Therapeutics, Inc. | 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs and the use thereof |
CN103130723B (zh) | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
CN102627610B (zh) * | 2012-04-11 | 2014-06-25 | 江苏先声药物研究有限公司 | 一类苯并咪唑类衍生物及其应用 |
US9096579B2 (en) | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
CN103420890B (zh) | 2012-05-15 | 2015-06-24 | 天津药物研究院 | 3-吡咯甲酸衍生物及其制备方法和用途 |
AR092211A1 (es) | 2012-09-24 | 2015-04-08 | Merck Patent Ges Mit Beschränkter Haftung | Derivados de hidropirrolopirrol |
RU2737434C2 (ru) | 2013-03-13 | 2020-11-30 | Форма Терапьютикс, Инк. | Новые соединения и композиции для ингибирования fasn |
CN105008329B (zh) | 2013-03-21 | 2018-01-05 | 默克专利股份公司 | 作为fasn抑制剂的哌嗪衍生物 |
WO2015014446A1 (en) | 2013-07-29 | 2015-02-05 | Merck Patent Gmbh | 1,3-disubstituted cyclopentane derivatives |
CA3014432A1 (en) | 2015-06-18 | 2016-12-22 | Cephalon, Inc. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
ES2821049T3 (es) | 2015-06-18 | 2021-04-23 | 89Bio Ltd | Derivados de piperidina 1,4 sustituidos |
DK3458448T3 (da) | 2016-04-25 | 2021-08-23 | Forma Therapeutics Inc | Fasn-inhibitorer til anvendelse til behandling af non-alkoholisk steatohepatitis |
-
2014
- 2014-03-11 RU RU2019111684A patent/RU2737434C2/ru active
- 2014-03-11 KR KR1020157028847A patent/KR102194745B1/ko active IP Right Grant
- 2014-03-11 PE PE2015001983A patent/PE20160122A1/es not_active Application Discontinuation
- 2014-03-11 ES ES19188403T patent/ES2861180T3/es active Active
- 2014-03-11 PL PL14779048T patent/PL2968316T3/pl unknown
- 2014-03-11 CA CA2905751A patent/CA2905751A1/en not_active Abandoned
- 2014-03-11 JP JP2016501223A patent/JP2016517412A/ja not_active Withdrawn
- 2014-03-11 PT PT147790489T patent/PT2968316T/pt unknown
- 2014-03-11 US US14/775,877 patent/US20160002188A1/en not_active Abandoned
- 2014-03-11 ME MEP-2019-282A patent/ME03564B/me unknown
- 2014-03-11 CU CUP2015000120A patent/CU24341B1/es unknown
- 2014-03-11 SG SG10201707409PA patent/SG10201707409PA/en unknown
- 2014-03-11 ES ES14779048T patent/ES2753386T3/es active Active
- 2014-03-11 DK DK14779048.9T patent/DK2968316T3/da active
- 2014-03-11 WO PCT/US2014/023388 patent/WO2014164749A1/en active Application Filing
- 2014-03-11 RS RSP20191323 patent/RS59411B1/sr unknown
- 2014-03-11 LT LT14779048T patent/LT2968316T/lt unknown
- 2014-03-11 MX MX2015012470A patent/MX364895B/es active IP Right Grant
- 2014-03-11 WO PCT/US2014/023420 patent/WO2014164767A1/en active Application Filing
- 2014-03-11 SG SG11201507486SA patent/SG11201507486SA/en unknown
- 2014-03-11 BR BR112015023279-5A patent/BR112015023279B1/pt not_active IP Right Cessation
- 2014-03-11 CN CN202011251734.9A patent/CN112521369A/zh active Pending
- 2014-03-11 EP EP14779048.9A patent/EP2968316B1/en active Active
- 2014-03-11 CN CN201480028031.6A patent/CN105492008B/zh not_active Expired - Fee Related
- 2014-03-11 RU RU2015141772A patent/RU2686323C2/ru active
- 2014-03-11 MY MYPI2015002324A patent/MY191366A/en unknown
- 2014-03-11 SI SI201431348T patent/SI2968316T1/sl unknown
- 2014-03-11 AU AU2014249003A patent/AU2014249003A1/en not_active Abandoned
- 2014-03-11 HU HUE14779048A patent/HUE045701T2/hu unknown
- 2014-03-11 EP EP19188403.0A patent/EP3587406B1/en active Active
-
2015
- 2015-09-13 SA SA515361086A patent/SA515361086B1/ar unknown
- 2015-09-14 PH PH12015502097A patent/PH12015502097A1/en unknown
- 2015-09-14 TN TN2015000420A patent/TN2015000420A1/en unknown
- 2015-09-14 CL CL2015002698A patent/CL2015002698A1/es unknown
- 2015-09-16 IL IL241699A patent/IL241699B/en unknown
- 2015-09-16 NI NI201500141A patent/NI201500141A/es unknown
- 2015-09-17 ZA ZA2015/06922A patent/ZA201506922B/en unknown
