US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
US6018030A
(en)
|
1986-11-04 |
2000-01-25 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
US5641648A
(en)
|
1986-11-04 |
1997-06-24 |
Protein Polymer Technologies, Inc. |
Methods for preparing synthetic repetitive DNA
|
US5770697A
(en)
|
1986-11-04 |
1998-06-23 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
US5514581A
(en)
|
1986-11-04 |
1996-05-07 |
Protein Polymer Technologies, Inc. |
Functional recombinantly prepared synthetic protein polymer
|
US4863457A
(en)
|
1986-11-24 |
1989-09-05 |
Lee David A |
Drug delivery device
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
US4997652A
(en)
|
1987-12-22 |
1991-03-05 |
Visionex |
Biodegradable ocular implants
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
CA2063431C
(en)
|
1989-07-06 |
2002-10-29 |
Lewis T. Williams |
Receptors for fibroblast growth factors
|
US5164188A
(en)
|
1989-11-22 |
1992-11-17 |
Visionex, Inc. |
Biodegradable ocular implants
|
US5766897A
(en)
|
1990-06-21 |
1998-06-16 |
Incyte Pharmaceuticals, Inc. |
Cysteine-pegylated proteins
|
AU8498091A
(en)
|
1990-08-02 |
1992-03-02 |
Regents Of The University Of Colorado, The |
Systematic polypeptide evolution by reverse translation
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
KR0185215B1
(ko)
|
1990-11-30 |
1999-05-01 |
요시다 쇼오지 |
서방성 안구삽입용 약제
|
US5773574A
(en)
|
1990-12-03 |
1998-06-30 |
The Scripps Research Institute |
Polypeptides for promoting cell attachment
|
US5235041A
(en)
|
1990-12-28 |
1993-08-10 |
Protein Polymer Technologies, Inc. |
Purification of structurally ordered recombinant protein polymers
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
US5792742A
(en)
|
1991-06-14 |
1998-08-11 |
New York University |
Fibrin-binding peptide fragments of fibronectin
|
ES2206447T3
(es)
|
1991-06-14 |
2004-05-16 |
Genentech, Inc. |
Anticuerpo humanizado para heregulina.
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
AU2313392A
(en)
|
1991-08-01 |
1993-03-02 |
University Research Corporation |
Systematic polypeptide evolution by reverse translation
|
US5587458A
(en)
|
1991-10-07 |
1996-12-24 |
Aronex Pharmaceuticals, Inc. |
Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
|
JPH07501451A
(ja)
|
1991-11-25 |
1995-02-16 |
エンゾン・インコーポレイテッド |
多価抗原結合タンパク質
|
AU675929B2
(en)
|
1992-02-06 |
1997-02-27 |
Curis, Inc. |
Biosynthetic binding protein for cancer marker
|
ES2149768T3
(es)
|
1992-03-25 |
2000-11-16 |
Immunogen Inc |
Conjugados de agentes enlazantes de celulas derivados de cc-1065.
|
EP0651761B1
(en)
|
1992-07-13 |
2002-10-09 |
Bionebraska, Inc. |
Method for modification of recombinant polypeptides
|
ES2162823T5
(es)
|
1992-08-21 |
2010-08-09 |
Vrije Universiteit Brussel |
Inmunoglobulinas desprovistas de cadenas ligeras.
