CA2978679A1 - Methode de traitement d'une tumeur cerebrale - Google Patents

Methode de traitement d'une tumeur cerebrale

Info

Publication number
CA2978679A1
CA2978679A1 CA2978679A CA2978679A CA2978679A1 CA 2978679 A1 CA2978679 A1 CA 2978679A1 CA 2978679 A CA2978679 A CA 2978679A CA 2978679 A CA2978679 A CA 2978679A CA 2978679 A1 CA2978679 A1 CA 2978679A1
Authority
CA
Canada
Prior art keywords
brain tumor
plinabulin
brain
mice
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2978679A
Other languages
English (en)
Inventor
Lan Huang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BeyondSpring Pharmaceuticals Inc
Original Assignee
BeyondSpring Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56880412&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2978679(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by BeyondSpring Pharmaceuticals Inc filed Critical BeyondSpring Pharmaceuticals Inc
Publication of CA2978679A1 publication Critical patent/CA2978679A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Les cancers du cerveau et du système nerveux comptent parmi les cancers les plus difficiles à traiter. Il y a toujours un besoin urgent d'améliorer les traitements des cancers du cerveau. Il est décrit des méthodes pour traiter les tumeurs cérébrales par l'administration de plinabuline. Certains modes de réalisation concernent l'utilisation de plinabuline pour traiter les tumeurs cérébrales, pour inhiber la prolifération d'une cellule de tumeur cérébrale, pour induire de l'apoptose dans une cellule de tumeur cérébrale, et/ou pour inhiber la progression d'une tumeur cérébrale, dans laquelle la tumeur cérébrale est une tumeur cérébrale métastatique ou un glioblastome multiforme.
CA2978679A 2015-03-06 2016-03-02 Methode de traitement d'une tumeur cerebrale Pending CA2978679A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562129623P 2015-03-06 2015-03-06
US62/129,623 2015-03-06
US201562249807P 2015-11-02 2015-11-02
US62/249,807 2015-11-02
PCT/US2016/020396 WO2016144636A1 (fr) 2015-03-06 2016-03-02 Méthode de traitement d'une tumeur cérébrale

Publications (1)

Publication Number Publication Date
CA2978679A1 true CA2978679A1 (fr) 2016-09-15

Family

ID=56880412

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2978679A Pending CA2978679A1 (fr) 2015-03-06 2016-03-02 Methode de traitement d'une tumeur cerebrale

Country Status (17)

Country Link
US (2) US10076518B2 (fr)
EP (1) EP3265091A4 (fr)
JP (2) JP6904570B2 (fr)
KR (1) KR102623404B1 (fr)
CN (1) CN107530340B (fr)
AU (2) AU2016229295B2 (fr)
BR (1) BR112017018964A2 (fr)
CA (1) CA2978679A1 (fr)
CL (1) CL2017002242A1 (fr)
HK (2) HK1250007A1 (fr)
IL (1) IL254262A0 (fr)
MX (1) MX2017011375A (fr)
MY (1) MY194341A (fr)
RU (1) RU2728796C2 (fr)
SG (1) SG11201707128TA (fr)
WO (1) WO2016144636A1 (fr)
ZA (1) ZA201706035B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2978679A1 (fr) 2015-03-06 2016-09-15 Beyondspring Pharmaceuticals, Inc. Methode de traitement d'une tumeur cerebrale
US10238650B2 (en) * 2015-03-06 2019-03-26 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
WO2017011399A1 (fr) 2015-07-13 2017-01-19 Beyondspring Pharmaceuticals, Inc Compositions de plinabuline
IL260933B2 (en) 2016-02-08 2023-04-01 Beyondspring Pharmaceuticals Inc Preparations containing tocorsol or its analogues
EP3463337A4 (fr) 2016-06-06 2020-02-12 Beyondspring Pharmaceuticals, Inc. Composition et méthode permettant de réduire la neutropénie
CN110431135A (zh) 2017-01-06 2019-11-08 大连万春布林医药有限公司 微管蛋白结合化合物及其治疗用途
CA3052190A1 (fr) 2017-02-01 2018-08-09 Beyondspring Pharmaceuticals, Inc. Methode de reduction de la neutropenie
BR112020014960A2 (pt) 2018-01-24 2020-12-22 Beyondspring Pharmaceuticals, Inc. Composição e método para redução de trombocitopenia
JP2021530507A (ja) 2018-07-18 2021-11-11 マンザニータ ファーマシューティカルズ，インク． 神経細胞に抗がん剤を送達するためのコンジュゲート、その使用方法及び製造方法
US20230061353A1 (en) * 2020-01-22 2023-03-02 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Abt-751 and ionizing radiation
BR112022020595A2 (pt) * 2020-04-10 2023-01-17 Lantern Pharma Inc Métodos hidroxiureametil-acilfulveno para tratamento de câncer do cérebro ou câncer do snc.
AU2022205447A1 (en) * 2021-01-08 2023-07-27 Lantern Pharma Inc. Treatment of brain metastases and cns metastases using illudins or hydroxylureamethyl acylfulvene
CA3215047A1 (fr) * 2021-04-09 2022-10-13 Lan Huang Compositions therapeutiques et methodes de traitement de tumeurs
CN117860672A (zh) * 2022-10-11 2024-04-12 大连万春布林医药有限公司 一种普那布林胶束组合物及其制备方法