- 2015-10-06 NO NO20151329A patent/NO20151329A1/en not_active Application Discontinuation
- 2015-10-13 EC ECIEPI201543280A patent/ECSP15043280A/es unknown
- 2015-10-13 CR CR20150541A patent/CR20150541A/es unknown
-
2016
- 2016-07-20 HK HK16108629.4A patent/HK1220409A1/zh unknown
-
2017
- 2017-10-17 US US15/786,539 patent/US10457655B2/en not_active Expired - Fee Related
- 2017-11-28 AU AU2017268536A patent/AU2017268536B2/en not_active Ceased
-
2018
- 2018-08-31 US US16/119,962 patent/US10399951B2/en not_active Expired - Fee Related
- 2018-10-29 JP JP2018203058A patent/JP6790040B2/ja active Active
-
2019
- 2019-04-12 US US16/383,296 patent/US10472342B2/en not_active Expired - Fee Related
- 2019-04-19 US US16/389,286 patent/US10450286B2/en not_active Expired - Fee Related
- 2019-09-10 US US16/566,119 patent/US10800750B2/en active Active
- 2019-10-08 AU AU2019246753A patent/AU2019246753B2/en not_active Ceased
- 2019-10-14 HR HRP20191860TT patent/HRP20191860T1/hr unknown
- 2019-11-05 CY CY20191101150T patent/CY1122244T1/el unknown
-
2020
- 2020-05-20 US US15/929,751 patent/US10995078B2/en active Active
-
2021
- 2021-02-26 US US17/187,061 patent/US20210214323A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2015002698A1 (es) | Nuevos compuestos y composiciones para la inhibicion de fasn | |
CL2014002873A1 (es) | Compuestos derivados de pirimidin-amina o triazin-amina, inhibidores de adn-pk; composicion farmaceutica; y su uso para el tratamiento del cancer. | |
CL2015000829A1 (es) | Inhibidores de histona desmetilasas | |
CL2015000942A1 (es) | Compuestos de benceno sustituido. | |
CL2016000952A1 (es) | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b | |
CL2015002767A1 (es) | Compuestos terapéuticos y composiciones | |
CL2016001231A1 (es) | Compuestos de inhibidor de autotaxina | |
CL2016002027A1 (es) | Ciclopropilamina como inhibidor de la lsd1 | |
MX2016013689A (es) | Compuestos 4-amino-imidazoquinolina. | |
CL2016000153A1 (es) | Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis b | |
DOP2020000102A (es) | Compuestos útiles para inhibir a cdk7 | |
CL2012003415A1 (es) | Compuestos derivados de 2-oxo-piperidina y 1,1-dioxido-tiazina, inhibidores de mdm2; composicion farmaceutica que los comprende; y su uso para el tratamiento del cancer . | |
CL2016000698A1 (es) | Derivados de quinolizina sustituidos útiles como inhibidores de integrasa del vih | |
CU24397B1 (es) | Derivados de piperidinil-indol como inhibidores del factor de complemento b | |
CL2015002394A1 (es) | Inhibidores de histona desmetilasas | |
CL2015001985A1 (es) | Compuestos de tiazolcarboxamidas y piridinacarboxamida, inhibidores de quinasa pim. | |
CL2016003422A1 (es) | Inhibidores de demetilasa-1 específico de lisina | |
UA116648C2 (uk) | Фумарати як проліки та їх застосування при лікуванні різних захворювань | |
CL2012002250A1 (es) | Compuestos heterociclicos fusionados derivados de pirimidinonas, inhibidores potentes de cdc7; composicion farmaceutica; y su uso en la prevencion o el tratamiento del cancer. | |
CL2014001858A1 (es) | Compuestos derivados de pirrolidina-2-carboxamidas sustituidas, antagonistas de mdm2; composicion farmacetica; y su uso en el tratamiento o profilaxis del cancer. | |
TR201813877T4 (tr) | Spi̇nal müsküler atrofi̇ni̇n tedavi̇ edi̇lmesi̇ne yöneli̇k bi̇leşi̇kler. | |
CL2016001918A1 (es) | Heteroaril amidas como inhibidores de agregación de proteína | |
CL2016003423A1 (es) | Inhibidores de demetilasa-1 específico de lisina | |
BR112014021531A2 (pt) | composto, composição farmacêutica e usos dos mesmos | |
CL2013002417A1 (es) | Compuestos derivados de fluoropiridinona; composición farmacéutica que los comprende; y su uso en el tratamiento de infecciones bacterianas. |