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
CA2149329C
(en)
|
1992-11-13 |
2008-07-15 |
Darrell R. Anderson |
Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma
|
WO1994017097A1
(en)
|
1993-01-19 |
1994-08-04 |
Regents Of The University Of Minnesota |
Synthetic fibronectin fragments as inhibitors of retroviral infections
|
KR100313268B1
(ko)
|
1993-02-26 |
2002-11-22 |
산텐 세이야꾸 가부시키가이샤 |
생체분해성공막플러그
|
AU8124694A
(en)
|
1993-10-29 |
1995-05-22 |
Affymax Technologies N.V. |
In vitro peptide and antibody display libraries
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
US5443505A
(en)
|
1993-11-15 |
1995-08-22 |
Oculex Pharmaceuticals, Inc. |
Biocompatible ocular implants
|
US5516522A
(en)
|
1994-03-14 |
1996-05-14 |
Board Of Supervisors Of Louisiana State University |
Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
US5559000A
(en)
|
1995-01-18 |
1996-09-24 |
The Scripps Research Institute |
Encoded reaction cassette
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
US5869079A
(en)
|
1995-06-02 |
1999-02-09 |
Oculex Pharmaceuticals, Inc. |
Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
|
US6369116B1
(en)
|
1995-06-02 |
2002-04-09 |
Oculex Pharmaceuticals, Inc. |
Composition and method for treating glaucoma
|
DE19646372C1
(de)
|
1995-11-11 |
1997-06-19 |
Evotec Biosystems Gmbh |
Genotyp und Phänotyp koppelnde Verbindung
|
CA2258518C
(en)
|
1996-06-27 |
2011-11-22 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Recognition molecules interacting specifically with the active site or cleft of a target molecule
|
GB9618960D0
(en)
|
1996-09-11 |
1996-10-23 |
Medical Science Sys Inc |
Proteases
|
US5922676A
(en)
|
1996-09-20 |
1999-07-13 |
The Burnham Institute |
Methods of inhibiting cancer by using superfibronectin
|
EP1477561B1
(en)
|
1996-10-17 |
2008-12-10 |
Mitsubishi Chemical Corporation |
Molecule assigning genotype to phenotype and use thereof
|
JP3837748B2
(ja)
|
1997-01-17 |
2006-10-25 |
東亞合成株式会社 |
Vegf結合性ポリペプチド
|
WO1998031700A1
(en)
|
1997-01-21 |
1998-07-23 |
The General Hospital Corporation |
Selection of proteins using rna-protein fusions
|
US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
AU7266898A
(en)
*
|
1997-04-30 |
1998-11-24 |
Enzon, Inc. |
Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
|
CA2304254C
(en)
|
1997-06-11 |
2012-05-22 |
Hans Christian Thogersen |
Trimerising module
|
US6673901B2
(en)
|
1997-06-12 |
2004-01-06 |
Research Corporation Technologies, Inc. |
Artificial antibody polypeptides
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
US6159722A
(en)
|
1997-12-03 |
2000-12-12 |
Boehringer Mannheim Gmbh |
Chimeric serine proteases
|
EP1068356B8
(en)
|
1998-04-03 |
2007-01-03 |
Adnexus Therapeutics, Inc. |
Addressable protein arrays
|
JP4108827B2
(ja)
|
1998-05-28 |
2008-06-25 |
大日本印刷株式会社 |
無機質系化粧板
|
AU776910B2
(en)
|
1998-12-08 |
2004-09-23 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Modifying protein immunogenicity
|
GB9827228D0
(en)
|
1998-12-10 |
1999-02-03 |
Univ Nottingham |
Cancer detection method and reagents
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
CA2351346C
(en)
|
1998-12-10 |
2015-09-01 |
Phylos, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
WO2000064946A2
(en)
*
|
1999-04-28 |
2000-11-02 |
Board Of Regents, The University Of Texas System |
Compositions and methods for cancer treatment by selectively inhibiting vegf
|
ES2383332T3
(es)
|
1999-07-27 |
2012-06-20 |
Bristol-Myers Squibb Company |
Procedimiento de ligación de aceptores de péptidos
|
US7057015B1
(en)
*
|
1999-10-20 |
2006-06-06 |
The Salk Institute For Biological Studies |
Hormone receptor functional dimers and methods of their use
|
AU765588C
(en)
|
1999-11-24 |
2004-12-16 |
Immunogen, Inc. |
Cytotoxic agents comprising taxanes and their therapeutic use
|
US20050287153A1
(en)
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
EP1268544A2
(en)
|
2000-03-31 |
2003-01-02 |
Institut Pasteur |
Peptides blocking vascular endothelial growth factor (vegf)-mediated angiogenesis, polynucleotides encoding said peptides and methods of use thereof
|
JP2004515219A
(ja)
|
2000-06-15 |
2004-05-27 |
ボード・オブ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム |
調節可能な触媒活性な核酸
|
US8263741B2
(en)
|
2000-07-11 |
2012-09-11 |
Research Corporation Technologies, Inc. |
Artificial antibody polypeptides
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
EP1332209B1
(en)
|
2000-09-08 |
2009-11-11 |
Universität Zürich |
Collections of repeat proteins comprising repeat modules
|
US7052686B2
(en)
|
2000-09-29 |
2006-05-30 |
Schering Corporation |
Pegylated interleukin-10
|
EP2141243A3
(en)
|
2000-10-16 |
2010-01-27 |
Brystol-Myers Squibb Company |
Protein scaffolds for antibody mimics and other binding proteins
|
US7598352B2
(en)
*
|
2000-11-17 |
2009-10-06 |
University Of Rochester |
Method of identifying polypeptide monobodies which bind to target proteins and use thereof
|
ES2250504T3
(es)
|
2000-11-29 |
2006-04-16 |
Allergan Inc. |
Prevencion del rechazo de injerto en el ojo.
