CL2008002996A1 - Metodo para la preparacion del acido montelukast usando un liquido ionico como medio de reaccion en una razon de 0,1 a 100 veces respecto a uno de los reactantes. - Google Patents
Metodo para la preparacion del acido montelukast usando un liquido ionico como medio de reaccion en una razon de 0,1 a 100 veces respecto a uno de los reactantes.Info
- Publication number
- CL2008002996A1 CL2008002996A1 CL2008002996A CL2008002996A CL2008002996A1 CL 2008002996 A1 CL2008002996 A1 CL 2008002996A1 CL 2008002996 A CL2008002996 A CL 2008002996A CL 2008002996 A CL2008002996 A CL 2008002996A CL 2008002996 A1 CL2008002996 A1 CL 2008002996A1
- Authority
- CL
- Chile
- Prior art keywords
- ionic liquid
- reactants
- preparation
- ratio
- respect
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Método para preparar ácido de montelukast en un medio líquido iónico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070101486A KR101072896B1 (ko) | 2007-10-09 | 2007-10-09 | 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008002996A1 true CL2008002996A1 (es) | 2009-04-13 |
Family
ID=40549354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008002996A CL2008002996A1 (es) | 2007-10-09 | 2008-10-09 | Metodo para la preparacion del acido montelukast usando un liquido ionico como medio de reaccion en una razon de 0,1 a 100 veces respecto a uno de los reactantes. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8426599B2 (es) |
EP (1) | EP2195295B1 (es) |
JP (1) | JP5210389B2 (es) |
KR (1) | KR101072896B1 (es) |
CN (1) | CN101808998B (es) |
AR (1) | AR068755A1 (es) |
CA (1) | CA2701912C (es) |
CL (1) | CL2008002996A1 (es) |
DK (1) | DK2195295T3 (es) |
ES (1) | ES2398732T3 (es) |
HR (1) | HRP20130103T1 (es) |
MX (1) | MX2010001864A (es) |
PE (2) | PE20131219A1 (es) |
PL (1) | PL2195295T3 (es) |
PT (1) | PT2195295E (es) |
RU (1) | RU2436774C1 (es) |
TW (1) | TWI350284B (es) |
WO (1) | WO2009048236A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP1000425A2 (en) | 2010-08-11 | 2012-03-28 | Richter Gedeon Nyrt | Process for the production of montelukast sodium |
CN103570618A (zh) * | 2013-09-30 | 2014-02-12 | 浙江车头制药股份有限公司 | 一种孟鲁司特钠盐的制备方法 |
CN105294556A (zh) * | 2014-06-06 | 2016-02-03 | 上海迪赛诺化学制药有限公司 | 一种制备孟鲁司特酸的方法 |
JP2021536467A (ja) | 2018-09-06 | 2021-12-27 | インノファーマスクリーン インコーポレイテッド | 喘息またはパーキンソン病の処置のための方法および組成物 |
KR102181155B1 (ko) * | 2019-09-26 | 2020-11-20 | 대봉엘에스 주식회사 | 이온성 액체를 매개로 한 에피나코나졸의 신규 제조방법 |
CN111892535B (zh) * | 2020-08-27 | 2023-04-11 | 鲁南制药集团股份有限公司 | 一种孟鲁司特钠的合成方法 |
CN111961083B (zh) * | 2020-08-27 | 2022-11-25 | 鲁南制药集团股份有限公司 | 一种孟鲁司特钠中间体化合物 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2114882T3 (es) | 1990-10-12 | 1998-06-16 | Merck Frosst Canada Inc | Acidos hidroxialquilquinolinos insaturados como antagonistas de leucotrienos. |
TW416948B (en) | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
US5523477A (en) | 1995-01-23 | 1996-06-04 | Merck & Co., Inc. | Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid |
US20050187243A1 (en) * | 2004-01-30 | 2005-08-25 | Valerie Niddam-Hildesheim | Montelukast free acid polymorphs |
US7547787B2 (en) * | 2004-04-21 | 2009-06-16 | Teva Pharmaceutical Industries Ltd. | Processes for preparing montelukast sodium |
JP2006089463A (ja) * | 2004-08-24 | 2006-04-06 | Sumitomo Chemical Co Ltd | アリールエーテル類の製造方法 |
