CH624932A5 - - Google Patents
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- Publication number
- CH624932A5 CH624932A5 CH141080A CH141080A CH624932A5 CH 624932 A5 CH624932 A5 CH 624932A5 CH 141080 A CH141080 A CH 141080A CH 141080 A CH141080 A CH 141080A CH 624932 A5 CH624932 A5 CH 624932A5
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- proline
- formula
- mixture
- product
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/657,792 US4046889A (en) | 1976-02-13 | 1976-02-13 | Azetidine-2-carboxylic acid derivatives |
US69843276A | 1976-06-21 | 1976-06-21 | |
US05/751,851 US4105776A (en) | 1976-06-21 | 1976-12-22 | Proline derivatives and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CH624932A5 true CH624932A5 (es) | 1981-08-31 |
Family
ID=27417986
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH170377A CH622503A5 (en) | 1976-02-13 | 1977-02-11 | Processes for the preparation of proline derivatives and of related compounds |
CH141080A CH624932A5 (es) | 1976-02-13 | 1980-02-21 | |
CH140980A CH624931A5 (es) | 1976-02-13 | 1980-02-21 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH170377A CH622503A5 (en) | 1976-02-13 | 1977-02-11 | Processes for the preparation of proline derivatives and of related compounds |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH140980A CH624931A5 (es) | 1976-02-13 | 1980-02-21 |
Country Status (31)
Country | Link |
---|---|
JP (1) | JPS604815B2 (es) |
AR (4) | AR222445A1 (es) |
AT (1) | AT365569B (es) |
AU (1) | AU509899B2 (es) |
BG (3) | BG37075A3 (es) |
CA (1) | CA1101864A (es) |
CH (3) | CH622503A5 (es) |
DD (1) | DD129442B3 (es) |
DE (2) | DE2759862C2 (es) |
DK (1) | DK157487C (es) |
ES (5) | ES455803A1 (es) |
FI (1) | FI66596C (es) |
FR (1) | FR2340932A1 (es) |
GB (1) | GB1576161A (es) |
GR (1) | GR69811B (es) |
HK (1) | HK20281A (es) |
HU (1) | HU181965B (es) |
IE (1) | IE44707B1 (es) |
IL (1) | IL51297A (es) |
IT (1) | IT1062293B (es) |
KE (1) | KE3136A (es) |
MY (2) | MY8200075A (es) |
NL (1) | NL168509C (es) |
NO (1) | NO146985C (es) |
NZ (1) | NZ183130A (es) |
PH (1) | PH12970A (es) |
PL (1) | PL118161B1 (es) |
RO (1) | RO69941A (es) |
SE (2) | SE423812B (es) |
SU (1) | SU747422A3 (es) |
YU (1) | YU40664B (es) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4206122A (en) * | 1978-04-14 | 1980-06-03 | E. R. Squibb & Sons, Inc. | Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde and intermediates therefor |
US4053651A (en) | 1976-05-10 | 1977-10-11 | E. R. Squibb & Sons, Inc. | Compounds and method for alleviating angiotensin related hypertension |
AU518147B2 (en) * | 1976-12-03 | 1981-09-17 | E.R. Squibb & Sons, Inc. | Derivatives of thiazolidine, thiazine and morpholine carboxylic acids |
US4129566A (en) * | 1978-02-15 | 1978-12-12 | E. R. Squibb & Sons, Inc. | Derivatives of dehydrocyclicimino acids |
US4113715A (en) * | 1977-01-17 | 1978-09-12 | E. R. Squibb & Sons, Inc. | Amino acid derivatives |
FR2412537A1 (fr) * | 1977-12-22 | 1979-07-20 | Science Union & Cie | Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique |
CA1120400A (en) * | 1977-12-27 | 1982-03-23 | Zola P. Horovitz | Method of treating hypertension and medicaments therefor |
PH15381A (en) * | 1978-02-21 | 1982-12-17 | Squibb & Sons Inc | Halogen substituted mercaptoacylamino acids |
JPS559058A (en) * | 1978-07-06 | 1980-01-22 | Dainippon Pharmaceut Co Ltd | 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative |
CA1109475A (en) * | 1978-07-27 | 1981-09-22 | Miguel A. Ondetti | Thiopropanoylamino acid derivatives |
CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
NZ190995A (en) * | 1978-09-05 | 1982-03-09 | American Cyanamid Co | Substituted omega propionyl or butyryl l-prolines and pharmaceutical compositions |