|
EP1341912B1
(en)
|
2000-12-13 |
2009-05-20 |
Anaphore, Inc. |
Method for the identification and isolation of binding polypeptides from combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains
|
US6509027B2
(en)
|
2001-02-12 |
2003-01-21 |
Supergen, Inc. |
Injectable pharmaceutical composition comprising coated particles of camptothecin
|
WO2002081497A2
(en)
|
2001-04-04 |
2002-10-17 |
University Of Rochester |
αξβ3 INTEGRIN-BINDING POLYPEPTIDE MONOBODIES AND THEIR USE
|
US20050089932A1
(en)
|
2001-04-26 |
2005-04-28 |
Avidia Research Institute |
Novel proteins with targeted binding
|
US20050053973A1
(en)
|
2001-04-26 |
2005-03-10 |
Avidia Research Institute |
Novel proteins with targeted binding
|
CA2444854A1
(en)
*
|
2001-04-26 |
2002-11-07 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
US20040175756A1
(en)
|
2001-04-26 |
2004-09-09 |
Avidia Research Institute |
Methods for using combinatorial libraries of monomer domains
|
US20050048512A1
(en)
|
2001-04-26 |
2005-03-03 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
US20030004561A1
(en)
|
2001-06-28 |
2003-01-02 |
Steve Bigus |
Peeling sheath for self-expanding stent
|
WO2003022858A2
(de)
|
2001-09-11 |
2003-03-20 |
Nascacell Gmbh |
Verfahren zum screenen von inhibitoren für die protein-protein-wechselwirkung sowie ribozyme hierzu
|
WO2003029462A1
(en)
|
2001-09-27 |
2003-04-10 |
Pieris Proteolab Ag |
Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
|
AU2001298053A1
(en)
|
2001-09-27 |
2003-04-14 |
Pieris Proteolab Ag |
Muteins of apolipoprotein D
|
WO2003049684A2
(en)
|
2001-12-07 |
2003-06-19 |
Centocor, Inc. |
Pseudo-antibody constructs
|
US7241444B2
(en)
|
2002-01-18 |
2007-07-10 |
Pierre Fabre Medicament |
Anti-IGF-IR antibodies and uses thereof
|
US20080193445A1
(en)
*
|
2002-01-18 |
2008-08-14 |
Liliane Goetsch |
Novel anti-IGF-IR antibodies and uses thereof
|
NZ534378A
(en)
|
2002-02-22 |
2006-10-27 |
Schering Corp |
Pharmaceutical formulations of antineoplastic agents, in particular temozolomide, processes of making and using the same
|
ATE475431T1
(de)
|
2002-03-04 |
2010-08-15 |
Imclone Llc |
Kdr-spezifische humane antikörper und deren anwendung
|
US7332585B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The California University |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
WO2003104418A2
(en)
|
2002-06-06 |
2003-12-18 |
Research Corporation Technologies, Inc. |
Reconstituted polypeptides
|
US8034904B2
(en)
|
2002-06-14 |
2011-10-11 |
Immunogen Inc. |
Anti-IGF-I receptor antibody
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
WO2004005335A2
(en)
|
2002-07-05 |
2004-01-15 |
Borean Pharma A/S |
Multimerised growth hormone fusion proteins
|
US20050074865A1
(en)
|
2002-08-27 |
2005-04-07 |
Compound Therapeutics, Inc. |
Adzymes and uses thereof
|
WO2004019878A2
(en)
|
2002-08-27 |
2004-03-11 |
Compound Therapeutics, Inc. |
Adzymes and uses thereof
|
US20040259155A1
(en)
|
2002-09-30 |
2004-12-23 |
Compound Therapeutics, Inc. |
Methods of engineering spatially conserved motifs in polypeptides
|
US20070010658A1
(en)
|
2002-10-29 |
2007-01-11 |
Holtet Thor L |
Trimeric binding proteins for trimeric cytokines
|
WO2005044858A1
(en)
|
2003-11-07 |