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS509164A (fr) 1973-05-11 1975-01-30
AU576322B2 (en) 1983-07-22 1988-08-25 Ici Australia Limited Alpha-substituted-alpha-cyanomethyl alcohols
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
JPS6411523A (en) 1987-07-06 1989-01-17 Kawashima Tekko Kk Dish feeder in tableware washing machine
JPH059164A (ja) 1991-07-02 1993-01-19 Sumitomo Chem Co Ltd 光学活性マンデロニトリル誘導体の製造方法
GB9217331D0 (en) 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds
EP1500393A1 (fr) 1992-11-27 2005-01-26 Mayne Pharma (USA) Inc. Composition injectable de taxol
JPH0725858A (ja) 1993-07-13 1995-01-27 Otsuka Pharmaceut Co Ltd ピペラジン誘導体
GB9402809D0 (en) 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9402807D0 (en) 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9426224D0 (en) 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
US5891877A (en) 1995-02-14 1999-04-06 Xenova Limited Pharmaceutical compounds
US5874443A (en) 1995-10-19 1999-02-23 Trega Biosciences, Inc. Isoquinoline derivatives and isoquinoline combinatorial libraries
US5886210A (en) 1996-08-22 1999-03-23 Rohm And Haas Company Method for preparing aromatic compounds
JP3131574B2 (ja) 1996-09-04 2001-02-05 新日本製鐵株式会社 新規抗腫瘍物質、該物質を製造するための微生物及び方法、並びに該物質を有効成分とする細胞周期阻害剤及び抗腫瘍剤
US5939098A (en) * 1996-09-19 1999-08-17 Schering Corporation Cancer treatment with temozolomide
US5922683A (en) 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
CA2310664C (fr) 1997-11-21 2008-03-11 Euro-Celtique S.A. 2-aminoacetamides substitues et leur utilisation
EP1051397B1 (fr) 1998-01-29 2008-12-31 Aventis Pharmaceuticals Inc. Procede de preparation d'un compose n- carbonyl(aliphatique ou aromatique) -2-aminoacetamide et d'un compose cyclise
US7141603B2 (en) 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
US6069146A (en) 1998-03-25 2000-05-30 The Regents Of The University Of California Halimide, a cytotoxic marine natural product, and derivatives thereof
US6333323B1 (en) 1998-03-26 2001-12-25 Shionogi & Co., Ltd. Indole derivatives with antiviral activity
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
FR2784988B1 (fr) 1998-10-23 2002-09-20 Adir Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6358957B1 (en) 1998-11-12 2002-03-19 Nereus Pharmaceuticals, Inc. Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
US7026322B2 (en) 1998-11-12 2006-04-11 Nereus Pharmaceuticals, Inc. Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
BR0013542A (pt) 1999-08-23 2002-05-14 Dana Farber Cancer Inst Inc Moléculas b7-4 e usos para as mesmas
JP4896327B2 (ja) 1999-08-23 2012-03-14 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド Ｐｄ−１、ｂ７−４の受容体、およびその使用
CA3016482A1 (fr) 1999-11-30 2001-06-07 Mayo Foundation For Medical Education And Research Nouvelle molecule immunoregulatrice b7-h1,
BRPI0017067B8 (pt) 2000-01-18 2021-05-25 Beyondspring Pharmaceuticals Inc inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto
KR100852965B1 (ko) 2000-05-09 2008-08-19 애드파르마 인코포레이티드 피페라진디온 화합물
US6583143B2 (en) 2000-12-28 2003-06-24 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
US7919497B2 (en) * 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
KR101049100B1 (ko) 2002-08-02 2011-07-15 니리어스 파마슈티컬즈, 인코퍼레이션 데하이드로페닐아히스틴 및 그의 동족체, 및 이들의 합성방법
US7935704B2 (en) 2003-08-01 2011-05-03 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
ES2367430T3 (es) 2002-12-23 2011-11-03 Wyeth Llc Anticuerpos contra pd-1 y sus usos.
KR101228104B1 (ko) * 2004-02-04 2013-02-01 니리어스 파마슈티컬즈, 인코퍼레이션 데하이드로페닐아히스틴 및 그의 동족체, 및 이들의합성방법
DE202004018940U1 (de) 2004-12-07 2006-04-13 Asf Verwaltungs Gmbh Druckverschluß, Druckverschlußband und wiederverschließbarer Beutel