WO2006064269A2 (en) | 2004-12-17 | 2006-06-22 | Cipla Limited | Salts of leukotriene antagonist montelukast |
GB0500029D0 (en) * | 2005-01-04 | 2005-02-09 | Univ Belfast | Basic ionic liquids |
CA2867194C (en) | 2005-10-07 | 2016-10-04 | The University Of Alabama | Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients |
EP1783117A1 (en) | 2005-11-04 | 2007-05-09 | Esteve Quimica, S.A. | Process for the preparation of a leukotriene antagonist and intermediates thereof |
US8178680B2 (en) | 2005-12-13 | 2012-05-15 | Msn Laboratories Limited | Process for the preparation of Montelukast and its pharmaceutically acceptable salts |
WO2007072114A1 (en) * | 2005-12-23 | 2007-06-28 | Glade Organics Private Limited | An improved process for the manufacture of montelukast sodium |
US7528254B2 (en) | 2006-02-27 | 2009-05-05 | Chemagis Ltd. | Process for preparing montelukast and salts thereof |
KR100774088B1 (ko) | 2006-12-14 | 2007-11-06 | 한미약품 주식회사 | 몬테루카스트의 제조방법 및 이에 사용되는 중간체 |
-
2007
- 2007-10-09 KR KR1020070101486A patent/KR101072896B1/ko active IP Right Grant
-
2008
- 2008-10-01 CA CA2701912A patent/CA2701912C/en not_active Expired - Fee Related
- 2008-10-01 JP JP2010528789A patent/JP5210389B2/ja not_active Expired - Fee Related
- 2008-10-01 DK DK08838092.8T patent/DK2195295T3/da active
- 2008-10-01 PT PT88380928T patent/PT2195295E/pt unknown
- 2008-10-01 WO PCT/KR2008/005794 patent/WO2009048236A1/en active Application Filing
- 2008-10-01 US US12/674,118 patent/US8426599B2/en not_active Expired - Fee Related
- 2008-10-01 MX MX2010001864A patent/MX2010001864A/es active IP Right Grant
- 2008-10-01 ES ES08838092T patent/ES2398732T3/es active Active
- 2008-10-01 CN CN2008801090046A patent/CN101808998B/zh not_active Expired - Fee Related
- 2008-10-01 EP EP08838092A patent/EP2195295B1/en not_active Not-in-force
- 2008-10-01 RU RU2010118618/04A patent/RU2436774C1/ru not_active IP Right Cessation
- 2008-10-01 PL PL08838092T patent/PL2195295T3/pl unknown
- 2008-10-08 TW TW097138680A patent/TWI350284B/zh not_active IP Right Cessation
- 2008-10-08 AR ARP080104395A patent/AR068755A1/es unknown
- 2008-10-09 PE PE2013000260A patent/PE20131219A1/es not_active Application Discontinuation
- 2008-10-09 PE PE2008001742A patent/PE20091369A1/es not_active Application Discontinuation
- 2008-10-09 CL CL2008002996A patent/CL2008002996A1/es unknown
-
2013
- 2013-02-06 HR HRP20130103AT patent/HRP20130103T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
TW200920737A (en) | 2009-05-16 |
EP2195295A1 (en) | 2010-06-16 |
CN101808998A (zh) | 2010-08-18 |
CN101808998B (zh) | 2012-10-24 |
PE20131219A1 (es) | 2013-11-16 |
TWI350284B (en) | 2011-10-11 |
KR101072896B1 (ko) | 2011-10-17 |
ES2398732T3 (es) | 2013-03-21 |
AR068755A1 (es) | 2009-12-02 |
WO2009048236A1 (en) | 2009-04-16 |
CA2701912C (en) | 2013-04-02 |
KR20090036349A (ko) | 2009-04-14 |
EP2195295B1 (en) | 2013-01-23 |
PE20091369A1 (es) | 2009-10-01 |
DK2195295T3 (da) | 2013-05-06 |
RU2436774C1 (ru) | 2011-12-20 |
PL2195295T3 (pl) | 2013-06-28 |
US8426599B2 (en) | 2013-04-23 |
JP2011500555A (ja) | 2011-01-06 |
JP5210389B2 (ja) | 2013-06-12 |
MX2010001864A (es) | 2010-03-15 |
PT2195295E (pt) | 2013-02-28 |
HRP20130103T1 (hr) | 2013-02-28 |
CA2701912A1 (en) | 2009-04-16 |
US20110105757A1 (en) | 2011-05-05 |
EP2195295A4 (en) | 2011-04-13 |
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