NL7809121A (nl) * | 1978-09-07 | 1980-03-11 | Oce Andeno B V Grubbenvorsterw | Optisch aktieve derivaten van mercapto-isoboterzuur. |
NL7809120A (nl) * | 1978-09-07 | 1980-03-11 | Oce Andeno B V Grubbenvorsterw | Werkwijze voor de bereiding van proline-derivaten. |
ZA794723B (en) * | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
US4690937A (en) * | 1979-08-14 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
GR73585B (es) * | 1978-09-11 | 1984-03-26 | Univ Miami | |
JPS5540622A (en) * | 1978-09-14 | 1980-03-22 | Santen Pharmaceut Co Ltd | Hypotensive agent |
US4483861A (en) * | 1978-10-31 | 1984-11-20 | Santen Pharmaceutical Co., Ltd. | Antihypertensive sulfur-containing compounds |
US4198515A (en) * | 1978-12-08 | 1980-04-15 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids |
US4347371A (en) * | 1978-12-30 | 1982-08-31 | Santen Pharmaceutical Co., Ltd. | Disulfide compounds |
US4410542A (en) | 1978-12-30 | 1983-10-18 | Santen Pharmaceutical Co., Ltd. | Disulfide compounds |
CA1138452A (en) * | 1979-01-15 | 1982-12-28 | John Krapcho | Carbamate derivatives of mercaptoacyl hydroxy prolines |
US4461896A (en) * | 1979-02-07 | 1984-07-24 | Norwich Eaton Pharmaceuticals, Inc. | 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids |
US4220791A (en) * | 1979-03-08 | 1980-09-02 | E. R. Squibb & Sons, Inc. | Mercaptoacylpyrazolidinone carboxylic acid derivatives |
ZA802420B (en) * | 1979-05-18 | 1981-04-29 | Squibb & Sons Inc | Aminoacyl derivatives of mercaptoacyl amino acids |
US4234489A (en) * | 1979-06-25 | 1980-11-18 | E. R. Squibb & Sons, Inc. | Pyroglutamic acid derivatives and analogs |
JPS5629403U (es) * | 1979-08-13 | 1981-03-20 | ||
DE2937779A1 (de) * | 1979-09-19 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
GB2066240A (en) * | 1979-12-10 | 1981-07-08 | Squibb & Sons Inc | Derivatives of mercaptoacyl amino acids |
JPS5683483A (en) * | 1979-12-13 | 1981-07-08 | Santen Pharmaceut Co Ltd | Thiazolidine compound |
GB2065643B (en) * | 1979-12-13 | 1983-08-24 | Kanegafuchi Chemical Ind | Optically active n-mercaptoalkanoylamino acids |
US4692458A (en) * | 1980-03-05 | 1987-09-08 | University Of Miami | Anti-hypertensive agents |
GB2070586A (en) * | 1980-03-21 | 1981-09-09 | Squibb & Sons Inc | Derivatives of Proline or Pipecolic Acid |
DE3011239A1 (de) * | 1980-03-22 | 1981-10-01 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituierte alkylthioacylaminosaeuren, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
SE8203245L (sv) * | 1981-05-27 | 1982-11-28 | Crc Ricerca Chim | Forfarande for enantioselektiv framstellning av n-substituerade prolinderivat |
KR860001391B1 (ko) * | 1984-07-23 | 1986-09-22 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
JPH06740B2 (ja) * | 1984-08-16 | 1994-01-05 | 三菱レイヨン株式会社 | 光学活性カルボン酸アミドの製造法 |
HU196369B (en) * | 1984-10-18 | 1988-11-28 | Egyt Gyogyszervegyeszeti Gyar | New process for producing n-acylized l-prolin derivatives |
KR870001570B1 (ko) * | 1984-12-19 | 1987-09-04 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
KR870001569B1 (ko) * | 1985-02-11 | 1987-09-04 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
AT395012B (de) * | 1986-06-27 | 1992-08-25 | Richter Gedeon Vegyeszet | Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen |
JP2863534B2 (ja) * | 1988-10-24 | 1999-03-03 | マリオン ラボラトリーズ,インコーポレイティド | 医薬組成物 |
US5026873A (en) * | 1989-11-06 | 1991-06-25 | E. R. Squibb & Sons, Inc. | Process for direct isolation of captopril |
DE4228455A1 (de) * | 1992-08-26 | 1994-09-15 | Beiersdorf Ag | Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Thiolen und/oder Thiolderivaten |
ES2102670T3 (es) * | 1992-08-26 | 1997-08-01 | Beiersdorf Ag | Uso de captadores de radicales como agentes inmunomoduladores en composiciones cosmeticas y dermatologicas. |
IT1266570B1 (it) * | 1993-07-30 | 1997-01-09 | Zambon Spa | Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari |
US7056935B2 (en) | 1995-06-07 | 2006-06-06 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
GB9704522D0 (en) * | 1997-03-05 | 1997-04-23 | Smithkline Beecham Plc | Compounds |
EP0915088B1 (en) | 1997-10-31 | 2002-09-18 | F. Hoffmann-La Roche Ag | D-Proline derivatives |
CA2457814A1 (en) * | 2001-08-07 | 2003-02-20 | Sunesis Pharmaceuticals, Inc. | Disulfide and thiosulfonate ligands and libraries comprising these ligands |
CN100361971C (zh) * | 2005-09-19 | 2008-01-16 | 华中师范大学 | 催化活性可调的双官能团l-脯氨酸衍生物及制备 |
KR101660059B1 (ko) | 2008-08-22 | 2016-09-26 | 박스알타 인코퍼레이티드 | 중합체 벤질 카르보네이트-유도체 |
US20130291227A1 (en) | 2012-04-27 | 2013-10-31 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA946836A (en) * | 1970-03-18 | 1974-05-07 | Miguel A. Ondetti | Enzyme inhibitor |
-
1977
- 1977-01-14 AU AU21347/77A patent/AU509899B2/en not_active Expired
- 1977-01-19 NZ NZ183130A patent/NZ183130A/xx unknown
- 1977-01-20 IL IL51297A patent/IL51297A/xx unknown
- 1977-01-21 CA CA270,184A patent/CA1101864A/en not_active Expired
- 1977-01-27 PH PH19390A patent/PH12970A/en unknown
- 1977-01-31 DE DE2759862A patent/DE2759862C2/de not_active Expired
- 1977-01-31 DE DE2703828A patent/DE2703828C2/de not_active Expired
- 1977-02-08 YU YU331/77A patent/YU40664B/xx unknown
- 1977-02-08 GR GR52745A patent/GR69811B/el unknown
- 1977-02-09 RO RO7789327A patent/RO69941A/ro unknown
- 1977-02-10 ES ES455803A patent/ES455803A1/es not_active Expired
- 1977-02-10 FI FI770437A patent/FI66596C/fi not_active IP Right Cessation
- 1977-02-11 NL NLAANVRAGE7701457,A patent/NL168509C/xx not_active IP Right Cessation
- 1977-02-11 IE IE305/77A patent/IE44707B1/en not_active IP Right Cessation
- 1977-02-11 DD DD77197339A patent/DD129442B3/de unknown
- 1977-02-11 SU SU772450455A patent/SU747422A3/ru active
- 1977-02-11 BG BG8362894A patent/BG37075A3/xx unknown
- 1977-02-11 DK DK059677A patent/DK157487C/da active
- 1977-02-11 AR AR266525A patent/AR222445A1/es active
- 1977-02-11 BG BG7735398A patent/BG37375A3/xx unknown
- 1977-02-11 BG BG8362893A patent/BG37074A3/xx unknown
- 1977-02-11 CH CH170377A patent/CH622503A5/fr not_active IP Right Cessation
- 1977-02-11 NO NO770464A patent/NO146985C/no unknown
- 1977-02-11 HU HU77SU939A patent/HU181965B/hu unknown
- 1977-02-11 SE SE7701561A patent/SE423812B/xx not_active IP Right Cessation
- 1977-02-11 IT IT48008/77A patent/IT1062293B/it active Protection Beyond IP Right Term
- 1977-02-12 PL PL1977195965A patent/PL118161B1/pl not_active IP Right Cessation
- 1977-02-12 JP JP52014542A patent/JPS604815B2/ja not_active Expired
- 1977-02-13 GB GB4088/77A patent/GB1576161A/en not_active Expired
- 1977-02-14 FR FR7704122A patent/FR2340932A1/fr active Granted
- 1977-02-14 AT AT0098977A patent/AT365569B/de not_active IP Right Cessation
- 1977-10-31 AR AR269794A patent/AR214649A1/es active
- 1977-10-31 AR AR269793A patent/AR222783A1/es active
-
1978
- 1978-02-16 ES ES467053A patent/ES467053A1/es not_active Expired
- 1978-02-16 ES ES467050A patent/ES467050A1/es not_active Expired
- 1978-02-16 ES ES467052A patent/ES467052A1/es not_active Expired
- 1978-05-16 ES ES467051A patent/ES467051A1/es not_active Expired
-
1979
- 1979-09-11 AR AR278014A patent/AR226290A1/es active
-
1980
- 1980-02-21 CH CH141080A patent/CH624932A5/fr not_active IP Right Cessation
- 1980-02-21 CH CH140980A patent/CH624931A5/fr not_active IP Right Cessation
-
1981
- 1981-05-14 HK HK202/81A patent/HK20281A/xx unknown
- 1981-06-18 KE KE3136A patent/KE3136A/xx unknown
- 1981-08-03 SE SE8104660A patent/SE426697B/sv not_active IP Right Cessation
-
1982
- 1982-12-30 MY MY75/82A patent/MY8200075A/xx unknown
-
1987
- 1987-09-30 MY MYPI87002538A patent/MY102705A/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PL | Patent ceased |