CL2015000572A1 - Etanercept correctamente plegado de alta pureza y excelente rendimiento. - Google Patents
Etanercept correctamente plegado de alta pureza y excelente rendimiento.Info
- Publication number
- CL2015000572A1 CL2015000572A1 CL2015000572A CL2015000572A CL2015000572A1 CL 2015000572 A1 CL2015000572 A1 CL 2015000572A1 CL 2015000572 A CL2015000572 A CL 2015000572A CL 2015000572 A CL2015000572 A CL 2015000572A CL 2015000572 A1 CL2015000572 A1 CL 2015000572A1
- Authority
- CL
- Chile
- Prior art keywords
- etanercept
- high purity
- correctly folded
- preparations
- folded
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
METODO DE CROMATOGRAFIA DE MODO MIXTO PARA SEPARAR LAS CONFORMACIONES CORRECTAMENTE PLEGADAS DE LAS INCORRCTAMENTE PLEGADAS DE UNA PROTEINA DADA. EL METODO ES MUY EFICAZ EN LA SEPARACIÓN DE ETANERCEPT CORRECTAMENTE PLEGADO DEL ETANERCEPT INCORRECTAMENTE PLEGADO Y DE AGREGADOS CON RENDIMIENTOS COMERCIALMENTE ATRACTIVOS QUE PERMITEN OBTENER PREPARACIONES DE ETANERCEPT DE UNA MUY ALTA PUREZA EN TÉNRMINOS DE ETANERCEPT CORRECTAMENTE PLEGADO VERSUS ETANERCEPT INCORRECTARNENTE PLEGADO. LA INVENCIÓN ESTÁ DIRIGIDA ADEMÁS A PREPARACIONES DE PROTEINAS Y FORMULACIONES QUE COMPRENDEN PROTEINAS CORRECTAMENTE PLEGADAS OBTENIDAS USANDO LOS MÉTODOS DE LA PR ESENTE, Y MÉTODOS DE TRATAMIENTO QUE EMPLEAN LAS PREPARACIONES DE GRAN PUREZA OBTENIDAS DEL METODO DE MODO MIXTO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261699552P | 2012-09-11 | 2012-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015000572A1 true CL2015000572A1 (es) | 2016-02-05 |
Family
ID=50233493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015000572A CL2015000572A1 (es) | 2012-09-11 | 2015-03-06 | Etanercept correctamente plegado de alta pureza y excelente rendimiento. |
Country Status (32)
Country | Link |
---|---|
US (6) | US20140072560A1 (es) |
EP (1) | EP2895188B1 (es) |
JP (3) | JP2015533797A (es) |
KR (2) | KR102133699B1 (es) |
CN (2) | CN110051823A (es) |
AR (1) | AR092532A1 (es) |
AU (2) | AU2013315750B9 (es) |
BR (1) | BR112015005161A2 (es) |
CA (1) | CA2882551A1 (es) |
CL (1) | CL2015000572A1 (es) |
CO (1) | CO7400876A2 (es) |
CY (1) | CY1120062T1 (es) |
DK (1) | DK2895188T3 (es) |
DO (1) | DOP2015000055A (es) |
EA (1) | EA031324B1 (es) |
EC (1) | ECSP15014138A (es) |
ES (1) | ES2657377T3 (es) |
HR (1) | HRP20180182T1 (es) |
HU (1) | HUE036524T2 (es) |
IL (2) | IL237311B (es) |
IN (1) | IN2015KN00452A (es) |
LT (1) | LT2895188T (es) |
MX (2) | MX360044B (es) |
NO (1) | NO2972131T3 (es) |
PE (2) | PE20150996A1 (es) |
PL (1) | PL2895188T3 (es) |
PT (1) | PT2895188T (es) |
RS (1) | RS57013B1 (es) |
SG (1) | SG11201501460RA (es) |
SI (1) | SI2895188T1 (es) |
TW (2) | TWI716649B (es) |
WO (1) | WO2014043103A1 (es) |
Families Citing this family (17)
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MX2007015476A (es) | 2005-06-14 | 2008-02-25 | Amgen Inc | Formulaciones de proteina autoamortiguadoras. |
US10485869B2 (en) | 2011-10-18 | 2019-11-26 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with meglumine |
PL2768525T3 (pl) | 2011-10-18 | 2019-10-31 | Coherus Biosciences Inc | Preparaty etanerceptu stabilizowane jonami magnezu |
AU2013315750B9 (en) * | 2012-09-11 | 2018-11-15 | Coherus Biosciences, Inc. | Correctly folded etanercept in high purity and excellent yield |
WO2015189832A1 (en) * | 2014-06-13 | 2015-12-17 | Lupin Limited | Process for the purification of tnfr:fc fusion protein |
EP2975050B1 (en) * | 2014-07-18 | 2019-05-29 | Sandoz Ag | Quantification of misfolded TNFR2:Fc |
MX2017008633A (es) | 2014-12-31 | 2018-04-26 | Lg Chemical Ltd | Procedimiento para preparar una proteina de fusion tnfr-fc que contiene un contenido objetivo de impurezas. |
WO2016149139A1 (en) | 2015-03-13 | 2016-09-22 | Samsung Bioepis Co., Ltd. | Anti-tnf-alpha polypeptide composition and use thereof |
SG11201804082XA (en) * | 2015-11-18 | 2018-06-28 | Merck Patent Gmbh | Improved protein separation in ion exchange chromatography |
BR112018009882A2 (pt) * | 2015-11-18 | 2018-11-13 | Merck Patent Gmbh | gradientes de ph-sal opostos para separações melhoradas de proteína |
AR108800A1 (es) * | 2016-06-17 | 2018-09-26 | Genentech Inc | Purificación de anticuerpos multiespecíficos |
CN114917185B (zh) | 2016-10-21 | 2023-11-14 | 美国安进公司 | 药物配制品及其制备方法 |
CA3057286A1 (en) * | 2017-03-24 | 2018-09-27 | Council Of Scientific And Industrial Research | A process for the purification of recombinant antibody fragments |