CN101213297B (zh) 2005-05-09 2013-02-13 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及单独使用或与其它免疫治疗剂联合使用抗pd-1抗体来治疗癌症的方法
KR101411165B1 (ko) 2005-07-01 2014-06-25 메다렉스, 엘.엘.시. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
AU2007207465B2 (en) * 2006-01-18 2012-12-06 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
US8129527B2 (en) 2006-11-03 2012-03-06 Nereus Pharmacuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
KR20100100949A (ko) 2008-01-08 2010-09-15 브리스톨-마이어스 스큅 컴퍼니 증식성 질환의 치료를 위한 튜불린 조정제와 항-ｃｔｌａ４ 항체의 조합물
EP2262837A4 (fr) 2008-03-12 2011-04-06 Merck Sharp & Dohme Protéines de liaison avec pd-1
PE20120341A1 (es) 2008-12-09 2012-04-24 Genentech Inc Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t
WO2010114922A1 (fr) * 2009-03-31 2010-10-07 Agios Pharmaceuticals, Inc. Procédés de traitement d'un cancer ayant un génotype egfr ou kras aberrant
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
DK2464218T3 (en) 2009-08-10 2015-07-20 Univ Texas Treatment of brain metastases with inhibitors of endothelin receptors in combination with a cytotoxic agent for chemotherapy
MX343747B (es) 2009-11-24 2016-11-22 Medimmune Ltd Agentes de union diana contra b7-h1.
EP2571577A1 (fr) 2010-05-17 2013-03-27 Bristol-Myers Squibb Company Régimes posologiques immunothérapeutiques améliorés et combinaisons de ceux-ci
WO2011151423A1 (fr) * 2010-06-04 2011-12-08 Exonhit S.A. Isoquinoléines substituées et leur utilisation en tant qu'inhibiteurs de polymérisation des tubulines
JP2012033526A (ja) 2010-07-28 2012-02-16 Fuji Electric Co Ltd 薄膜太陽電池およびその製造方法
WO2012035436A1 (fr) 2010-09-15 2012-03-22 Tokyo University Of Pharmacy And Life Sciences Analogues de promédicaments à base de plinabuline et utilisations thérapeutiques associées
TWI386203B (zh) 2011-01-07 2013-02-21 Univ China Medical 治療腦癌或用以降低腦癌細胞對替莫唑胺之抗藥性之醫藥組合物及其應用
SI2699264T1 (en) 2011-04-20 2018-08-31 Medimmune Llc Antibodies and other molecules that bind B7-H1 and PD-1
AU2013204313C1 (en) * 2012-06-01 2016-04-07 Bionomics Limited Combination Therapy
US11285169B2 (en) 2013-03-13 2022-03-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for modulating chemotherapeutic cytotoxicity
EP2988668B1 (fr) 2013-04-24 2019-07-24 Tel HaShomer Medical Research Infrastructure and Services Ltd. Cartes de résonance magnétique pour analyse de tissu
CN105705148B (zh) 2013-10-11 2021-03-23 大连万春布林医药有限公司 使用普那布林和紫杉烷的组合的癌症疗法
US9850225B2 (en) 2014-04-14 2017-12-26 Bristol-Myers Squibb Company Compounds useful as immunomodulators
EP3256130A4 (fr) 2015-02-12 2018-08-01 Beyondspring Pharmaceuticals, Inc. Utilisation de plinabuline en combinaison avec des inhibiteurs du point de contrôle immunitaire
US10238650B2 (en) 2015-03-06 2019-03-26 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
CA2978679A1 (fr) 2015-03-06 2016-09-15 Beyondspring Pharmaceuticals, Inc. Methode de traitement d'une tumeur cerebrale
WO2017011399A1 (fr) 2015-07-13 2017-01-19 Beyondspring Pharmaceuticals, Inc Compositions de plinabuline
IL260933B2 (en) 2016-02-08 2023-04-01 Beyondspring Pharmaceuticals Inc Preparations containing tocorsol or its analogues
EP3463337A4 (fr) 2016-06-06 2020-02-12 Beyondspring Pharmaceuticals, Inc. Composition et méthode permettant de réduire la neutropénie
CN110431135A (zh) 2017-01-06 2019-11-08 大连万春布林医药有限公司 微管蛋白结合化合物及其治疗用途
CA3052190A1 (fr) 2017-02-01 2018-08-09 Beyondspring Pharmaceuticals, Inc. Methode de reduction de la neutropenie
SG11201908420WA (en) 2017-03-13 2019-10-30 Beyondspring Pharmaceuticals Inc Compositions of plinabulin and use thereof