2005-05-19 |
Ablynx N.V. |
Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor
|
CN102584997A
(zh)
|
2002-11-08 |
2012-07-18 |
埃博灵克斯股份有限公司 |
针对肿瘤坏死因子-α的单结构域抗体及其用途
|
EP1603948A1
(en)
|
2003-03-14 |
2005-12-14 |
Pharmacia Corporation |
Antibodies to igf-i receptor for the treatment of cancers
|
US8541200B2
(en)
|
2003-04-23 |
2013-09-24 |
Hoffmann-La Roche Inc. |
Cleavage of fusion proteins using Granzyme B protease
|
AR046071A1
(es)
|
2003-07-10 |
2005-11-23 |
Hoffmann La Roche |
Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos
|
US7053701B2
(en)
|
2003-11-04 |
2006-05-30 |
Vice Michael W |
Power amplifier output stage with multiple power states and improved efficiency
|
WO2005047714A1
(en)
|
2003-11-17 |
2005-05-26 |
Telezygology Inc |
Fasteners and other assemblies
|
KR20060129246A
(ko)
*
|
2003-12-05 |
2006-12-15 |
컴파운드 쎄라퓨틱스, 인크. |
타입 2 혈관 내피 성장 인자 수용체의 억제제
|
US20080220049A1
(en)
*
|
2003-12-05 |
2008-09-11 |
Adnexus, A Bristol-Myers Squibb R&D Company |
Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins
|
BRPI0507026A
(pt)
|
2004-02-09 |
2007-04-17 |
Human Genome Sciences Inc |
proteìnas de fusão de albumina
|
CN1980952A
(zh)
|
2004-02-23 |
2007-06-13 |
伯瑞恩药物私人有限公司 |
多聚化hiv融合抑制物
|
BRPI0507949A
(pt)
|
2004-02-23 |
2007-07-24 |
Borean Pharma As |
inibidores de fusão de hiv multimerizados
|
US20070059336A1
(en)
|
2004-04-30 |
2007-03-15 |
Allergan, Inc. |
Anti-angiogenic sustained release intraocular implants and related methods
|
US20050244472A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
|
US20050244469A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Extended therapeutic effect ocular implant treatments
|
US20060182783A1
(en)
|
2004-04-30 |
2006-08-17 |
Allergan, Inc. |
Sustained release intraocular drug delivery systems
|
JP2008512352A
(ja)
|
2004-07-17 |
2008-04-24 |
イムクローン システムズ インコーポレイティド |
新規な四価の二重特異性抗体
|
US7597884B2
(en)
*
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
CA2582374A1
(en)
|
2004-10-04 |
2006-04-20 |
Qlt Usa, Inc. |
Ocular delivery of polymeric delivery formulations
|
DE102004049479A1
(de)
|
2004-10-11 |
2006-04-13 |
Scil Proteins Gmbh |
Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie
|
KR20070095296A
(ko)
|
2004-11-22 |
2007-09-28 |
보리안 파마 에이피에스 |
Tnf 길항제
|
WO2006056464A2
(en)
|
2004-11-26 |
2006-06-01 |
Pieris Ag |
Compound with affinity for the cytotoxic t lymphocyte-associated antigen (ctla-4)
|
US20060122162A1
(en)
|
2004-12-02 |
2006-06-08 |
Schering Corporation |
Methods of using temozolomide formulation intrathecally in the treatment of cancers
|
WO2006091209A2
(en)
|
2005-02-23 |
2006-08-31 |
Merrimack Pharmaceuticals, Inc. |
Bispecific binding agents for modulating biological activity
|
FR2888850B1
(fr)
|
2005-07-22 |
2013-01-11 |
Pf Medicament |
Nouveaux anticorps anti-igf-ir et leurs applications
|
US7612181B2
(en)
*
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
US20070072933A1
(en)
|
2005-09-26 |
2007-03-29 |
Peyman Gholam A |
Delivery of an ocular agent
|
AP2008004418A0
(en)
*
|
2005-10-07 |
2008-04-30 |
Univ California |
Nucleic acids encoding modified cytochrome p450 enzyme and methods of use thereof
|
KR101430760B1
(ko)
|
2005-10-18 |
2014-08-19 |
알러간, 인코포레이티드 |
