CL2012001601A1 - Compuestos derivados de tiazoles biciclicos, composición farmacéutica; proceso para preparar la composición farmacéutica; kit farmacéutico que los comprende; y su uso en la prevención o tratamiento de enfermedades en las cuales el efecto neuromodulador de los moduladores alostericos de mglur5 es beneficioso. - Google Patents

Compuestos derivados de tiazoles biciclicos, composición farmacéutica; proceso para preparar la composición farmacéutica; kit farmacéutico que los comprende; y su uso en la prevención o tratamiento de enfermedades en las cuales el efecto neuromodulador de los moduladores alostericos de mglur5 es beneficioso.

Info

Publication number
CL2012001601A1
CL2012001601A1 CL2012001601A CL2012001601A CL2012001601A1 CL 2012001601 A1 CL2012001601 A1 CL 2012001601A1 CL 2012001601 A CL2012001601 A CL 2012001601A CL 2012001601 A CL2012001601 A CL 2012001601A CL 2012001601 A1 CL2012001601 A1 CL 2012001601A1
Authority
CL
Chile
Prior art keywords
pharmaceutical composition
mglur5
prevention
treatment
compounds
Prior art date
Application number
CL2012001601A
Other languages
English (en)
Inventor
Gregor James Macdonald
Andres Avelino Trabanco-Suarez
Gary John Tresadern
Susana Conde-Ceide
Nebreda Jose Manuel Bartolome
Joaquin Pastor-Fernandez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2012001601A1 publication Critical patent/CL2012001601A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Addiction (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DERIVADOS DE TIAZOLES BICICLICOS LOS CUALES SON MODULADORES ALOSTÉRICOS POSITIVOS DEL SUBTIPO 5 RECEPTOR DE GLUTAMATO METABOTRÓPICO ("MGLUR5") Y LOS CUALES SON ÚTILES PARA EL TRATAMIENTO O PREVENCIÓN DE TRASTORNOS ASOCIADOS CON LA DIFUSIÓN DE GLUTAMATO Y ENFERMEDADES EN LAS CUALES EL SUBTIPO MGLUR5 DE RECEPTORES ESTÁ INVOLUCRADO. LAS COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS COMPUESTOS, SUS PROCESOS PARA PREPARAR DICHAS COMPOSICIONES, AL USO DE DICHOS COMPUESTOS PARA LA PREVENCIÓN Y TRATAMIENTO DE TRASTORNOS EN LOS CUALES MGLURR5 ESTÁ INVOLUCRADO, EN PARTICULAR EN TRASTORNOS NEUROLÓGICOS O SIQUIÁTRICOS COMO ESQUIZOFRENIA. TRASTORNO DEPRESIVO, TRASTORNO SICÓTICO, ALZHEIMER, PARKINSON. LOS COMPUESTOS DE FÓRMULA 1, O SU SAL O SOLVATO FARMACÉUTICAMENTE ACEPTABLE TIENE LA SIGUIENTE ESTRUCTURA.
CL2012001601A 2009-12-18 2012-06-14 Compuestos derivados de tiazoles biciclicos, composición farmacéutica; proceso para preparar la composición farmacéutica; kit farmacéutico que los comprende; y su uso en la prevención o tratamiento de enfermedades en las cuales el efecto neuromodulador de los moduladores alostericos de mglur5 es beneficioso. CL2012001601A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09179850 2009-12-18
EP10193019 2010-11-29

Publications (1)

Publication Number Publication Date
CL2012001601A1 true CL2012001601A1 (es) 2012-10-05

Family

ID=43743677

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012001601A CL2012001601A1 (es) 2009-12-18 2012-06-14 Compuestos derivados de tiazoles biciclicos, composición farmacéutica; proceso para preparar la composición farmacéutica; kit farmacéutico que los comprende; y su uso en la prevención o tratamiento de enfermedades en las cuales el efecto neuromodulador de los moduladores alostericos de mglur5 es beneficioso.

Country Status (19)

Country Link
US (1) US9040707B2 (es)
EP (1) EP2513117B1 (es)
JP (1) JP5763672B2 (es)
KR (1) KR20120097400A (es)
CN (1) CN102666552B (es)
AR (1) AR079509A1 (es)
AU (1) AU2010332811B2 (es)
BR (1) BR112012014436A2 (es)
CA (1) CA2782950A1 (es)
CL (1) CL2012001601A1 (es)
CO (1) CO6541615A2 (es)
EA (1) EA019980B1 (es)
ES (1) ES2431302T3 (es)
IL (1) IL220360A (es)
MX (1) MX2012007006A (es)
NZ (1) NZ600605A (es)
SG (1) SG181716A1 (es)
WO (1) WO2011073339A1 (es)
ZA (1) ZA201204433B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102666552B (zh) 2009-12-18 2014-11-26 詹森药业有限公司 作为mglur5受体的变构调节剂的双环噻唑
CA2782947A1 (en) 2009-12-18 2011-06-23 Janssen Pharmaceutica Nv Bicyclic thiazoles as allosteric modulators of mglur5 receptors
KR102371784B1 (ko) * 2014-02-18 2022-03-07 다이이찌 산쿄 가부시키가이샤 활성화 혈액 응고 제 X 인자 (FXa) 의 저해약의 제조 방법

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JP2002105085A (ja) * 2000-09-28 2002-04-10 Yamanouchi Pharmaceut Co Ltd 新規イミダゾチアゾール誘導体
JP2006513996A (ja) * 2002-10-24 2006-04-27 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体結合用トレーサーとしてのアルキン誘導体
TWI301760B (en) 2004-02-27 2008-10-11 Merz Pharma Gmbh & Co Kgaa Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
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ATE474839T1 (de) 2005-01-14 2010-08-15 Hoffmann La Roche Thiazol-4-carboxamid-derivate als mglur5- antagonisten
US20110053910A1 (en) * 2005-07-09 2011-03-03 Mckerrecher Darren 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
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JP2011507910A (ja) * 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
US20120029190A1 (en) 2009-04-03 2012-02-02 Douglas Burdi Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
CN102666552B (zh) 2009-12-18 2014-11-26 詹森药业有限公司 作为mglur5受体的变构调节剂的双环噻唑
CN102753173A (zh) 2009-12-18 2012-10-24 贝林格尔.英格海姆国际有限公司 Hcv组合疗法

Also Published As

Publication number Publication date
US9040707B2 (en) 2015-05-26
KR20120097400A (ko) 2012-09-03
AU2010332811B2 (en) 2014-07-24
CN102666552A (zh) 2012-09-12
IL220360A (en) 2015-03-31
MX2012007006A (es) 2012-07-03
EA201290532A1 (ru) 2012-11-30
NZ600605A (en) 2013-08-30
US20120258955A1 (en) 2012-10-11
WO2011073339A1 (en) 2011-06-23
CO6541615A2 (es) 2012-10-16
EP2513117A1 (en) 2012-10-24
EP2513117B1 (en) 2013-08-28
JP5763672B2 (ja) 2015-08-12
ES2431302T3 (es) 2013-11-25
AR079509A1 (es) 2012-02-01
CA2782950A1 (en) 2011-06-23
AU2010332811A1 (en) 2012-06-21
CN102666552B (zh) 2014-11-26
JP2013514325A (ja) 2013-04-25
SG181716A1 (en) 2012-07-30
BR112012014436A2 (pt) 2019-09-24
EA019980B1 (ru) 2014-07-30
ZA201204433B (en) 2014-11-26

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