CL2010000254A1 - Procedimiento de sintesis de ivabradina por formacion de una imina; y los compuestos intermediarios considerados en el procedimiento. - Google Patents

Procedimiento de sintesis de ivabradina por formacion de una imina; y los compuestos intermediarios considerados en el procedimiento.

Info

Publication number
CL2010000254A1
CL2010000254A1 CL2010000254A CL2010000254A CL2010000254A1 CL 2010000254 A1 CL2010000254 A1 CL 2010000254A1 CL 2010000254 A CL2010000254 A CL 2010000254A CL 2010000254 A CL2010000254 A CL 2010000254A CL 2010000254 A1 CL2010000254 A1 CL 2010000254A1
Authority
CL
Chile
Prior art keywords
synthesis
procedure
ivabradine
imine
formation
Prior art date
Application number
CL2010000254A
Other languages
English (en)
Inventor
Peglion Jean-Louis
Serkiz Bernard
Dessinges Aimée
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40984744&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2010000254(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of CL2010000254A1 publication Critical patent/CL2010000254A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO DE SÍNTESIS DEL COMPUESTO DE FORMULA (VII), EN FORMA RACEMICA U OPTICAMENTE  ACTIVA : EN LA QUE R REPRESENTA UN ÁTOMO DE HIDRÓGENO 0 UN GRUPO METILO, Y COMPUESTOS INTERMEDIARIOS
CL2010000254A 2009-03-31 2010-03-22 Procedimiento de sintesis de ivabradina por formacion de una imina; y los compuestos intermediarios considerados en el procedimiento. CL2010000254A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0901555A FR2943667B1 (fr) 2009-03-31 2009-03-31 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.

Publications (1)

Publication Number Publication Date
CL2010000254A1 true CL2010000254A1 (es) 2011-04-25

Family

ID=40984744

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2010000254A CL2010000254A1 (es) 2009-03-31 2010-03-22 Procedimiento de sintesis de ivabradina por formacion de una imina; y los compuestos intermediarios considerados en el procedimiento.

Country Status (37)

Country Link
US (1) US8101747B2 (es)
EP (1) EP2241554B1 (es)
JP (1) JP5107382B2 (es)
KR (1) KR101166630B1 (es)
CN (2) CN101851205B (es)
AR (1) AR075977A1 (es)
AT (1) ATE523494T1 (es)
AU (1) AU2010201058B2 (es)
BR (1) BRPI1000735A2 (es)
CA (1) CA2697562C (es)
CL (1) CL2010000254A1 (es)
CY (1) CY1112136T1 (es)
DK (1) DK2241554T3 (es)
EA (1) EA016335B1 (es)
ES (1) ES2373369T3 (es)
FR (1) FR2943667B1 (es)
GE (1) GEP20125460B (es)
HK (2) HK1148748A1 (es)
HR (1) HRP20110915T1 (es)
JO (1) JO2782B1 (es)
MA (1) MA31745B1 (es)
ME (1) ME00987B (es)
MX (1) MX2010003184A (es)
MY (1) MY145611A (es)
NZ (1) NZ584309A (es)
PE (1) PE20100714A1 (es)
PL (1) PL2241554T3 (es)
PT (1) PT2241554E (es)
RS (1) RS51962B (es)
SA (1) SA110310240B1 (es)
SG (1) SG165254A1 (es)
SI (1) SI2241554T1 (es)
TW (1) TWI419879B (es)
UA (1) UA102232C2 (es)
UY (1) UY32500A (es)
WO (1) WO2010112704A1 (es)
ZA (1) ZA201002121B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2473544C2 (ru) * 2007-05-30 2013-01-27 Инд-Свифт Лабораториз Лимитед Способ получения ивабрадина гидрохлорида и его полиморфных модификаций
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法
CN103724266B (zh) * 2014-01-20 2018-12-04 山东诚创医药技术开发有限公司 去甲伊伐布雷定盐及其制备方法和应用
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN108530359A (zh) * 2017-03-01 2018-09-14 浙江京新药业股份有限公司 一种伊伐布雷定杂质的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140049A (en) * 1965-04-02 1969-01-15 Alphachimie S A N-substituted tetrahydrobenzazepines
US3743731A (en) * 1971-03-16 1973-07-03 Schering Corp Substituted benzazepines for producing skeletal muscle relaxation
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
ES2381771T3 (es) * 2006-11-30 2012-05-31 Cadila Healthcare Limited Procedimiento para la preparación de hidrocloruro de ivabradina
CN101284813B (zh) * 2007-04-12 2012-08-15 上海优拓医药科技有限公司 伊伐布雷定的制备方法
RU2473544C2 (ru) 2007-05-30 2013-01-27 Инд-Свифт Лабораториз Лимитед Способ получения ивабрадина гидрохлорида и его полиморфных модификаций

Also Published As

Publication number Publication date
NZ584309A (en) 2010-11-26
EA016335B1 (ru) 2012-04-30
US20100249397A1 (en) 2010-09-30
JP2010241809A (ja) 2010-10-28
KR101166630B1 (ko) 2012-07-19
HK1148748A1 (en) 2011-09-16
US8101747B2 (en) 2012-01-24
AR075977A1 (es) 2011-05-11
MA31745B1 (fr) 2010-10-01
PE20100714A1 (es) 2010-10-30
ZA201002121B (en) 2010-11-24
ATE523494T1 (de) 2011-09-15
ME00987B (me) 2012-06-20
CN101851205B (zh) 2013-02-13
CY1112136T1 (el) 2015-11-04
HK1169827A1 (en) 2013-02-08
PT2241554E (pt) 2011-10-17
DK2241554T3 (da) 2011-12-12
MX2010003184A (es) 2010-10-05
TW201040144A (en) 2010-11-16
CN102603634A (zh) 2012-07-25
PL2241554T3 (pl) 2012-01-31
UY32500A (es) 2010-09-30
JO2782B1 (en) 2014-03-15
AU2010201058A1 (en) 2010-10-14
EA201000397A1 (ru) 2010-12-30
FR2943667A1 (fr) 2010-10-01
CA2697562A1 (fr) 2010-09-30
EP2241554A1 (fr) 2010-10-20
SA110310240B1 (ar) 2013-07-28
RS51962B (en) 2012-02-29
CN101851205A (zh) 2010-10-06
GEP20125460B (en) 2012-03-26
HRP20110915T1 (hr) 2011-12-31
FR2943667B1 (fr) 2011-05-06
EP2241554B1 (fr) 2011-09-07
JP5107382B2 (ja) 2012-12-26
TWI419879B (zh) 2013-12-21
KR20100109526A (ko) 2010-10-08
CA2697562C (fr) 2012-05-15
SG165254A1 (en) 2010-10-28
MY145611A (en) 2012-03-05
AU2010201058B2 (en) 2015-02-05
BRPI1000735A2 (pt) 2011-04-19
ES2373369T3 (es) 2012-02-02
UA102232C2 (uk) 2013-06-25
WO2010112704A1 (fr) 2010-10-07
CN102603634B (zh) 2014-04-16
SI2241554T1 (sl) 2012-01-31

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