CA2369272A1 - Compositions medicinales et leur procede de preparation - Google Patents
Compositions medicinales et leur procede de preparation Download PDFInfo
- Publication number
- CA2369272A1 CA2369272A1 CA002369272A CA2369272A CA2369272A1 CA 2369272 A1 CA2369272 A1 CA 2369272A1 CA 002369272 A CA002369272 A CA 002369272A CA 2369272 A CA2369272 A CA 2369272A CA 2369272 A1 CA2369272 A1 CA 2369272A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- glycoalkaloid
- group
- bec
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 109
- 238000000034 method Methods 0.000 title claims description 47
- 238000002360 preparation method Methods 0.000 title claims description 25
- 229930008677 glyco alkaloid Natural products 0.000 claims abstract description 74
- 235000000346 sugar Nutrition 0.000 claims abstract description 54
- 150000008163 sugars Chemical class 0.000 claims abstract description 25
- 150000001875 compounds Chemical class 0.000 claims abstract description 17
- 230000003993 interaction Effects 0.000 claims abstract description 5
- 238000011282 treatment Methods 0.000 claims description 55
- 206010028980 Neoplasm Diseases 0.000 claims description 50
- 210000004027 cell Anatomy 0.000 claims description 32
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 27
- JXWLYDNHVXFBJA-UHFFFAOYSA-N solasodine Natural products CC1CCC2(NC1)NC3CC4C5CC=C6CC(O)CCC6(C)C5CCC4(C)C3C2C JXWLYDNHVXFBJA-UHFFFAOYSA-N 0.000 claims description 27
- -1 enol salts Chemical class 0.000 claims description 24
- 229930182470 glycoside Natural products 0.000 claims description 24
- KNLOWJPFLKGYGQ-UHFFFAOYSA-N Solasodine 3-O-??-L-rhamnopyranosyl (1‘Â∆2)-O-[??-D-glucopyranosyl (1‘Â∆4)]-??-D-glucopyranoside Natural products O1C2(NCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC(C(C1O)OC2C(C(O)C(O)C(C)O2)O)OC(CO)C1OC1OC(CO)C(O)C(O)C1O KNLOWJPFLKGYGQ-UHFFFAOYSA-N 0.000 claims description 16
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- QCTMYNGDIBTNSK-QCNFCIKQSA-N Solasonine Natural products O([C@@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O2)[C@@H](O[C@@H]2CC=3[C@@](C)([C@@H]4[C@H]([C@H]5[C@@](C)([C@H]6[C@@H](C)[C@@]7(O[C@H]6C5)NC[C@H](C)CC7)CC4)CC=3)CC2)O[C@@H](CO)[C@@H]1O)[C@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 QCTMYNGDIBTNSK-QCNFCIKQSA-N 0.000 claims description 16
- RCTKRNCKOYYRIO-UHFFFAOYSA-N alpha-Solamarine Natural products O1C2(NCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC(C1O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O RCTKRNCKOYYRIO-UHFFFAOYSA-N 0.000 claims description 16
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- MBWUSSKCCUMJHO-ZGXDEBHDSA-N Solamargine Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@H](O)[C@@H](O)[C@H](C)O1)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@H]5[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]([C@]1(NC[C@H](C)CC1)O5)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O MBWUSSKCCUMJHO-ZGXDEBHDSA-N 0.000 claims description 15
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- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 claims description 15
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- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 12
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- 230000002159 abnormal effect Effects 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
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- 239000000463 material Substances 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 206010040882 skin lesion Diseases 0.000 claims description 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical group O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 4
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Chemical group OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 4
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Chemical group OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 4
- 239000007857 degradation product Substances 0.000 claims description 4
- MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical group OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 claims description 4
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- 231100000444 skin lesion Toxicity 0.000 claims description 4
- 206010004146 Basal cell carcinoma Diseases 0.000 claims description 3
- 208000001126 Keratosis Diseases 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
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- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- PDAMYJQSVHOENP-QWWPJTHSSA-N C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H]3O[C@H](CCC(CN)C)[C@@H](C)[C@@H]3[C@@]1(C)CC2 Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H]3O[C@H](CCC(CN)C)[C@@H](C)[C@@H]3[C@@]1(C)CC2 PDAMYJQSVHOENP-QWWPJTHSSA-N 0.000 description 1
