CH572909A5 - Pyrryl-aminoethanols - prepd by redn of arylalkyl- pyrrylglyoxylamides with metal-hydrides - Google Patents
Pyrryl-aminoethanols - prepd by redn of arylalkyl- pyrrylglyoxylamides with metal-hydridesInfo
- Publication number
- CH572909A5 CH572909A5 CH1582672A CH1582672A CH572909A5 CH 572909 A5 CH572909 A5 CH 572909A5 CH 1582672 A CH1582672 A CH 1582672A CH 1582672 A CH1582672 A CH 1582672A CH 572909 A5 CH572909 A5 CH 572909A5
- Authority
- CH
- Switzerland
- Prior art keywords
- arylalkyl
- pyrryl
- prepd
- metal
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Cpds. of formula (I): (where R = arylalkyl); R1 and R2 are same or different opt. branched 1-4C alkyl)are prepd. by reacting an 1-arylalkylpyrrole with an oxalylhalide and acid-binding agent to give the 1-arylalkyl-2-pyrrylglyoxyhalide which is reacted with NHR1R2 or its acid-addition salt in the presence of acid-binding agent to give a cpd. (II): This is reacted with a metal- or organometal hydride pref. sodium-bis-(2-methoxyethoxy)-aluminiumhydride in inert solvent at room temp. - boiling point of solvent. Cpds. (I) esp. known 1- 1'-(o-chlorobenzyl)-2'-pyrryl -2-di-sec. butylaminoethanol (Virimolo) have analgesic act.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT3058571 | 1971-10-30 | ||
IT3058671 | 1971-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH572909A5 true CH572909A5 (en) | 1976-02-27 |
Family
ID=26328881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH1582672A CH572909A5 (en) | 1971-10-30 | 1972-10-30 | Pyrryl-aminoethanols - prepd by redn of arylalkyl- pyrrylglyoxylamides with metal-hydrides |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS5530514B2 (en) |
CA (1) | CA996941A (en) |
CH (1) | CH572909A5 (en) |
CS (1) | CS179403B2 (en) |
DK (1) | DK133670B (en) |
ES (1) | ES408077A1 (en) |
FI (1) | FI54705C (en) |
HU (1) | HU164701B (en) |
NL (1) | NL7214581A (en) |
RO (1) | RO62754A (en) |
SE (1) | SE396601B (en) |
SU (1) | SU453834A3 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59113021U (en) * | 1983-09-22 | 1984-07-31 | 奈良 康則 | A rice transplanter equipped with a storage device that makes it easy to remove empty cases. |
-
1972
- 1972-10-27 SE SE7213898A patent/SE396601B/en unknown
- 1972-10-27 DK DK533372AA patent/DK133670B/en unknown
- 1972-10-27 NL NL7214581A patent/NL7214581A/xx not_active Application Discontinuation
- 1972-10-27 CA CA155,096A patent/CA996941A/en not_active Expired
- 1972-10-28 ES ES408077A patent/ES408077A1/en not_active Expired
- 1972-10-30 RO RO7272674A patent/RO62754A/en unknown
- 1972-10-30 JP JP10808672A patent/JPS5530514B2/ja not_active Expired
- 1972-10-30 HU HUWI222A patent/HU164701B/hu unknown
- 1972-10-30 FI FI3005/72A patent/FI54705C/en active
- 1972-10-30 CH CH1582672A patent/CH572909A5/en not_active IP Right Cessation
- 1972-10-30 SU SU1847863A patent/SU453834A3/en active
- 1972-10-30 CS CS7200007289A patent/CS179403B2/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK133670B (en) | 1976-06-28 |
SE396601B (en) | 1977-09-26 |
NL7214581A (en) | 1973-05-02 |
ES408077A1 (en) | 1976-02-01 |
CS179403B2 (en) | 1977-10-31 |
FI54705B (en) | 1978-10-31 |
HU164701B (en) | 1974-03-28 |
CA996941A (en) | 1976-09-14 |
DK133670C (en) | 1976-11-15 |
JPS4852765A (en) | 1973-07-24 |
FI54705C (en) | 1979-02-12 |
JPS5530514B2 (en) | 1980-08-11 |
RO62754A (en) | 1982-09-09 |
SU453834A3 (en) | 1974-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PL | Patent ceased |