CA2628924C - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

Info

Publication number: CA2628924C
Authority: CA; Canada
Prior art keywords: parent; ions; precursor ions; ion; mass
Prior art date: 2005-11-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

CA2628924A

Other languages

English (en)

French (fr)

Other versions

CA2628924A1 (en

Inventor

Robert Harold Bateman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Micromass UK Ltd

Original Assignee

Micromass UK Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-23

Filing date

2006-11-23

Publication date

2017-09-05

2005-11-23 Priority claimed from US11/286,141 external-priority patent/US20060151689A1/en

2006-11-23 Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd

2006-11-23 Priority to CA2835314A priority Critical patent/CA2835314A1/en

2007-05-31 Publication of CA2628924A1 publication Critical patent/CA2628924A1/en

2017-09-05 Application granted granted Critical

2017-09-05 Publication of CA2628924C publication Critical patent/CA2628924C/en

Status Active legal-status Critical Current

2026-11-23 Anticipated expiration legal-status Critical

Links

150000002500 ions Chemical class 0.000 claims abstract description 1125
238000013467 fragmentation Methods 0.000 claims abstract description 366
238000006062 fragmentation reaction Methods 0.000 claims abstract description 366
238000006243 chemical reaction Methods 0.000 claims abstract description 245
238000010494 dissociation reaction Methods 0.000 claims abstract description 50
230000005593 dissociations Effects 0.000 claims abstract description 50
238000000034 method Methods 0.000 claims abstract description 45
238000001211 electron capture detection Methods 0.000 claims abstract description 36
238000001077 electron transfer detection Methods 0.000 claims abstract description 36
238000004949 mass spectrometry Methods 0.000 claims abstract description 19
239000002243 precursor Substances 0.000 claims description 507
239000012634 fragment Substances 0.000 claims description 223
238000005040 ion trap Methods 0.000 claims description 32
239000003153 chemical reaction reagent Substances 0.000 claims description 18
238000001360 collision-induced dissociation Methods 0.000 claims description 14
230000005855 radiation Effects 0.000 claims description 12
238000011144 upstream manufacturing Methods 0.000 claims description 12
238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 10
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238000010265 fast atom bombardment Methods 0.000 claims description 6
238000009616 inductively coupled plasma Methods 0.000 claims description 6
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BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 15
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NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 3
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NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 3
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SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
238000002545 neutral loss scan Methods 0.000 description 2
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BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
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102000002068 Glycopeptides Human genes 0.000 description 1
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102000003886 Glycoproteins Human genes 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
ILZZTQYNTRWQSJ-UHFFFAOYSA-N Phe-Phe-Val-Ala-Pro-Phe-Pro-Glu-Val-Phe-Gly-Lys Natural products CC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(N)Cc2ccccc2)C(=O)NC(C)C(=O)N3CCCC3C(=O)NC(Cc4ccccc4)C(=O)N5CCCC5C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)NC(Cc6ccccc6)C(=O)NCC(=O)NC(CCCCN)C(=O)O ILZZTQYNTRWQSJ-UHFFFAOYSA-N 0.000 description 1
102000006382 Ribonucleases Human genes 0.000 description 1
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238000005349 anion exchange Methods 0.000 description 1
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238000005341 cation exchange Methods 0.000 description 1
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Classifications

- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H01J49/0068—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with a surface, e.g. surface induced dissociation
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes

Landscapes

Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nanotechnology (AREA)
Condensed Matter Physics & Semiconductors (AREA)
Composite Materials (AREA)
General Physics & Mathematics (AREA)
Materials Engineering (AREA)
Crystallography & Structural Chemistry (AREA)
Physics & Mathematics (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Electron Tubes For Measurement (AREA)

CA2628924A 2005-11-23 2006-11-23 Mass spectrometer Active CA2628924C (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA2835314A CA2835314A1 (en)	2005-11-23	2006-11-23	Mass spectrometer

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US11/286,141 US20060151689A1 (en)	2002-07-24	2005-11-23	Mass spectrometer
GBGB0523806.8A GB0523806D0 (en)	2005-11-23	2005-11-23	Mass spectrometer
GB0523806.8		2005-11-23
US11/286,141		2005-11-23
PCT/GB2006/004362 WO2007060421A2 (en)	2005-11-23	2006-11-23	Mass spectrometer

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2835314A Division CA2835314A1 (en)	2005-11-23	2006-11-23	Mass spectrometer

Publications (2)

Publication Number	Publication Date
CA2628924A1 CA2628924A1 (en)	2007-05-31
CA2628924C true CA2628924C (en)	2017-09-05

Family

ID=35601028

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CA2628924A Active CA2628924C (en)	2005-11-23	2006-11-23	Mass spectrometer
CA2835314A Abandoned CA2835314A1 (en)	2005-11-23	2006-11-23	Mass spectrometer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CA2835314A Abandoned CA2835314A1 (en)	2005-11-23	2006-11-23	Mass spectrometer

Country Status (5)