US11253569B2 (en) | 2018-05-03 | 2022-02-22 | Seattle Children's Hospital | Methods of treating Kawasaki Disease |
CN112876567A (zh) * | 2019-11-29 | 2021-06-01 | 广东菲鹏制药股份有限公司 | Fc融合蛋白及其纯化方法 |
AU2022236913A1 (en) * | 2021-03-16 | 2023-10-26 | Kashiv Biosciences, Llc | Novel formulation of fusion protein |
WO2022234412A1 (en) * | 2021-05-03 | 2022-11-10 | Lupin Limited | A process for purification of fc-fusion proteins |
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PL2768525T3 (pl) | 2011-10-18 | 2019-10-31 | Coherus Biosciences Inc | Preparaty etanerceptu stabilizowane jonami magnezu |
US10485869B2 (en) * | 2011-10-18 | 2019-11-26 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with meglumine |
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AU2013315750B9 (en) * | 2012-09-11 | 2018-11-15 | Coherus Biosciences, Inc. | Correctly folded etanercept in high purity and excellent yield |
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2013
- 2013-09-10 AU AU2013315750A patent/AU2013315750B9/en not_active Ceased
- 2013-09-10 ES ES13838016.7T patent/ES2657377T3/es active Active
- 2013-09-10 SG SG11201501460RA patent/SG11201501460RA/en unknown
- 2013-09-10 PE PE2015000316A patent/PE20150996A1/es unknown
- 2013-09-10 PE PE2019002512A patent/PE20200607A1/es unknown
- 2013-09-10 KR KR1020157009386A patent/KR102133699B1/ko active IP Right Grant
- 2013-09-10 MX MX2015003090A patent/MX360044B/es active IP Right Grant
- 2013-09-10 WO PCT/US2013/058994 patent/WO2014043103A1/en active Application Filing
- 2013-09-10 JP JP2015531311A patent/JP2015533797A/ja active Pending
- 2013-09-10 PT PT138380167T patent/PT2895188T/pt unknown
- 2013-09-10 KR KR1020207019733A patent/KR102250937B1/ko active IP Right Grant
- 2013-09-10 BR BR112015005161A patent/BR112015005161A2/pt not_active Application Discontinuation
- 2013-09-10 CN CN201811633164.2A patent/CN110051823A/zh active Pending
- 2013-09-10 DK DK13838016.7T patent/DK2895188T3/en active
- 2013-09-10 CA CA2882551A patent/CA2882551A1/en active Pending
- 2013-09-10 HU HUE13838016A patent/HUE036524T2/hu unknown
- 2013-09-10 SI SI201330936T patent/SI2895188T1/en unknown
- 2013-09-10 CN CN201380058650.5A patent/CN104902914B/zh active Active
- 2013-09-10 IN IN452KON2015 patent/IN2015KN00452A/en unknown
- 2013-09-10 EA EA201590542A patent/EA031324B1/ru unknown
- 2013-09-10 EP EP13838016.7A patent/EP2895188B1/en active Active
- 2013-09-10 LT LTEP13838016.7T patent/LT2895188T/lt unknown
- 2013-09-10 RS RS20180095A patent/RS57013B1/sr unknown
- 2013-09-10 PL PL13838016T patent/PL2895188T3/pl unknown
- 2013-09-11 AR ARP130103250A patent/AR092532A1/es not_active Application Discontinuation
- 2013-09-11 US US14/023,736 patent/US20140072560A1/en not_active Abandoned
- 2013-09-11 TW TW106136921A patent/TWI716649B/zh active
- 2013-09-11 TW TW102132831A patent/TWI609877B/zh active
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2014
- 2014-03-13 NO NO14719160A patent/NO2972131T3/no unknown
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2015
- 2015-02-19 IL IL237311A patent/IL237311B/en active IP Right Grant
- 2015-03-06 CL CL2015000572A patent/CL2015000572A1/es unknown
- 2015-03-10 MX MX2018012749A patent/MX2018012749A/es unknown
- 2015-03-10 DO DO2015000055A patent/DOP2015000055A/es unknown
- 2015-04-07 CO CO15076746A patent/CO7400876A2/es unknown
- 2015-04-10 EC ECIEPI201514138A patent/ECSP15014138A/es unknown
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2017
- 2017-09-29 US US15/720,291 patent/US11001627B2/en active Active
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2018
- 2018-01-31 HR HRP20180182TT patent/HRP20180182T1/hr unknown
- 2018-02-13 CY CY20181100172T patent/CY1120062T1/el unknown
- 2018-10-10 AU AU2018247244A patent/AU2018247244B2/en not_active Ceased
- 2018-10-11 JP JP2018192476A patent/JP6913066B2/ja active Active
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2019
- 2019-06-17 US US16/443,688 patent/US10947306B2/en active Active
- 2019-06-17 US US16/443,721 patent/US10954295B2/en active Active
- 2019-06-17 US US16/443,594 patent/US10954294B2/en active Active
- 2019-06-17 US US16/443,514 patent/US10954293B2/en active Active
- 2019-06-18 IL IL267452A patent/IL267452B/en active IP Right Grant
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2021
- 2021-02-22 JP JP2021025939A patent/JP2021100929A/ja active Pending
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