CL2004000194A1 - Compuestos derivados de diamidas piridina sustituidas y sus sales; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer. - Google Patents

Compuestos derivados de diamidas piridina sustituidas y sus sales; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer.

Info

Publication number
CL2004000194A1
CL2004000194A1 CL200400194A CL2004000194A CL2004000194A1 CL 2004000194 A1 CL2004000194 A1 CL 2004000194A1 CL 200400194 A CL200400194 A CL 200400194A CL 2004000194 A CL2004000194 A CL 2004000194A CL 2004000194 A1 CL2004000194 A1 CL 2004000194A1
Authority
CL
Chile
Prior art keywords
rent
piridina
diamides
cancer
salts
Prior art date
Application number
CL200400194A
Other languages
English (en)
Inventor
Georg Fertig
Frank Herting
Manfred Kubbies
Anja Limberg
Ulrike Reiff
Michael Weidner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2004000194A1 publication Critical patent/CL2004000194A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Abstract

NUEVOS DERIVADOS DMONOACILADOS DE OFENILENDIMINAS DE LA FORFMULA EN LA QUE AR, ES TIOFENO-2,5-DIILO, PIRIDINA-2,5-DIILI, PIRIDINA-5,2-DIILO, PIRIDINA-2,6DIILO, PIRIDINA-2,4-DIILO O 1,4-FENILENO. R1,R2 CON INDEPENDENCIA ENTRE SI SIGNIFICAN HIDROGENO, ALQUILO C1-12, ALQUENILO C2-12, ALQUINILO C2-12, CICLOALQUILO C3-12, LOS GRUPOS ALQUILO, ALQUENILO, ALQUINILO Y CICLOALQUILO ESTAN EVENTUALMENTE MONO- O MULTISUSTITUIDOS POR HIDROXI, HALOGENO, CICLOALQUILO C3-12, ALCOXI, ALUILSULFANILO, ACILOXI, ALCOXICARBONILO, ACILO, ALQUILO C1-6)-NH-C(O)-, (ALQUILO C1-6)-C(O)NH- O -NR3R4, O COMO ALTERNATIVA.......
CL200400194A 2003-02-06 2004-02-04 Compuestos derivados de diamidas piridina sustituidas y sus sales; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer. CL2004000194A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03002545 2003-02-06
EP03016692 2003-08-04

Publications (1)

Publication Number Publication Date
CL2004000194A1 true CL2004000194A1 (es) 2005-01-14

Family

ID=32852233

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400194A CL2004000194A1 (es) 2003-02-06 2004-02-04 Compuestos derivados de diamidas piridina sustituidas y sus sales; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer.

Country Status (8)

Country Link
US (2) US7071219B2 (es)
EP (1) EP1592667A2 (es)
JP (1) JP2006516553A (es)
AR (1) AR043111A1 (es)
CA (1) CA2513408A1 (es)
CL (1) CL2004000194A1 (es)
TW (1) TW200424174A (es)
WO (1) WO2004069803A2 (es)

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DK1485354T3 (da) 2002-03-13 2008-09-01 Janssen Pharmaceutica Nv Sulfonylamino-derivater som nye inhibitorer af histandeacetylase
NZ552865A (en) 2004-07-28 2009-09-25 Janssen Pharmaceutica Nv Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
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NZ589276A (en) 2005-02-03 2012-06-29 Topotarget Uk Ltd Combination therapies using hdac inhibitors and erlotinib (tarceva)
DK2494969T3 (en) 2005-05-13 2015-06-15 Topotarget Uk Ltd Pharmaceutical formulations of the HDAC inhibitors
AU2006248938B2 (en) 2005-05-18 2011-09-29 Janssen Pharmaceutica N.V. Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
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MX2008002364A (es) * 2005-08-17 2008-03-18 Schering Corp Ligandos novedosos de cinasa basados en tiofeno y en furano de alta afinidad.
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US8828392B2 (en) 2005-11-10 2014-09-09 Topotarget Uk Limited Histone deacetylase (HDAC) inhibitors (PXD101) for the treatment of cancer alone or in combination with chemotherapeutic agent
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CA2630717C (en) 2006-01-19 2015-02-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
DK1979328T3 (da) 2006-01-19 2013-03-25 Janssen Pharmaceutica Nv Pyridin- og pyrimidinderivater i deres egenskab af histondeacetylasehæmmere
WO2007082876A1 (en) 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
WO2007082873A1 (en) 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase
AU2007206950B2 (en) 2006-01-19 2012-02-02 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
AU2012202993B2 (en) * 2007-03-01 2015-06-25 Novartis Ag Pim kinase inhibitors and methods of their use
MX2009009304A (es) 2007-03-01 2009-11-18 Novartis Ag Inhibidores de cinasa pim y metodos para su uso.
EP2135620A4 (en) 2007-03-28 2010-12-29 Santen Pharmaceutical Co Ltd AGAINST OKULAR HYPOTONIA CONNECTED TO HISTONE DEACETYLASE INHIBITION AS AN ACTIVE SUBSTANCE
WO2008117861A1 (ja) * 2007-03-28 2008-10-02 Santen Pharmaceutical Co., Ltd. フェニレンジアミン誘導体を有効成分とする眼圧下降剤
CA2693967A1 (en) * 2007-07-19 2009-01-29 Schering Corporation Heterocyclic amide compounds as protein kinase inhibitors
CN101868446A (zh) 2007-09-25 2010-10-20 托波塔吉特英国有限公司 某些异羟肟酸化合物的合成方法
CA2702536A1 (en) * 2007-10-10 2009-04-16 Orchid Research Laboratories Limited Novel histone deacetylase inhibitors
EP2060565A1 (en) 2007-11-16 2009-05-20 4Sc Ag Novel bifunctional compounds which inhibit protein kinases and histone deacetylases
JP5640005B2 (ja) 2008-07-14 2014-12-10 ギリアード サイエンシーズ， インコーポレイテッド Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物
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Also Published As

Publication number Publication date
CA2513408A1 (en) 2004-08-19
US7071219B2 (en) 2006-07-04
US20040162317A1 (en) 2004-08-19
WO2004069803A2 (en) 2004-08-19
TW200424174A (en) 2004-11-16
AR043111A1 (es) 2005-07-20
US20060089403A1 (en) 2006-04-27
JP2006516553A (ja) 2006-07-06
WO2004069803A3 (en) 2004-11-18
EP1592667A2 (en) 2005-11-09
US7501451B2 (en) 2009-03-10

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