Also Published As

Publication number Publication date
EP3265091A4 (fr) 2018-08-01
AU2016229295B2 (en) 2021-11-04
US20190000841A1 (en) 2019-01-03
US20180042921A1 (en) 2018-02-15
MX2017011375A (es) 2018-01-23
CN107530340B (zh) 2021-06-08
RU2017131448A (ru) 2019-04-08
KR20170123642A (ko) 2017-11-08
JP2021091695A (ja) 2021-06-17
RU2728796C2 (ru) 2020-07-31
CL2017002242A1 (es) 2018-04-02
BR112017018964A2 (pt) 2018-05-22
RU2017131448A3 (fr) 2019-08-20
JP7264331B2 (ja) 2023-04-25
CN107530340A (zh) 2018-01-02
AU2021254549A1 (en) 2021-11-18
HK1249051A1 (zh) 2018-10-26
JP2018507245A (ja) 2018-03-15
US10076518B2 (en) 2018-09-18
EP3265091A1 (fr) 2018-01-10
AU2016229295A1 (en) 2017-09-28
HK1250007A1 (zh) 2018-11-23
JP6904570B2 (ja) 2021-07-21
WO2016144636A1 (fr) 2016-09-15
US10357491B2 (en) 2019-07-23
IL254262A0 (en) 2017-10-31
SG11201707128TA (en) 2017-09-28
ZA201706035B (en) 2019-12-18
MY194341A (en) 2022-11-29
KR102623404B1 (ko) 2024-01-11

Similar Documents

Publication Publication Date Title
US10357491B2 (en) Method of treating a brain tumor
US11918574B2 (en) Method of treating cancer associated with a RAS mutation
US11707472B2 (en) Compositions for the treatment of fibrosis
CA3101612A1 (fr) Composition et procede de traitement du cancer associe a une mutation egfr
ES2743769T3 (es) Tratamiento medicinal de enfermedades dérmicas en animales de compañía con norketotifeno
US20230310407A1 (en) Radiation mitigator and method of use thereof
EP2982382A1 (fr) Composés pour prévenir l'ototoxicité
NZ749857B2 (en) Method of treating a brain tumor
NZ749857A (en) Method of treating a brain tumor
JP6654773B2 (ja) インターロイキン３６受容体アンタゴニスト欠損症の治療薬

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210302

EEER Examination request

Effective date: 20210302

EEER Examination request

Effective date: 20210302

EEER Examination request

Effective date: 20210302

EEER Examination request

Effective date: 20210302

EEER Examination request

Effective date: 20210302

EEER Examination request

Effective date: 20210302