CA2693742A1 - Molecules pour cibler des composes vers divers organes, tissus ou cellules tumorales selectionnes - Google Patents
Molecules pour cibler des composes vers divers organes, tissus ou cellules tumorales selectionnes Download PDFInfo
- Publication number
- CA2693742A1 CA2693742A1 CA2693742A CA2693742A CA2693742A1 CA 2693742 A1 CA2693742 A1 CA 2693742A1 CA 2693742 A CA2693742 A CA 2693742A CA 2693742 A CA2693742 A CA 2693742A CA 2693742 A1 CA2693742 A1 CA 2693742A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- neuronal
- cells
- moiety
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07112313.7 | 2007-07-12 | ||
| EP07112313 | 2007-07-12 | ||
| PCT/NL2008/050470 WO2009008725A2 (fr) | 2007-07-12 | 2008-07-11 | Molécules pour cibler des composés vers divers organes, tissus ou cellules tumorales sélectionnés |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2693742A1 true CA2693742A1 (fr) | 2009-01-15 |
Family
ID=39433771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2693742A Abandoned CA2693742A1 (fr) | 2007-07-12 | 2008-07-11 | Molecules pour cibler des composes vers divers organes, tissus ou cellules tumorales selectionnes |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8609065B2 (fr) |
| EP (1) | EP2167135A2 (fr) |
| JP (1) | JP2010533170A (fr) |
| CN (1) | CN101790385A (fr) |
| AU (1) | AU2008273094B2 (fr) |
| CA (1) | CA2693742A1 (fr) |
| WO (1) | WO2009008725A2 (fr) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60138535D1 (de) * | 2000-02-04 | 2009-06-10 | Children S Hospital Res Founda | Verwendung von lysosomal acid lipase zur behandlung von atherosklerose und ähnlichen krankheiten |
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| CA2596506C (fr) | 2005-02-09 | 2021-04-06 | Avi Biopharma, Inc. | Composition antisens et methode permettant de traiter une atrophie musculaire |
| WO2007030375A2 (fr) * | 2005-09-08 | 2007-03-15 | Children's Hospital Medical Center | Therapie a base de lipase acide lysosomiale destinee au traitement de la steatose hepatique non alcoolique et de maladies associees |
| CA2660523C (fr) | 2006-08-11 | 2019-03-19 | Prosensa Technologies B.V. | Procedes et moyens de traitement de troubles genetiques associes a l'instabilite des repetitions de l'adn |
| EP3238737B1 (fr) | 2007-10-26 | 2022-04-06 | Academisch Ziekenhuis Leiden | Moyens et procédés de contrecarrage des troubles musculaires |
| EP2119783A1 (fr) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Procédé pour l'omission efficace de l'exon (44) dans la dystrophie musculaire de Duchenne et moyens connexes |
| RU2537262C2 (ru) * | 2009-07-08 | 2014-12-27 | Общество С Ограниченной Ответственностью "Фарма Ген" | Молекулярные конъюгаты с поликатионным участком и лигандом для доставки в клетку и ядро клетки днк и рнк |
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| EP3650039A1 (fr) | 2010-09-09 | 2020-05-13 | Alexion Pharmaceuticals, Inc. | Utilisation de lipase acide lysosomale pour le traitement de la déficience en lipase acide lysosomale chez des patients |
| WO2012112681A1 (fr) | 2011-02-15 | 2012-08-23 | Shire Human Genetic Therapies, Inc. | Procédés de traitement d'un déficit en lipase acide lysosomale |
| US20130085139A1 (en) | 2011-10-04 | 2013-04-04 | Royal Holloway And Bedford New College | Oligomers |
| EP4043039A1 (fr) | 2012-01-27 | 2022-08-17 | BioMarin Technologies B.V. | Oligonucléotides de modulation arn ayant des caractéristiques améliorées pour le traitement de la dystrophie musculaire de duchenne et becker |
| US9475840B2 (en) | 2012-02-27 | 2016-10-25 | Universitat De Barcelona | Protease-resistant compounds useful as shuttles through the blood-brain barrier and shuttle-cargo constructs |
| CN111235149B (zh) | 2013-09-05 | 2024-04-16 | 萨罗塔治疗公司(美国) | 酸性α-葡糖苷酶中反义诱导的外显子2纳入 |
| WO2015120450A1 (fr) * | 2014-02-10 | 2015-08-13 | Ohio State Innovation Foundation | Oligonucléotides antisens dans le traitement de l'amyotrophie spinale |
| EP3221445B1 (fr) | 2014-11-20 | 2021-07-14 | The Regents of The University of California | Compositions et méthodes relatives à la récupération hématologique |
| MA41795A (fr) | 2015-03-18 | 2018-01-23 | Sarepta Therapeutics Inc | Exclusion d'un exon induite par des composés antisens dans la myostatine |
| WO2016196670A1 (fr) | 2015-06-01 | 2016-12-08 | Sarepta Therapeutics, Inc. | Exclusion d'exon induite pat technologie antisens dans le collagène de type vii |
| BR112018007066A2 (pt) | 2015-10-09 | 2018-10-23 | Sarepta Therapeutics Inc | composições e métodos para tratamento da distrofia muscular de duchene e distúrbios relacionados |
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| US10358648B2 (en) | 2016-02-02 | 2019-07-23 | Olix Pharmaceuticals, Inc. | Treatment of atopic dermatitis and asthma using RNA complexes that target IL4Rα, TRPA1, or F2RL1 |
| KR102522059B1 (ko) | 2016-04-18 | 2023-04-14 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 안티센스 올리고머, 및 산성 알파-글루코시다제 유전자와 연관된 질환을 치료하기 위한 이의 사용 방법 |
| CA3022303A1 (fr) | 2016-04-29 | 2017-11-02 | Sarepta Therapeutics, Inc. | Analogues d'oligonucleotide ciblant lmna humain |
| MX2018016052A (es) | 2016-06-30 | 2019-05-02 | Sarepta Therapeutics Inc | Oligomeros de omision de exon para distrofia muscular. |
| WO2018017814A1 (fr) | 2016-07-20 | 2018-01-25 | President And Fellows Of Harvard College | Inhibiteurs de peptidoglycane glycosyltransférase utilisées pour le traitement d'infections bactériennes. |
| WO2018053142A2 (fr) | 2016-09-14 | 2018-03-22 | President And Fellows Of Harvard College | Procédés et compositions pour moduler l'érythropoïèse |
| WO2018112033A1 (fr) | 2016-12-13 | 2018-06-21 | President And Fellows Of Harvard College | Méthodes et compositions pour le ciblage de tregs infiltrant les tumeurs |
| EP4122497B1 (fr) | 2016-12-19 | 2024-04-10 | Sarepta Therapeutics, Inc. | Conjugués d'oligomères induisant le saut d'exons pour la dystrophie musculaire |
| EP3554552B1 (fr) | 2016-12-19 | 2022-08-17 | Sarepta Therapeutics, Inc. | Conjugués oligomères de sauts d'exons pour la dystrophie musculaire |
| PL3554553T3 (pl) | 2016-12-19 | 2022-11-07 | Sarepta Therapeutics, Inc. | Koniugaty oligomerów z pominięciem egzonu w dystrofii mięśniowej |
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| CN110536694A (zh) | 2017-04-20 | 2019-12-03 | Atyr 医药公司 | 用于治疗肺部炎症的组合物和方法 |
| EA201991450A1 (ru) | 2017-09-22 | 2019-12-30 | Сарепта Терапьютикс, Инк. | Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии |
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| EP3687519A1 (fr) | 2017-09-28 | 2020-08-05 | Sarepta Therapeutics, Inc. | Polythérapies pour traiter une dystrophie musculaire |
| US20210145852A1 (en) | 2017-09-28 | 2021-05-20 | Sarepta Therapeutics, Inc. | Combination Therapies for Treating Muscular Dystrophy |
| WO2019079637A2 (fr) | 2017-10-18 | 2019-04-25 | Sarepta Therapeutics, Inc. | Composés oligomères antisens |
| US10765760B2 (en) | 2018-05-29 | 2020-09-08 | Sarepta Therapeutics, Inc. | Exon skipping oligomer conjugates for muscular dystrophy |
| EP4219717A3 (fr) | 2018-06-13 | 2023-12-20 | Sarepta Therapeutics, Inc. | Oligomères à saut d'exon pour la dystrophie musculaire |
| TW202020153A (zh) | 2018-07-27 | 2020-06-01 | 美商薩羅塔治療公司 | 用於肌肉萎縮症之外顯子跳躍寡聚物 |
| US11273137B2 (en) | 2018-09-04 | 2022-03-15 | Board Of Trustees Of Michigan State University | Methods and compositions to prevent and treat disorders associated with mutations in the ODC1 gene |
| WO2020123574A1 (fr) | 2018-12-13 | 2020-06-18 | Sarepta Therapeutics, Inc. | Conjugués oligomères à saut d'exon pour dystrophie musculaire |
| IL295153A (en) | 2019-03-12 | 2022-09-01 | Harvard College | Methods and preparations for the treatment of cancer |
| CA3135170A1 (fr) | 2019-04-05 | 2020-10-08 | Tauc3 Biologics Limited | Anticorps anti-tauc3 et leurs utilisations |
| JP2022528459A (ja) | 2019-04-05 | 2022-06-10 | ビー － ポータル バイオロジクス、インコーポレイテッド | 融合構築物及びその使用 |
| EP3955966A1 (fr) | 2019-04-18 | 2022-02-23 | Sarepta Therapeutics, Inc. | Compositions pour le traitement de la dystrophie musculaire |
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-
2008
- 2008-07-11 WO PCT/NL2008/050470 patent/WO2009008725A2/fr active Application Filing
- 2008-07-11 EP EP08779018A patent/EP2167135A2/fr not_active Withdrawn
- 2008-07-11 CA CA2693742A patent/CA2693742A1/fr not_active Abandoned
- 2008-07-11 AU AU2008273094A patent/AU2008273094B2/en not_active Expired - Fee Related
- 2008-07-11 CN CN200880101820A patent/CN101790385A/zh active Pending
- 2008-07-11 JP JP2010515991A patent/JP2010533170A/ja active Pending
-
2010
- 2010-01-08 US US12/684,534 patent/US8609065B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2167135A2 (fr) | 2010-03-31 |
| WO2009008725A3 (fr) | 2009-08-13 |
| JP2010533170A (ja) | 2010-10-21 |
| CN101790385A (zh) | 2010-07-28 |
| US20100184947A1 (en) | 2010-07-22 |
| WO2009008725A2 (fr) | 2009-01-15 |
| AU2008273094A1 (en) | 2009-01-15 |
| AU2008273094B2 (en) | 2013-05-09 |
| US8609065B2 (en) | 2013-12-17 |
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