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- ZGVSETXHNHBTRK-OTYSSXIJSA-N solanine Chemical compound O([C@H]1[C@@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@@H]1[C@@H]([C@H](O)[C@@H](O)[C@H](C)O1)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5N6C[C@@H](C)CC[C@@H]6[C@H]([C@@H]5[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O ZGVSETXHNHBTRK-OTYSSXIJSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Cette invention se rapporte à une composition médicinale comprenant au moins un composé pouvant interagir avec une cellule cible, ce ou ces composés étant constitués par un glycoalcaloïde, représenté par la formule générale (I), où cette composition est essentiellement exempte de sucres libres empêchant l'interaction entre le ou les glycoalcaloïdes et une cellule cible.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPP9686 | 1999-04-09 | ||
AUPP9686A AUPP968699A0 (en) | 1999-04-09 | 1999-04-09 | Therapeutic compositions and method for their preparation |
PCT/AU2000/000300 WO2000061153A1 (fr) | 1999-04-09 | 2000-04-10 | Compositions medicinales et leur procede de preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2369272A1 true CA2369272A1 (fr) | 2000-10-19 |
Family
ID=3813885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002369272A Abandoned CA2369272A1 (fr) | 1999-04-09 | 2000-04-10 | Compositions medicinales et leur procede de preparation |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1181022A4 (fr) |
AU (1) | AUPP968699A0 (fr) |
CA (1) | CA2369272A1 (fr) |
WO (1) | WO2000061153A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9923076D0 (en) | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
EP1430073B1 (fr) | 2001-09-28 | 2005-12-07 | GlycoMed Sciences Limited | Procede d'extraction de solvant |
WO2003030915A1 (fr) * | 2001-10-09 | 2003-04-17 | Glycomed Sciences Limited | Utilisation de solamargine pour le traitement de tumeurs de la peau |
WO2003030884A2 (fr) * | 2001-10-09 | 2003-04-17 | Glycomed Sciences Limited | Utilisation de solasonine |
US6984725B2 (en) | 2002-06-28 | 2006-01-10 | Solbec Pharmaceuticals Ltd. | Method for the separation of triglycoalkaloids |
AUPS326302A0 (en) * | 2002-06-28 | 2002-07-18 | Solbec Pharmaceuticals Limited | Method for the separation of solamargine and solasonine |
AU2003900194A0 (en) * | 2003-01-15 | 2003-01-30 | Solbec Pharmaceuticals Limited | Methods of modulating il-6 |
TWI300352B (en) | 2003-06-05 | 2008-09-01 | G & E Herbal Biotechnology Co Ltd | Water soluble extract from plant of solanum genus and the preparation process thereof, and pharmaceutical composition containing the water soluble extract |
EP1508334B1 (fr) * | 2003-08-22 | 2010-03-17 | G & E Herbal Biotechnology Co., Ltd. | Extrait soluble dans l'eau de solanum, procédé de préparation et composition pharmaceutique de l'extrait hydrosoluble |
GB0329667D0 (en) | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
US20080182801A1 (en) | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
GB0513881D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
EP1858526A1 (fr) * | 2005-03-02 | 2007-11-28 | Solbec Pharmaceuticals Limited | Combinaisons d'un glycoalcaloïde et d'un agoniste de tlr et diverses applications desdites combinaisons |
GB0513888D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
WO2007038421A2 (fr) * | 2005-09-27 | 2007-04-05 | University Of Kentucky Research Foundation | Preparations et extraits de baies |
TWI414304B (zh) * | 2011-05-04 | 2013-11-11 | G & E Herbal Biotechnology Co Ltd | 使用茄屬植物的水溶性萃取物來治療疣 |
TWI476012B (zh) * | 2011-05-12 | 2015-03-11 | G & E Herbal Biotechnology Co Ltd | 使用茄屬植物的水溶性萃取物來治療和/或預防發炎與皮膚光損害以及光防護皮膚 |
AU2012268036B2 (en) * | 2011-06-06 | 2017-04-06 | THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF STATE OF THE DEPARTMENT OF VETERANS AFFAIRS | Methods of inhibiting muscle atrophy |
CN105192820A (zh) * | 2015-08-20 | 2015-12-30 | 泰山医学院 | 一种降血脂蛹虫草多糖饮料及其制备方法 |
WO2017147659A1 (fr) | 2016-03-03 | 2017-09-08 | Bill Elliot Cham | Combinaisons de glycoalcaloïdes et leurs diverses utilisations |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU540812B2 (en) * | 1979-05-02 | 1984-12-06 | Aruba Qld Pty. Ltd. | Steroid alkaloids |
SG50585A1 (en) * | 1990-01-18 | 1998-07-20 | Cura Nominees Pty Ltd | Glycoalkaloids |
-
1999
- 1999-04-09 AU AUPP9686A patent/AUPP968699A0/en not_active Abandoned
-
2000
- 2000-04-10 EP EP00913972A patent/EP1181022A4/fr not_active Withdrawn
- 2000-04-10 WO PCT/AU2000/000300 patent/WO2000061153A1/fr active IP Right Grant
- 2000-04-10 CA CA002369272A patent/CA2369272A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000061153A1 (fr) | 2000-10-19 |
EP1181022A1 (fr) | 2002-02-27 |
AUPP968699A0 (en) | 1999-05-06 |
EP1181022A4 (fr) | 2004-02-11 |
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Legal Events
Date | Code | Title | Description |
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EEER | Examination request | ||
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 20100930 |