CL2009000557A1 - Preparacion solida de desintegracion oral de liberacion controlada de un principio activo, tal como lansoprazol, que comprende granulos finos que comprenden una capa de recubrimiento que contiene un copolimero de acido metacrilico–metilacrilato–metilmetacrilato, y tienen un tamaño de partícula promedio de 500 µm o menos - Google Patents
Preparacion solida de desintegracion oral de liberacion controlada de un principio activo, tal como lansoprazol, que comprende granulos finos que comprenden una capa de recubrimiento que contiene un copolimero de acido metacrilico–metilacrilato–metilmetacrilato, y tienen un tamaño de partícula promedio de 500 µm o menosInfo
- Publication number
- CL2009000557A1 CL2009000557A1 CL2009000557A CL2009000557A CL2009000557A1 CL 2009000557 A1 CL2009000557 A1 CL 2009000557A1 CL 2009000557 A CL2009000557 A CL 2009000557A CL 2009000557 A CL2009000557 A CL 2009000557A CL 2009000557 A1 CL2009000557 A1 CL 2009000557A1
- Authority
- CL
- Chile
- Prior art keywords
- active principle
- solid preparation
- methylacrylate
- fine granules
- methacrylic acid
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La solicitud 200900557 presenta a una preparación sólida de desintegración oral que comprende gránulos finos que muestran una liberación controlada de un principio activo para uso farmacéutico, en donde los gránulos finos consisten de un gránulo central que comprende el principio activo, una capa intermedia, una a tres capas de recubrimiento que comprende un polímero entérico que comprende al menos un copolímero de ácido metacrílico–metilacrilato-metilmetacrilato, y una capa externa. La preparación sólida de desintegración oral además comprende un aditivo derivado de un alcohol de azúcar (polialcohol) y un desintegrante (que se mezclan con los gránulos para preparar comprimidos de desintegración oral).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008061673 | 2008-03-11 | ||
JP2008334920 | 2008-12-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009000557A1 true CL2009000557A1 (es) | 2010-10-01 |
Family
ID=40791576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009000557A CL2009000557A1 (es) | 2008-03-11 | 2009-03-10 | Preparacion solida de desintegracion oral de liberacion controlada de un principio activo, tal como lansoprazol, que comprende granulos finos que comprenden una capa de recubrimiento que contiene un copolimero de acido metacrilico–metilacrilato–metilmetacrilato, y tienen un tamaño de partícula promedio de 500 µm o menos |
Country Status (26)
Country | Link |
---|---|
US (2) | US9241910B2 (es) |
EP (1) | EP2254556A2 (es) |
JP (1) | JP5604304B2 (es) |
KR (1) | KR20100129761A (es) |
CN (2) | CN104127368A (es) |
AR (1) | AR070863A1 (es) |
AU (1) | AU2009224254A1 (es) |
BR (1) | BRPI0909439A2 (es) |
CA (1) | CA2717947C (es) |
CL (1) | CL2009000557A1 (es) |
CO (1) | CO6321224A2 (es) |
CR (1) | CR11709A (es) |
DO (1) | DOP2010000273A (es) |
EA (1) | EA021792B1 (es) |
EC (1) | ECSP10010538A (es) |
GE (1) | GEP20135845B (es) |
IL (1) | IL207989A0 (es) |
MA (1) | MA32174B1 (es) |
MX (1) | MX2010009824A (es) |
MY (1) | MY173730A (es) |
NZ (1) | NZ588407A (es) |
PE (2) | PE20141034A1 (es) |
TW (1) | TWI441658B (es) |
UY (1) | UY31698A (es) |
WO (1) | WO2009113703A2 (es) |
ZA (1) | ZA201006679B (es) |
