CA2320403A1 - Amelioration de la demi-vie circulante de proteines hybrides a base d'anticorps - Google Patents

Amelioration de la demi-vie circulante de proteines hybrides a base d'anticorps Download PDF

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Publication number
CA2320403A1
CA2320403A1 CA002320403A CA2320403A CA2320403A1 CA 2320403 A1 CA2320403 A1 CA 2320403A1 CA 002320403 A CA002320403 A CA 002320403A CA 2320403 A CA2320403 A CA 2320403A CA 2320403 A1 CA2320403 A1 CA 2320403A1
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CA
Canada
Prior art keywords
xaa xaa
antibody
fusion protein
protein
based fusion
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Abandoned
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CA002320403A
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English (en)
Inventor
Stephen D. Gillies
Kin-Ming Lo
Yan Lan
John Wesolowski
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Merck Patent GmbH
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Individual
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Publication of CA2320403A1 publication Critical patent/CA2320403A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

On décrit des procédés de construction génétique et d'expression de protéines hybrides à base d'anticorps ayant une demi-vie circulante améliorée. Les protéines hybrides de l'invention sont incapables de se lier aux récepteurs pour le fragment Fc des immunoglobulines, soit en conséquence de l'utilisation de l'isotype des anticorps pour construire la protéine hybride, soit par mutagenèse dirigée des isotypes des anticorps qui se lient normalement aux récepteurs pour le fragment Fc. Les protéines hybrides de l'invention peuvent également contenir un domaine fonctionnel capable de lier un récepteur de protection des immunoglobulines.
CA002320403A 1998-02-25 1999-02-24 Amelioration de la demi-vie circulante de proteines hybrides a base d'anticorps Abandoned CA2320403A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7588798P 1998-02-25 1998-02-25
US60/075,887 1998-02-25
PCT/US1999/003966 WO1999043713A1 (fr) 1998-02-25 1999-02-24 Amelioration de la demi-vie circulante de proteines hybrides a base d'anticorps

Publications (1)

Publication Number Publication Date
CA2320403A1 true CA2320403A1 (fr) 1999-09-02

Family

ID=22128576

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002320403A Abandoned CA2320403A1 (fr) 1998-02-25 1999-02-24 Amelioration de la demi-vie circulante de proteines hybrides a base d'anticorps

Country Status (12)

Country Link
EP (1) EP1060194A1 (fr)
JP (1) JP2002505086A (fr)
CN (1) CN1204147C (fr)
AU (1) AU758240B2 (fr)
BR (1) BR9908226A (fr)
CA (1) CA2320403A1 (fr)
CZ (1) CZ20003099A3 (fr)
HK (1) HK1036286A1 (fr)
HU (1) HUP0100813A3 (fr)
NO (1) NO20004218L (fr)
PL (1) PL199659B1 (fr)
WO (1) WO1999043713A1 (fr)

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PL199659B1 (pl) 2008-10-31
HUP0100813A2 (hu) 2001-06-28
BR9908226A (pt) 2000-10-24
CZ20003099A3 (cs) 2002-04-17
JP2002505086A (ja) 2002-02-19
HUP0100813A3 (en) 2003-08-28
PL342497A1 (en) 2001-06-04
NO20004218L (no) 2000-10-24
AU2784299A (en) 1999-09-15
EP1060194A1 (fr) 2000-12-20
AU758240B2 (en) 2003-03-20

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