후안부 조직으로 선택적으로 침투하는 글루코코르티코이드유도체를 사용한 안과 요법
|
WO2007053807A2
(en)
|
2005-10-31 |
2007-05-10 |
Wisconsin Alumni Research Foundation |
Calcitriol for treating intraocular diseases associated with angiogenesis
|
WO2007059120A2
(en)
|
2005-11-16 |
2007-05-24 |
The Brigham & Women's Hospital, Inc. |
Allelic form of the hmga2 gene predisposing women to the formation of leiomyomas
|
KR20160137665A
(ko)
*
|
2005-11-23 |
2016-11-30 |
악셀레론 파마 인코포레이티드 |
액티빈-actrⅱa 길항제 및 골 성장을 촉진하기 위한 이들의 용도
|
EP2407171A3
(en)
|
2006-02-02 |
2012-04-11 |
Allergan, Inc. |
Compositions and methods for the treatment of ophthalmic disease
|
KR20080097188A
(ko)
*
|
2006-02-24 |
2008-11-04 |
키에시 파르마슈티시 엣스. 피. 에이. |
항아밀로이드 면역성성분, 그 제조방법 및 용도
|
JP2009534331A
(ja)
*
|
2006-04-21 |
2009-09-24 |
トランジェーヌ、ソシエテ、アノニム |
Hpv‐18を主体とするパピローマウイルスワクチン
|
US20070269422A1
(en)
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
RU2009107494A
(ru)
|
2006-08-04 |
2010-09-10 |
Астразенека Аб (Se) |
АНТИТЕЛА К ErbB2
|
WO2008031098A1
(en)
*
|
2006-09-09 |
2008-03-13 |
The University Of Chicago |
Binary amino acid libraries for fibronectin type iii polypeptide monobodies
|
US20110143953A1
(en)
*
|
2006-10-16 |
2011-06-16 |
Arizona Board Of Regents, A Body Corporate Of The State Of Arizona |
Synthetic Antibodies
|
AU2007325838B2
(en)
|
2006-11-22 |
2013-09-19 |
Bristol-Myers Squibb Company |
Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
|
US20100144599A1
(en)
|
2007-02-02 |
2010-06-10 |
Bristol-Myers Squibb Company |
Vegf pathway blockade
|
WO2008108986A2
(en)
|
2007-03-02 |
2008-09-12 |
Amgen Inc. |
Methods and compositions for treating tumor diseases
|
US11078262B2
(en)
|
2007-04-30 |
2021-08-03 |
Allergan, Inc. |
High viscosity macromolecular compositions for treating ocular conditions
|
MX2009012609A
(es)
|
2007-05-22 |
2009-12-07 |
Amgen Inc |
Composiciones y metodos para producir proteinas de fusion bioactivas.
|
JP5781762B2
(ja)
|
2007-08-10 |
2015-09-24 |
プロテリックス、インク |
ユニバーサルiii型フィブロネクチン結合ドメインのライブラリ
|
US8470966B2
(en)
|
2007-08-10 |
2013-06-25 |
Protelica, Inc. |
Universal fibronectin type III binding-domain libraries
|
US8680019B2
(en)
|
2007-08-10 |
2014-03-25 |
Protelica, Inc. |
Universal fibronectin Type III binding-domain libraries
|
WO2009025806A2
(en)
|
2007-08-20 |
2009-02-26 |
Adnexus, A Bristol-Myers Squibb R & D Company |
Use of vegfr-2 inhibitors for treating metastatic cancer
|
WO2009046407A2
(en)
|
2007-10-04 |
2009-04-09 |
Zymogenetics, Inc. |
B7 FAMILY MEMBER zB7H6 AND RELATED COMPOSITIONS AND METHODS
|
RU2010121967A
(ru)
|
2007-10-31 |
2011-12-10 |
Медиммун, Ллк (Us) |
Белковые каркасные структуры
|
WO2009073115A1
(en)
|
2007-11-28 |
2009-06-11 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with mtor inhibitors
|
CA2709994A1
(en)
|
2007-12-19 |
2009-07-09 |
Centocor Ortho Biotech Inc. |
Non-antibody scaffold protein fusions phage display via fusion to pix of m13 phage
|
CA2710835A1
(en)
|
2007-12-27 |
2009-07-09 |
Novartis Ag |
Improved fibronectin-based binding molecules and their use
|
MX2010008874A
(es)
|
2008-02-14 |
2010-09-22 |
Bristol Myers Squibb Co |
Terapeuticos dirigidos a base de proteinas manipuladas que se unen al receptor de factor de crecimiento epidermico.
|
EP2274331B1
(en)
|
2008-05-02 |
2013-11-06 |
Novartis AG |
Improved fibronectin-based binding molecules and uses thereof
|
AR071874A1
(es)
*
|
2008-05-22 |
2010-07-21 |
Bristol Myers Squibb Co |
Proteinas de dominio de armazon basadas en fibronectina multivalentes
|
US8415291B2
(en)
|
2008-10-31 |
2013-04-09 |
Centocor Ortho Biotech Inc. |
Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
|
CA2741834C
(en)
|
2008-10-31 |
2022-04-05 |
Centocor Ortho Biotech Inc. |
Fibronectin type iii domain based scaffold compositions, methods and uses
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之egfr/igfir結合分子
|
EA201100943A1
(ru)
|
2008-12-16 |
2012-05-30 |
Новартис Аг |
Системы дрожжевого дисплея
|
WO2010093771A1
(en)
|
2009-02-11 |
2010-08-19 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with temozolomide
|
EP2396011B1
(en)
|
2009-02-12 |
2016-04-13 |
Janssen Biotech, Inc. |
Fibronectin type iii domain based scaffold compositions, methods and uses
|
US8067201B2
(en)
|
2009-04-17 |
2011-11-29 |
Bristol-Myers Squibb Company |
Methods for protein refolding
|
US20120270797A1
(en)
|
2009-08-13 |
2012-10-25 |
Massachusetts Institute Of Technology |
Engineered proteins including mutant fibronectin domains
|
US9139825B2
(en)
|
2009-10-30 |
2015-09-22 |
Novartis Ag |
Universal fibronectin type III bottom-side binding domain libraries
|
WO2011051466A1
(en)
|
2009-11-02 |
2011-05-05 |
Novartis Ag |
Anti-idiotypic fibronectin-based binding molecules and uses thereof
|
US20110123545A1
(en)
|
2009-11-24 |
2011-05-26 |
Bristol-Myers Squibb Company |
Combination of vegfr2 and igf1r inhibitors for the treatment of proliferative diseases
|
WO2011092233A1
(en)
|
2010-01-29 |
2011-08-04 |
Novartis Ag |
Yeast mating to produce high-affinity combinations of fibronectin-based binders
|
WO2011100700A2
(en)
|
2010-02-12 |
2011-08-18 |
University Of Rochester |
Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies
|
AU2011218243A1
(en)
|
2010-02-18 |
2012-10-04 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind IL-23
|
US8420098B2
(en)
|
2010-04-13 |
2013-04-16 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind to PCSK9
|
MX341119B
(es)
|
2010-04-13 |
2016-08-09 |
Medimmune Llc |
Estructuras multiméricas específicas para ligando inductor de apoptosis relacionada con el factor de necrosis tumoral r2 (trail).
|
AU2011245225B2
(en)
|
2010-04-30 |
2015-09-17 |
Janssen Biotech, Inc. |
Stabilized fibronectin domain compositions, methods and uses
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
ES2573108T3
(es)
|
2010-05-26 |
2016-06-06 |
Bristol-Myers Squibb Company |
Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada
|
AU2011283646B2
(en)
|
2010-07-30 |
2015-07-09 |
Novartis Ag |
Fibronectin cradle molecules and libraries thereof
|
JP2014504587A
(ja)
|
2010-12-22 |
2014-02-24 |
ブリストル−マイヤーズ スクイブ カンパニー |
Il−23に結合するフィブロネクチンをベースとするスカフォールドドメインタンパク質
|
HUE033008T2
(hu)
|
2011-04-13 |
2017-11-28 |
Bristol Myers Squibb Co |
FC fúziós proteinek, amelyek tartalmaznak új linkereket
|
EP2710382B1
(en)
|
2011-05-17 |
2017-10-18 |
Bristol-Myers Squibb Company |
Improved methods for the selection of binding proteins
|
EP2709669A1
(en)
|
2011-05-17 |
2014-03-26 |
Bristol-Myers Squibb Company |
Methods for maintaining pegylation of polypeptides
|
KR102035713B1
(ko)
|
2011-09-27 |
2019-10-24 |
얀센 바이오테크 인코포레이티드 |
대체 결합 표면을 가진 피브로넥틴 유형 iii 반복체 기반의 단백질 스캐폴드
|
US9522951B2
(en)
*
|
2011-10-31 |
2016-12-20 |
Bristol-Myers Squibb Company |
Fibronectin binding domains with reduced immunogenicity
|