CA2603830A1 - Pyridine [2,3-b] pyrazinones - Google Patents

Pyridine [2,3-b] pyrazinones Download PDF

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Publication number
CA2603830A1
CA2603830A1 CA002603830A CA2603830A CA2603830A1 CA 2603830 A1 CA2603830 A1 CA 2603830A1 CA 002603830 A CA002603830 A CA 002603830A CA 2603830 A CA2603830 A CA 2603830A CA 2603830 A1 CA2603830 A1 CA 2603830A1
Authority
CA
Canada
Prior art keywords
pyrazinones
pyridino
pde
inhibitors
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA002603830A
Other languages
English (en)
Inventor
Andrew Simon Bell
Brent Virgil Mischke
Alan George Benson
Dafydd Rhys Owen
Yvette Marlene Fobian
Michael John Palmer
John Major Molyneaux
Joseph Blair Moon
Christopher Phillips
David Louis Brown
John Keith Walker
Michael Brent Tollefson
Todd Michael Maddux
David Graham Brown
John Nicholas Freskos
Steven Edward Heasley
Donald Joseph Rogier Jr
Robert Owen Hughes
Eric Jon Jacobsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of CA2603830A1 publication Critical patent/CA2603830A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
CA002603830A 2005-05-24 2006-05-17 Pyridine [2,3-b] pyrazinones Pending CA2603830A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68413005P 2005-05-24 2005-05-24
PCT/IB2006/001386 WO2006126081A2 (fr) 2005-05-24 2006-05-17 Pyridine [2,3-b] pyrazinones

Publications (1)

Publication Number Publication Date
CA2603830A1 true CA2603830A1 (fr) 2006-11-30

Family

ID=37046762

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002603830A Pending CA2603830A1 (fr) 2005-05-24 2006-05-17 Pyridine [2,3-b] pyrazinones

Country Status (2)

Country Link
CA (1) CA2603830A1 (fr)
WO (1) WO2006126081A2 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100210643A1 (en) * 2007-05-12 2010-08-19 Bayer Schering Pharma Aktiengesellschaft sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS
EP2247292B1 (fr) * 2008-03-05 2017-04-12 Merck Patent GmbH Dérivés de pyridopyrazinone comme stimulateurs de la sécrétion d insuline, leurs procédés d obtention et leur utilisation pour le traitement du diabète
AU2009278442B2 (en) 2008-08-05 2013-09-26 Daiichi Sankyo Company, Limited Imidazopyridin-2-one Derivatives
CN101747282A (zh) 2008-12-10 2010-06-23 上海特化医药科技有限公司 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途
WO2012131539A1 (fr) 2011-03-31 2012-10-04 Pfizer Inc. Nouvelles pyridones bicycliques
WO2012172449A1 (fr) 2011-06-13 2012-12-20 Pfizer Inc. Lactames convenant comme inhibiteurs des bêta-sécrétases
ES2605565T3 (es) 2011-08-31 2017-03-15 Pfizer Inc Compuestos de hexahidropirano [3,4-D][1,3]tiazin-2-amina
WO2013164730A1 (fr) 2012-05-04 2013-11-07 Pfizer Inc. Composés d'hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitués par des hétérocycliques à titre d'inhibiteurs d'app, bace1 et bace2
JP2015529239A (ja) 2012-09-20 2015-10-05 ファイザー・インク アルキル置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
CA2893256A1 (fr) 2012-12-11 2014-06-19 Pfizer Inc. Composes d'hexahydropyrano [3,4-d][1,3]thiazin-2-amine en tant qu'inhibiteurs de bace1
CA2893333C (fr) 2012-12-19 2017-10-24 Pfizer Inc. Composes hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitues carbocycliques et heterocycliques
EP2956458B1 (fr) 2013-02-13 2017-08-09 Pfizer Inc Composés hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitués par un hétéroaryle
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
KR20150119370A (ko) 2013-02-19 2015-10-23 화이자 인코포레이티드 Cns 장애 및 다른 장애의 치료를 위한 pde4 동종효소의 억제제로서의 아자벤즈이미다졸 화합물
CA2925743C (fr) 2013-10-04 2018-03-06 Pfizer Inc. Nouvelles pyridinones bicycliques utilisees comme modulateurs de gamma-secretase
AP2016009465A0 (en) 2014-04-01 2016-09-30 Pfizer Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators
WO2015155626A1 (fr) 2014-04-10 2015-10-15 Pfizer Inc. Amides 2-amino-6-méthyl-4,4a,5,6-tétrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl-1,3-thiazol-4-yle
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
PE20170295A1 (es) 2014-08-06 2017-03-30 Pfizer Compuestos de imidazopiridazina
AU2016214102B2 (en) 2015-02-03 2018-09-27 Pfizer Inc. Novel cyclopropabenzofuranyl pyridopyrazinediones
CR20170572A (es) 2015-06-17 2018-03-20 Pfizer Compuestos tricíclicos y su uso como inhibidores de la fosfodiesterasa
JP2018531924A (ja) 2015-09-24 2018-11-01 ファイザー・インク テトラヒドロピラノ［３，４−ｄ］［１，３］オキサジン誘導体、およびｂａｃｅ阻害剤としてのその使用
AU2016325665A1 (en) 2015-09-24 2018-03-08 Pfizer Inc. N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3] thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl] amides
JP2018534251A (ja) 2015-09-24 2018-11-22 ファイザー・インク Ｂａｃｅ阻害剤として有用なｎ−［２−（３−アミノ−２，５−ジメチル−１，１−ジオキシド−５，６−ジヒドロ−２ｈ−１，２，４−チアジアジン−５−イル）−１，３−チアゾール−４−イル］アミド
ES2775674T3 (es) 2016-02-23 2020-07-27 Pfizer Compuestos de 6,7-dihidro-5H-pirazolo[5,1-b][1,3]oxazina-2-carboxamida
EP3872078A1 (fr) 2016-07-01 2021-09-01 Pfizer Inc. Dérivés de 5,7-dihydro-pyrrolo-pyridine destinés à être utilisés dans le traitement de la dépression, l'angoisse et les troubles paniques
DK3642202T3 (da) 2017-06-22 2023-01-30 Pfizer Dihydro-pyrrolo-pyridin-derivater
CN109400463B (zh) * 2017-08-16 2021-10-22 北京颖泰嘉和生物科技股份有限公司 2-正丙氧基乙酰氯的制备方法
ES2942837T3 (es) 2018-03-23 2023-06-07 Pfizer Derivados de azaespiro piperazina
MX2021008661A (es) * 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

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GB9413975D0 (en) * 1994-07-11 1994-08-31 Fujisawa Pharmaceutical Co New heterobicyclic derivatives
GB9526558D0 (en) * 1995-12-27 1996-02-28 Fujisawa Pharmaceutical Co Heterobicyclic derivatives
US6465465B1 (en) * 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
EP1364950A4 (fr) * 2001-02-26 2005-03-09 Tanabe Seiyaku Co Derive de pyridopyrimidine ou naphthyridine

Also Published As

Publication number Publication date
WO2006126081A2 (fr) 2006-11-30
WO2006126081A3 (fr) 2007-01-18

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