CL2008002996A1 - Metodo para la preparacion del acido montelukast usando un liquido ionico como medio de reaccion en una razon de 0,1 a 100 veces respecto a uno de los reactantes. - Google Patents

Metodo para la preparacion del acido montelukast usando un liquido ionico como medio de reaccion en una razon de 0,1 a 100 veces respecto a uno de los reactantes.

Info

Publication number
CL2008002996A1
CL2008002996A1 CL2008002996A CL2008002996A CL2008002996A1 CL 2008002996 A1 CL2008002996 A1 CL 2008002996A1 CL 2008002996 A CL2008002996 A CL 2008002996A CL 2008002996 A CL2008002996 A CL 2008002996A CL 2008002996 A1 CL2008002996 A1 CL 2008002996A1
Authority
CL
Chile
Prior art keywords
ionic liquid
reactants
preparation
ratio
respect
Prior art date
Application number
CL2008002996A
Other languages
English (en)
Inventor
Sun Lee Gwan
Jung Lim Eun
Park Chul-Hyun
Park Eun-Ju
Man Jang Suk
Kil Chang Young
Lee Jaeheon
Kim Choong-Hahn
Original Assignee
Hanmi Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40549354&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008002996(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hanmi Science Co Ltd filed Critical Hanmi Science Co Ltd
Publication of CL2008002996A1 publication Critical patent/CL2008002996A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Método para preparar ácido de montelukast en un medio líquido iónico.
CL2008002996A 2007-10-09 2008-10-09 Metodo para la preparacion del acido montelukast usando un liquido ionico como medio de reaccion en una razon de 0,1 a 100 veces respecto a uno de los reactantes. CL2008002996A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020070101486A KR101072896B1 (ko) 2007-10-09 2007-10-09 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법

Publications (1)

Publication Number Publication Date
CL2008002996A1 true CL2008002996A1 (es) 2009-04-13

Family

ID=40549354

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002996A CL2008002996A1 (es) 2007-10-09 2008-10-09 Metodo para la preparacion del acido montelukast usando un liquido ionico como medio de reaccion en una razon de 0,1 a 100 veces respecto a uno de los reactantes.

Country Status (18)

Country Link
US (1) US8426599B2 (es)
EP (1) EP2195295B1 (es)
JP (1) JP5210389B2 (es)
KR (1) KR101072896B1 (es)
CN (1) CN101808998B (es)
AR (1) AR068755A1 (es)
CA (1) CA2701912C (es)
CL (1) CL2008002996A1 (es)
DK (1) DK2195295T3 (es)
ES (1) ES2398732T3 (es)
HR (1) HRP20130103T1 (es)
MX (1) MX2010001864A (es)
PE (2) PE20131219A1 (es)
PL (1) PL2195295T3 (es)
PT (1) PT2195295E (es)
RU (1) RU2436774C1 (es)
TW (1) TWI350284B (es)
WO (1) WO2009048236A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP1000425A2 (en) 2010-08-11 2012-03-28 Richter Gedeon Nyrt Process for the production of montelukast sodium
CN103570618A (zh) * 2013-09-30 2014-02-12 浙江车头制药股份有限公司 一种孟鲁司特钠盐的制备方法
CN105294556A (zh) * 2014-06-06 2016-02-03 上海迪赛诺化学制药有限公司 一种制备孟鲁司特酸的方法
JP2021536467A (ja) 2018-09-06 2021-12-27 インノファーマスクリーン インコーポレイテッド 喘息またはパーキンソン病の処置のための方法および組成物
KR102181155B1 (ko) * 2019-09-26 2020-11-20 대봉엘에스 주식회사 이온성 액체를 매개로 한 에피나코나졸의 신규 제조방법
CN111892535B (zh) * 2020-08-27 2023-04-11 鲁南制药集团股份有限公司 一种孟鲁司特钠的合成方法
CN111961083B (zh) * 2020-08-27 2022-11-25 鲁南制药集团股份有限公司 一种孟鲁司特钠中间体化合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2114882T3 (es) 1990-10-12 1998-06-16 Merck Frosst Canada Inc Acidos hidroxialquilquinolinos insaturados como antagonistas de leucotrienos.
TW416948B (en) 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists
US5523477A (en) 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US20050187243A1 (en) * 2004-01-30 2005-08-25 Valerie Niddam-Hildesheim Montelukast free acid polymorphs
US7547787B2 (en) * 2004-04-21 2009-06-16 Teva Pharmaceutical Industries Ltd. Processes for preparing montelukast sodium
JP2006089463A (ja) * 2004-08-24 2006-04-06 Sumitomo Chemical Co Ltd アリールエーテル類の製造方法
WO2006064269A2 (en) 2004-12-17 2006-06-22 Cipla Limited Salts of leukotriene antagonist montelukast
GB0500029D0 (en) * 2005-01-04 2005-02-09 Univ Belfast Basic ionic liquids
CA2867194C (en) 2005-10-07 2016-10-04 The University Of Alabama Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
EP1783117A1 (en) 2005-11-04 2007-05-09 Esteve Quimica, S.A. Process for the preparation of a leukotriene antagonist and intermediates thereof
US8178680B2 (en) 2005-12-13 2012-05-15 Msn Laboratories Limited Process for the preparation of Montelukast and its pharmaceutically acceptable salts
WO2007072114A1 (en) * 2005-12-23 2007-06-28 Glade Organics Private Limited An improved process for the manufacture of montelukast sodium
US7528254B2 (en) 2006-02-27 2009-05-05 Chemagis Ltd. Process for preparing montelukast and salts thereof
KR100774088B1 (ko) 2006-12-14 2007-11-06 한미약품 주식회사 몬테루카스트의 제조방법 및 이에 사용되는 중간체

Also Published As

Publication number Publication date
TW200920737A (en) 2009-05-16
EP2195295A1 (en) 2010-06-16
CN101808998A (zh) 2010-08-18
CN101808998B (zh) 2012-10-24
PE20131219A1 (es) 2013-11-16
TWI350284B (en) 2011-10-11
KR101072896B1 (ko) 2011-10-17
ES2398732T3 (es) 2013-03-21
AR068755A1 (es) 2009-12-02
WO2009048236A1 (en) 2009-04-16
CA2701912C (en) 2013-04-02
KR20090036349A (ko) 2009-04-14
EP2195295B1 (en) 2013-01-23
PE20091369A1 (es) 2009-10-01
DK2195295T3 (da) 2013-05-06
RU2436774C1 (ru) 2011-12-20
PL2195295T3 (pl) 2013-06-28
US8426599B2 (en) 2013-04-23
JP2011500555A (ja) 2011-01-06
JP5210389B2 (ja) 2013-06-12
MX2010001864A (es) 2010-03-15
PT2195295E (pt) 2013-02-28
HRP20130103T1 (hr) 2013-02-28
CA2701912A1 (en) 2009-04-16
US20110105757A1 (en) 2011-05-05
EP2195295A4 (en) 2011-04-13

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