Country	Link
EP (1)	EP1952422A2 (ja)
JP (1)	JP4959712B2 (ja)
CA (2)	CA2628924C (ja)
GB (4)	GB0523806D0 (ja)
WO (1)	WO2007060421A2 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201122178D0 (en)	2011-12-22	2012-02-01	Thermo Fisher Scient Bremen	Method of tandem mass spectrometry
CN104813162B (zh) *	2012-11-22	2017-03-08	株式会社岛津制作所	串联四极型质量分析装置
US9352020B2 (en)	2013-03-15	2016-05-31	Mead Johnson Nutrition Company	Reducing proinflammatory response
US9289461B2 (en)	2013-03-15	2016-03-22	Mead Johnson Nutrition Company	Reducing the risk of autoimmune disease
US8889633B2 (en)	2013-03-15	2014-11-18	Mead Johnson Nutrition Company	Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
US9138455B2 (en)	2013-03-15	2015-09-22	Mead Johnson Nutrition Company	Activating adiponectin by casein hydrolysate
CN104345107B (zh) *	2013-07-24	2016-08-17	上海科倍斯生物科技有限公司	一种乳或乳制品中牛乳血清白蛋白定量检测试剂盒
US9991103B2 (en)	2014-04-23	2018-06-05	Micromass Uk Limited	Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences
GB201407123D0 (en) *	2014-04-23	2014-06-04	Micromass Ltd	Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences
US11335547B2 (en) *	2018-04-10	2022-05-17	Dh Technologies Development Pte. Ltd.	Top down analysis of antibodies in mass spectrometry

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3300602B2 (ja) *	1996-06-20	2002-07-08	株式会社日立製作所	大気圧イオン化イオントラップ質量分析方法及び装置
JP2000241390A (ja) *	1999-02-17	2000-09-08	Japan Atom Energy Res Inst	中性種の解離を用いる電荷逆転質量分析法
US6545268B1 (en) *	2000-04-10	2003-04-08	Perseptive Biosystems	Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
CA2340150C (en) *	2000-06-09	2005-11-22	Micromass Limited	Methods and apparatus for mass spectrometry
ATE321356T1 (de) *	2001-03-22	2006-04-15	Univ Syddansk	Massenspektrometrisches verfahren mit elektroneneinfang durch ionen und massenspektrometer zum durchführen des verfahrens
US6744040B2 (en) *	2001-06-13	2004-06-01	Bruker Daltonics, Inc.	Means and method for a quadrupole surface induced dissociation quadrupole time-of-flight mass spectrometer
GB0121172D0 (en) *	2001-08-31	2001-10-24	Shimadzu Res Lab Europe Ltd	A method for dissociating ions using a quadrupole ion trap device
JP4161125B2 (ja) *	2002-04-24	2008-10-08	滋雄早川	質量分析法および質量分析装置
CA2643534C (en) *	2002-05-31	2011-08-02	Analytica Of Branford, Inc.	Fragmentation methods for mass spectrometry
GB2390935A (en) *	2002-07-16	2004-01-21	Anatoli Nicolai Verentchikov	Time-nested mass analysis using a TOF-TOF tandem mass spectrometer
GB0305796D0 (en) *	2002-07-24	2003-04-16	Micromass Ltd	Method of mass spectrometry and a mass spectrometer
AU2002952747A0 (en) *	2002-11-18	2002-12-05	Ludwig Institute For Cancer Research	Method for analysing peptides
GB2402260B (en) *	2003-05-30	2006-05-24	Thermo Finnigan Llc	All mass MS/MS method and apparatus
JP4275545B2 (ja) *	2004-02-17	2009-06-10	株式会社日立ハイテクノロジーズ	質量分析装置
EP2239574A1 (en) *	2004-03-12	2010-10-13	University Of Virginia Patent Foundation	Electron transfer dissociation for biopolymer sequence analysis

2005
- 2005-11-23 GB GBGB0523806.8A patent/GB0523806D0/en not_active Ceased
2006
- 2006-11-23 GB GB0801093A patent/GB2443571B/en active Active
- 2006-11-23 WO PCT/GB2006/004362 patent/WO2007060421A2/en active Application Filing
- 2006-11-23 JP JP2008541816A patent/JP4959712B2/ja not_active Expired - Fee Related
- 2006-11-23 GB GB0623376A patent/GB2435713B/en active Active
- 2006-11-23 GB GB0816195A patent/GB2451962B/en active Active
- 2006-11-23 CA CA2628924A patent/CA2628924C/en active Active
- 2006-11-23 CA CA2835314A patent/CA2835314A1/en not_active Abandoned
- 2006-11-23 EP EP06808640A patent/EP1952422A2/en not_active Withdrawn

Also Published As

Publication number	Publication date
GB0523806D0 (en)	2006-01-04
WO2007060421A2 (en)	2007-05-31
GB0623376D0 (en)	2007-01-03
GB2443571A (en)	2008-05-07
JP2009516842A (ja)	2009-04-23
GB2443571B (en)	2010-05-12
GB2451962B (en)	2010-02-17
EP1952422A2 (en)	2008-08-06
JP4959712B2 (ja)	2012-06-27
GB0816195D0 (en)	2008-10-15
GB2435713A (en)	2007-09-05
GB0801093D0 (en)	2008-02-27
GB2451962A (en)	2009-02-18
CA2628924A1 (en)	2007-05-31
WO2007060421A3 (en)	2008-05-08
CA2835314A1 (en)	2007-05-31
GB2435713B (en)	2010-06-16

Legal Events

Date	Code	Title	Description
2011-11-18	EEER	Examination request

Publication	Publication Date	Title
US10083825B2 (en)	2018-09-25	Mass spectrometer with bypass of a fragmentation device
US7928363B2 (en)	2011-04-19	Mass spectrometer
CA2628924C (en)	2017-09-05	Mass spectrometer
CA2628927C (en)	2017-09-05	Mass spectrometer