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EP2319504A1 (en) * | 2009-11-07 | 2011-05-11 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical solid dosage form |
US20130216617A1 (en) * | 2010-06-29 | 2013-08-22 | Cadila Healthcare Limited | Pharmaceutical compositions of (r)-lansoprazole |
EA028217B1 (ru) * | 2010-12-27 | 2017-10-31 | Такеда Фармасьютикал Компани Лимитед | Разрушающаяся во рту таблетка (варианты) |
CN102716097A (zh) * | 2012-05-29 | 2012-10-10 | 浙江华海药业股份有限公司 | 控制口腔崩解片药物释放速率的方法 |
FI126168B (en) | 2012-09-18 | 2016-07-29 | Novaldmedical Ltd Oy | A method for coating pharmaceutical substrates |
JP6539274B2 (ja) | 2013-08-12 | 2019-07-03 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ,インコーポレーテッド | 押出成形された即放性乱用抑止性丸剤 |
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ES2700364T3 (es) * | 2015-02-10 | 2019-02-15 | Fujifilm Corp | Comprimido de disgregación oral y método para su fabricación |
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JP7336187B2 (ja) * | 2017-11-30 | 2023-08-31 | 日本ケミファ株式会社 | 多層構造を有する粒子状医薬組成物 |
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2009
- 2009-03-10 CN CN201410370293.2A patent/CN104127368A/zh active Pending
- 2009-03-10 AU AU2009224254A patent/AU2009224254A1/en not_active Abandoned
- 2009-03-10 CA CA2717947A patent/CA2717947C/en active Active
- 2009-03-10 JP JP2010536259A patent/JP5604304B2/ja not_active Expired - Fee Related
- 2009-03-10 MX MX2010009824A patent/MX2010009824A/es not_active Application Discontinuation
- 2009-03-10 NZ NZ588407A patent/NZ588407A/en not_active IP Right Cessation
- 2009-03-10 AR ARP090100842A patent/AR070863A1/es unknown
- 2009-03-10 GE GEAP2009011969 patent/GEP20135845B/en unknown
- 2009-03-10 KR KR1020107022551A patent/KR20100129761A/ko not_active Application Discontinuation
- 2009-03-10 EP EP09720410A patent/EP2254556A2/en not_active Withdrawn
- 2009-03-10 US US12/921,731 patent/US9241910B2/en active Active
- 2009-03-10 WO PCT/JP2009/054983 patent/WO2009113703A2/en active Application Filing
- 2009-03-10 TW TW098107630A patent/TWI441658B/zh not_active IP Right Cessation
- 2009-03-10 MY MYPI2010004253A patent/MY173730A/en unknown
- 2009-03-10 CL CL2009000557A patent/CL2009000557A1/es unknown
- 2009-03-10 EA EA201071054A patent/EA021792B1/ru not_active IP Right Cessation
- 2009-03-10 PE PE2014000364A patent/PE20141034A1/es not_active Application Discontinuation
- 2009-03-10 UY UY0001031698A patent/UY31698A/es not_active Application Discontinuation
- 2009-03-10 BR BRPI0909439A patent/BRPI0909439A2/pt not_active Application Discontinuation
- 2009-03-10 PE PE2009000349A patent/PE20091620A1/es not_active Application Discontinuation
- 2009-03-10 CN CN200980116971.XA patent/CN102026627B/zh not_active Expired - Fee Related
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2010
- 2010-09-05 IL IL207989A patent/IL207989A0/en unknown
- 2010-09-10 DO DO2010000273A patent/DOP2010000273A/es unknown
- 2010-09-17 ZA ZA2010/06679A patent/ZA201006679B/en unknown
- 2010-09-29 MA MA33210A patent/MA32174B1/fr unknown
- 2010-09-30 CR CR11709A patent/CR11709A/es unknown
- 2010-10-11 EC EC2010010538A patent/ECSP10010538A/es unknown
- 2010-10-11 CO CO10125889A patent/CO6321224A2/es not_active Application Discontinuation
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2014
- 2014-10-21 US US14/519,979 patent/US20150037423A1/en not_active Abandoned
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