CA2466033A1 - Methode de traitement de troubles lies a un taux de cholesterol eleve - Google Patents
Methode de traitement de troubles lies a un taux de cholesterol eleve Download PDFInfo
- Publication number
- CA2466033A1 CA2466033A1 CA002466033A CA2466033A CA2466033A1 CA 2466033 A1 CA2466033 A1 CA 2466033A1 CA 002466033 A CA002466033 A CA 002466033A CA 2466033 A CA2466033 A CA 2466033A CA 2466033 A1 CA2466033 A1 CA 2466033A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- compound
- alkyl
- hydroxy
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
L'invention concerne une méthode destinée à traiter des troubles liés à un taux de cholestérol élevé. Cette méthode consiste à administrer à un sujet nécessitant un traitement un composé de formule (I). L'invention concerne également des procédés, des nécessaires, des combinaisons et des compositions qui sont utilisés pour traiter des troubles chez un sujet lorsqu'un activateur du récepteur alpha X du foie est indiqué, par exemple pour traiter une maladie liée à un taux de cholestérol élevé.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34802001P | 2001-11-08 | 2001-11-08 | |
US60/348,019 | 2001-11-08 | ||
PCT/US2002/035900 WO2003039480A2 (fr) | 2001-11-08 | 2002-11-08 | Methode de traitement de troubles lies a un taux de cholesterol eleve |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2466033A1 true CA2466033A1 (fr) | 2003-05-15 |
Family
ID=23366328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002466033A Abandoned CA2466033A1 (fr) | 2001-11-08 | 2002-11-08 | Methode de traitement de troubles lies a un taux de cholesterol eleve |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1450816A4 (fr) |
JP (1) | JP2005508368A (fr) |
CA (1) | CA2466033A1 (fr) |
TW (1) | TW200300078A (fr) |
WO (1) | WO2003039480A2 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7078396B2 (en) | 2001-05-03 | 2006-07-18 | Arch Development Corporation | Method of treating disorder related to high cholesterol concentration |
US8399441B2 (en) | 2004-10-25 | 2013-03-19 | Virginia Commonwealth University | Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis |
WO2006047022A1 (fr) | 2004-10-25 | 2006-05-04 | Virginia Commonwealth University | Oxysterol sulfate nucleaire, regulateur homeostatique du cholesterol agissant puissamment dans le traitement de l'hypercholesterolemie, de l'hyperlipidemie et de l'atherosclerose |
US7923573B2 (en) | 2004-10-27 | 2011-04-12 | Daiichi Sankyo Company, Limited | Benzene compound having 2 or more substituents |
CA2668661A1 (fr) | 2006-11-13 | 2008-05-29 | Novartis Ag | Composes de pyrazole et de triazole substitues comme inhibiteurs de ksp |
CA2769203A1 (fr) | 2009-07-29 | 2011-02-03 | University Of Chicago | Agonistes du recepteur x du foie |
US9034859B2 (en) | 2011-04-06 | 2015-05-19 | Virginia Commonwealth University | Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation |
BR112014005373B1 (pt) * | 2011-09-08 | 2022-04-19 | Sage Therapeutics, Inc | Compostos esteróides neuroativos, composições e usos destes |
EP3865135A3 (fr) * | 2013-03-13 | 2021-11-03 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs destinés à l'utilisation thérapeutique |
EP2968369B1 (fr) | 2013-03-13 | 2018-08-29 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs et leurs procédés d'utilisation |
JP2016193835A (ja) * | 2013-09-04 | 2016-11-17 | 学校法人常翔学園 | 核内受容体肝臓x受容体アゴニスト |
TWI816417B (zh) | 2013-12-24 | 2023-09-21 | 維吉尼亞聯邦大學 | 氧化膽固醇硫酸鹽(ocs)之用途 |
US10259840B2 (en) | 2014-06-18 | 2019-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
SI3319612T1 (sl) | 2015-07-06 | 2021-11-30 | Sage Therapeutics, Inc. | Oksisteroli in postopki za uporabo le-teh |
MX2020011449A (es) | 2015-07-06 | 2022-02-28 | Sage Therapeutics Inc | Oxiesteroles y metodos de uso de los mismos. |
US10696712B2 (en) | 2015-07-06 | 2020-06-30 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
DK3436022T3 (da) | 2016-04-01 | 2022-06-20 | Sage Therapeutics Inc | Oxysteroler og fremgangsmåder til anvendelse heraf |
WO2017193046A1 (fr) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxystérols et méthodes d'utilisation associées |
ES2884071T3 (es) | 2016-07-07 | 2021-12-10 | Sage Therapeutics Inc | 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA |
JP2019524772A (ja) | 2016-08-02 | 2019-09-05 | ヴァージニア コモンウェルス ユニバーシティ | 5−コレステン−3,25−ジオール,3−サルフェート(25hc3s)又は薬学的に許容される塩及び少なくとも1種の環状オリゴ糖を含む組成物 |
JP7149266B2 (ja) | 2016-09-30 | 2022-10-06 | セージ セラピューティクス, インコーポレイテッド | C7置換オキシステロールおよびnmdaモジュレーターとしての方法 |
CA3041077A1 (fr) | 2016-10-18 | 2018-04-26 | Sage Therapeutics, Inc. | Oxysterols et leurs procedes d'utilisation |
RU2019115113A (ru) | 2016-10-18 | 2020-11-24 | Сейдж Терапьютикс, Инк. | Оксистеролы и способы их применения |
GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4976857A (fr) * | 1972-12-06 | 1974-07-24 | ||
US3963765A (en) * | 1973-04-01 | 1976-06-15 | Yehuda Mazur | Preparation of derivatives of cholesterol |
US4217288A (en) * | 1977-03-24 | 1980-08-12 | Wisconsin Alumni Research Foundation | Anti-vitamin D compounds |
JPS61254599A (ja) * | 1985-05-07 | 1986-11-12 | Sumitomo Pharmaceut Co Ltd | コレステロ−ルのフツ素誘導体 |
IL105050A0 (en) * | 1992-03-27 | 1993-07-08 | Lilly Co Eli | Steroid derivatives |
IT1255241B (it) * | 1992-07-22 | 1995-10-20 | Simos Contos | Derivato di acido biliare e suo uso in terapia |
JP2002543216A (ja) * | 1999-04-30 | 2002-12-17 | アーチ ディベロップメント コーポレイション | ステロイド誘導体 |
PT1392713E (pt) * | 2001-05-03 | 2008-01-25 | Univ Chicago | ''agonistas de receptores x hepáticos'' |
-
2002
- 2002-11-08 EP EP02802882A patent/EP1450816A4/fr not_active Withdrawn
- 2002-11-08 JP JP2003541772A patent/JP2005508368A/ja active Pending
- 2002-11-08 WO PCT/US2002/035900 patent/WO2003039480A2/fr active Application Filing
- 2002-11-08 CA CA002466033A patent/CA2466033A1/fr not_active Abandoned
- 2002-11-08 TW TW091132850A patent/TW200300078A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2003039480A2 (fr) | 2003-05-15 |
JP2005508368A (ja) | 2005-03-31 |
WO2003039480A3 (fr) | 2003-06-19 |
TW200300078A (en) | 2003-05-16 |
EP1450816A2 (fr) | 2004-09-01 |
EP1450816A4 (fr) | 2008-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |